全文获取类型
收费全文 | 1056篇 |
免费 | 75篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 55篇 |
儿科学 | 22篇 |
妇产科学 | 29篇 |
基础医学 | 120篇 |
口腔科学 | 26篇 |
临床医学 | 118篇 |
内科学 | 145篇 |
皮肤病学 | 27篇 |
神经病学 | 93篇 |
特种医学 | 28篇 |
外科学 | 227篇 |
综合类 | 11篇 |
预防医学 | 68篇 |
眼科学 | 14篇 |
药学 | 84篇 |
中国医学 | 7篇 |
肿瘤学 | 60篇 |
出版年
2024年 | 1篇 |
2023年 | 7篇 |
2022年 | 23篇 |
2021年 | 46篇 |
2020年 | 27篇 |
2019年 | 40篇 |
2018年 | 48篇 |
2017年 | 32篇 |
2016年 | 38篇 |
2015年 | 36篇 |
2014年 | 46篇 |
2013年 | 66篇 |
2012年 | 98篇 |
2011年 | 91篇 |
2010年 | 63篇 |
2009年 | 46篇 |
2008年 | 63篇 |
2007年 | 51篇 |
2006年 | 55篇 |
2005年 | 38篇 |
2004年 | 44篇 |
2003年 | 28篇 |
2002年 | 24篇 |
2001年 | 17篇 |
2000年 | 14篇 |
1999年 | 8篇 |
1998年 | 6篇 |
1997年 | 8篇 |
1996年 | 6篇 |
1995年 | 2篇 |
1994年 | 6篇 |
1993年 | 2篇 |
1992年 | 5篇 |
1991年 | 6篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1985年 | 7篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有1134条查询结果,搜索用时 437 毫秒
91.
Kumar R Bumb RA Ansari NA Mehta RD Salotra P 《The American journal of tropical medicine and hygiene》2007,76(5):896-901
Identification of new foci of cutaneous leishmaniasis (CL), along with reports of Leishmania donovani causing the disease, is an issue of concern. Clinico-epidemiologic analysis of 98 cases in the endemic regions of Rajasthan state, India, suggested the preponderance of infection in men (62.24%) compared with women (37.75%). Species characterization by internal transcribed spacer 1 (ITS1) polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP), kDNA-PCR, and immunofluorescence assay established L. tropica as the causative organism. When applied directly to 32 clinical samples, kDNA PCR had a sensitivity of 96.6%, whereas ITS1 PCR had a sensitivity of 82.75%, thus facilitating diagnosis and species identification. Either parasite culture or direct microscopy alone detected 48.2% and 65.5% of the positive samples, respectively, whereas culture and microscopy together improved overall sensitivity to 89.3% (25/28). Except for the kDNA PCR, all other assays were 100% specific. This study provides the first comprehensive molecular and immunologic studies of CL in India. 相似文献
92.
93.
Zamani Naghmeh Osgoei Laya Takbiri Aliaghaei Abbas Zamani Nasim Hassanian-Moghaddam Hossein 《Metabolic brain disease》2023,38(1):323-338
Metabolic Brain Disease - Methadone is a centrally-acting synthetic opioid analgesic widely used in the methadone maintenance therapy (MMT) programs throughout the world. Considering its neurotoxic... 相似文献
94.
95.
Madheswaran Gopinath Nasim Pinaz Ballae Ganeshrao Shonraj Raman Rajiv Ve Ramesh S. 《International ophthalmology》2022,42(6):1975-1986
International Ophthalmology - Recent research has found variable evidence on the role of mesopic and dark-adapted scotopic microperimetry assessment in age-related macular degeneration. This... 相似文献
96.
Conti M Prevedello DM Madhok R Faure A Ricci UM Schwarz A Robert R Kassam AB 《Clinical neurology and neurosurgery》2008,110(7):682-686
OBJECTIVE: Vascular damage in the cavernous sinus can cause ischemic injury to the cranial nerves. An appropriate anatomical knowledge of the blood supply to the cranial nerves can help to reduce the morbidity associated with cavernous sinus surgery. MATERIAL AND METHODS: Three formalin-fixed and six adult cadaveric fresh heads, with common carotid arteries injected, were used for anatomical dissection in this study. A fronto-temporal craniotomy was performed and the cavernous sinus was explored according to the Dolenc technique. With microsurgical dissection and photographic documentation, we demonstrate the anatomy of the superior orbital fissure artery in the antero-medial triangle. RESULTS: The 12 explored cavernous sinuses demonstrated the presence of two principal branches directly from the intracavernous internal carotid artery that supply the cranial nerves: the infero-lateral trunk and the meningohypophyseal trunk. The artery of the Superior Orbital Fissure (SOF), originated more often from the infero-lateral trunk, and vascularized the III, IV, VI, and VI, and ophtalmic division of the trigeminal nerve (TGN VI) at their entry in the fissure. CONCLUSION: In this study we demonstrate that the superior orbital fissure artery is a branch from the infero-lateral trunk which runs immediately under the reticularis layer at the level of the anteromedial triangle in the lateral wall of the cavernous sinus. The blood supply to all cranial nerves in the SOF is at risk to injury when the lateral wall of the cavernous sinus is transgressed at the anteromedial triangle since the SOF-artery runs superficially at this level. 相似文献
97.
