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41.
42.
Associations Between Lean Mass,Muscle Strength and Power,and Skeletal Size,Density and Strength in Older Men
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Didier Chalhoub Robert Boudreau Susan Greenspan Anne B Newman Joseph Zmuda Andrew W Frank‐Wilson Nayana Nagaraj Andrew R Hoffman Nancy E Lane Marcia L Stefanick Elizabeth Barrett‐Connor Tien Dam Peggy M Cawthon Eric S Orwoll Jane A Cauley for the Osteoporotic Fractures in Men Study Research Group 《Journal of bone and mineral research》2018,33(9):1612-1621
43.
Increased fructosamine in non-diabetic rheumatoid arthritis patients: role of lipid peroxides and glutathione. 总被引:1,自引:0,他引:1
Narsimhan Prakash Babu Zachariah Bobby Nambiar Selvaraj Belgode N Harish 《Clinical chemistry and laboratory medicine》2006,44(7):848-852
Modification of proteins by non-enzymatic glycation is one of the underlying factors known to play a major role in the pathogenesis of many clinical disorders. Glycation of plasma proteins is enhanced by elevated glucose concentrations. However, increased fructosamine has been documented in rheumatoid arthritis patients without any history of diabetes. Collective evidence reveals that malondialdehyde and reduced glutathione can modulate the glycation process. This study was undertaken to unravel the possible association of malondialdehyde and glutathione with fructosamine in rheumatoid arthritis patients. A case-control study was performed on 15 rheumatoid arthritis patients and 15 control subjects. Whole blood glutathione, plasma malondialdehyde, fructosamine and fasting glucose were analyzed in both groups. Partial correlation analysis was performed to predict the independent association of malondialdehyde, glutathione and fasting glucose on fructosamine. In rheumatoid arthritis patients, while fructosamine and malondialdehyde levels were significantly increased, glutathione levels were significantly decreased compared with controls. With partial correlation analysis, fructosamine was found to have a significant positive correlation with malondialdehyde and a negative correlation with glutathione. These data suggest that plasma fructosamine levels are closely associated with malondialdehyde and glutathione in rheumatoid arthritis patients, warranting extra precaution in interpreting fructosamine as a measure of glycemic control in these patients. 相似文献
44.
Somnath S. Kumar K.P. Selvarajan Chettiar Rakul Nambiar 《Journal of the National Medical Association》2018,110(4):352-357
Background
Several studies have been published in the western literature on the incidence, clinical course and outcome of patients with ARDS. However, there is limited data about ARDS in the tropics and moreover, the etiology and outcomes of ARDS in tropical countries are different from those of western nations. In tropical countries like India, resources are limited and costs of therapy play a major role in deciding treatment options. This prospective observational study was designed to analyze the clinical profile, outcomes and predictors of mortality of patients with ARDS in an urban tropical setting.Methods
75 patients ≥13 years, admitted in the medical intensive care unit of a teaching hospital in Kerala, India between March 2013 and February 2014, satisfying Berlin definition for ARDS were enrolled in the study. Lung protective ventilation strategy as laid by ARDS Network protocol was followed for every patient on mechanical ventilation. Due to scarcity of ventilators in our institution, invasive ventilation could not be provided for all ARDS patients. The criteria used for patient selection for non-invasive ventilation were hemodynamic stability, well compliant to the use of NIV mask and PaO2/FiO2 ratio >180 at the time of admission.Results
Out of the 75 patients, 51% were females and the mean age of the study population was 39.8 ± 3.3 years. Common aetiologies were leptospirosis (18.7%), bronchopneumonia (17.3%), scrub typhus and dengue (12% each). Lung injury score and sequential organ failure assessment score scores had statistically significant association with the severity of ARDS. Forty patients (53.3%) received invasive mechanical ventilation and 35 patients were managed with non-invasive ventilation at the time of admission. The mortality in our study was 45%. Altered sensorium (p-0.002), central cyanosis (p-0.024), elevated creatinine (p-0.036), acidosis (p < 0.001), hypotension (p < 0.001), multiorgan dysfunction (p-0.017), PEEP >12 cm H2O (p-0.036), days on ventilator <7 (p-0.014), PaO2/FiO2 Ratio <100 (p < 0.001), LIS>2.5 (p < 0.001) and SOFA score>11 (p < 0.001) were individual predictors of mortality.Conclusion
Tropical infections form a major etiological component of ARDS in a developing country like India. More studies are required for determining criteria for using NIV in mild ARDS patients which would be helpful in resource limited countries. Timely administration of effective antimicrobial therapy in patients in the rural tropics may help to reduce mortality and financial burden due to ARDS. 相似文献45.
