全文获取类型
收费全文 | 6304篇 |
免费 | 463篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 184篇 |
儿科学 | 214篇 |
妇产科学 | 158篇 |
基础医学 | 849篇 |
口腔科学 | 107篇 |
临床医学 | 584篇 |
内科学 | 1183篇 |
皮肤病学 | 220篇 |
神经病学 | 546篇 |
特种医学 | 307篇 |
外科学 | 858篇 |
综合类 | 44篇 |
预防医学 | 631篇 |
眼科学 | 62篇 |
药学 | 419篇 |
中国医学 | 2篇 |
肿瘤学 | 408篇 |
出版年
2023年 | 97篇 |
2022年 | 116篇 |
2021年 | 224篇 |
2020年 | 178篇 |
2019年 | 224篇 |
2018年 | 228篇 |
2017年 | 174篇 |
2016年 | 162篇 |
2015年 | 193篇 |
2014年 | 255篇 |
2013年 | 321篇 |
2012年 | 395篇 |
2011年 | 441篇 |
2010年 | 209篇 |
2009年 | 176篇 |
2008年 | 286篇 |
2007年 | 311篇 |
2006年 | 287篇 |
2005年 | 283篇 |
2004年 | 240篇 |
2003年 | 213篇 |
2002年 | 178篇 |
2001年 | 85篇 |
2000年 | 103篇 |
1999年 | 97篇 |
1998年 | 46篇 |
1997年 | 40篇 |
1996年 | 44篇 |
1995年 | 46篇 |
1994年 | 37篇 |
1993年 | 30篇 |
1992年 | 58篇 |
1991年 | 72篇 |
1990年 | 68篇 |
1989年 | 54篇 |
1988年 | 58篇 |
1987年 | 83篇 |
1986年 | 76篇 |
1985年 | 61篇 |
1984年 | 50篇 |
1983年 | 44篇 |
1982年 | 21篇 |
1981年 | 27篇 |
1980年 | 23篇 |
1979年 | 44篇 |
1978年 | 32篇 |
1976年 | 33篇 |
1975年 | 28篇 |
1974年 | 28篇 |
1973年 | 28篇 |
排序方式: 共有6776条查询结果,搜索用时 15 毫秒
101.
Jeff Reeve Georg A. Böhmig Farsad Eskandary Gunilla Einecke Gaurav Gupta Katelynn Madill‐Thomsen Martina Mackova Philip F. Halloran INTERCOMEX MMDx‐Kidney Study Group 《American journal of transplantation》2019,19(10):2719-2731
We previously reported a system for assessing rejection in kidney transplant biopsies using microarray‐based gene expression data, the Molecular Microscope® Diagnostic System (MMDx). The present study was designed to optimize the accuracy and stability of MMDx diagnoses by replacing single machine learning classifiers with ensembles of diverse classifier methods. We also examined the use of automated report sign‐outs and the agreement between multiple human interpreters of the molecular results. Ensembles generated diagnoses that were both more accurate than the best individual classifiers, and nearly as stable as the best, consistent with expectations from the machine learning literature. Human experts had ≈93% agreement (balanced accuracy) signing out the reports, and random forest‐based automated sign‐outs showed similar levels of agreement with the human experts (92% and 94% for predicting the expert MMDx sign‐outs for T cell–mediated (TCMR) and antibody‐mediated rejection (ABMR), respectively). In most cases disagreements, whether between experts or between experts and automated sign‐outs, were in biopsies near diagnostic thresholds. Considerable disagreement with histology persisted. The balanced accuracies of MMDx sign‐outs for histology diagnoses of TCMR and ABMR were 73% and 78%, respectively. Disagreement with histology is largely due to the known noise in histology assessments (ClinicalTrials.gov NCT01299168). 相似文献
102.
103.
Thomas T. Thomsen Laura B. Madsen Helle H. Hansson Elsa V. E. Tomás Derek Charlwood Ib C. Bygbjerg Michael Alifrangis 《The American journal of tropical medicine and hygiene》2013,88(3):536-541
Chloroquine (CQ) use in Mozambique was stopped in 2002 and artemether-lumefantrine (AL) was implemented in 2008. In light of no use of CQ and extensive use of AL, we determined the frequency of molecular markers of Plasmodium falciparum drug resistance/tolerance to CQ and AL in persons living in Linga-Linga, an isolated peninsula and in Furvela village, which is located 8 km inland. The P. falciparum chloroquine resistance transporter gene CVMNK wild type increased in frequency from 43.9% in 2009 to 66.4% in 2010 (P ≤ 0.001), and combined P. falciparum multidrug resistance gene 1 N86-184F-D1246 haplotype increased significantly between years (P = 0.039). The combination of P. falciparum chloroquine resistance transporter gene CVMNK and P. falciparum multidrug resistance gene NFD increased from 24.3% (2009) to 45.3% in (2010, P = 0.017). The rapid changes observed may largely be caused by decreased use of CQ and large-scale use of AL. In the absence of a clear AL-resistance marker and the (almost) continent-wide use of AL in sub-Saharan Africa, and when considering CQ reintroduction, continued monitoring of these markers is needed. 相似文献
104.
