全文获取类型
收费全文 | 946篇 |
免费 | 66篇 |
国内免费 | 18篇 |
专业分类
儿科学 | 13篇 |
妇产科学 | 88篇 |
基础医学 | 69篇 |
口腔科学 | 7篇 |
临床医学 | 64篇 |
内科学 | 391篇 |
皮肤病学 | 21篇 |
神经病学 | 15篇 |
特种医学 | 72篇 |
外科学 | 76篇 |
综合类 | 11篇 |
预防医学 | 14篇 |
眼科学 | 1篇 |
药学 | 54篇 |
肿瘤学 | 134篇 |
出版年
2023年 | 5篇 |
2022年 | 3篇 |
2021年 | 24篇 |
2020年 | 4篇 |
2019年 | 13篇 |
2018年 | 17篇 |
2017年 | 11篇 |
2016年 | 11篇 |
2015年 | 16篇 |
2014年 | 19篇 |
2013年 | 43篇 |
2012年 | 47篇 |
2011年 | 45篇 |
2010年 | 37篇 |
2009年 | 28篇 |
2008年 | 43篇 |
2007年 | 73篇 |
2006年 | 36篇 |
2005年 | 49篇 |
2004年 | 50篇 |
2003年 | 51篇 |
2002年 | 53篇 |
2001年 | 41篇 |
2000年 | 33篇 |
1999年 | 28篇 |
1998年 | 20篇 |
1997年 | 17篇 |
1996年 | 14篇 |
1995年 | 17篇 |
1994年 | 22篇 |
1993年 | 13篇 |
1992年 | 10篇 |
1991年 | 14篇 |
1990年 | 9篇 |
1989年 | 12篇 |
1988年 | 13篇 |
1987年 | 12篇 |
1986年 | 22篇 |
1985年 | 14篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 6篇 |
1980年 | 5篇 |
1979年 | 2篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 7篇 |
1968年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有1030条查询结果,搜索用时 15 毫秒
41.
A randomized comparison of direct stenting with conventional stent implantation in selected patients with acute myocardial infarction. 总被引:11,自引:0,他引:11
Christophe Loubeyre Marie-Claude Morice Thierry Lefèvre Jean-Fran?ois Piéchaud Yves Louvard Pierre Dumas 《Journal of the American College of Cardiology》2002,39(1):15-21
OBJECTIVES: We sought to determine whether direct stenting might prevent the adverse events associated with stent implantation during primary angioplasty and to compare it with conventional stent implantation in patients with acute myocardial infarction (AMI). BACKGROUND: No trial has demonstrated that stents favorably influence mortality rate. Recent studies have even suggested a negative impact of stents on coronary blood flow and clinical outcome. METHODS: Of 409 patients treated by primary angioplasty with stent implantation in our center, 206 (50%) were enrolled in this randomized, single-center trial and allocated to direct stent implantation (n = 102) or stent implantation after balloon pre-dilation (n = 104). The study end points included angiographic results (final corrected Thrombolysis In Myocardial Infarction [TIMI] frame count and a composite end point of slow and no-reflow or distal embolization), an electrocardiogram marker of myocardial reperfusion assessment (ST-segment resolution) and in-hospital clinical outcome (death and recurrent infarction). RESULTS: Direct stent implantation failed in eight patients but succeeded after pre-dilation in all. A non-significant increase in TIMI flow grade 3 was achieved after direct stenting (95.1% vs. 93.3%, p = 0.74) without significant difference in the corrected TIMI frame count (31.5 +/- 17 and 35.2 +/- 20 frames after direct and conventional stent, respectively, p = 0.42). The composite angiographic end point was significantly reduced by direct stent implantation (11.7% vs. 26.9%, p = 0.01). ST-segment resolution was also significantly improved after direct stent (no ST-segment resolution in 20.2% vs. 38.1% after direct and conventional stent, respectively, p = 0.01). Death and/or recurrent infarction occurred in six patients after conventional stent implantation and in two patients after direct stenting (p = 0.28). CONCLUSIONS: In selected patients with AMI, direct stenting can be applied safely and effectively. This strategy may result in a significant reduction of microvascular injury, as suggested by improved ST-segment resolution after reperfusion with major potential clinical consequences. 相似文献
42.
Gill Louise Buchanan Alaide Chieffo Emanuele Meliga Roxana Mehran Seung-Jung Park Yoshinobu Onuma Piera Capranzano Marco Valgimigli Inga Narbute Raj R. Makkar Igor F. Palacios Young-Hak Kim Piotr P. Buszman Tarun Chakravarty Imad Sheiban Christoph Naber Ronan Margey Arvind Agnihotri Sebastiano Marra Davide Capodanno Victoria Allgar Martin B. Leon Jeffrey W. Moses Jean Fajadet Thierry Lefevre Marie-Claude Morice Andrejs Erglis Corrado Tamburino Ottavio Alfieri Patrick W. Serruys Antonio Colombo 《The American journal of cardiology》2014
43.
Can we predict postprocedural paravalvular leak after Edwards SAPIEN transcatheter aortic valve implantation?
下载免费PDF全文
![点击此处可从《Catheterization and cardiovascular interventions》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Yusuke Watanabe MD Thierry Lefèvre MD Takahide Arai MD PhD Kentaro Hayashida MD PhD Erik Bouvier MD Thomas Hovasse MD Mauro Romano MD Bernard Chevalier MD Philippe Garot MD Patrick Donzeau‐Gouge MD Arnaud Farge MD Bertrand Cormier MD Marie‐Claude Morice MD 《Catheterization and cardiovascular interventions》2015,86(1):144-151
44.
