全文获取类型
收费全文 | 50239篇 |
免费 | 2355篇 |
国内免费 | 273篇 |
专业分类
耳鼻咽喉 | 791篇 |
儿科学 | 841篇 |
妇产科学 | 853篇 |
基础医学 | 6403篇 |
口腔科学 | 1347篇 |
临床医学 | 3520篇 |
内科学 | 12258篇 |
皮肤病学 | 725篇 |
神经病学 | 3973篇 |
特种医学 | 1657篇 |
外科学 | 8823篇 |
综合类 | 237篇 |
一般理论 | 2篇 |
预防医学 | 1748篇 |
眼科学 | 754篇 |
药学 | 4022篇 |
中国医学 | 109篇 |
肿瘤学 | 4804篇 |
出版年
2023年 | 283篇 |
2022年 | 587篇 |
2021年 | 1001篇 |
2020年 | 508篇 |
2019年 | 716篇 |
2018年 | 904篇 |
2017年 | 639篇 |
2016年 | 849篇 |
2015年 | 906篇 |
2014年 | 1148篇 |
2013年 | 1448篇 |
2012年 | 2400篇 |
2011年 | 2547篇 |
2010年 | 1445篇 |
2009年 | 1215篇 |
2008年 | 2320篇 |
2007年 | 2506篇 |
2006年 | 2413篇 |
2005年 | 2399篇 |
2004年 | 2294篇 |
2003年 | 2241篇 |
2002年 | 2233篇 |
2001年 | 1697篇 |
2000年 | 1835篇 |
1999年 | 1576篇 |
1998年 | 575篇 |
1997年 | 477篇 |
1996年 | 426篇 |
1995年 | 362篇 |
1994年 | 348篇 |
1993年 | 302篇 |
1992年 | 1134篇 |
1991年 | 952篇 |
1990年 | 922篇 |
1989年 | 961篇 |
1988年 | 864篇 |
1987年 | 854篇 |
1986年 | 798篇 |
1985年 | 790篇 |
1984年 | 551篇 |
1983年 | 441篇 |
1982年 | 225篇 |
1979年 | 489篇 |
1978年 | 281篇 |
1977年 | 260篇 |
1975年 | 212篇 |
1974年 | 227篇 |
1971年 | 230篇 |
1969年 | 230篇 |
1968年 | 217篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
102.
Tranilast is an oral antiallergic agent developed in Japan. This study investigated the effect of prolonged administration of Tranilast on the bronchial sensitivity of 18 asthmatic subjects. They were treated for either less than 3 months or more than 3 months continuously. Methacholine loading testing was used to assess bronchial reactivity, and the respiratory parameters were recorded on an Astograph. Patients treated for longer than 3 months showed a significant decrease in bronchial sensitivity (p less than 0.05). The anticholinergic and bronchodilatory properties of Tranilast were also investigated in 8 subjects. No significant anticholinergic or bronchodilatory effects were observed following a single oral dose of 100 mg of Tranilast. 相似文献
103.
In 20 cases of fresh cervical hip fracture, treated with primary prosthetic replacement, preoperative 99mTc-MDP scintimetry was compared with histologic findings of the extracted femoral heads. The radionuclide uptake was classified into three types according to the activity distribution; overall increase, focal decrease, and overall decrease. Histologically, the location and extent of ischemic necrosis in the femoral heads were closely related to the distribution of decreased activity. 相似文献
104.
105.
To clarify the role of serotonin in cerebral ischemia, we examined the effects of selective serotonin reuptake inhibitors, citalopram and clomipramine, on ischemic neuronal damage in the gerbil. Pretreatment with citalopram (40 mg/kg i.p.) and clomipramine (20 mg/kg i.p.) protected against neuronal destruction of hippocampal CA1 pyramidal cells following 5 min of forebrain ischemia. Furthermore, microdialysis assays showed that a striking increase in extracellular excitatory amino acid levels during ischemia was significantly inhibited by pretreatment with citalopram and clomipramine. However, citalopram (40 mg/kg i.p.) did not alter the extracellular amino acid concentrations in normal gerbils. Thus, serotonin reuptake inhibitors have a protective effect against ischemic neuronal damage. Furthermore, the present result suggests that the protective effect is mediated through prevention of the accumulation of extracellular excitatory amino acids during and after ischemia. 相似文献
106.
107.
