全文获取类型
收费全文 | 5149篇 |
免费 | 231篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 47篇 |
儿科学 | 122篇 |
妇产科学 | 53篇 |
基础医学 | 566篇 |
口腔科学 | 158篇 |
临床医学 | 355篇 |
内科学 | 1203篇 |
皮肤病学 | 51篇 |
神经病学 | 357篇 |
特种医学 | 200篇 |
外科学 | 897篇 |
综合类 | 19篇 |
预防医学 | 294篇 |
眼科学 | 64篇 |
药学 | 534篇 |
中国医学 | 9篇 |
肿瘤学 | 466篇 |
出版年
2023年 | 25篇 |
2022年 | 50篇 |
2021年 | 90篇 |
2020年 | 44篇 |
2019年 | 58篇 |
2018年 | 74篇 |
2017年 | 73篇 |
2016年 | 73篇 |
2015年 | 69篇 |
2014年 | 107篇 |
2013年 | 153篇 |
2012年 | 209篇 |
2011年 | 261篇 |
2010年 | 132篇 |
2009年 | 83篇 |
2008年 | 187篇 |
2007年 | 219篇 |
2006年 | 202篇 |
2005年 | 230篇 |
2004年 | 212篇 |
2003年 | 190篇 |
2002年 | 206篇 |
2001年 | 203篇 |
2000年 | 190篇 |
1999年 | 185篇 |
1998年 | 62篇 |
1997年 | 56篇 |
1996年 | 56篇 |
1995年 | 47篇 |
1994年 | 54篇 |
1993年 | 54篇 |
1992年 | 171篇 |
1991年 | 166篇 |
1990年 | 140篇 |
1989年 | 128篇 |
1988年 | 119篇 |
1987年 | 104篇 |
1986年 | 111篇 |
1985年 | 110篇 |
1984年 | 60篇 |
1983年 | 59篇 |
1982年 | 30篇 |
1981年 | 28篇 |
1980年 | 23篇 |
1979年 | 44篇 |
1975年 | 23篇 |
1974年 | 27篇 |
1971年 | 21篇 |
1969年 | 20篇 |
1968年 | 20篇 |
排序方式: 共有5395条查询结果,搜索用时 15 毫秒
71.
72.
Masahiro Toda Kanehisa Morimoto 《Scandinavian journal of clinical and laboratory investigation》2013,73(8):823-825
We measured salivary adiponectin levels in saliva samples collected in two different ways and compared the results. Using the Salivette system, we collected samples from 30 healthy females into test tubes. Salivary adiponectin levels were evaluated using a commercial enzyme immunoassay kit for plasma but with a slightly modified method. While there was a significant correlation between adiponectin levels in plasma and test‐tube saliva (p<0.05), no correlation between adiponectin levels in plasma and Salivette‐sampled saliva was apparent. These findings suggest that test‐tube sampling is more reliable than use of the Salivette system for measuring salivary adiponectin levels. 相似文献
73.
Kitaoka H Kuwahara T Nishida K Morimoto K Kubo T Okawa M Furuno T Doi Y 《Journal of cardiology》2005,45(4):155-159
A 41-year-old man was referred to our hospital for further examination because of abnormal electrocardiography findings at a health-check examination. Transthoracic echocardiography showed left ventricular hypertrophy confined to the most distal portion of the left ventricle, which is a typical feature of apical hypertrophic cardiomyopathy. Ten years later, he was again admitted for the evaluation of chest pain. Echocardiography showed asymmetrical septal hypertrophy in addition to apical hypertrophy. These findings demonstrate morphologic evolution in hypertrophic cardiomyopathy from apical hypertrophy to asymmetrical septal hypertrophy. 相似文献
74.
T Tono T Tsujimura U Koshimizu T Kasugai S Adachi K Isozaki S Nishikawa M Morimoto Y Nishimune S Nomura 《Blood》1992,80(6):1448-1453
75.
