全文获取类型
收费全文 | 16127篇 |
免费 | 747篇 |
国内免费 | 88篇 |
专业分类
耳鼻咽喉 | 136篇 |
儿科学 | 204篇 |
妇产科学 | 188篇 |
基础医学 | 1927篇 |
口腔科学 | 367篇 |
临床医学 | 1015篇 |
内科学 | 3605篇 |
皮肤病学 | 1099篇 |
神经病学 | 1582篇 |
特种医学 | 629篇 |
外科学 | 2706篇 |
综合类 | 99篇 |
一般理论 | 2篇 |
预防医学 | 415篇 |
眼科学 | 140篇 |
药学 | 1478篇 |
中国医学 | 36篇 |
肿瘤学 | 1334篇 |
出版年
2023年 | 79篇 |
2022年 | 149篇 |
2021年 | 270篇 |
2020年 | 143篇 |
2019年 | 197篇 |
2018年 | 274篇 |
2017年 | 217篇 |
2016年 | 291篇 |
2015年 | 294篇 |
2014年 | 380篇 |
2013年 | 418篇 |
2012年 | 669篇 |
2011年 | 676篇 |
2010年 | 376篇 |
2009年 | 314篇 |
2008年 | 642篇 |
2007年 | 696篇 |
2006年 | 667篇 |
2005年 | 675篇 |
2004年 | 707篇 |
2003年 | 689篇 |
2002年 | 670篇 |
2001年 | 591篇 |
2000年 | 657篇 |
1999年 | 616篇 |
1998年 | 240篇 |
1997年 | 158篇 |
1996年 | 165篇 |
1995年 | 144篇 |
1994年 | 126篇 |
1993年 | 105篇 |
1992年 | 438篇 |
1991年 | 388篇 |
1990年 | 400篇 |
1989年 | 418篇 |
1988年 | 399篇 |
1987年 | 366篇 |
1986年 | 317篇 |
1985年 | 285篇 |
1984年 | 168篇 |
1983年 | 151篇 |
1982年 | 80篇 |
1979年 | 163篇 |
1978年 | 82篇 |
1977年 | 83篇 |
1974年 | 71篇 |
1973年 | 80篇 |
1972年 | 84篇 |
1970年 | 74篇 |
1969年 | 69篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
Lin Zhang Yukihiko Shirayama Masaomi Iyo Kenji Hashimoto 《Neuropsychopharmacology》2007,32(9):2004-2010
The present study was undertaken to examine whether the second generation antibiotic drug minocycline attenuates behavioral changes (eg, acute hyperlocomotion and prepulse inhibition (PPI) deficits) in mice after the administration of the N-methyl-D-aspartate (NMDA) receptor antagonist (+)-MK-801 (dizocilpine). Dizocilpine (0.1 mg/kg)-induced hyperlocomotion was significantly attenuated by pretreatment with minocycline (40 mg/kg). Furthermore, the PPI deficits after a single administration of dizocilpine (0.1 mg/kg) were attenuated by pretreatment with minocycline (10, 20, or 40 mg/kg), in a dose-dependent manner. Moreover, in vivo microdialysis study in the free-moving mice revealed that pretreatment with minocycline (40 mg/kg, i.p.) significantly attenuated the increase of extracellular dopamine (DA) levels in the frontal cortex and striatum after administration of dizocilpine (0.1 mg/kg), suggesting that the inhibition of dizocilpine-induced DA release by minocycline may, at least in part, be implicated in the mechanism of action of minocycline with respect to dizocilpine-induced behavioral changes in mice. These findings suggest that minocycline could attenuate behavioral changes in mice after the administration of the NMDA receptor antagonist dizocilpine. Therefore, it is possible that minocycline would be a potential therapeutic drug for schizophrenia. 相似文献
12.
FR900403, a new antifungal antibiotic produced by a Kernia sp 总被引:3,自引:0,他引:3
T Iwamoto A Fujie Y Tsurumi K Nitta S Hashimoto M Okuhara 《The Journal of antibiotics》1990,43(9):1183-1185
13.
A Fujie T Iwamoto N Shigematsu M Ezaki M Hino S Hashimoto M Okuhara M Kohsaka H Imanaka 《The Journal of antibiotics》1990,43(5):449-455
FR112123 is a new oligopeptide antibiotic produced by Streptomyces viridochromogenes No. 7587. The structure of FR112123 is elucidated as N-(N6-(N2-glycyl-L-glutaminyl)-D-lysyl)-D-alanine (1) by spectroscopic and chemical evidence. It resembles a partial structure of peptidoglycan in bacteria. The compound has a superior activity against an Escherichia coli mutant sensitive to inhibitors of cell wall synthesis, although it has a weak activity against the parent strain. These suggest that FR112123 might act on the biosynthesis of bacterial cell wall. 相似文献
14.