Oliver W. Quarrell Angus J. Clarke Cecilia Compton Christine E.M. de Die‐Smulders Alan Fryer Sian Jenkins Nayana Lahiri Rhona MacLeod Zosia Miedzybrodzka Patrick J. Morrison Hannah Musgrave Mary O'Driscoll Mark Strong Martine J. van Belzen Sascha Vermeer Corien C. Verschuuren‐Bemelmans Emilia K. Bijlsma 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2018,177(1):35-39
46.
Ersfeld DL Rao DS Body JJ Sackrison JL Miller AB Parikh N Eskridge TL Polinske A Olson GT MacFarlane GD 《Clinical biochemistry》2004,37(10):867-874
OBJECTIVE: Methods to assess serum 25 OH vitamin D have improved in accuracy, precision, and ease of use. We describe the analytical and clinical validation of an automated, antibody- and microparticle-based, chemiluminescent immunoassay method for the determination of 25 OH vitamin D. DESIGN AND METHODS: The LIAISON 25 OH Vitamin D assay is a rapid automated method with first results available in 40 min, and a subsequent throughput of 180 samples per hour. Assay performance characteristics of precision and recovery were determined according to the National Committee for Clinical Laboratory Standards (NCCLS) protocols. Analytical and functional sensitivity were determined according to standard protocols. Samples for method comparison studies were obtained from routine clinical samples submitted for 25 OH Vitamin D determination or from apparently healthy normal volunteers. RESULTS: The detection limit for this assay was <2.0 nmol/L across three lots of materials. Functional sensitivity (inter-assay imprecision <20%) was 17.5 nmol/L. Total imprecision (CV) was <15% at 42.5-137.5 nmol/L. Mean (SD) recovery was 101% (13%). The assay was linear on dilution. Comparison with radioimmunoassay (RIA) yielded acceptable correlation (r = 0.88) and clinical equivalence in the range from 37.5 to 150 nmol/L. CONCLUSIONS: The LIAISON 25 OH Vitamin D assay is a rapid, accurate, and precise tool for the measurement of 25 OH vitamin D. 相似文献
47.
Ultrasound‐based clinical prediction rule model for detecting papillary thyroid cancer in cervical lymph nodes: A pilot study
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48.
Recombinant paraoxonase 1 protects against sarin and soman toxicity following microinstillation inhalation exposure in guinea pigs 总被引:1,自引:0,他引:1
Valiyaveettil M Alamneh Y Rezk P Perkins MW Sciuto AM Doctor BP Nambiar MP 《Toxicology letters》2011,202(3):203-208
To explore the efficacy of paraoxonase 1 (PON1) as a catalytic bioscavenger, we evaluated human recombinant PON1 (rePON1) expressed in Trichoplusia ni larvae against sarin and soman toxicity using microinstillation inhalation exposure in guinea pigs. Animals were pretreated intravenously with catalytically active rePON1, followed by exposure to 1.2 X LCt50 sarin or soman. Administration of 5 units of rePON1 showed mild increase in the blood activity of the enzyme after 30 min, but protected the animals with a significant increase in survival rate along with minimal signs of nerve agent toxicity. Recombinant PON1 pretreated animals exposed to sarin or soman prevented the reduction of blood O2 saturation and pulse rate observed after nerve agent exposure. In addition, rePON1 pretreated animals showed significantly higher blood PON1, acetylcholinesterase (AChE), and butyrylcholinesterase activity after nerve agent exposure compared to the respective controls without treatments. AChE activity in different brain regions of rePON1 pretreated animals exposed to sarin or soman were also significantly higher than respective controls. The remaining activity of blood PON1, cholinesterases and brain AChE in PON1 pretreated animals after nerve agent exposure correlated with the survival rate. In summary, these data suggest that human rePON1 protects against sarin and soman exposure in guinea pigs. 相似文献
49.
50.
Seijas R Catalán-Larracoechea JM Ares-Rodríguez O Joshi N de la Fuente JP Pérez-Domínguez M 《Archives of orthopaedic and trauma surgery》2009,129(1):39-41
Hydatid disease is a parasitic infection generally occurring in specific geographical areas. Exclusive involvement of the
muscles is extremely uncommon, because implantation at this site would require passage through the filters of the liver and
lung. We describe a patient with a mass in the popliteal fossa of the knee for 7 years who was seen for pain and was found
to have hydatid disease. 相似文献