全文获取类型
收费全文 | 3474篇 |
免费 | 223篇 |
国内免费 | 66篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 76篇 |
妇产科学 | 45篇 |
基础医学 | 480篇 |
口腔科学 | 280篇 |
临床医学 | 326篇 |
内科学 | 708篇 |
皮肤病学 | 72篇 |
神经病学 | 220篇 |
特种医学 | 268篇 |
外科学 | 307篇 |
综合类 | 32篇 |
预防医学 | 445篇 |
眼科学 | 60篇 |
药学 | 283篇 |
中国医学 | 34篇 |
肿瘤学 | 95篇 |
出版年
2024年 | 6篇 |
2023年 | 44篇 |
2022年 | 74篇 |
2021年 | 125篇 |
2020年 | 101篇 |
2019年 | 101篇 |
2018年 | 146篇 |
2017年 | 74篇 |
2016年 | 93篇 |
2015年 | 127篇 |
2014年 | 151篇 |
2013年 | 163篇 |
2012年 | 218篇 |
2011年 | 272篇 |
2010年 | 148篇 |
2009年 | 116篇 |
2008年 | 182篇 |
2007年 | 190篇 |
2006年 | 146篇 |
2005年 | 123篇 |
2004年 | 103篇 |
2003年 | 86篇 |
2002年 | 84篇 |
2001年 | 75篇 |
2000年 | 38篇 |
1999年 | 42篇 |
1998年 | 62篇 |
1997年 | 42篇 |
1996年 | 62篇 |
1995年 | 49篇 |
1994年 | 48篇 |
1993年 | 51篇 |
1992年 | 16篇 |
1991年 | 23篇 |
1990年 | 29篇 |
1989年 | 36篇 |
1988年 | 38篇 |
1987年 | 38篇 |
1986年 | 31篇 |
1985年 | 41篇 |
1984年 | 20篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 23篇 |
1980年 | 20篇 |
1979年 | 17篇 |
1978年 | 12篇 |
1977年 | 19篇 |
1976年 | 11篇 |
1975年 | 12篇 |
排序方式: 共有3763条查询结果,搜索用时 31 毫秒
111.
112.
Artefact expression associated with several cone‐beam computed tomographic machines when imaging root filled teeth
下载免费PDF全文
![点击此处可从《International endodontic journal》网站下载免费的PDF全文](/ch/ext_images/free.gif)
113.
114.
115.
Bruna Romana‐Souza Adriana P. Nascimento Patricia C. Brum Andréa Monte‐Alto‐Costa 《International journal of experimental pathology》2014,95(5):330-341
The α2‐adrenoceptors regulate the sympathetic nervous system, controlling presynaptic catecholamine release. However, the role of the α2‐adrenoceptors in cutaneous wound healing is poorly understood. Mice lacking both the α2A/α2C‐adrenoceptors were used to evaluate the participation of the α2‐adrenoceptor during cutaneous wound healing. A full‐thickness excisional lesion was performed on the dorsal skin of the α2A/α2C‐adrenoceptor knockout and wild‐type mice. Seven or fourteen days later, the animals were euthanized and the lesions were formalin‐fixed and paraffin‐embedded or frozen. Murine skin fibroblasts were also isolated from α2A/α2C‐adrenoceptor knockout and wild‐type mice, and fibroblast activity was evaluated. The in vivo study demonstrated that α2A/α2C‐adrenoceptor depletion accelerated wound contraction and re‐epithelialization. A reduction in the number of neutrophils and macrophages was observed in the α2A/α2C‐adrenoceptor knockout mice compared with wild‐type mice. In addition, α2A/α2C‐adrenoceptor depletion enhanced the levels of nitrite and hydroxyproline, and the protein expression of transforming growth factor‐β and vascular endothelial growth factor. Furthermore, α2A/α2C‐adrenoceptor depletion accelerated blood vessel formation and myofibroblast differentiation. The in vitro study demonstrated that skin fibroblasts isolated from α2A/α2C‐adrenoceptor knockout mice exhibited enhanced cell migration, α‐smooth muscle actin _protein expression and collagen deposition compared with wild‐type skin fibroblasts. In conclusion, α2A/α2C‐adrenoceptor deletion accelerates cutaneous wound healing in mice. 相似文献
116.
