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101.
Brian Walls Oisín Murtagh Sergey I. Bozhko Andrei Ionov Andrey A. Mazilkin Daragh Mullarkey Ainur Zhussupbekova Dmitry A. Shulyatev Kuanysh Zhussupbekov Nikolai Andreev Nataliya Tabachkova Igor V. Shvets 《Materials》2022,15(21)
The strongly correlated electron material, vanadium dioxide (VO), has seen considerable attention and research application in metal-oxide electronics due to its metal-to-insulator transition close to room temperature. Vacuum annealing a VO(010) single crystal results in Wadsley phases (VO, n > 1) and VO. The resistance changes by a factor of 20 at 342 K, corresponding to the metal-to-insulator phase transition of VO. Macroscopic voltage-current measurements with a probe separation on the millimetre scale result in Joule heating-induced resistive switching at extremely low voltages of under a volt. This can reduce the hysteresis and facilitate low temperature operation of VO devices, of potential benefit for switching speed and device stability. This is correlated to the low resistance of the system at temperatures below the transition. High-resolution transmission electron microscopy measurements reveal a complex structural relationship between VO, VO and VO crystallites. Percolation paths incorporating both VO and metallic VO are revealed, which can reduce the resistance below the transition and result in exceptionally low voltage resistive switching. 相似文献
102.
103.
Natalia A. Stefanova Natalia A. Muraleva Elena E. Korbolina Elena Kiseleva Kseniya Yi. Maksimova Nataliya G. Kolosova 《Oncotarget》2015,6(3):1396-1413
The amyloid cascade hypothesis posits that deposition of the amyloid β (Aβ) peptide in the brain is a key event in the initiation of Alzheimer''s disease (AD). Nonetheless, it now seems increasingly unlikely that amyloid toxicity is the cause of sporadic AD, which leads to cognitive decline. Here, using accelerated-senescence nontransgenic OXYS rats, we confirmed that aggregation of Aβ is a later event in AD-like pathology. We showed that an age-dependent increase in the levels of Aβ1–42 and extracellular Aβ deposits in the brain of OXYS rats occur later than do synaptic losses, neuronal cell death, mitochondrial structural abnormalities, and hyperphosphorylation of the tau protein. We identified the variants of the genes that are strongly associated with the risk of either late-onset or early-onset AD, including App, Apoe4, Bace1, Psen1, Psen2, and Picalm. We found that in OXYS rats nonsynonymous SNPs were located only in the genes Casp3 and Sorl1. Thus, we present proof that OXYS rats may be a model of sporadic AD. It is possible that multiple age-associated pathological processes may precede the toxic amyloid accumulation, which in turn triggers the final stage of the sporadic form of AD and becomes a hallmark event of the disease. 相似文献
104.
Oleksiy Buznyk Nataliya Pasyechnikova M. Mirazul Islam Stanislav Iakymenko Per Fagerholm May Griffith 《CTS Clinical and Translational Science》2015,8(5):558-562
Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of transplant failure. These patients suffered from corneal ulcers and recurrent erosions preoperatively. The implants provided relief from pain and discomfort, restored corneal integrity by promoting endogenous regeneration of corneal tissues, and improved vision in two of three patients. Such implants could in the future be alternatives to donor corneas for high‐risk patients, and therefore, merits further testing in a clinical trial. 相似文献
105.
Boyarchuk Oksana Makukh Halyna Kostyuchenko Larysa Yarema Nataliya Haiboniuk Ivanna Kravets Volodymyr Shulhai Oleksandra Tretyak Bohdan 《Immunologic research》2021,69(5):436-444
Immunologic Research - The aim of the study was to determine the TREC/KREC levels in the patients diagnosed with ataxia-telangiectasia (AT) and to establish their informative value for early... 相似文献
106.
