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51.
Protein C activation in NIDDM patients 总被引:6,自引:0,他引:6
E. C. Gabazza H. Takeya H. Deguchi Y. Sumida O. Taguchi K. Murata K. Nakatani Y. Yano M. Mohri M. Sata T. Shima J. Nishioka K. Suzuki 《Diabetologia》1996,39(12):1455-1461
Summary Enhanced activation of the clotting system has been recently implicated in the pathogenesis of vascular complications in
patients with diabetes mellitus. Abnormalities of the anticoagulant system may constitute a potential trigger factor for the
haemostatic activation observed in diabetic subjects. The current study aimed to evaluate anticoagulant activity in diabetic
patients by assessing the plasma levels of activated protein C-protein C inhibitor complex; and by measuring the anticoagulant
response to exogenous thrombomodulin. This study comprised 61 patients (34 men, 27 women) with non-insulin-dependent diabetes
mellitus (NIDDM) of whom 22 showed microalbuminuria and 39 normoalbuminuria. Data obtained in 31 non-obese and non-diabetic
subjects were available for comparison. The plasma levels of fibrinogen (p < 0.02), prothrombin fragment 1 + 2 (p < 0.05), fibrin monomer (p < 0.0001), protein C antigen (p < 0.005), total protein S antigen (p < 0.02), soluble thrombomodulin (p < 0.005) and soluble E-selectin (p < 0.005) were significantly higher in diabetic patients than in healthy subjects. The plasma level of activated protein C-protein
C inhibitor complex (7.4 ± 3.8 vs 3.0 ± 0.4 pmol/l) was significantly higher (p < 0.0001) and the anticoagulant response to exogenous thrombomodulin (23.4 ± 2.6 vs 35.3 ± 3.0 ng/ml) was markedly lower
(p = 0.005) in all diabetic patients than in healthy subjects. Cases with microalbuminuria presented low plasma levels of activated
protein C-protein C inhibitor complex (5.5 ± 0.6 vs 8.6 ± 0.7 pmol/l, p < 0.05) and significantly decreased values of the anticoagulant response to exogenous thrombomodulin (16.5 ± 2.9 vs 23.4
± 2.6 %, p = 0.03) as compared to those with normoalbuminuria. The present study suggests that the hyper-coagulable state in NIDDM is
associated with an increased activation of protein C but with a poor plasma reactivity to the anticoagulant effect of thrombomodulin.
[Diabetologia (1996) 39: 1455–1461]
Received: 27 February 1996 and in revised form: 3 June 1996 相似文献
52.
Keisuke Kidoguchi Yasushi Kubota Shun Fujimoto Yasuhisa Sakata Haruna Kizuka-Sano Kyosuke Yamaguchi Hiroshi Ureshino Hiroo Katsuya Toshihiko Ando Motohiro Esaki Shinya Kimura 《Internal medicine (Tokyo, Japan)》2021,60(10):1601
Cronkhite-Canada syndrome (CCS) is a rare polyposis disorder accompanied by alopecia and onychodystrophy. A 63-year-old man with a history of CCS and repeated embolism developed progressive thrombocytopenia and mild anemia. Laboratory testing, a bone marrow examination, and magnetic resonance imaging of the spine resulted in a diagnosis of concurrent aplastic anemia (AA). Paroxysmal nocturnal hemoglobinuria (PNH)-type cells were detected in a peripheral blood specimen. In addition, human leukocyte antigen (HLA) included DRB1*15:01 and DRB1*15:02. Mesalazine was discontinued in consideration of possible drug-induced pancytopenia. Immunosuppressive therapy ameliorated both the gastrointestinal symptoms of CCS and pancytopenia. A common autoimmune abnormality might underlie both CCS and AA. 相似文献
53.
Lehtolainen P Takeya M Ylä-Herttuala S 《Arteriosclerosis, thrombosis, and vascular biology》2000,20(1):52-60
The type II, class A macrophage scavenger receptor (SR-A) plays an important role in the pathogenesis of atherosclerosis and foam cell formation. However, its role in nonmacrophage cell lines remains unknown. To test the hypothesis that SR-A activity leads to proatherogenic changes in nonmacrophage cell lines, we generated Moloney murine leukemia virus- and vesicular stomatitis virus G protein-pseudotyped retroviruses containing SR-A type II cDNA, which were used for stable transfection of SR-A activity into mouse fibroblasts and rabbit aortic smooth muscle cells (SMCs). beta-Galactosidase-transfected cell lines were used as controls. Transfected cell lines expressed functional SR-A mRNA and protein. Expression of SR-A activity was stable for at least 9 months. By electron microscopy, transfected receptors were located in coated pits and in intracellular structures resembling endocytotic vesicles. Expression of SR-A on the cell surface was verified by flow cytometry and by uptake and degradation of (125)I-labeled acetylated low density lipoprotein (LDL). Increases of 5- to 25-fold and of 6- to 8-fold in the rate of acetylated LDL degradation were observed in transfected fibroblasts and SMCs, respectively, compared with beta-galactosidase-transfected control cell lines. Incubation of the transfected SMCs and fibroblasts with acetylated or oxidized LDL led to foam cell formation. Incubation with oxidized LDL also led to increased apoptosis and cell death. An altered morphology with increased cell size and granularity was observed in the most active SR-A SMC clones. It is concluded that stable overexpression of SR-A leads to foam cell formation and other proatherogenic changes in nonmacrophage cell lines. Stable SMC and fibroblast cell lines can be used as models for foam cell formation. The results also suggest that increased SR activity may play an important role in SMC-related pathology in atherosclerotic arteries. 相似文献
54.
