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41.
Masahiro Miyoshi Rika Komagome Setsuko Ishida Hideki Nagano Kenichi Takahashi Motohiko Okano 《Archives of virology》2013,158(4):775-784
We determined four complete nucleotide sequences of echovirus 6 (E6) isolated from an epidemic of aseptic meningitis (AM) in Hokkaido, Japan, in 2011. Phylogenetic analysis of the genes encoding viral capsid protein 1 revealed that the strains were closely related to E6 strains isolated in China in recent years, but they were distantly related to E6 strains isolated from patients with AM in Osaka Prefecture, Japan, in 2011. The genes encoding the viral protease and RNA-dependent RNA polymerase (3CD) were closely related to those of several non-E6 strains of the species Human enterovirus B isolated in China, South Korea, and Australia from 1999 to 2010, resulting in a novel cluster in the phylogenetic tree. These results suggest that the incidence of AM in Japan in 2011 was caused by at least two lineages of E6 strains, and a lineage of the 3CD gene was interspersed among different serotypic strains isolated in Western Pacific countries. 相似文献
42.
Granulomas of the gut in Crohn's disease 总被引:1,自引:0,他引:1
Dr. Shu Kuramoto M.D. Takeshi Oohara M.D. Osamu Ihara M.D. Ryo Shimazu M.D. Yoshio Kondo M.D. 《Diseases of the colon and rectum》1987,30(1):6-11
To investigate the distribution of granulomas in Crohn's disease, a step sectioning study of the surgically resected intestines
was carried out. This study proved that granulomas in Crohn's disease are found in the seemingly uninvolved intestinal mucosa
as well as in the affected mucosa. Granulomas in the apparently involved mucosa were close to the mucosal surface (less than
500 μm) and small (80 to 160 μm across), while in the affected mucosa they were farther away from the mucosal surface (more
than 500 μm) and larger (more than 160 μm across). We emphasize that these small granulomas, namely microgranulomas, in the
apparently uninvolved intestinal mucosa, are of great value in diagnosing Crohn's disease. 相似文献
43.
Tanaka M Izeki M Miyazaki Y Horigome M Yoneda T Tsuyuki S Takami S Aiba M 《Internal medicine (Tokyo, Japan)》2002,41(11):967-971
A 43-year-old Japanese woman presented hypertension, hypokalemia and typical Cushingoid signs. Autonomous secretion of both aldosterone and cortisol was shown. Abdominal computed tomography demonstrated a single tumor in the right adrenal gland, which established the diagnosis of combined primary aldosteronism and Cushing's syndrome. The resected tumor was a golden yellow-colored adenoma (diameter 4.3 cm) which expressed P450(aldo) and P450(11beta), causing oversecretion of both hormones from this adenoma. After tumor resection, overproduction of both hormones disappeared and she developed adrenal insufficiency, suggesting the strong suppression of normal adrenal function. This case was complicated by Hashimoto's thyroiditis. 相似文献
44.
Three‐Dimensional Visualization of Developing Neurovascular Architecture in the Craniofacial Region of Embryonic Mice 下载免费PDF全文
Toshiaki Sugimoto Yuji Taya Yoshihito Shimazu Yuuichi Soeno Kaori Sato Takaaki Aoba 《Anatomical record (Hoboken, N.J. : 2007)》2015,298(11):1824-1835
Recent studies have highlighted the mechanism of vascular and axonal guidance to ensure proper morphogenesis and organogenesis. We aimed to perform global mapping of developing neurovascular networks during craniofacial development of embryonic mice. To this end, we developed histology‐based three‐dimensional (3D) reconstructions using paraffin‐embedded serial sections obtained from mouse embryos. All serial sections were dual‐immunolabeled with Pecam1 and Pgp9.5/Gap43 cocktail antibodies. All immunolabeled serial sections were digitized with virtual microscopy to acquire high spatial resolution images. The 3D reconstructs warranted superior positional accuracy to trace the long‐range connectivity of blood vessels and individual cranial nerve axons. It was feasible to depict simultaneously the details of angiogenic sprouting and axon terminal arborization and to assess quantitatively the locoregional proximity between blood vessels and cranial nerve axons. Notably, 3D views of the craniofacial region revealed the following: Branchial arch arteries and blood capillary plexi were formed without accompanying nerves at embryonic day (E) 9.5. Cranial nerve axons began to grow into the branchial arches, developing a labyrinth of small blood vessels at E10.5. Vascular remodeling occurred, and axon terminals of the maxillary, mandibular, chorda tympani, and hypoglossal nerve axons had arborized around the lateral lingual swellings at E11.5. The diverged patterning of trigeminal nerves and the arterial branches from the carotid artery became congruent at E11.5. The overall results support the advantage of dual‐immunolabeling and 3D reconstruction technology to document the architecture and wiring of the developing neurovascular networks in mouse embryos. Anat Rec, 298:1824–1835, 2015. © 2015 Wiley Periodicals, Inc. 相似文献
45.
