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991.
Ahmet Hilmi Kaya Adnan Dagcinar Mustafa Onur Ulu Arif Topal Yasar Bayri Aykan Ulus Cem Kopuz Bulent Sam 《Journal of clinical neuroscience》2010,17(1):80-84
The perforating branches of the P1 segment of the posterior cerebral artery are vulnerable to injury. Because of their close proximity to the basilar artery, the vulnerability occurs especially during surgical interventions for vascular pathologies such as basilar apex aneurysms. Therefore, extensive knowledge of the microsurgical anatomy of this area is mandatory to prevent poor post-operative outcomes. We microscopically examined 28 P1 segments obtained from 14 adult fresh cadaver brains (6 silicone injected, 8 freshly examined). The P1 segments ranged between 2.8 mm and 12.2 mm (mean 6.8 mm) in length with a mean outer diameter of 1.85 mm (range 0.8–4.5 mm). All 94 thalamoperforating branches identified in 27 P1 segments (mean 3.35 branches per segment) arose from the postero-superior aspect of P1 and were the most proximally originating branch in nearly all specimens (96.4%). In addition in 28 P1s, 12 short circumflex arteries (42.8%; mean 0.42 branches per segment), 16 long circumflex arteries (57.1%; mean 0.57 branches per segment) and 10 medial posterior choroidal arteries (35.7%; mean 0.35 branches per segment) were identified and all originated from the posterior or postero-inferior surface of the P1 segment. When the P1 segment had more than one type of branch, it was the short circumflex arteries that were always more proximal in origin than the others. The medial posterior choroidal arteries were always more distal in origin. All three branches were not observed together in any of the P1 segments. The findings in this, and future, anatomical studies may help to reduce the post-surgical morbidity and mortality rates after surgery for posterior circulation aneurysms. 相似文献
992.
993.
Necip Ermis Hakan Gullu Mustafa Caliskan Aydan Unsal Mustafa Kulaksizoglu Haldun Muderrisoglu 《Journal of diabetes and its complications》2010,24(4):229-233
PurposeDiabetic cardiac neuropathy, which is characterized by reduced heart rate variability (HRV), frequently coexists with peripheral neuropathy. Gabapentin has been used for the treatment of diabetic neuropathy. We aimed to evaluate the possible effect of gabapentin treatment on autonomic function in patients with type 2 diabetes via HRV.MethodsThirty patients with type 2 diabetes mellitus and peripheral neuropathy and 28 age- and sex-matched healthy controls were consecutively registered. Each patient underwent HRV measurements, and diabetic patients were administered gabapentin. After 3 months of gabapentin therapy, HRV parameters were measured again.ResultsBaseline HRV parameters were blunted in patients with diabetes mellitus according to the controls [standard deviation of all NN intervals (SDNN, ms): 106.3±29.9 vs. 148.8±36.5, P=.001; power spectrum of the high-frequency band (HF, ms2): 133.6±98.3 to 231.4±197.6, P=.02; power spectrum of the low-frequency band (LF, ms2): 341.8±247.8 to 511.5±409.4, P=.048; LF/HF ratio: 3.3±2.4 to 2.6±1.5, P=.33]. After 3 months of treatment with gabapentin, some HRV parameters showed some improvement. SDNN (106.2±29.8 to 119.4 ± 25, P=.016) and HF (133.6±98.3 to 167.6±118.3, P=.021) increased significantly. LF/HF ratio decreased (from 3.3±2.4 to 2.3±1.9, P=.039) and LF remained unchanged (341.8±247.8 to 352.3±228.9, P=.88).ConclusionsTherapeutic doses of gabapentin not only alleviate neuropathic symptoms but also improve cardiac autonomic function in diabetic patients with peripheral neuropathy. 相似文献
994.
Ayda Turkoz Aysu Kocum H. Evren Eker Hacer Ulgen Mustafa Uysalel Gulnaz Arslan 《Journal of anesthesia》2010,24(1):43-48
Purpose
We investigated whether inserting an intrathecal catheter and leaving it in place for 24 h after an unintentional dural puncture in orthopedic patients reduced the incidence of post-dural puncture headache (PDPH).Methods
The study consisted of 427 patients in whom a total of 21 unintentional dural punctures had occurred during orthopedic surgery performed between 2002 and 2006. Seven patients (phase I; evaluated retrospectively) each underwent placement of an epidural catheter at another level after dural puncture during the period January 2002 to February 2004. Fourteen patients (phase II; evaluated prospectively) received an epidural catheter through the dural tear after an unintentional dural puncture during the period February 2004–March 2006Results
In phase I, 5 of the 7 patients experienced PDPH, and one required an epidural blood patch. In phase II, only one of the 14 patients complained of PDPH, which resolved after 48 h of medical therapy. No patient experienced paresthesia, neurologic or hemorrhagic complication, or infection.Conclusion
Inserting an epidural catheter through the dural tear following an unintentional dural puncture and leaving it in place for 24 h significantly reduces the incidence of PDPH. 相似文献995.