Lymphoepithelioma-like carcinoma (LELC) of the lung is an undifferentiated carcinoma with prominent lymphoid stroma. We encountered a case of synchronous primary lung cancers of LELC and papillary adenocarcinoma in a 67-year-old Japanese woman. By in situ hybridization, Epstein-Barr virus (EBV) genome was detected in malignant epithelial cells of LELC but not in the papillary adenocarcinoma. Tumor-infiltrating lymphocytes in LELC were predominantly CD8+ and T cell intracytoplasmic antigen (TIA-1)+ cytotoxic T cells with closely associated with HLA-DR-positive LELC cells by double immunostaining. These data indicate that the exaggerated lymphoid infiltration in and around the EBV-infected carcinoma cells may represent the enhanced tumor immunity, suggesting a better prognostic indicator. 相似文献
55.
56.
A novel technique using three‐dimensionally documented biopsy mapping allows precise re‐visiting of prostate cancer foci with serial surveillance of cell cycle progression gene panel 下载免费PDF全文
57.
58.
Torikai E Kageyama Y Suzuki M Ichikawa T Nagano A 《Modern rheumatology / the Japan Rheumatism Association》2008,18(5):486-491
It has been reported that nearly 90% of patients with rheumatoid arthritis (RA) have problems with their feet. Several methods
of treating hallux valgus deformity in RA have previously been reported, including arthrodesis and joint resection, and good
results have been observed with surgical procedures. In this report, we compare the clinical and radiological outcomes of
resection arthroplasty alone (the first method) and resection arthroplasty with arthrodesis of the first MTP joint (the second
method) for the treatment of forefoot deformities of RA patients. On clinical assessment, the American Orthopaedic Foot and
Ankle Society (AOFAS) scale score significantly improved in both methods; however, the second method gave better results than
the first method in relation to the footwear and alignment components. On radiographic assessment, in the first method there
were no significant changes in the valgus angle (H–V angle) and the fifth metatarsal bone (M1/5) angle between preoperation
and last follow-up. In contrast, these angles were decreased in the second method. One of the most important issues in the
treatment of forefoot deformities in RA patients is to correct splaying foot deformity. We believe that the second method,
which can correct splaying foot deformity, is currently the most reliable treatment method. 相似文献
59.
60.
Hideki Ishikura Takeya Ono Sadaaki Oki Yasukazu Saito Namiko Umei Wakako Tsumiyama Atsushi Tasaka Kazuki Aihara Yuta Sato Tomohiro Matsumoto Akira Otsuka 《Journal of Physical Therapy Science》2015,27(9):2821-2823
[Purpose] The purpose of this study was to investigate how a stretching torque affects
muscular contractures. [Subjects] The subjects of this study were 48 male Wistar rats.
[Methods] Subjects were divided into 4 groups as follows: Group 1 was the control; Group 2
had muscles in continuous fixation; Group 3 had muscles stretched in the direction of
dorsiflexion by a spring balancer set at a torque of 0.3N for a period of 30 minutes after
continuous fixation; and Group 4 had muscles stretched in the direction of dorsiflexion by
a spring balancer set at a torque of 3.0N for a period of 30 minutes after continuous
fixation. Joint fixation periods were for 2 and 4-weeks. Ankle joint range of motion and
soleus flexibility were analyzed. [Results] For the 2-week joint fixation, soleus
flexibility in Group 4 showed an increase compared with that of Group 3. For both fixation
periods, range of motion in Group 4 showed an increase compared with that of Group 3.
[Conclusion] For both fixation periods, stretching improved joint range of motion. In the
2-week joint fixation, soleus flexibility improved. However, soleus flexibility did not
improve in the 4-week joint fixation.Key words: Muscular contracture, Stretching, Muscular flexibility 相似文献