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161.
Lisa R. Sammaritano Bonnie L. Bermas Eliza E. Chakravarty Christina Chambers Megan E. B. Clowse Michael D. Lockshin Wendy Marder Gordon Guyatt D. Ware Branch Jill Buyon Lisa Christopher‐Stine Rachelle Crow‐Hercher John Cush Maurice Druzin Arthur Kavanaugh Carl A. Laskin Lauren Plante Jane Salmon Julia Simard Emily C. Somers Virginia Steen Sara K. Tedeschi Evelyne Vinet C. Whitney White Jinoos Yazdany Medha Barbhaiya Brittany Bettendorf Amanda Eudy Arundathi Jayatilleke Amit Aakash Shah Nancy Sullivan Laura L. Tarter Mehret Birru Talabi Marat Turgunbaev Amy Turner Kristen E. D'Anci 《Arthritis care & research》2020,72(4):461-488
162.
Sullivan PG Rippy NA Dorenbos K Concepcion RC Agarwal AK Rho JM 《Annals of neurology》2004,55(4):576-580
Fatty acids are known to enhance mitochondrial uncoupling protein (UCP) activity. We asked whether a high-fat ketogenic diet (KD) increases UCP levels and activity in hippocampi of juvenile mice. Maximum mitochondrial respiration rates were significantly (p < 0.001) higher in KD- versus standard diet (SD)-treated animals, indicating increased UCP-mediated proton conductance that can reduce reactive oxygen species (ROS) production. Western blots showed significant (p < 0.05) or borderline significant increases in UCP2, UCP4, and UCP5 protein levels, and increased immunoreactivity to these three UCP isoforms was most prominently seen in the dentate gyrus of KD-fed mice. Finally, we found that oligomycin-induced ROS production was significantly (p < 0.05) lower in KD-fed mice than in SD controls. Collectively, our data suggest that a KD may exert neuroprotective effects by diminishing ROS production through activation of mitochondrial UCPs. 相似文献
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164.
Bhuvaneswari S. Aakash V. Bala Ramalakshmi N. Arunkumar S. 《Pharmaceutical Chemistry Journal》2021,55(9):886-907
Pharmaceutical Chemistry Journal - Quantitative structure–activity relationship (QSAR) analysis was carried out for a series of 61 compounds with thiazole and benzthiazole moiety for... 相似文献
165.
Aakash Parashar Vijay Goni Deepak Neradi Uday Guled Karthick Rangasamy Y. K. Batra 《Indian Journal of Orthopaedics》2021,55(2):449
PurposeTo compare the effects of three modalities of pain management i.e. SSNB (suprascapular nerve block) with NIR (non invasive rehabilitation), IAI (intra articular injection) with NIR and, NIR alone in idiopathic frozen shoulder patients.MethodsA double blinded randomized clinical trial was conducted. 60 cases of idiopathic frozen shoulder were selected and randomly divided into three treatment groups; group 1: NIR, group 2: NIR + SSNB, group 3: NIR +IAI. Range of motion, pain score and disability (SPADI: shoulder pain and disability index) score were evaluated pre-treatment and at 12 weeks follow up.ResultsAll three groups were homogenous and comparable regarding their age, sex ratio, pretreatment pain score, disability score and range of motion. There was significant improvement (p < 0.05) post treatment in all three groups with respect to pain score, disability score and range of motion. SSNB with NIR group patients demonstrated better improvement in all parameters examined, which was statistically significant in pain score, disability score and internal rotation but was statistically equivalent for total range of motion and external rotation as compared to shoulder injection group.ConclusionSSNB in combination with non invasive rehabilitation is an effective and safe mode of treatment for idiopathic frozen shoulder. Present study also proves that SSNB with NIR is a more effective mode of treatment for idiopathic frozen shoulder as compared to NIR alone or in combination with IAI.Level of evidence: Level 1. 相似文献
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167.
Raffaella Panza Nicola Laforgia Ioannis Bellos Aakash Pandita 《Acta paediatrica (Oslo, Norway : 1992)》2020,109(11):2219-2225
168.
Amy Ahn Chris Ferrer Chris Park Daniel J. Snyder Samuel Z. Maron Christopher Mikhail Aakash Keswani Ilda B. Molloy Michael J. Bronson Wayne E. Moschetti David S. Jevsevar Jashvant Poeran Leesa M. Galatz Calin S. Moucha 《The Journal of arthroplasty》2019,34(10):2290-2296.e1
BackgroundThe purpose of this study is to define value in bundled total joint arthroplasty (TJA) from the differing perspectives of the patient, payer/employer, and hospital/provider.MethodsDemographic, psychosocial, clinical, financial, and patient-reported outcomes (PROs) data from 2017 to 2018 elective TJA cases at a multihospital academic health system were queried. Value was defined as improvement in PROs (preoperatively to 1 year postoperatively) for patients, improvement in PROs per $1000 of bundle cost for payers, and the normalized sum of improvement in PROs and hospital bundle margin for providers. Bivariate analysis was used to compare high value vs low value (>50th percentile vs <50th percentile). Multivariate analysis was performed to identify predictors.ResultsA total of 280 patients had PRO data, of which 71 had Medicare claims data. Diabetes (odds ratio [OR], 0.45; P = .02) predicted low value for patients; female gender (OR, 0.25), hypertension (OR, 0.17), pulmonary disease (OR, 0.12), and skilled nursing facility discharge (OR, 0.17) for payers (P ≤ .03 for all); and pulmonary disease (OR, 0.16) and skilled nursing facility discharge (OR, 0.19) for providers (P ≤ .04 for all).ConclusionThis is the first article to define value in TJA under a bundle payment model from multiple perspectives, providing a foundation for future studies analyzing value-based TJA. 相似文献
169.
Aakash A. Bavishi Rachel M. Kaplan Graham Peigh Celso L. Diaz Jayson R. Baman Amar Trivedi Jeremiah Wasserlauf Mark J. Shen Prasongchai Sattayaprasert Alexandru B. Chicos Susan Kim Nishant Verma Rishi Arora Albert Lin Bradley P. Knight Rod S. Passman 《Pacing and clinical electrophysiology : PACE》2019,42(6):694-704