全文获取类型
收费全文 | 1610篇 |
免费 | 73篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 44篇 |
儿科学 | 117篇 |
妇产科学 | 66篇 |
基础医学 | 148篇 |
口腔科学 | 81篇 |
临床医学 | 144篇 |
内科学 | 341篇 |
皮肤病学 | 63篇 |
神经病学 | 93篇 |
特种医学 | 33篇 |
外科学 | 351篇 |
综合类 | 9篇 |
预防医学 | 32篇 |
眼科学 | 45篇 |
药学 | 85篇 |
中国医学 | 1篇 |
肿瘤学 | 41篇 |
出版年
2024年 | 2篇 |
2023年 | 21篇 |
2022年 | 28篇 |
2021年 | 66篇 |
2020年 | 42篇 |
2019年 | 55篇 |
2018年 | 47篇 |
2017年 | 43篇 |
2016年 | 59篇 |
2015年 | 67篇 |
2014年 | 62篇 |
2013年 | 89篇 |
2012年 | 113篇 |
2011年 | 107篇 |
2010年 | 59篇 |
2009年 | 61篇 |
2008年 | 101篇 |
2007年 | 144篇 |
2006年 | 116篇 |
2005年 | 103篇 |
2004年 | 96篇 |
2003年 | 49篇 |
2002年 | 50篇 |
2001年 | 36篇 |
2000年 | 40篇 |
1999年 | 10篇 |
1998年 | 9篇 |
1997年 | 7篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1989年 | 1篇 |
1987年 | 1篇 |
排序方式: 共有1694条查询结果,搜索用时 15 毫秒
31.
32.
33.
Kılavuz Sebile Basaranoglu Murat Epcacan Serdar Bako Derya Ozer Arife Donmez Yasemin Nuran Ceylan Emine Ipek Tukun Ajlan Ceylaner Serdar Geylani Hadi Mungan Halise Neslihan Onenli 《Metabolic brain disease》2022,37(4):1283-1287
Metabolic Brain Disease - Gaucher disease type 2 is the most progressive and the rarest form of Gaucher disease, defined as the acute neuronopathic type. We presented two GD2 patients who died... 相似文献
34.
The aim of this study was to evaluate the total antioxidant status (TAS), total oxidative status (TOS) and oxidative stress
index (OSI) in patients with postmenopausal osteoporosis. We also investigate the relation between bone mineral density and
oxidative/antioxidative parameters. Thirty-nine patients with osteoporosis and 26 healthy controls were included in the study.
Plasma TAS, TOS levels were determined by using a novel automated methods. Plasma TOS and OSI value were significantly higher,
and plasma TAS level was lower in patients than in healthy controls (P < 0.001 for all). There was a significant negative correlation between OSI and BMD in lumbar and femoral neck region (r = −0.63, P < 0.001; r = 0.40, P = 0.018). The results of this study indicated that increased osteoclastic activity and decreased osteoblastic activity may
be associated with an imbalance between oxidant and antioxidant status in postmenopausal osteoporosis. Therefore, supplementation
of antioxidant-enriched diet to the therapy might shed light on the development of novel therapeutic strategies for osteoporosis. 相似文献
35.