Infectious mononucleosis (IM) is one of the representative, usually benign, acute diseases associated with primary Epstein-Barr virus (EBV) infection. IM is generally self-limiting and is characterized mostly by transient fever, lymphadenopathy and hepatosplenomegaly. However, very rarely primary EBV infection results in severe or fatal conditions such as hemophagocytic lymphohistiocytosis together with fulminant hepatitis designated as severe or fatal IM or EBV-associated hemophagocytic lymphohistiocytosis alone. In addition, chronic EBV-associated diseases include Burkitt's lymphoma, undifferentiated nasopharyngeal carcinoma, Hodgkin lymphoma, T-cell lymphoproliferative disorder (LPD)/lymphoma, natural killer-cell LPD including leukemia or lymphoma, gastric carcinoma, pyothorax-associated lymphoma and senile B-cell LPD as well as chronic active EBV infection and LPD/lymphoma in patients with immunodeficiency. The number of chronic life-threatening diseases linked to the EBV infection is increasingly reported and many of these diseases have a poor prognosis. This review will focus on the historical, pathogenetic, diagnostic, therapeutic and prophylactic issues of EBV-associated life-threatening diseases. 相似文献
46.
Kasuya K Tsuchida A Nagakawa Y Suzuki Y Suzuki M Aoki T Abe Y Shimazu M Itoi T Sofuni A 《Hepato-gastroenterology》2012,59(117):1609-1613
47.
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49.
Noriyuki Fuku Seijiro Mori Haruka Murakami Yuko Gando Heying Zhou Hideki Ito Masashi Tanaka Motohiko Miyachi 《Geriatrics & Gerontology International》2012,12(2):292-297
Aim: Sarcopenia is the significant degenerative loss of skeletal muscle mass and strength associated with aging, and it is one of the components of frailty. We previously reported an association between the 29C>T polymorphism in the transforming growth factor‐β1 gene (rs1800470) and the prevalence of vertebral fractures in subjects with postmenopausal osteoporosis. The association was not attributable to bone mineral density, which suggests that polymorphism influences some aspects of bone quality that affects strength and/or frailty rather than bone strength itself. Thus, we examined the relationship between genetic polymorphism and lean body mass in a Japanese population. Methods: A total of 479 adults comprising 143 men and 336 women, age 23 to 85 years, participated in the present study. Fat‐free mass was measured by dual energy X‐ray absorptiometry, and the relative skeletal muscle index was calculated as the ratio of appendicular (sum of arms and legs) fat‐free mass to the square of height. Results: Total, leg, and appendicular fat‐free mass as well as the relative skeletal muscle index were significantly lower in male subjects with CT/TT genotypes compared to those with CC genotype. Female subjects did not show any genotype‐dependent differences when analyzed as a group, but when those without menstruation (postmenopausal women) were analyzed, arm fat‐free mass was significantly lower in the CT/TT genotypes than in the CC genotype. Conclusions: T allele of the 29C>T polymorphism in the transforming growth factor‐β1 gene might be a risk factor of sarcopenia in a Japanese population. Geriatr Gerontol Int 2012; 12: 292–297. 相似文献
50.
Takashi Muramatsu Motohiko Furuichi Tatsuhiko Nishii Shinichirou Ishimoto Motomi Shiono 《Surgery today》2013,43(5):539-541
A 31-year-old woman was transferred to our hospital for treatment of a right pneumothorax. She had presented initially with moderate dyspnea and coughing at a local clinic, where a chest radiograph showed a collapsed right lung. Chest computed tomography showed overinflation of the middle lobe and a large bulla. We diagnosed congenital lobar emphysema of the middle lobe with pneumothorax and performed middle lobectomy by video-assisted thoracic surgery via four ports (5–12 mm in size). The patient had an uneventful postoperative course and was discharged from hospital 5 days after surgery. 相似文献