Gardner PA Kassam AB Snyderman CH Carrau RL Mintz AH Grahovac S Stefko S 《Journal of neurosurgery》2008,109(1):6-16
OBJECT: Craniopharyngiomas are challenging tumors that most frequently occur in the sellar or suprasellar regions. Microscopic transsphenoidal resections with various extensions and variations have been performed with good results. The addition of the endoscope as well as the further expansion of the standard and extended transsphenoidal approaches has not been well evaluated for the treatment of this pathological entity. METHODS: The authors performed a retrospective review of all patients who underwent a purely endoscopic, expanded endonasal approach (EEA) for the resection of craniopharyngiomas at their institution between June 1999 and February 2006. Endocrine and ophthalmological outcomes, extent of resection, and complications were evaluated. RESULTS: Sixteen patients underwent endoscopic EEA for the resection of craniopharyngiomas. Five patients (31%) presented with recurrent disease. Complete resection was planned in 11 of the 16 patients. Three elderly patients with vision loss underwent planned debulking, 1 patient with vision loss and a moderate-sized tumor had express wishes for debulking, and 1 patient had a separate, third ventricular nodule that was not resected. Of those in whom complete resection was planned, 91% underwent near-total (2/11) or gross-total (8/11) resection. No patient who underwent gross-total resection suffered a recurrence. The mean follow-up period was 34 months. Of the 14 patients who presented with vision loss, 93% had improvement or complete recovery and 1 patient's condition remained stable. No patient experienced visual worsening. Eighteen percent of patients (without preexisting hypopituitarism) developed panhypopituitarism and 8% developed permanent diabetes insipidus. There were no cases of new obesity. The postoperative cerebrospinal fluid leak rate was 58%. All leaks were resolved, and there were no cases of bacterial meningitis. There was 1 vascular injury (posterior cerebral artery perforator branch) resulting in the only new neurological deficit. No patient died. CONCLUSIONS: Endoscopic EEA for the resection of craniopharyngiomas provides acceptable results and holds the potential to improve outcomes. 相似文献
98.
Expanded endonasal approach: vidian canal as a landmark to the petrous internal carotid artery 总被引:2,自引:0,他引:2
Kassam AB Vescan AD Carrau RL Prevedello DM Gardner P Mintz AH Snyderman CH Rhoton AL 《Journal of neurosurgery》2008,108(1):177-183
The purpose of this study was to describe the technique used to safely identify the petrous carotid artery during expanded endonasal approaches to the skull base. A series of 20 cadaveric studies was undertaken to isolate the vidian artery and nerve and to use them as landmarks to the petrous internal carotid artery (ICA). Twenty-five consecutive paraclival endoscopic cases were also reviewed to determine the consistency of the vidian artery in vivo as an intraoperative landmark to the ICA. These data were then correlated with results from a separate study in which computed tomography scans from 44 patients were evaluated to delineate the course of the vidian canal and its relationship to the petrous ICA. In all 20 cadaveric dissections and all 25 surgical cases, the vidian artery was consistently identified and could be reliably used as a landmark to the ICA. The correlation between anatomical and clinical data in this paper supports the consistent use of the vidian artery as an important landmark to the petrous ICA. 相似文献
99.
Ali Almasirad Abbas Shafiee Mohammad Abdollahi Amir Noeparast Nasir Shahrokhinejad Nasim Vousooghi Sayyed Abbas Tabatabai Reza Khorasani 《Medicinal chemistry research》2011,20(4):435-442
A series of new 1,3,4-oxadiazoles and 1,2,4-triazoles were synthesized in order to obtain new compounds with potential analgesic
activity. Compounds were evaluated for their analgesic activities by formalin-induced nociception test. Mefenamic acid (as
the reference drug) did not show any activity in the early phase of the formalin test, while compounds 7b, 7c, 8c, and 9a significantly reduced the nociception in this phase. However in the late phase of formalin test all of the target compounds
and mefenamic acid showed analgesic activity in comparison to control. 相似文献
100.
Stephen M. Pirris Ian F. Pollack Carl H. Snyderman Ricardo L. Carrau Richard M. Spiro Elizabeth Tyler-Kabara Amin B. Kassam 《Child's nervous system》2007,23(4):377-384
Introduction Clival chordomas are rare tumors, especially in the pediatric population. In this report, we present the case of a 3-year-old
boy who was found to have a large posterior pharyngeal, clival, and posterior fossa tumor detected on a CT scan after a closed
head injury.
Discussion Further questioning revealed a history of ataxia and dysphagia. Imaging confirmed severe extrinsic brain stem compression.
The tumor was resected in multiple stages utilizing a minimally invasive endoscopic endonasal technique along with open transfacetal,
transcondylar approach through the carotid–vertebral window. The child suffered no permanent complications as a result of
our treatment and his dysphagia significantly improved. Although a complete resection was not feasible due to vascular encasement
by the tumor, extensive decompression was obtained with minimal morbidity.
Conclusion We present this case to illustrate a new paradigm of skull base surgical approaches for large clival lesions in pediatric
patients that allows aggressive resection with minimal morbidity. 相似文献