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41.
双头加压螺纹钉贴股骨距内固定治疗股骨颈骨折 总被引:8,自引:0,他引:8
在X光电视下采用双头加压螺纹钉贴股骨距内固定治疗新鲜股骨颈骨折42例,随访平均2.5年,其中16例随访3年以上,骨折愈合率95.2%,骨折不愈合并股骨头缺血性坏死率4.76%。认为加压螺纹钉贴股骨距内固定可使钉的受力由较大剪应力变为较大轴向力承受,减少骨折处的剪应力,并加压于骨折端能促进骨折愈合。具有操作简单、进钉准确、创伤小、固定牢靠、并发症少等优点。 相似文献
42.
D—氨基葡萄糖盐酸盐的制备研究 总被引:14,自引:0,他引:14
从龙虾壳制备的甲壳素,经盐酸水解得D-氨基葡萄糖盐酸盐,收率>50%,纯度>98.7%。水解条件考察表明,以12mol/LHCl水解2.5~3h效果最佳。 相似文献
43.
Jung Han Kim Sang Jun Lee Young Bok Han Jung Jo Moon Jong Bae Kim 《Archives of pharmacal research》1994,17(2):115-118
This paper describes the isolation of isoguanosine from Croton tiglium L. and its cytotoxic effect against several tumor cell lines in culture and newly reports that isoguanosine has an antitumor activity against implanted S-180 ascitic tumor mice. Isoguanosine is effective at the dose of 24 mg/kg/day x 5, with T/C value of 168%. Isoguanosine inhibits the growth of S-180 and Ehrlich solid tumor in mice at the optimal doses of 96 mg/kg/day x 12 and 48 mg/kg/day x 12, with 1-T/C values of 65% and 60%, respectively. 相似文献
44.
Kyung Bok Lee Jong Sig Kim Sang Tae Kwak Wonbo Sim Jong Hwan Kwak Yeong Shik Kim 《Archives of pharmacal research》1998,21(5):555-558
Chondroitin sulfates were isolated from the mud snail. For the quantitative analysis of enzymatic digestion products of isolated
chondroitin sulfates, strong anion exchange-high performance liquid chromatography (SAX-HPLC) was performed. By the action
of chondroitinase ABC, three unsaturated disaccharides 2-acetamide-2-deoxy-3-O-(β-D-gluco-4-enepyranosyluronic acid)-D-galactose (ΔDi-OS), 2-acetamide-2-deoxy-3-O-(β-D-gluco-4-enepyranosyluronic acid)-6-O-sulfo-D-galactose (ΔDi-6S) and 2-acetamide-2-deoxy-3-O-(β-D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose (ΔDi-4S) were produced from the mud snail chondroitin sulfates. The analysis showed that relative proportion
of ΔDi-OS/ΔDi-6S/ΔDi-4S was 58.7/3.1/38.2. The immunomodulating activity of chondroitin sulfate was examined by cell proliferation
assay and these results suggest that it might be a immunosuppressant. 相似文献
45.
J. K. Kang Sang Won Lee Min Woo Baik Byung Chul Son Yong Kil Hong Chul Ku Jung Keon Hee Ryu 《Child's nervous system》1998,14(7):297-301
Accurate assessment and replacement of blood loss and fluid–electrolyte deficit during craniosynostosis repair is difficult
owing to patient size and the diversity of surgical technique. Forty-three patients undergoing primary craniosynostosis repair
over a 10-year period were studied retrospectively to determine blood loss and fluid deficit and to assess blood transfusion
practices during both intraoperative and postoperative periods. Blood loss was calculated on the basis of estimated red cell
mass (ERCM) and fluid-electrolyte imbalance was investigated with blood samplings. Blood transfusion was considered appropriate
if the postoperative or posttransfusion ERCM was within 12% of the preoperative value. Estimated fluid requirement (EFR) was
used in 4 ml kg–1 h–1 except for neonates. Intraoperatively, 80% of all patients were appropriately managed with respect to blood transfusion and
EFR. Postoperatively only 20% of the patients receiving transfusions were transfused appropriately. In 23.3% of these patients
(10/43) unexpected respiratory distress developed immediately after their recovery from the anesthesia. With the measurement
of estimated blood volume and allowable blood loss, appropriate transfusion could be achieved for the successful treatment
of the primary craniosynostosis.
Received: 16 February 1998 相似文献
46.
47.
48.
