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21.
Schuerwegen Alana Huys Wim Coppens Violette De Neef Nele Henckens Josée Goethals Kris Morrens Manuel 《Archives of sexual behavior》2021,50(3):1197-1206
Archives of Sexual Behavior - Despite the gaining popularity in mainstream media of the phenomenon that is BDSM, empirical research on the motives and underlying psychological mechanisms driving... 相似文献
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T. L. Peeters G. Matthijs G. Vantrappen 《Naunyn-Schmiedeberg's archives of pharmacology》1991,343(2):202-208
Summary Recent studies suggested that certain erythromycin A (EM-A) derivatives are motilin receptor agonists. As proposed by Itoh they may be called motilides. We have investigated the Ca2+-dependence of contractions induced by two potent motilides, ME-34 [de(N-methyl) 8,9-anhydroeryhtromycin A 6,9-hemiacetal] and EM-523 [de(N-methyl)-N-ethyl-8,9-anhydro-erythromycin A 6,9-hemiacetal], in duodenal tissues and compared the results with those previously obtained with motilin.Isometric and isotonic contractile responses of isolated longitudinal muscle sheets from the rabbit duodenum were tested under normal, Ca2+-free and depolarizing conditions. Prior to stimulation with motilides, the maximal response to acetylcholine was recorded and all responses were always expressed as a percentage of this response. Both motilides induced contractions in normally polarized tissue, with an EC50 of 26 ± 5 nM for ME-34 (n = 7), and 27 ± 5 nM for EM-5231 (n = 16) and maximal responses of respectively 88 ± 4% and 80 ± 3%. Like motilin, both compounds induced an extra-contraction in depolarized tissues. The EM-523 response in 140 mM K+under isotonic conditions was 84 ± 3% (n = 5) at 10–5
M, with an EC50 that was shifted to 65 ± 18 nM. Similar figures were obtained for ME-34. When Ca2+ was added to Ca2+-depleted strips, half-maximal Ca2+ values (in mM) were 1.10 ± 0.11 (n = 9) for EM-523 and 1.13 ± 0.12 (n = 3) for ME-34, as compared with 1.12 ± 0.13 (n = 7) for motilin and 2.8 ± 1.1 (n = 9) for K+. Both ME-34 and EM-523 also induced a transient contraction in Ca+-free solutions under isometric conditions. The response to EM-523 (5 × 10–6
M) was 49 ± 15% (n = 4) after 3 min. A maximal EM-523 -stimulation reduced a subsequent ACh response by 78 ± 7%, whereas EM-523 and ME-34 could not induce a contraction after ACh.We conclude that motilides depend upon external Ca2+ to a similar extent to motilin. Like motilin, they are also able to mobilize intracellular Ca Z + stores. Our results support the hypothesis that motilides act on motilin receptors.
Send offprint requests to T. L. Peeters at the above address 相似文献
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Nele Friedrich Sabine Schwarz Jens Thonack Ulrich John Henri Wallaschofski Henry Völzke 《Autoimmunity》2013,46(2):174-180
Background: Autoimmune thyroid disease (AIT) is more common in females than in males. Furthermore, it is well documented that the risk of thyroid autoimmunity increases during pregnancy and in the postpartum period. The objective of the present study was to analyse the association between parity and AIT by using ultrasound and serological data.Methods: The study population included 2156 women, aged 20–79 years. Serum thyroperoxidase antibodies (anti-TPO) and thyrotropin levels were measured and thyroid ultrasonography was performed. AIT was defined according to the combined presence of a hypoechogenic thyroid pattern and positive anti-TPO levels (>200 IU/ml). Odds ratios (OR) and 95% confidence intervals (CI) were calculated.Results: The analyses revealed an association between parity and AIT. Women with at least one pregnancy had increased odds for AIT (OR 4.6 [95%-CI 1.4–15.1], p < 0.05) compared to women who have never been pregnant. Similar results were observed using hypoechogenic thyroid pattern (OR 1.7 [95%-CI 1.0–2.9], p < 0.05) and positive anti-TPO levels (OR 1.8 [95%-CI 1.0–3.3], p = 0.05) as separate dependent variables or using number of births as alternate independent variable.Conclusion: In this female population we found an association between parity and AIT and conclude that parity appears to be a potential risk factor for AIT. 相似文献
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Anti‐inflammatory effects of the GAG‐binding CXCL9(74‐103) peptide in dinitrofluorobenzene‐induced contact hypersensitivity in mice
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Marjolein M. N. Leeuwenburgh MD PhD Hein B. A. C. Stockmann MD PhD Wim H. Bouma MD PhD Alexander P. J. Houdijk MD PhD Matthijs F. Verhagen MD Bart Vrouenraets MD PhD Lodewijk P. J. Cobben MD PhD Patrick M. M. Bossuyt PhD Jaap Stoker MD PhD Marja A. Boermeester MD PhD the OPTIMAP Study Group 《Academic emergency medicine》2014,21(5):487-496
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