全文获取类型
收费全文 | 678篇 |
免费 | 61篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 27篇 |
妇产科学 | 26篇 |
基础医学 | 102篇 |
口腔科学 | 8篇 |
临床医学 | 116篇 |
内科学 | 133篇 |
皮肤病学 | 7篇 |
神经病学 | 55篇 |
特种医学 | 13篇 |
外科学 | 65篇 |
综合类 | 5篇 |
预防医学 | 73篇 |
眼科学 | 5篇 |
药学 | 54篇 |
中国医学 | 7篇 |
肿瘤学 | 36篇 |
出版年
2023年 | 11篇 |
2022年 | 30篇 |
2021年 | 41篇 |
2020年 | 19篇 |
2019年 | 35篇 |
2018年 | 44篇 |
2017年 | 27篇 |
2016年 | 25篇 |
2015年 | 22篇 |
2014年 | 33篇 |
2013年 | 43篇 |
2012年 | 66篇 |
2011年 | 62篇 |
2010年 | 28篇 |
2009年 | 24篇 |
2008年 | 52篇 |
2007年 | 28篇 |
2006年 | 40篇 |
2005年 | 22篇 |
2004年 | 22篇 |
2003年 | 27篇 |
2002年 | 20篇 |
2001年 | 2篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 5篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1992年 | 2篇 |
1988年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有741条查询结果,搜索用时 15 毫秒
731.
Mehri Salari Nahid Beladi Moghadam Sevim Soleimani Masoud Etemadifar 《Clinical Case Reports》2022,10(7)
Huntington''s disease is a progressive neurodegenerative disease that typically manifests with Choreic movements, psychological disorders, and cognitive decline. Some patients can initially present atypical movements other than the usual symptoms, such as parkinsonism, ataxia, and dystonia. In this report, we present an HD patient who presented with atypical parkinsonism. 相似文献
732.
Lina Lin Le Li Lexin Xiao Cong Zhang Xueqing Li Md. Nahid Pervez Youqing Zhang Md. Nuruzzaman Md. Ibrahim H. Mondal Yingjie Cai Vincenzo Naddeo 《Materials》2022,15(21)
As an edible oil, palm oil is also safe and reliable in dyeing, and the residual palm oil after dyeing can be recycled and used continuously, which is green and environmentally friendly and has great research prospects. In this research, raw ramie yarn, used for traditional grass cloth, was dyed in a palm oil medium using Reactive Blue 194. Studying the adsorption and diffusion behaviour in the dyeing process is necessary. Additionally, the kinetics and isotherm model of dyeing raw ramie yarn with Reactive Blue 194 in palm oil is studied, and the adsorption behaviour between them is discussed. For a better understanding, the raw ramie yarn dyeing adsorption behaviour was also carried out in a water medium. It was found that the dyeing rates in palm oil are distinctly faster than in water. Kinetics data suggested that the pseudo-second-order model fitted for both dyeing mediums (palm oil and water) of the adsorption of the Reactive Blue 194 dye onto raw ramie yarn. Afterward, the adsorption isotherms’ results denote that the Langmuir model was suitable for palm oil dyeing medium while the Freundlich model was suited for water medium. Overall, this study has demonstrated that raw ramie yarn dyeing in a palm oil medium could be a sustainable colouration route for textile fibres with a greater dye exhaustion percentage. 相似文献
733.
734.
735.
736.
737.
738.
Danial FazilatPanah Nahid Ahmadi Dariush Moslemi Masoumeh Karimi Alireza Taji Mansoureh Dehghani Ali Emadi Torghabeh Zahra Keshtpour Amlashi Mohammadreza Saghafi Maedeh Alsadat Fatemi 《Clinical Case Reports》2021,9(10)
Despite the fact that prostate cancer is the most prevalent cancer in men, metastases to the central nervous system including leptomeningeal involvement by prostate carcinoma is a rare event. The prognosis of metastatic prostate cancer is very poor due to lack of CNS penetrating therapeutic agents. 相似文献
739.
Adenrele M. Gleason Andrea D'Souza Emory Ryan Angela R. Grochowsky Camille R. Carter Ozlem Goker-Alpan Grisel Lopez Nahid Tayebi Ellen Sidransky 《American journal of medical genetics. Part A》2023,191(7):1783-1791
Gaucher disease (GD) is an autosomal recessive disorder resulting from glucocerebrosidase deficiency due to pathologic variants in GBA1. While clinically heterogeneous, GD encompasses three types, non-neuronopathic (GD1), acute neuronopathic (GD2), and chronic neuronopathic (GD3). Newborn screening (NBS), which has made remarkable inroads in detecting certain diseases before detrimental health consequences and fatality ensues, is now being piloted for GD in several states and countries. Early on, clinical features of GD2 can overlap with GD3; hence, predicting outcome is challenging. As NBS for GD becomes more available, the increased detection of GD in neonates is inevitable. As a result, health care providers and families will be faced with uncertainty with respect to clinical management. Since more severe GBA1 variants are generally associated with neuronopathic GD, there has been an increased dependence on genotypic information. We present an infant detected by NBS with genotype D409H(p.Asp448His)/RecNciI (p.Leu483Pro; p.Ala495Pro;p.Val499=). To assist in genetic counseling, we performed a retrospective review of other patients in our cohort carrying D409H and reviewed the literature. The study illustrates the challenges faced in counseling for infants with neuronopathic GD, even with known GBA1 variants, and the tough management decisions that can ensue from detection in newborns. 相似文献
740.
The kidneys, by equilibrating the outputs to the inputs, are essential for maintaining the constant volume, pH, and electrolyte composition of the internal milieu. Inability to do so, either because of internal kidney dysfunction (primary alteration) or because of some external factors (secondary alteration), leads to pathologies of varying severity, leading to modification of these parameters and affecting the functions of other organs. Alterations of the functions of the collecting duct (CD), the most distal part of the nephron, have been extensively studied and have led to a better diagnosis, better management of the related diseases, and the development of therapeutic tools. Thus, dysfunctions of principal cell–specific transporters such as ENaC or AQP2 or its receptors (mineralocorticoid or vasopressin receptors) caused by mutations or by compounds present in the environment (lithium, antibiotics, etc.) have been demonstrated in a variety of syndromes (Liddle, pseudohypoaldosteronism type-1, diabetes insipidus, etc.) affecting salt, potassium, and water balance. In parallel, studies on specific transporters (H+-ATPase, anion exchanger 1) in intercalated cells have revealed the mechanisms of related tubulopathies like distal renal distal tubular acidosis or Sjögren syndrome. In this review, we will recapitulate the mechanisms of most of the primary and secondary alteration of the ion transport system of the CD to provide a better understanding of these diseases and highlight how a targeted perturbation may affect many different pathways due to the strong crosstalk and entanglements between the different actors (transporters, cell types). 相似文献