Arata Tabuchi Ryoji Taniguchi Kanako Takahashi Hirokazu Kondo Mitsunori Kawato Takeshi Morimoto Takeshi Kimura Toru Kita Hisanori Horiuchi 《Circulation journal》2008,72(3):420-426
BACKGROUND: There are few monitoring systems widely used in clinical practice for evaluating the effectiveness of aspirin therapy, so in the present study aspirin's antiplatelet effects we investigated with a whole blood aggregometer using a screen filtration pressure (SFP) method. METHODS AND RESULTS: Thirty-five healthy male volunteers took 100 mg/day aspirin for 14 days. Whole-blood aggregation was analyzed at baseline and on days 7 and 14, using collagen and adenosine diphosphate as the stimuli, and compared with the platelet-rich plasma (PRP) aggregation measured by optical aggregometer. The platelet-aggregation threshold index (PATI) for both methods, which was defined as the putative agonist-concentration giving half-maximal aggregation, and the PRP-maximal aggregation rate were analyzed. The maximal aggregation rate induced by 1.6 mg/L collagen decreased from 85.5% (80.8-92.8) [median (interquartile range)] at baseline to 51.5% (39-63.8) on day 14 (p<0.0001). The PRP-PATI and whole-blood PATI for collagen increased from 0.32 (0.28-0.70) to 1.82 mg/L (1.25-2.89) (p<0.0001) and from 0.28 (0.22-0.3) to 1.06 mg/L (1.01-1.29) (p<0.0001) respectively. CONCLUSIONS: The whole-blood PATI and PRP-PATI for collagen, as well as the maximal PRP aggregation rate, clearly distinguish platelet aggregability before and after aspirin intake. However, whole-blood analysis by the SFP-method is easier to perform, and is a promising method of monitoring aspirin's effects. 相似文献
76.
Yushiro Endo Shin-ya Kawashiri Shimpei Morimoto Ayako Nishino Momoko Okamoto Sosuke Tsuji Ayuko Takatani Toshimasa Shimizu Remi Sumiyoshi Takashi Igawa Tomohiro Koga Naoki Iwamoto Kunihiro Ichinose Mami Tamai Hideki Nakamura Tomoki Origuchi Yukitaka Ueki Tamami Yoshitama Nobutaka Eiraku Naoki Matsuoka Akitomo Okada Keita Fujikawa Hideo Otsubo Hirokazu Takaoka Hiroaki Hamada Tomomi Tsuru Shuji Nagano Arinobu Yojiro Toshihiko Hidaka Yoshifumi Tada Atsushi Kawakami 《Medicine》2021,100(1)
We aimed to evaluate the utility of a simplified ultrasonography (US) scoring system, which is desired in daily clinical practice, among patients with rheumatoid arthritis (RA) receiving biological/targeted synthetic disease-modifying antirheumatic drugs (DMARDs).A total of 289 Japanese patients with RA who were started on tumor necrosis factor inhibitors, abatacept, tocilizumab, or Janus kinase inhibitors between June 2013 and April 2019 at one of the 15 participating rheumatology centers were reviewed. We performed US assessment of articular synovia over 22 joints among bilateral wrist and finger joints, and the 22-joint (22j)-GS and 22-joint (22j)-PD scores were evaluated as an indicator of US activity using the sum of the GS and PD scores, respectively.The top 6 most affected joints included the bilateral wrist and second/third metacarpophalangeal joints. Therefore, 6-joint (6j)-GS and -PD scores were defined as the sum of the GS and PD scores from the 6 synovial sites over the aforementioned 6 joints, respectively. Although the 22j- or 6j-US scores were significantly correlated with DAS28-ESR or -CRP scores, the correlations were weak. Conversely, 6j-US scores were significantly and strongly correlated with 22j-US scores not only at baseline but also after therapy initiation.Using a multicenter cohort data, our results indicated that a simplified US scoring system could be adequately tolerated during any disease course among patients with RA receiving biological/targeted synthetic DMARDs. 相似文献
77.
Hiroaki Shikano Hidenori Ohnishi Hisashi Fukutomi Kimiko Ito Masahiro Morimoto Takahide Teramoto Mitsuhiro Aoki Takezumi Nishihori Yukihiro Akeda Kazunori Oishi Toshiyuki Fukao 《Pediatrics international》2015,57(6):1192-1195
Mondini dysplasia is rare, but has an important association with recurrent bacterial meningitis. We herein describe the case of a 3‐year‐old girl with unilateral sensorineural hearing loss who presented with three independent episodes of bacterial meningitis within 8 months. Temporal bone computed tomography indicated the characteristic features of Mondini dysplasia in the right inner ear. This was treated by surgical closure of the inner ear defect via oval window and additional vaccination was administered. Appropriate vaccination might prevent the recurrent bacterial meningitis associated with Mondini dysplasia. 相似文献
78.