Ibrahim Turkcuer Mustafa Serinken Ozgur Karcioglu Mehmet Zencir M. Kemal Keysan 《Urological research》2010,38(1):29-33
Acute severe colicky pain in the flank region is termed as renal colic (RC), which is commonly diagnosed and treated in the
emergency department (ED). The present study is designed to investigate the hospital costs of patients with RC admitted to
the ED and factors affecting the figures. Retrospective analysis includes all patients diagnosed with RC following physical
examination and X-ray, ultrasound, computed tomography together with laboratory investigations in the university-based ED
between February 2007 and February 2009. The study included 574 patients eligible for the predefined criteria. Mean total
hospital cost in patients admitted to the ED due to RC was calculated to be 55.77 Euro. The greatest contribution to the total
cost was made by radiological investigations in the ED (40.5%) followed by treatment costs (19.7%). Size and location of the
stone and stay times in the ED were the independent variables affecting the costs. The costs were higher as the stones were
bigger and as they were more distal in the ureter. Renal stones were associated with the lowest hospital costs. Radiological
investigations are the greatest contributors in the ED costs in patients with RC. Effective measures need to be undertaken
to reduce resultant costs. Preventive measures as well as diagnostic and therapeutic procedures should be standardized in
the ED in accordance with technological advances and also cost-effectiveness when appropriate. 相似文献
996.
Emin Ozbek Yusuf Ozlem Ilbey Abdulmuttalip Simsek Mustafa Cekmen Fatih Mete Adnan Somay 《International urology and nephrology》2010,42(3):579-587
Nephrotoxicity is a major complication of gentamicin (GEN), which is widely used in the treatment of severe gram-negative
infections. Reactive oxygen spaces (ROS) are important mediators of gentamicin-induced nephrotoxicity. Peroxisome proliferator-activated
receptors (PPARs) have different activities including antioxidant properties. This study was performed to investigate the
protective role of PPAR-γ agonist against GEN-induced nephrotoxicity. Male Wistar Albino rats were randomly divided into the
following four groups, each of which consisted of six animals: (1) control; (2) intraperitoneally injected with GEN for 14
consecutive days (100 mg/kg/day); (3) treatment with rosiglitazone (RSG) via nasogastric gavage (10 mg/kg/daily for 14 days);
(4) treatment with GEN + RSG combination for 14 day. Rats were decapitated on the 15th day and kidneys were removed. Urine
was collected for every 24 h for the determination of daily urine volume. Urea, creatinine, Na+ and K+ levels were measured in blood. Malondialdehyde (MDA), reduced glutathion (GSH), and nitric oxide (NO) levels along with glutathione
peroxidase (GSH-Px), catalase (CAT), and superoxide dismutase (SOD) activities were determined in the renal tissue. Changes
in body weight were recorded. GEN treatment was found to cause nephrotoxicity as evidenced by elevation of serum urea and
creatinine levels. Renal impairment was also assessed by the renal histology. The significant decrease in GSH and increases
in MDA and NO levels as well as a decrease in GSH-Px, CAT, and SOD activities indicated that GEN-induced renal damage was
mediated through oxidative reactions. On the other hand, RSG administration protected kidney tissue against GEN-induced and
free radical-mediated oxidative renal damage in rats. 相似文献
997.
Erdal Karakaya Oğuz Ateş Feza M. Akgür Mustafa Olguner 《International urology and nephrology》2010,42(2):357-360
Recently, anti-inflammatory and tissue protective effects of statins have been shown independent from its anti-hyperlipidemic
effect. It has been shown that one of the statins, rosuvastatin, may reduce ischemia/reperfusion (I/R)-induced tissue injury
in the brain, intestines, and heart. We planned an experimental study to evaluate the effect of rosuvastatin on I/R injury
encountered after the detorsion of the testicular torsion. Rats were divided into three groups. In group 1, testis basal blood
flow (basal value) was measured with LASER Doppler flowmeter (LDF). Testis was relocated into the scrotum without torsion.
Two and 3 h after the basal measurement, testis was brought out from the same incision, and the second (second value) and
third (third value) testicular blood flow measurements were done, respectively. In group 2, after the measurement of basal
value testicular torsion was created. Second and third value measurements were obtained with LDF at the end of the 2 h of
testicular torsion just before the detorsion and 1 h after detorsion. In group 3, same procedures in torsion/detorsion group
were repeated in this group, but 10 mg/kg rosuvastatin was injected intraperitoneally 30 min before detorsion. Second values
in groups 2 and 3 were significantly lower than group 1. Third values were significantly low in group 2 compared to groups
1 and 3. Regarding the third measurement, there was no significant difference between the groups 1 and 3. Tissue injury is
closely related with condition of microvascular perfusion after I/R. Rosuvastatin can protect tissue perfusion in the experimental
testicular torsion model. 相似文献
998.
Background
To investigate how the risk of active tuberculosis disease is influenced by time since original infection and to determine whether the risk of reactivation of tuberculosis increases or decreases with age. 相似文献999.
1000.
de Bono JS Oudard S Ozguroglu M Hansen S Machiels JP Kocak I Gravis G Bodrogi I Mackenzie MJ Shen L Roessner M Gupta S Sartor AO;TROPIC Investigators 《Lancet》2010,376(9747):1147-1154