Electrochemotherapy is a novel antitumor treatment involving the systemic administration of bleomycin followed by the delivery
of electrical pulses to the tumor. The present study investigates the effects of electrochemotherapy on the growth of colon
26 cells inoculated subcutaneously into the backs of BALB/c mice. The mice were divided into the following four experimental
groups: 20 that received no further treatment after the inoculation of colon 26 cells (control group); 20 that received 500
μg of bleomycin intraperitoneally 7 and 9 days after the inoculation (BLM group); 20 that received electric pulses to the
tumor 7 and 9 days after the inoculation (EP group); and 30 that received electrochemotherapy 7 and 9 days after the inoculation
(ECT group). During 28 days of observation, no deaths due to tumor progression occurred in the ECT group, but there were 18
in the control group, 11 in the BLM group, and 18 in the EP group. While weight loss was observed in all groups, it was most
remarkable in the control group. Tumor growth was significantly inhibited in the ECT group, compared to the other experimental
groups (P<0.01). The results of this study demonstrated that electrochemotherapy significantly inhibited the growth of colon 26 tumors
in mice, without causing any remarkable adverse effects. 相似文献
108.
Minoru Yagi Takeshi Mishina Tsukasa Fujishima Kazutoshi Date Hiroshi Saito Nobuo Suzuki 《Surgery today》1997,27(1):84-87
The acute onset of peritoneal signs and shock in a 7year-old boy who had been hit in the epigastrium by a log-seesaw mandated surgical treatment. Enhanced computed tomography (CT) demonstrated complete laceration of the pancreas as well as duodenal injury, and a duodenoduodenostomy with distal pancreaticogastrostomy was subsequently performed. Temporary external drainage of the stomach and distal pancreas led to an uneventful recovery in the early postoperative period. Although the patient's postoperative development was appropriate for his age, the orifice of the distal pancreas spontaneously closed 2.5 years following surgery. We present this report to stress the fact that every effort should be made to preserve the pancreas following abdominal injury in children. 相似文献
109.
Monoclonality of both pale cells and cuboidal cells of sclerosing hemangioma of the lung. 总被引:26,自引:0,他引:26 下载免费PDF全文
S. Niho K. Suzuki T. Yokose T. Kodama Y. Nishiwaki H. Esumi 《The American journal of pathology》1998,152(4):1065-1069
Sclerosing hemangioma of the lung remains poorly understood, and it is still unclear whether this lesion is neoplastic or not. It consists of two major cell types, pale cells and cuboidal cells. We analyzed the clonality of each cell types from six female cases of surgically resected sclerosing hemangioma. The pale cells and cuboidal cells were separated by microdissection from methanol-fixed sections, and DNA was extracted for clonal analysis based on an X-chromosome-linked polymorphic marker, the human androgen receptor (HUMARA) gene or the phosphoglycerate kinase (PGK) gene. The HUMARA and PGK genes were found to be amplified with or without digestion by the methylation-sensitive restrictive endonuclease HpaII. Five of six cases were informative. Pale cells and cuboidal cells showed the same monoclonality in all of the informative cases, whereas the control cells showed a polyclonal pattern. Our results demonstrated that sclerosing hemangioma is caused by monoclonal expansion of cells, confirming that it is a neoplasia. Moreover, the present data indicate that both pale cells and cuboidal cells are derived from the same cell. 相似文献
110.
A Kitami K Suzuki G Hori T Akizawa M Narushima E Noguchi Y Iida F Sagawa 《Nihon Kyōbu Shikkan Gakkai zasshi》1991,29(11):1505-1508
A 66-year-old woman visited our hospital for further investigation of a coin-shaped lesion in the right lower lung field. After admission, CT-scan revealed an anterior mediastinal tumor. Thymoma and lung metastasis from thymoma were suspected. At thoracotomy, an invasive thymoma involving the left phrenic nerve, the left upper lobe, and the pericardium was found, and the diagnosis of lung metastasis was made. Postoperative pathological findings showed a predominantly lymphocytic thymoma with round and oval-shaped epithelial cells, and the metastatic lung lesion revealed the same findings. Postoperative radiotherapy (4000 rads) and chemotherapy with a combination of CDDP, VDS, and CPA were administered. The metastasis of thymoma is not rare, but most often it is found after operation. In this case the diagnosis of metastatic thymoma was made pre-operatively from a solitary lung lesion. 相似文献