全文获取类型
收费全文 | 754篇 |
免费 | 97篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 58篇 |
基础医学 | 108篇 |
口腔科学 | 36篇 |
临床医学 | 151篇 |
内科学 | 188篇 |
皮肤病学 | 16篇 |
神经病学 | 18篇 |
特种医学 | 107篇 |
外科学 | 91篇 |
综合类 | 8篇 |
预防医学 | 31篇 |
药学 | 35篇 |
肿瘤学 | 14篇 |
出版年
2023年 | 3篇 |
2020年 | 4篇 |
2019年 | 9篇 |
2018年 | 10篇 |
2017年 | 16篇 |
2016年 | 10篇 |
2015年 | 8篇 |
2014年 | 15篇 |
2013年 | 29篇 |
2012年 | 16篇 |
2011年 | 33篇 |
2010年 | 42篇 |
2009年 | 25篇 |
2008年 | 15篇 |
2007年 | 34篇 |
2006年 | 20篇 |
2005年 | 19篇 |
2004年 | 15篇 |
2003年 | 16篇 |
2002年 | 19篇 |
2001年 | 22篇 |
2000年 | 20篇 |
1999年 | 24篇 |
1998年 | 43篇 |
1997年 | 45篇 |
1996年 | 39篇 |
1995年 | 21篇 |
1994年 | 32篇 |
1993年 | 19篇 |
1992年 | 22篇 |
1991年 | 15篇 |
1990年 | 12篇 |
1989年 | 21篇 |
1988年 | 39篇 |
1987年 | 17篇 |
1986年 | 9篇 |
1985年 | 14篇 |
1984年 | 16篇 |
1983年 | 13篇 |
1982年 | 16篇 |
1981年 | 15篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1977年 | 5篇 |
1976年 | 4篇 |
1975年 | 2篇 |
1968年 | 2篇 |
1954年 | 2篇 |
1943年 | 1篇 |
排序方式: 共有873条查询结果,搜索用时 15 毫秒
51.
ANTEROVENTRAL WALL OF THE THIRD VENTRICLE AND DORSAL LAMINA TERMINALIS: HEADQUARTERS FOR CONTROL OF BODY FLUID HOMEOSTASIS? 总被引:3,自引:0,他引:3
MJ McKinley GL Pennington BJ Oldfield 《Clinical and experimental pharmacology & physiology》1996,23(4):271-281
1. The subfornical organ, median preoptic nucleus and the organum vasculosum of the lamina terminalis (OVLT) are a series of structures situated in the anterior wall of the third ventricle and form the lamina terminalis. The OVLT and ventral part of the median preoptic nucleus are part of a region known as the anteroventral third ventricle region.
2. Data from many laboratories, using techniques ranging from lesions, electrophysiology, neuropharmacology, Fos expression, immunohistochemistry and receptor localization, indicate that the tissue in the lamina terminalis plays a major role in many aspects of body fluid and electrolyte balance.
3. The subfornical organ and OVLT lack the blood-brain barrier and detect alterations in plasma tonicity and the concentrations of circulating hormones such as angiotensin II and possibly atrial natriuretic peptide and relaxin.
4. This information is then integrated within the lamina terminalis (probably in the median preoptic nucleus) with neural signals from other brain regions. The neural output from the lamina terminalis is distributed to a number of effector sites including the paraventricular (both parvo- and magno-cellular parts) and supraoptic nuclei and influences vasopressin secretion, water drinking, salt intake, renin secretion, renal sodium excretion and cardiovascular regulation. 相似文献
2. Data from many laboratories, using techniques ranging from lesions, electrophysiology, neuropharmacology, Fos expression, immunohistochemistry and receptor localization, indicate that the tissue in the lamina terminalis plays a major role in many aspects of body fluid and electrolyte balance.
3. The subfornical organ and OVLT lack the blood-brain barrier and detect alterations in plasma tonicity and the concentrations of circulating hormones such as angiotensin II and possibly atrial natriuretic peptide and relaxin.
4. This information is then integrated within the lamina terminalis (probably in the median preoptic nucleus) with neural signals from other brain regions. The neural output from the lamina terminalis is distributed to a number of effector sites including the paraventricular (both parvo- and magno-cellular parts) and supraoptic nuclei and influences vasopressin secretion, water drinking, salt intake, renin secretion, renal sodium excretion and cardiovascular regulation. 相似文献
52.
53.
