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Munetada?Kamimoto Motoshi?Kikuchi Takashi?Yashiro Aki?Nihe Yusei?Kariya Yuichi?Hoshino 《Journal of orthopaedic science》2003,8(3):400-407
To investigate the proliferative potencies of the two types of synovial lining cells (types A and B), we used immunohistochemical
techniques under light and electron microscopy to survey the complete process of arthritis in a rat model system. Complete
Freund's adjuvant (0.1 ml) containing 5 mg of heat-inactivated Mycobacterium butyricum was administered intradermally into the right hind paws of 25 male Sprague-Dawley rats. Five animals were killed at weeks
1, 2, 3, and 4 after the immunological challenge, respectively, and the infrapatellar adipose synovium was removed from each
animal. Using proliferative cell nuclear antigen (PCNA) as a cell proliferation marker, we quantified the locations of proliferative
cells under light microscopy and then identified the cell type with immunoelectron microscopy. The number of PCNA-positive
cells was high in the deep layer at week 2, and most of them were determined to be B cells. At week 3, the number of PCNA-positive
cells increased in the superficial layer, and most were identified as A cells. Our results support the idea that cells of
the synovial lining proliferate in situ during the course of arthritis.
Received: August 27, 2002 / Accepted: December 9, 2002
RID="*"
ID="*" Offprint requests to: M. Kamimoto
Acknowledgments. We are grateful to K. Inose and M. Yatabe for their excellent support for this study. 相似文献
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Hb Himeji or beta 140 (H18) Ala----Asp. A slightly unstable hemoglobin with increased beta N-terminal glycation 总被引:1,自引:0,他引:1
Y Ohba T Miyaji M Murakami S Kadowaki T Fujita M Oimomi H Hatanaka K Ishikawa S Baba K Hitaka 《Hemoglobin》1986,10(2):109-125
A fast-moving abnormal hemoglobin found in a diabetic patient was identified as beta 140 (H18) Ala----Asp. It comprised about 40% of the total hemoglobin. The beta N-terminal glycation in the abnormal hemoglobin was estimated to be 3 times as much as that in Hb A in the same blood sample. The abnormal hemoglobin was slightly unstable. Oxygen affinity of the stripped hemoglobin was decreased, but that of red cells from the carrier was slightly higher than normal because of the reduced effect of 2,3-diphosphoglycerate. 相似文献
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Kawaguchi T Igaki N Kinoshita S Matsuda T Kida A Moriguchi R Sakai M Tamada F Oimomi M Goto T 《Internal medicine (Tokyo, Japan)》2003,42(2):211-218
We searched for innovative treatments specifically targeted to the cytokines of three critically ill patients with streptococcal toxic shock syndrome (STSS). Direct hemoperfusion with polymyxin B-immobilized fiber improved the hemodynamics in all three patients who had developed shock at presentation. Continuous hemodiafiltration coupled with plasma exchange for simultaneous removal of several mediators of the inflammatory cascade improved outcome in case 2 and lessened the aggressive clinical course and prolonged survival in case 3. The application of these technologies appears to open new and interesting therapeutic options and may lead to improved survival in STSS. 相似文献
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AN UNUSUAL CASE WHICH BEGAN WITH SUBCUTANEOUS PANNICULITIS FOLLOWED BY FEVER, SEVERE HEPATIC INVOLVEMENT AND HYPERLIPIDEMIA 总被引:1,自引:0,他引:1
Kichihei Miyasaki Yutaka Ooiso Isao Nakamura Munetada Oimomi Tadashi Tai Kunihiko Saito 《Pathology international》1977,27(2):213-224
A 25-year-old man was at first dermatologically suspected as suffering from Weber-Christian syndrome because of subcutaneous panniculitis, but his skin lesions disappeared completely during the course. Hyperlipidemla, disturbances In liver function, and leukemoid reaction became remarkable, and he died of subarachnoid hemorrhage eleven months after onset. Necropsy revealed subarachnoid hemorrhage at the base of the brain, lipogranulomatous and inflammatory lesions in the upper lobe of the left lung, a remarkable fatty liver, splenomegaly, pericarditis, and foam cells in the spleen, liver, and bone marrow. A comparison with 57 autopsy cases of Weber-Christian syndrome reported in the literature showed our case to be an exceptional instance of Weber-Christian syndrome, If the present case is not to be regarded as a different disease entity. ACTA PATH. JAP. 27:213–224, 1977. 相似文献
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Glycation of cataractous lens in non-diabetic senile subjects and in diabetic patients 总被引:2,自引:0,他引:2
M Oimomi Y Maeda F Hata Y Kitamura S Matsumoto S Baba T Iga M Yamamoto 《Experimental eye research》1988,46(3):415-420
Early- and advanced-stage products in the Maillard reaction, glycation, were measured in patients with diabetic or senile cataracts. Early-stage products were measured by means of furosine, which is an acid-hydrolysis product derived from fructose-lysine. Advanced-stage products were measured by fluorometry using high-performance liquid chromatography. Furosine levels were high (listed in descending order) in capsule, cortex and nucleus in both diabetic and senile cataracts. The advanced-stage products were also high (listed in descending order) in nucleus, cortex and capsule in both diabetic and senile cataracts. These results suggest that advanced-stage products might accumulate in larger amounts in the nucleus and cortex than in the capsule, resulting in the formation of cataracts. The study also revealed that the Maillard reaction plays an important role in causing not only diabetic cataracts but also senile cataracts. 相似文献