Paired kidney analysis of tacrolimus and cyclosporine microemulsion-based therapy in Chinese cadaveric renal transplant recipients 总被引:5,自引:0,他引:5
Chi Yuen Cheung Kim Ming Wong Hoi Wong Chan Yan Lun Liu Yiu Han Chan Ho Sing Wong Wai Leung Chak Koon Shing Choi Ka Foon Chau Chun Sang Li 《Transplant international》2006,19(8):657-666
Few studies used paired kidneys for comparison between tacrolimus and cyclosporine in renal transplantation. Most of the published data used whole blood trough levels for drug monitoring. However, the use of limited sampling strategy and abbreviated formula to estimate the 12-h area under concentration-time curve (AUC(0-12)) allowed better prediction of drug exposure. Sixty-six first cadaveric renal transplant recipients receiving paired kidneys were randomized to receive either tacrolimus-based (n = 33) or cyclosporine microemulsion (Neoral)-based therapies (n = 33). Abbreviated AUC(0-12) was used for drug monitoring and dose titration. Mean follow-up duration was 2.8 +/- 2 years. The patient and graft survival were comparable. Fewer incidence of acute rejection was observed in tacrolimus group (15% vs. 27.3%) though the difference was not significant (P = 0.23). The absolute value and the rate of decline of creatinine clearance were both significantly better in tacrolimus-treated patients. Prevalence of hypertension, post-transplant diabetes mellitus, infection, and malignancy were similar in both groups. Prevalence of hypercholesterolemia (11/33 vs. 4/33) and gum hypertrophy (6/33 vs. 1/33) was more common in cyclosporine-treated patients (P = 0.04 in both parameters). This was the first prospective, randomized study with paired kidney analysis showing the renal function was significantly better in tacrolimus-treated patients than in cyclosporine-treated patients. 相似文献
49.
Spinal entry route for ventral root afferent fibers in the cat 总被引:1,自引:0,他引:1
Hong Kee Shin Jun Kim Sang Chae Nam Kwang Se Paik Jin Mo Chung 《Experimental neurology》1986,94(3):714-725
Twelve anesthetized and paralyzed cats were used to study the spinal entry routes of ventral root afferent fibers. In all animals, the spinal cord was transected at two different levels, L5 and S2. The L5 through S2 dorsal roots were cut bilaterally, making spinal cord segments L5-S2 neurally isolated from the body except for the L5-S2 ventral roots. From this preparation, a powerful excitation of the discharge rate of motor neurons and dorsal horn cells within the isolated spinal segments was observed after intraarterial injection of bradykinin (50 micrograms in 0.5 ml saline). This excitation of the spinal neurons can be considered the most convincing evidence of the potential physiologic role of the ventral root afferent fibers entering the spinal cord directly through the ventral root, because the apparent route of neuronal input from the periphery is through the ventral roots. However, additional control experiments conducted in the present study showed that the excitation persisted even after cutting all ventral roots within the isolated spinal segments, indicating that excitation was not mediated by the ventral roots. Furthermore, direct application of bradykinin on the dorsal surface of the spinal cord also increased the motoneuronal discharge rate, suggesting that excitation of spinal neurons produced by intraarterial injection of bradykinin is due to a direct action of bradykinin on the spinal cord. Thus, we provided an alternate explanation for the most convincing evidence indicating that physiologically important ventral root afferent fibers enter the spinal cord directly through the ventral root. Based on existing experimental evidence, it is likely that the majority of physiologically active ventral root afferent fibers travel distally toward the dorsal root ganglion and then enter the spinal cord through the dorsal root. 相似文献
50.
目的:探讨近年来败血症病原菌变迁和对常用抗菌药物的敏感状况以及影响败血症预后的因素。方法:回顾性分析1998~2004年的98例经血培养和临床资料证实的败血症。结果:98例败血症患者血培养共分离出致病菌102株,属社区获得性败血症81例(82.7%),医院获得性17例(17.3%)。革兰阳性菌、革兰阴性菌和真菌感染分别占34.3%、60.8%、4.9%。社区获得性败血症以大肠埃希菌为主,其次是金黄色葡萄球菌和肺炎克雷伯菌。医院获得性败血症以大肠埃希菌、真菌和不动杆菌为主。23抹金葡菌中苯唑西林耐药率39.1%,未发现对万古霉素耐药的菌株;31株大肠埃希菌对氨苄西林、阿米卡星和左氧氟沙星耐药率分别占90.3%、61.3%和45.2%,但对头孢三代、四代及酶抑制剂耐药率较低(12.9%~19.1%),未发现对亚胺培南-西司他丁耐药菌株。院内感染、血小板下降、血糖升高及休克增加了败血症患者病死率。结论:院内感染败血症病原菌中真菌和不动杆菌呈上升趋势,大肠埃希菌和金葡菌感染首选亚胺培南-西司他丁和万古霉素,大肠埃希菌院外败血症可首选头孢三代或亚胺培南-西司他丁。 相似文献