S Takamoto H Tsuchiya T Onishi S Morimoto S Imanaka S Mori Y Seino T Uozumi Y Kumahara 《The Journal of clinical endocrinology and metabolism》1985,61(1):7-11
Patients with acromegaly have alterations in mineral metabolism. To determine the effect of correction of excess GH secretion on calcium metabolism, we studied 12 acromegalic patients before and 3-4 weeks after pituitary adenomectomy. Treatment of acromegaly resulted in significant decreases in both serum calcium [from 9.3 +/- 0.2 to 8.7 +/- 0.1 mg/dl (mean +/- SEM); P less than 0.01] and urinary calcium excretion (from 200 +/- 24 to 88 +/- 12 mg/24 h; P less than 0.0002). Serum phosphate also decreased significantly (P less than 0.01) from 4.8 +/- 0.2 to 4.3 +/- 0.2 mg/dl. Both serum immunoreactive PTH and calcitonin levels were normal initially and did not change after surgery. The mean serum 25-hydroxyvitamin D (25OHD) level was significantly (P less than 0.01) lower and the 1,25-dihydroxyvitamin D [1,25-(OH)2D] level was significantly (P less than 0.0001) higher in acromegaly compared with measurements in 25 normal subjects. After surgery, the serum 25OHD level did not change; however, the serum 1,25-(OH)2D concentration fell significantly (P less than 0.0001) from 60 +/- 4 to 43 +/- 2 pg/ml. A positive correlation was found between the decrements in urinary calcium excretion and the serum 1,25-(OH)2D level when the comparison was made between the decrements as percentages of pretreatment values (r = 0.64; P less than 0.05). The accumulated data suggest that the hypercalciuria in acromegaly might be due to intestinal calcium hyperabsorption, which could be attributed to the elevated circulating 1,25-(OH)2D level. Excessive GH secretion might stimulate the production of 1,25-(OH)2D and might also directly stimulate calcium absorption. 相似文献
79.
Yutaka Ueda Tomotaka Sobue Akiko Morimoto Tomomi Egawa-Takata Chie Hashizume Hisayo Kishida Satomi Okamoto Kiyoshi Yoshino Masami Fujita Takayuki Enomoto Yoshimi Tomine Jun Fukuyoshi Tadashi Kimura 《Journal of epidemiology / Japan Epidemiological Association》2015,25(1):50-56
Background
Finding ways to improve the cervical cancer screening rates among young women has been seen as a critical national health problem in many countries, including Japan. The aim of the present study was to evaluate the effects of a free-coupon program for cervical cancer screening conducted by a local government under financial support from the Japanese national government.Methods
The personal cervical cancer screening information was analyzed for all female residents of Toyonaka City, including any past screening history and clinical results since the year 2009, when a free-coupon program for screening was started. These results were compared to results from 2008, prior to implementation of the free-coupon screening program.Results
The screening rates of women eligible for the free-coupon peaked dramatically compared to women of similar age who paid for their screening; however, the rates for the ineligible-age population also increased significantly in parallel to those in the free-coupon program, possibly by indirect peer and publicity effects. In women aged 20 to 25 years, the consecutive screening rate after a free-coupon screening was significantly lower than for those women who received a regular residential screening. After a free-coupon screening, the rate for participating in consecutive screenings depended significantly on the institution where the participant received her first screening test.Conclusions
These results suggest that, for a generation of young women 20–25 years of age, a free-coupon program for cervical cancer screening was effective in increasing the first-time participation rate for screening; however, the increase in first-time participation did not lead to the expected increase in consecutive screenings.Key words: cervical cancer screening, free-coupon, screening rate, consecutive screening 相似文献80.
Maki Komiyama Yuka Ozaki Yusuke Miyazaki Akihiro Yasoda Hiromichi Wada Hajime Yamakage Noriko Satoh-Asahara Tatsuya Morimoto Akira Shimatsu Yuko Takahashi Koji Hasegawa 《Internal medicine (Tokyo, Japan)》2021,60(8):1175
Objective The psychological status is a key factor in smoking continuance. However, details on short-term changes in mild depressive states after smoking cessation (SC) are still unknown. The purpose of the present study was to investigate these short-term changes. Methods A total of 989 patients who visited our SC Clinic were assessed using the Zung Self-Rating-Depression-Scale (SDS), an official instrument to measure depressive tendencies. The participants were classified into normal and neurotic groups based on their SDS scores during their initial visit; they were assessed again 2, 4, 8, and 12 weeks thereafter. Results The majority of patients in the neurotic group were women. These patients were also younger, with a higher nicotine dependence, and presented with a lower successful SC rate than the patients in the normal group. A decrease in SDS scores after starting the SC treatment was observed only in the neurotic group, especially during the first two weeks. In patients who continued to smoke, no improvement in depressive tendencies was noted in this period. Conclusion Depressive tendencies of patients with neurosis improve in the initial stages of the SC treatment (i.e., within two weeks after starting the treatment). This finding fills the mentioned knowledge gap regarding the effects of SC on mild depressive states in the short term. 相似文献