Sara S. Kilic Mustafa Ozel Demet Hafizoglu Neslihan Edeer Karaca Guzide Aksu Necil Kutukculer 《Journal of clinical immunology》2013,33(1):74-83
Purpose
Primary immunodeficiency diseases (PIDs) are inherited disorders of the immune system resulting in increased susceptibility to unusual infections and predisposition to autoimmunity and malignancies. The European Society for Immunodeficiencies (ESID) has developed an internet-based database for clinical and research data on patients with PID. This study aimed to provide a minimum estimate of the prevalence of each disorder and to determine the clinical characteristics and outcomes of patients with PID in Turkey.Methods
Clinical features of 1435 patients with primary immunodeficiency disorders are registered in ESID Online Patient Registry by the Pediatric Immunology Departments of the Medical Faculties of Uludag University and Ege University Between 2004 and 2010. These two centers are the major contributors reporting PID patients to ESID database from Turkey.Results
Predominantly antibody immunodeficiency (73.5 %) was the most common category followed by autoinflammatory disorders (13.3 %), other well defined immunodeficiencies (5.5 %), congenital defects of phagocyte number, function or both 3.5 %), combined T and B cell immunodeficiencies (2 %), defects in innate immunity (1 %), and diseases of immune dysregulation (0.7 %). Patients between 0 and 18 years of age constitued 94 % of total and the mean age was 9.2?±?6 years. The consanguinity rate within the registered patients was 14.3 % (188 of 1130 patients). The prevalance of all PID cases ascertained from the registry was 30.5/100.000. The major cause of the mortality was severe infection which was seen in forty-two of seventy five deceased patients. The highest mortality was observed in patients with severe combined immunodeficiencies and ataxia-telangiectasia.Conclusion
Promoting the awareness of PID among the medical professionals and the general public is required if premature death and serious morbidity occurs due to late diagnosis of the wider spectrum of PID are to be avoided. 相似文献36.
Cakir Karabas Hulya Ozcan Ilknur Erturk Ahmet Faruk Guray Beliz Unsal Gurkan Senel Sukriye Neslihan 《Oral Radiology》2021,37(3):403-411
Oral Radiology - The purpose of this study is to evaluate CBCT images of impacted mandibular canines in detail and to discuss implications for diagnosis and treatment. CBCT images of dental... 相似文献
37.
Murat Cakir Ahmet Tekin Tevfik Kucukkartallar Husamettin Vatansev Adil Kartal 《International surgery》2015,100(5):897-902
Multiple organ failure and pancreatic necrosis are the factors that determine prognosis in acute pancreatitis attacks. We investigated the effects of collagenase on the debridement of experimental pancreatic necrosis. The study covered 4 groups; each group had 10 rats. Group I was the necrotizing pancreatitis group. Group II was the collagenase group with pancreatic loge by isotonic irrigation following necrotizing pancreatitis. Group III was the collagenase group with pancreatic loge following necrotizing pancreatitis. Group IV was the intraperitoneal collagenase group following necrotizing pancreatitis. The progress of the groups was compared hematologically and histopathologically. There was no difference among the groups regarding the levels of leukocyte, hemogram, and urea. The differences in AST levels between Group I and II; and differences in glucose, calcium, LDH, AST, and amylase between Group II and III; between Group II and IV; between Group I and III; and between Group I and IV were statistically significant (P < 0.05). There were statistically significant differences between Group II and III, and Group II and IV regarding edema, acinar necrosis, inflammatory cell infiltration, hemorrhage, and fat necrosis (P < 0.05). In conclusion, the collagenase preparation used in this experimental pancreatitis model was found to be effective in the debridement of pancreatic necrosis.Key words: Acute pancreatitis, Necrose, Collagenase, DebridementAcute pancreatitis (AP) is a nonbacterial inflammatory disease of the pancreas that can range from interstitial edema to pancreatic necrosis in its severest form. In about 20% of AP attacks necrosis can develop in the pancreas while the disease limits itself and regresses in a couple of days in many patients (80%).1The definitions that are still widely in effect today regarding the classification of acute pancreatitis were determined in 1992 at the Atlanta Conference.2 The conference aimed at achieving a common classification for AP and its complications. Within severe acute pancreatitis, of which necrotizing pancreatitis is a part, organ failure and local complications can be seen (necrosis, pseudocyst, and abscess). Multiple organ failure and pancreatic necrosis are the factors that determine the prognosis. Half of the mortalities are observed within a period of 1 or 2 weeks. Necrotizing pancreatitis makes up for the 10–20% of AP cases. Severe pancreatitis has a high mortality rate and functional diseases like diabetes are seen in one-third to one-fifth of the recovered patients.3While the mortality rates are about 10% in the presence of sterile pancreatic necrosis, they go up over 30% in the existence of infected necrosis.1 Regarding acute necrotizing pancreatitis, there is still no consensus on surgical indications and the time of surgical intervention, the surgical method to be used, and which patients need conservative treatment and which ones need surgical treatment. The goal in the surgical treatment of acute necrotizing pancreatitis is to isolate the necrotic tissue that might cause sepsis and multiple organ failure and to reduce the risk of mortality. The timing of necrosectomy as well as the way in which necrosectomy is performed is significant in necrotizing pancreatitis. The issue of the possibility that necrosectomy can be performed through minimally-invasive interventions instead of open surgery is still being discussed.3We planned to investigate the activity of collagenase clostridiopeptidase A (EC 3.424.3), which has never been attempted before in the debridement of experimental pancreatic necrosis (but which has been used for enzymatic debridement), and the enzyme preparation containing the accompanying proteases (Sterile Novuxol®, Abbott, Uetersen, Germany). We aimed to evaluate the response of the disease to treatment through laboratory and histopathologic data, by using the enzyme preparation to treat necrotizing pancreatitis. 相似文献
38.