K Suzuki Y Ichinose K Hashimoto K Matsumoto T Suzuki K Imai H Yamanaka 《Hinyokika kiyo. Acta urologica Japonica》1990,36(5):557-560
Transrectal ultrasonotomography is useful in following patients with benign prostatic hypertrophy, because prostatic shape and weight are precisely assumed. We studied the effect of chlormadinone acetate (CMA) on benign prostatic hypertrophy. CMA (50 mg/day) was administered to 30 patients with benign prostatic hypertrophy. Weight reduction over 10% of the gland was noticed in 24 cases (80%). Mictional conditions were improved in 70% subjectively and in 71.4% objectively. However, the number of nocturia decreased in only 18.9%. Reduction rate of the weight was unrelated with the weight of prostate before administration of CMA. Duration of administration of CMA and the reduction rate were estimated. There was no definite difference in reduction rate for the first 15 months, but there was a slightly high reduction rate after administration of CMA for more than 24 months. In 3 cases, the shape and weight of prostate were studied after discontinuation of CMA. The size of prostate showed a tendency to increase gradually. 相似文献
15.
Sumie Yamanaka Masanori Hashimoto Masuo Tobe Kazuo Kobayashi Jun Sekizawa Masao Nishimura 《Archives of toxicology》1990,64(4):262-268
We proposed a simple method for screening assessment of acute oral and dermal toxicity using only three rats and mice of each sex at each dose level. Animals were first treated with chemicals at a dose of 2000 mg/kg and were carefully observed for compound-related morbidity and mortality. If none of the animals died, the following toxicity tests were suspended. If some of the animals died, toxicity tests at doses of 200 and 20 mg/kg were performed. The approximate LD50 values calculated by this method showed little difference between two separate laboratories and were in good agreement with LD50 values reported in the literature. Our toxicological data also showed that LD50 values were about 2–2.5 times the MNLD (maximum non lethal dose) in acute oral and dermal toxicity. This meant that a chemical could be regarded as having an LD50 of about 4000 mg/kg or higher when there was no mortality at the dose of 2000 mg/kg. A chemical with such low toxicity would not require further testing for lethal effects. Therefore, this simple method combining the fixed-dose procedure with the limit test is suitable for determination of approximate LD50 values of chemicals and for screening for necessity for classical full LD50 test using many animals.This work was supported by a grant from Ministry of Health and Welfare in Japan (No. 467 and 511) 相似文献
16.
Nobuyuki Takemura Yasuhiko Sugawara Takuya Hashimoto Nobuhisa Akamatsu Yoji Kishi Sumihito Tamura Masatoshi Makuuchi 《Liver transplantation》2005,11(3):356-360
The incidence of hepatic venous stenosis is higher in partial liver transplantation. New methods for hepatic venous reconstruction in left liver transplantation, which secure wide anastomosis, were devised and are reported here. In the graft, the right side of the middle hepatic vein or the left side of the left hepatic vein was cut longitudinally and a rectangular-shaped vein patch was attached for venoplasty. In the recipient, after the left and middle hepatic veins were joined, the right side of the middle hepatic vein was cut toward the closed right hepatic vein, making a horizontal cavotomy for anastomosis. Of 92 patients who underwent conventional hepatic vein reconstruction, 3 were complicated by hepatic venous stenosis (median follow-up 43 months). By contrast, there were no hepatic vein complications in the 20 patients who underwent the new technique (7 months). The current method appears to be technically feasible for outflow reconstruction in left liver graft transplantation. 相似文献
17.
Distribution of thymic tissue in the mediastinal adipose tissue. 总被引:5,自引:0,他引:5
I Fukai Y Funato T Mizuno T Hashimoto A Masaoka 《The Journal of thoracic and cardiovascular surgery》1991,101(6):1099-1102
The distribution of thymic tissue in the anterior mediastinal, retrocarinal, and preaortic fat was examined histologically in 27 autopsy subjects. Thymic tissue was found in the anterior mediastinal fat in 12 subjects (44.4%), in the retrocarinal fat in two (7.4%), and in the preaortic fat in none. The finding of ectopic thymic tissue in these areas has not been reported previously, would appear to be surgically inaccessible via a median sternotomy, and may be responsible in part for some of the failures of thymectomy in the treatment of myasthenia gravis. 相似文献
18.
A Numata T Masuda T Okayasu M Hashimoto T Tanabe 《[Zasshi] [Journal]. Nihon Kyōbu Geka Gakkai》1989,37(2):350-354
A case of benign fibrous histiocytoma of the lung in a 8 years old boy was presented. He was first admitted in May, 1983, with recurrent pneumonia. Chest X-ray showed a ill-defined mass in the right lower lobe. Bronchoscopy revealed a round tumor, 1 cm. in maximum diameter, with complete obstruction of the Truncus Intermedius. Endoscopic resection was performed and partial obstruction of the Truncus Intermedius remained. He was re-admitted with pneumonia of the right middle lobe in March, 1986. Bronchoscopy showed severe stenosis of the Truncus Intermedius. Right middle and lower lobectomy was performed. The 4 X 4 X 3 cm tumor was located in the median of the Truncus Intermedius. Microscopically, the lesion composed of fibroblast-like cells and histiocyte-like cells. The patient's post-operative course was uneventful. He has no signs of local recurrence or metastasis. We believe, this is the first reported primary benign fibrous histiocytoma of the lung in a child in Japan. 相似文献
19.
20.