To assess the value of phrenic nerve stimulation in the investigation of diaphragm function, transdiaphragmatic pressures were measured in 20 healthy subjects and in 15 patients with diaphragm weakness, during unilateral and bilateral transcutaneous phrenic nerve stimulation at 1 Hz at functional residual capacity (twitch Pdi). Diaphragm function was initially assessed by measuring transdiaphragmatic pressure during a voluntary manoeuvre, the maximal sniff (sniff Pdi); normal readings were confirmed in the control subjects (102-157 (normal greater than 98) cm H2O in the 10 men, 79-102 (normal greater than 70) cm H2O in the 10 women) and reduced values were found in the 15 patients with diaphragm weakness (7.5-90 cm H2O in the 13 men, 23 and 53 cm H2O in the two women). Twitch Pdi during bilateral phrenic nerve stimulation ranged from 8.8 to 33 cm H2O in the control subjects and from 3.1 to 27 cm H2O in the 10 patients in whom a measurement could be obtained. Bilateral twitch Pdi correlated with sniff Pdi both in the control subjects and in the patients with diaphragm weakness (r = 0.75). Only four patients had a bilateral twitch Pdi below the lowest value seen in the control group, including the three with the lowest sniff Pdi (3.1-8.5 cm H2O). These results indicate that transdiaphragmatic pressure recorded during bilateral phrenic nerve stimulation discriminated between control subjects and patients with known weakness of the diaphragm only when this was severe. 相似文献
54.
55.
Extrusive loads of 0.01–1.0 N were applied to the impeded mandibular incisors of 12 rabbits. Tooth position was monitored continuously with a variable capacitance displacement transducer. On suddenly applying an extrusive load, a biphasic displacement of the tooth was recorded. A rapid extrusive phase was followed by a more gradual extrusion. A similar, but intrusive, biphasic recovery response was seen on suddenly removing the load. The group-mean displacements showed that for all phases the responses were force-dependent, though not linearly graded. For a given load, the group-mean displacements during the first phases of the extrusive and recovery cycles did not show significant differences. However, the displacement during the second phase of the extrusive cycle was significantly greater than that of the recovery cycle for a load between 0.2 and 1.0 N. Extrusive loads were also applied to unimpeded teeth. Though no differences between impeded and unimpeded teeth were observed in the biphasic displacement patterns, significantly greater mobility was seen for the unimpeded incisors in all phases. The findings show that biomechanical changes of the periodontal tissues, of importance to studies on tooth eruption, occur in the chronically unimpeded tooth. 相似文献
56.
The finding of hemidiaphragm elevation on a chest radiograph, in absence of an ipsilateral lung disease, is assumed to indicate severe hemidiaphragm dysfunction. To test this hypothesis we retrospectively reviewed chest radiograph findings and corresponding twitch transdiaphragmatic pressure (T(W)P(DI)) results from 42 (17 female, age range 22-79 years) consecutive patients who underwent phrenic nerve stimulation studies. Chest radiographs were independently reviewed in a blind manner by two radiologists. The interobserver agreement was moderate, the kappa value ranging from 0.48 (left hemidiaphragm) to 0.59 (lung parenchyma). Hemidiaphragm dysfunction was diagnosed if T(W)P(DI) of corresponding hemidiaphragm was less than 3.5 cm H2O. The prevalence of patients with an elevated unilateral hemidiaphragm on chest radiograph was 64% and of patients with unilateral paralysis judged by T(W)P(DI) was 24%. Sensitivity, specificity, positive and negative predictive values for chest radiograph, as a diagnostic test for unilateral diaphragm dysfunction were 0.90, 0.44, 0.33 and 0.93, respectively. We conclude that the isolated elevation of hemidiaphragm on chest radiograph is of little value in the diagnosis of unilateral hemidiaphragm paralysis, though the condition is unlikely if diaphragm elevation is absent. 相似文献
57.
58.
59.
Sharshar T Hopkinson NS Ross ET Jonville S Dayer MJ Nickol AH Lofaso F Moxham J Polkey MI 《Respiratory physiology & neurobiology》2005,146(1):5-19
The costal and crural parts of the diaphragm differ in their embryological development and physiological function. It is not known if this is reflected in differences in their motor cortical representation. We compared the response of the costal and crural diaphragms using varying intensities of transcranial magnetic stimulation of the motor cortex at rest and during submaximal and maximal inspiratory efforts. The costal and crural motor evoked potential recruitment curves during submaximal inspiratory efforts were similar. The response to stimulation before, during and at 10 and 30 min after 44 consecutive maximal inspiratory efforts was also the same. Using paired stimulations to investigate intra-cortical facilitatory and inhibitory circuits we found no difference between the costal and crural response with varying interstimulus intervals, or when conditioning and test stimulus intensity were varied. We conclude that supraspinal control of the costal and crural diaphragm is identical during inspiratory tasks. 相似文献
60.