Tadeu Uggere de Andrade Silvia Cruz Goes Coutinho Haguihara Raiana Maria Prucoli Falsoni Cristiane Lyrio da Silva Dionísio Gonzaga Dubois Filho Flvia de Souza Andrade Moraes Andrews Marques do Nascimento Girlandia Alexandre Brasil Ewelyne Miranda de Lima 《Basic & clinical pharmacology & toxicology》2019,124(4):360-369
The aim of the study was to evaluate the effect of an anabolic steroid, stanozolol, in a model of atherosclerosis and to investigate the involvement of the modulation of the inflammatory cytokines and oxidative stress in vascular lipid deposition. Low‐density lipid receptor‐deficient (LDLr?/?) mice were fed a standard chow diet and were each week injected subcutaneously either saline (control C group) or 20 mg/kg stanozolol (S group). After 8 weeks, the levels of cholesterol, oxidized LDL (OxLDL) and cytokines were measured in plasma, lipid deposition in aorta was evaluated by en face analysis, and thiobarbituric acid‐reactive substances and oxidation protein were determined in liver. The S group demonstrated increases in vascular lipid deposition, triglycerides and non‐HDL cholesterol levels. Stanozolol increased tumour necrosis factor alpha (TNF‐α) and decreased interleukin‐10 as well as increased the TNF‐α/IL‐10 ratio. Furthermore, oxidative stress was observed in the S group, as indicated by an increase in the plasma OxLDL, as well as by lipid peroxidation and oxidation of proteins in the liver. Chronic treatment with stanozolol promoted lipid deposition in the LDLr?/? mice that could be attributed to a modification of the circulating cytokine levels and systemic oxidative stress. Our results suggest that the anabolic steroid stanozolol in the absence of functional LDL receptors by increasing systemic inflammation and oxidative stress may increase the risk of development and progression of atherosclerosis. 相似文献
117.
Antonio Eduardo Monteiro de Almeida Ricardo Stein Miguel Gus Jo?o Agnaldo Nascimento Karlyse Claudino Belli Jorge Rene Garcia Arévalo Flávio Dani Fuchs Jorge Pinto Ribeiro 《Arquivos brasileiros de cardiologia》2014,103(4):338-347
Background
The importance of measuring blood pressure before morning micturition and in the afternoon, while working, is yet to be established in relation to the accuracy of home blood pressure monitoring (HBPM). Objective: To compare two HBPM protocols, considering 24-hour ambulatory blood pressure monitoring (wakefulness ABPM) as gold-standard and measurements taken before morning micturition (BM) and in the afternoon (AM), for the best diagnosis of systemic arterial hypertension (SAH), and their association with prognostic markers.Methods
After undergoing 24-hour wakefulness ABPM, 158 participants (84 women) were randomized for 3- or 5-day HBPM. Two variations of the 3-day protocol were considered: with measurements taken before morning micturition and in the afternoon (BM+AM); and with post-morning-micturition and evening measurements (PM+EM). All patients underwent echocardiography (for left ventricular hypertrophy - LVH) and urinary albumin measurement (for microalbuminuria - MAU).Result
Kappa statistic for the diagnosis of SAH between wakefulness-ABPM and standard 3-day HBPM, 3-day HBPM (BM+AM) and (PM+EM), and 5-day HBPM were 0.660, 0.638, 0.348 and 0.387, respectively. The values of sensitivity of (BM+AM) versus (PM+EM) were 82.6% × 71%, respectively, and of specificity, 84.8% × 74%, respectively. The positive and negative predictive values were 69.1% × 40% and 92.2% × 91.2%, respectively. The comparisons of intraclass correlations for the diagnosis of LVH and MAU between (BM+AM) and (PM+EM) were 0.782 × 0.474 and 0.511 × 0.276, respectively.Conclusions
The 3 day-HBPM protocol including measurements taken before morning micturition and during work in the afternoon showed the best agreement with SAH diagnosis and the best association with prognostic markers. 相似文献118.
Feedforward and feedback connections and their relation to the cytox modules of V2 in Cebus monkeys
下载免费PDF全文
![点击此处可从《The Journal of comparative neurology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Sheila Nascimento‐Silva Carmen Pinõn Juliana G.M. Soares Ricardo Gattass 《The Journal of comparative neurology》2014,522(13):3091-3105
To study the circuitry related to the ventral stream of visual information processing and its relation to the cytochrome oxidase (CytOx) modules in visual area V2, we injected anterograde and retrograde cholera toxin subunit B (CTb) tracer into nine sites in area V4 in five Cebus apella monkeys. The injection site locations ranged from 2° to 10° eccentricity in the lower visual field representation of V4. Alternate cortical sections, cut tangentially to the pial surface or in the coronal plane, were stained for CTb immunocytochemistry or for CytOx histochemistry or for Nissl. Our results indicate that the V4‐projecting cells and terminal‐like labeling were located in interstripes and thin CytOx‐rich stripes and avoided the CytOx‐rich thick stripes in V2. The feedforward projecting cell bodies in V2 were primarily located in the supragranular layers and sparsely located in the infragranular layers, whereas the feedback projections (i.e., the terminal‐like labels) were located in the supra‐ and infragranular layers. V4 injections of CTb resulted in labeling of the thin stripes and interstripes of V2 and provided an efficient method of distinguishing the V2 modules that were related to the ventral stream from the CytOx‐rich thick stripes, related to the dorsal stream. In V2, there was a significant heterogeneity in the distribution of projections: feedforward projections were located in CytOx‐rich thin stripes and in the CytOx‐poor interstripes, whereas the feedback projections were more abundant in the thin stripes than in the interstripes. J. Comp. Neurol. 522:3091–3105, 2014. © 2014 Wiley Periodicals, Inc. 相似文献
119.
120.