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131.
Fikriye Yasemin
ZATK Orhan
ZATK Yasemin TEKEN Semra YTASLAN Neziha Senem ARI 《Turkish Journal of Medical Sciences》2021,51(3):1530
Backround/aimCyclophosphamide (CP) is a drug used for treatment of many malignant diseases. However, it can cause serious side effects such as hemorrhagic cystitis and male infertility. Hydrogen sulfide (H2S) is a gaseous mediator and is suggested to have antioxidant, antiinflammatory, and antiapoptotic effects. In this study, dose-dependent effects of H2S donor sodium hydrosulfide (NaHS) on cyclophosphamide-induced hemorrhagic cystitis and testicular dysfunction were investigated in rats.Material and methodsRats were divided into 5 groups (n = 8): control, CP, NaHS25 μmol/kg, NaHS50 μmol/kg, and NaHS100 μmol/ kg. After treatment for 7 days intraperitoneally (ip), a single ip dose of CP 200 mg/kg was given on the 8th day. Then, treatment was continued for 7 days. In bladder and testicular tissues, IL 6, IL 10, cGMP, NO, H2S, FSH, LH, and testosterone levels were measured by ELISA. Histopathological examination with H&E staining, as well as immunohistochemical staining for acrolein in bladder and caspase-3 and APAF-1 in testis were performed.ResultsNaHS prevented the increased IL 6 and IL 10 values induced by CP as well as prevented the decrease in cGMP values associated with CP. There was no significant change in FSH values, but the LH value, which increased with CP, decreased with 25, 50, and 100 μmol/kg NaHS. In contrast, testosterone decreased in the CP group and increased in the treatment groups. NaHS was effective in many biochemical and histopathological parameters at 25 and 50 μmol/kg doses, and this effect decreased at 100 μmol/kg dose.ConclusionH2S has a protective and therapeutic effect on hemorrhagic cystitis and testicular dysfunction induced by cyclophosphamide. It can be suggested that H2S is a promising molecule in facilitating cancer treatment. 相似文献
132.
目的:探讨RSS椎弓根钉内固定结合植骨融合治疗腰椎间盘突出症伴腰椎不稳的临床效果。方法将本院2011年9月~2013年9月收治的44例腰椎间盘突出症伴腰椎不稳患者按不同手术治疗方案随机分为对照组21例和观察组23例,对照组采用髓核摘除+经后路关节突单纯植骨融合手术治疗,观察组采用RSS椎弓根钉内固定+植骨融合手术治疗,比较两组的围术期情况、JOA评分、植骨融合情况。结果两组的手术耗时、术中出血量及住院时间比较差异无统计学意义(P〉0.05)。两组术后6个月的JOA评分均明显高于术前(P〈0.05);观察组术后6个月的JOA评分高于对照组(P〈0.05)。两组植骨融合成功率比较差异有统计学意义(P〈0.05)。结论RSS椎弓根钉内固定结合植骨融合治疗腰椎间盘突出症伴腰椎不稳具有植骨融合率高、远期恢复效果显著等优点,值得临床推广应用。 相似文献
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用离子交换高效液相色谱法分析对苯二甲酸中的微量杂质,并对该方法进行了系统的优化。通过选择流动相pH值使缓冲溶液的浓度降低至0.13mol/L,分析周期缩短至10min以下。结果表明:该方法的工作曲线相关系数在0.9998以上,回收率为98.7%~102.2%,相对标准偏差小于3.6%。 相似文献
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The prevalence of psychiatric morbidity on a coronary care ward 总被引:1,自引:0,他引:1
Numerous studies have documented the high prevalence of psychological and emotional disorders in patients seen in general medical settings. However, despite the emphasis placed on holistic approaches to nursing care in all professional models of nursing practice, much of this distress is still missed by nursing staff. The Hospital Anxiety and Depression (HAD) scale is an easy-to-use self-administered screening instrument purportedly designed to detect psychological distress amongst hospitalized patients with physical illnesses. On using the HAD scale on patients admitted to a coronary care ward of a district general hospital, 44% were found to be suffering high levels of anxiety or depression. This figure is consistent with the results of similar studies in other cardiac wards and out-patient clinics. In most cases, the levels of distress found were not sufficiently severe to warrant seeking specialist psychiatric support. Instead, there is much that the general nurse can do to alleviate the understandable fears and worries of patients being treated for cardiac disease. However, to respond appropriately, nursing staff must be able to identify psychological distress in patients. The HAD scale, if it can be validated in cardiac in-patient settings, provides an instrument which could easily become part of the routine assessment of patients' nursing needs. 相似文献
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