A. L. Pozdnyakova 《Bulletin of experimental biology and medicine》1988,106(4):1371-1373
Laboratory of Functional Synaptology, Brain Institute, All-Union Mental Health Research Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. V. Snezhnevskii.*) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 106, No. 10, pp. 393–395, October, 1988. 相似文献
107.
Robert Bain Rebecca Cosgriff Marco Zampoli Alexander Elbert Pierre-Régis Burgel Siobhán B Carr Claudio Castaños Carla Colombo Harriet Corvol Albert Faro Christopher H Goss Hector Gutierrez Andreas Jung Nataliya Kashirskaya Bruce C Marshall Joel Melo Pedro Mondejar-Lopez Isabelle de Monestrol Malcolm Brodlie 《Journal of cystic fibrosis》2021,20(1):25-30
BackgroundThe presence of co-morbidities, including underlying respiratory problems, has been identified as a risk factor for severe COVID-19 disease. Information on the clinical course of SARS-CoV-2 infection in children with cystic fibrosis (CF) is limited, yet vital to provide accurate advice for children with CF, their families, caregivers and clinical teams.MethodsCases of SARS-CoV-2 infection in children with CF aged less than 18 years were collated by the CF Registry Global Harmonization Group across 13 countries between 1 February and 7 August 2020.ResultsData on 105 children were collated and analysed. Median age of cases was ten years (interquartile range 6–15), 54% were male and median percentage predicted forced expiratory volume in one second was 94% (interquartile range 79–104). The majority (71%) of children were managed in the community during their COVID-19 illness. Out of 24 children admitted to hospital, six required supplementary oxygen and two non-invasive ventilation. Around half were prescribed antibiotics, five children received antiviral treatments, four azithromycin and one additional corticosteroids. Children that were hospitalised had lower lung function and reduced body mass index Z-scores. One child died six weeks after testing positive for SARS-CoV-2 following a deterioration that was not attributed to COVID-19 disease.ConclusionsSARS-CoV-2 infection in children with CF is usually associated with a mild illness in those who do not have pre-existing severe lung disease. 相似文献
108.
Effectiveness and cost of radiofrequency ablation and stereotactic body radiotherapy for treatment of early‐stage hepatocellular carcinoma: An analysis of SEER‐medicare
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109.
Fedor V. Shirshikov Georgy V. Cherepnev Olga N. Ilinskaya Nataliya V. Kalacheva 《Medical hypotheses》2013
The exact mechanism by which cytotoxic ribonucleases reach the cytosol of tumor cells remains unclear. The interaction of ribonucleases with a lipid bilayer is involved in the translocation of ribonucleases across the endosomal membrane. Here, we aimed to study the hydropathy character of toxic antitumor ribonucleases (bovine seminal ribonuclease and binase) and two non-toxic ribonucleases (bovine pancreatic ribonuclease and human pancreatic ribonuclease) by sliding-window hydrophobicity analysis. Comparative hydropathy plot analysis of the non-toxic pancreatic ribonucleases and their toxic variants was also performed. The data obtained indicate that some cytotoxic ribonucleases have a hydrophobic segment, which is sterically available for the hydrophobic interaction with a tumor cell membrane and endosomal membrane. After dissociation, subunits of dimeric ribonucleases are probably capable of thermodynamically favorable interaction with the interfacial region of a lipid bilayer. Remarkably the hydrophobic segment is not identified in the amino acid sequences of non-toxic ribonucleases. The paper describes the hydrophobic properties of toxic RNases that are essential for both the model of a lipid–protein interaction and the cytotoxicity mechanism unraveling. 相似文献
110.
Goldhar Hart A. Gazel Ummugulsum Ivory Catherine Maltez Nancy Humphrey-Murto Susan Milman Nataliya Zehra Aydin Sibel 《Clinical rheumatology》2022,41(9):2839-2844
Clinical Rheumatology - The aim was to evaluate patient satisfaction with virtual care, and identify factors associated with level of satisfaction. Surveys were mailed to all patients who had a... 相似文献