Turker Tekin Erguzel Serhat Ozekes Selahattin Gultekin Nevzat Tarhan Gokben Hizli Sayar Ali Bayram 《Psychiatry investigation》2015,12(1):61-65
Objective
The combination of repetitive transcranial magnetic stimulation (rTMS), a non-pharmacological form of therapy for treating major depressive disorder (MDD), and electroencephalogram (EEG) is a valuable tool for investigating the functional connectivity in the brain. This study aims to explore whether pre-treating frontal quantitative EEG (QEEG) cordance is associated with response to rTMS treatment among MDD patients by using an artificial intelligence approach, artificial neural network (ANN).Methods
The artificial neural network using pre-treatment cordance of frontal QEEG classification was carried out to identify responder or non-responder to rTMS treatment among 55 MDD subjects. The classification performance was evaluated using k-fold cross-validation.Results
The ANN classification identified responders to rTMS treatment with a sensitivity of 93.33%, and its overall accuracy reached to 89.09%. Area under Receiver Operating Characteristic (ROC) curve (AUC) value for responder detection using 6, 8 and 10 fold cross validation were 0.917, 0.823 and 0.894 respectively.Conclusion
Potential utility of ANN approach method can be used as a clinical tool in administering rTMS therapy to a targeted group of subjects suffering from MDD. This methodology is more potentially useful to the clinician as prediction is possible using EEG data collected before this treatment process is initiated. It is worth using feature selection algorithms to raise the sensitivity and accuracy values. 相似文献39.
Neslihan Duruturk Eda Tonga Metin Karatas Ersin Doganozu 《Journal of Physical Therapy Science》2015,27(7):2023-2028
[Purpose] To describe the functional consequences of patients with cardiac diseases and
analyze associations between activity limitations and quality of life. [Subjects and
Methods] Seventy subjects (mean age: 60.1±12.0 years) were being treated by Physical
Medicine and Rehabilitation and Cardiology Departments were included in the study.
Activity limitations and participation restrictions as perceived by the individual were
measured by the Canadian Occupational Performance Measure (COPM). The Nottingham Extended
Activities of Daily Living (NEADL) Scale was used to describe limitations in daily living
activities. To detect the impact of activity limitations on quality of life the Nottingham
Health Profile (NHP) was used. [Results] The subjects described 46 different types of
problematic activities. The five most identified problems were walking (45.7%), climbing
up the stairs (41.4%), bathing (30%), dressing (28.6%) and outings (27.1%). The
associations between COPM performance score with all subgroups of NEADL and NHP; total,
energy, physical abilities subgroups, were statistically significant. [Conclusion] Our
results showed that patients with cardiac diseases reported problems with a wide range of
activities, and that also quality of life may be affected by activities of daily living.
COPM can be provided as a patient-focused outcome measure, and it may be a useful tool for
identifying those problems.Key words: Activity limitation, Cardiac diseases, Quality of life 相似文献
40.