Natasha Maximoff Tammy V. Abernathy 《Residential treatment for children & youth》2017,34(3-4):266-291
This study examined the transition from most-to-least possible restrictive environments for youth with emotional and behavioral disorders. Components of positive transition experiences were identified from the literature as planning for transition at intake in such a way as to promote continuity of care, family involvement, academic and employment success, and assistance in navigating the adult mental health system and services. In this phenomenological study, transition service providers were interviewed to explore the transition practices currently utilized, and results were compared to recommended practices in the literature. Transition professionals were able to identify consistency, gradual change, individualization, communication between providers, opportunities for community experiences, and youth involvement in the transition as necessary to successful transition. 相似文献
105.
Henrik W. Schytz Faisal M. Amin Rigmor H. Jensen Louise Carlsen Stine Maarbjerg Nunu Lund Karen Aegidius Lise L. Thomsen Flemming W. Bach Dagmar Beier Hanne Johansen Jakob M. Hansen Helge Kasch Signe B. Munksgaard Lars Poulsen Per Schmidt Srensen Peter T. Schmidt-Hansen Vlasta V. Cvetkovic Messoud Ashina Lars Bendtsen 《The journal of headache and pain》2021,22(1)
106.
Susan M. Wcislak William S. King Benjamin R. Waller Natasha Goins Paxton V. Dickson 《Surgery》2019,165(1):228-231
Background
Multifocal pheochromocytoma/paraganglioma presenting at an early age is commonly associated with a hereditary syndrome.Case Report
A 29-year-old woman was referred for evaluation of multifocal pheochromocytoma/paraganglioma. Interestingly, her family history did not include pheochromocytoma/paraganglioma, and comprehensive genetic testing for the well-documented pheochromocytoma/paraganglioma susceptibility genes was negative. Of note, this patient had a history of a complex cardiac defect resulting in cyanotic congenital heart disease and had never undergone operative repair. Thus she lived in a chronic hypoxic state with a baseline oxygen saturation of about 80%. Laboratory evaluation found marked increases in plasma norepinephrine and normetanephrines with normal epinephrine and metanephrines. Imaging revealed 4 aortocaval masses and a right adrenal mass. After appropriate preoperative preparation she underwent successful resection of each of the neoplasms, with pathologic testing revealing multifocal pheochromocytoma/paraganglioma.Discussion
This case highlights a growing recognition of the potential development of pheochromocytoma/paraganglioma in patients with cyanotic congenital heart disease. The underlying pathophysiology and phenotypic similarities between pheochromocytoma/paraganglioma in patients with cyanotic congenital heart disease and those with mutations that lead to cellular pseudohypoxia are reviewed. 相似文献107.
108.
Yasmeen Niazi Hauke Thomsen Bozena Smolkova Ludmila Vodickova Sona Vodenkova Michal Kroupa Veronika Vymetalkova Alena Kazimirova Magdalena Barancokova Katarina Volkovova Marta Staruchova Per Hoffmann Markus M. Nöthen Maria Dušinská Ludovit Musak Pavel Vodicka Kari Hemminki Asta Försti 《Environmental and molecular mutagenesis》2019,60(1):17-28
Chromosomal aberrations (CAs) in human peripheral blood lymphocytes (PBL) measured with the conventional cytogenetic assay have been used for human biomonitoring of genotoxic exposure for decades. CA frequency in peripheral blood is a marker of cancer susceptibility. Previous studies have shown associations between genetic variants in metabolic pathway, DNA repair and major mitotic checkpoint genes and CAs. We conducted a genome-wide association study on 576 individuals from the Czech Republic and Slovakia followed by a replication in two different sample sets of 482 (replication 1) and 1288 (replication 2) samples. To have a broad look at the genetic susceptibility associated with CA frequency, the sample sets composed of individuals either differentially exposed to smoking, occupational/environmental hazards, or they were untreated cancer patients. Phenotypes were divided into chromosome- and chromatid-type aberrations (CSAs and CTAs, respectively) and total chromosomal aberrations (CAtot). The arbitrary cutoff point between individuals with high and low CA frequency was 2% for CAtot and 1% for CSA and CTA. The data were analyzed using age, sex, occupation/cancer and smoking history as covariates. Altogether 11 loci reached the P-value of 10−5 in the GWAS. Replication 1 supported the association of rs1383997 (8q13.3) and rs2824215 (21q21.1) in CAtot and rs983889 (5p15.1) in CTA analysis. These loci were found to be associated with genes involved in mitosis, response to environmental and chemical factors and genes involved in syndromes linked to chromosomal abnormalities. Identification of new genetic variants for the frequency of CAs offers prediction tools for cancer risk in future. Environ. Mol. Mutagen. 60:17–28, 2019. © 2018 Wiley Periodicals, Inc. 相似文献
109.