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31.
ISAAC T. MANYONDA Registrar C. ROSS WELCH Registrar NORMAN A. MCWHINNEY Consultant LESLIE D. ROSS Consultant 《BJOG : an international journal of obstetrics and gynaecology》1990,97(7):608-612
Summary. A questionnaire was circulated to 1147 members (consultant status) and fellows of the Royal College of Obstetricians and Gynaecologists to survey the current management of the vaginal vault following abdominal hysterectomy. Of the 56% who responded, the majority (87%) routinely close the vault. An interrupted mattress suture is used by 60%, a continuous suture by 43% and the Lembert suture by 2%. Chromic catgut is favoured by 60%, a synthetic polymer by 33% and plain catgut by 6%. We then organized a prospective, randomized trial involving 114 women who underwent total abdominal hysterectomy for benign indications. No. 1 polygalactide (Vicryl) was used in 58 women, and No. 1 chromic catgut in 56. Overall, 37 (32%) had vault granulations 6 weeks post-operatively. Chromic catgut had been used in 25 (68%) and polygalactide in the remaining 12 (32%) ( P = 0·01). Only 2 (5%) of these women denied any symptoms, while the rest complained of vaginal discharge, bleeding or both. Neither the patients' age, weight or parity, nor the status of the surgeon influenced the occurrence of granulations. We conclude that the widespread use of chromic catgut revealed by our survey is unacceptable: polygalactide, a synthetic polymer, is associated with fewer vaginal vault granulations than chromic catgut. 相似文献
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Studies of Plasma Fe59 Disappearance--A Manifestation of Ineffective Erythropoiesis and of Hemolysis 总被引:1,自引:0,他引:1
1. Studies of the plasma radioiron disappearance data have revealed arelative "elevation" of plasma radioactivity after the second day in normalsubjects, and after the first day in patients with hemolytic anemia, megaloblastic anemia and thalassemia. This elevation in plasma radioactivity in normal subjects may be interpreted as due to the return to plasma of radioironfrom those cells that are "ineffectively" produced and are hemolyzed in themarrow. Other interpretations are also presented.2. Dyspoieses involving ineffective red cell economy, but not detectably affecting iron economy are contrasted with disorders involving ineffectiveutilization of iron and of pigment alone.3. After the first day plasma radioiron activity shows a diurnal variationsimilar to the diurnal variation in plasma iron concentration. Submitted on July 17, 1964 Accepted on September 29, 1964 相似文献
34.
New optical technologies for earlier endoscopic diagnosis of premalignant gastrointestinal
lesions 总被引:2,自引:0,他引:2
RALPH S DACOSTA BRIAN C WILSON NORMAN E MARCON† 《Journal of gastroenterology and hepatology》2002,17(S1):S85-S104
Gastrointestinal malignancies continue to be the second leading cause of cancer-related deaths in the developed world. The early detection and treatment of gastrointestinal preneoplasms has been demonstrated to significantly improve patient survival. Conventional screening tools include standard white light endoscopy (WLE) and frequent surveillance with biopsy. Well-defined endoscopic surveillance biopsy protocols aimed at early detection of dysplasia and malignancy have been undertaken for groups at high risk. Unfortunately, the poor sensitivity associated with WLE is a significant limitation. In this regard, major efforts continue in the development and evaluation of alternative diagnostic techniques. This review will focus on notable developments made at the forefront of research in modern gastrointestinal endoscopy based on novel optical endoscopic modalities, which rely on the interactions of light with tissues. Here we present the 'state - of - the - art' in fluorescence endoscopic imaging and spectroscopy, Raman spectroscopy, optical coherence tomography, light scattering spectroscopy, chromoendoscopy, confocal fluorescence endoscopy, and immunofluorescence endoscopy. These new developments may offer significant improvements in the diagnosis of early lesions by allowing for targeted mucosal excisional biopsies, and perhaps may even provide 'optical biopsies' of equivalent histological accuracy. This enhancement of the endoscopist's ability to detect subtle preneoplastic changes in the gastrointestional mucosa in real time and improved staging of lesions could lead to curative endoscopic ablation of these lesions and, in the long term, improve patient survival and quality of life. 相似文献
35.
Eimeria tenella: quantitative in vitro and in vivo studies on the effects of mouse polyclonal and monoclonal antibodies on sporozoites 总被引:2,自引:0,他引:2
MARK ST. J. CRANE DEBORAH J. NORMAN MARK J. GNOZZIO ANN C. TATE MAUREEN GAMMON P. KEITH MURRAY 《Parasite immunology》1986,8(5):467-480
Murine, polyclonal and monoclonal antibodies, raised against sporozoites of Eimeria tenella, were tested for their ability to neutralize sporozoite infectivity in vitro and in vivo. Neutralization was effected via three mechanisms. Firstly, sporozoites fixed complement, at low titres, and lysis occurred by the alternative pathway of complement activation. Secondly, in the absence of complement activity, the murine heat-inactivated, hyperimmune antiserum neutralized sporozoites at relatively low titres. At high titres, even though sporozoites were agglutinated, neither the heat-inactivated hyperimmune antiserum nor the monoclonal antibody neutralized sporozoites. Finally, in the presence of complement and specific antibodies, at titres which by themselves would not neutralize sporozoites, neutralization was effected due to lysis via the classical pathway of complement activation. 相似文献
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