DC-SIGN是DC表面识别多种病原微生物的受体.一方面,DC借助DC-SIGN对固有免疫及适应性免疫发挥免疫调节作用;另一方面,DC-SIGN又成为某些病原微生物如肝炎病毒借以逃逸机体免疫防御功能的靶分子.我们就DC-SIGN的结构及功能、与病毒的相互作用等方面进行阐述. 相似文献
45.
Adriano Caixeta MD PhD Martin B. Leon MD Alexandra J. Lansky MD Eugenia Nikolsky MD PhD Jiro Aoki MD PhD Jeffrey W. Moses MD Joachim Schofer MD Marie-Claude Morice MD Erick Schampaert MD Ajay J. Kirtane MD SM Jeffrey J. Popma MD Helen Parise DSc Martin Fahy MSc Roxana Mehran MD 《Journal of the American College of Cardiology》2009,54(10):894-902
46.
A web-based simulation of a longitudinal clinic used in a 4-week ambulatory rotation: a cohort study
Background
Residency training takes place primarily on inpatient wards. In the absence of a resident continuity clinic, internal medicine residents rely on block rotations to learn about continuity of care. Alternate methods to introduce continuity of care are needed. 相似文献47.
Pulmonary vasodilatory action of testosterone: evidence of a calcium antagonistic action 总被引:6,自引:0,他引:6
Jones RD English KM Pugh PJ Morice AH Jones TH Channer KS 《Journal of cardiovascular pharmacology》2002,39(6):814-823
Recent evidence supports a beneficial effect of testosterone on the cardiovascular system. Testosterone acts as a coronary vasodilator and reduces myocardial ischemia in men with coronary heart disease. The aim of the current study was to determine whether testosterone has a similar vasodilatory action in the pulmonary circulation and to characterize the underlying mechanism of action. The vasodilatory action of testosterone was studied in pulmonary arteries (n = 132, mean internal diameter = 344 +/- 8 microm) isolated from male rats (n = 48, mass = 396 +/- 7 g) mounted in a small vessel wire myograph and loaded to a tension equivalent to 17.5 mm Hg. Micromolar concentrations of testosterone induced dilatation in pulmonary arteries preconstricted with prostaglandin F2alpha (100 microM) within seconds of application. Dilatation to testosterone was similar in vessels treated with N-gamma-nitro-l-arginine methyl ester (l-NAME) (10 microM) or vehicle (5 microl distilled water), -38.2 +/- 2.9%, and -38.1 +/- 3.4%, respectively, and in vessels treated with indomethacin (10 microM), flutamide (10 microM), or vehicle (5 microl ethanol), -35.5 +/- 2.8%, -43.2 +/- 3.6%, and -35.7 +/- 4.6%, respectively (all p > 0.05). Maximal dilatation to testosterone occurred following preconstriction with agents that activated voltage-gated calcium channels such as prostaglandin F2alpha (-34.6 +/- 5.0%), BAY K8644 (-32.9 +/- 8.7), or potassium chloride (-26.7 +/- 1.5%), compared with calcium-independent protein kinase C activation by phorbol dibutyrate (-14.7 +/- 1.6%) or capacitative calcium entry via thapsigargin (-5.1 +/- 0.9%). This study demonstrates that testosterone induces pulmonary dilatation via a mechanism that is independent of the classic androgen receptor and also of the release of nitric oxide or dilator prostaglandins. The data support a calcium antagonistic action for testosterone in the pulmonary circulation, primarily against voltage-gated calcium channels. 相似文献
48.
Patients' and carers' preferences in two models of care for acute exacerbations of COPD: results of a randomised controlled trial 总被引:4,自引:2,他引:2
下载免费PDF全文
![点击此处可从《Thorax》网站下载免费的PDF全文](/ch/ext_images/free.gif)
BACKGROUND: Patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD) were randomised to either hospital at home (HaH) or inpatient management, and patient and carer preferred site of management and satisfaction with care received in the two arms was determined. METHODS: Emergency admissions with an acute exacerbation of COPD were randomised to inpatient care or HaH care. After discharge an independent observer administered a questionnaire to both patients and carers on the preferred site of care and scored satisfaction with the care received. RESULTS: Of 60 patients recruited, 30 were randomised to receive HaH care. Retrospective patient preference for HaH care was 96.3% in the domiciliary arm and 59.3% in the conventional arm; carer preference figures were 85.7% and 42.9%, respectively. There was a higher preference for domiciliary care by both patients and carers in the HaH arm than in the inpatient arm (p=0.001 and p=0.01, respectively). Patients recorded equal satisfaction with care in the two arms (88.1% in the conventional arm, 91.7% in the domiciliary arm); carer scores were 91.3% and 91.9%, respectively. CONCLUSIONS: The results of this study show that both patients and carers were significantly more likely to prefer domiciliary care if they were in the HaH arm. Since patients had to be willing to be looked after at home, both patients' and carers' perceptions of the benefits of HaH care were reinforced by their experience. HaH care of acute exacerbations of COPD is the preferred option in suitable patients. 相似文献
49.
50.
Conservative management of malignant and borderline ovarian tumor 总被引:11,自引:0,他引:11
Morice P Camatte S Wickart-Poque F Rouzier R Pautier P Pomel C Lhommé C Haie-Meder C Duvillard P Castaigne D 《Bulletin du cancer》2002,89(12):1019-1026
Conservative management of at least a part of one ovary and the uterus, in order to preserve fertility-potential, could be propose in most of patients with nonepithelial and borderline ovarian tumor. This conservative management could be performed even in patients with borderline ovarian tumor associated with noninvasive peritoneal implants (if complete resection of peritoneal disease). A removal of the preserved ovary after completion of the pregnancy(ies) is not necessary if patients agree to a careful follow-up procedure. In patient with epithelial ovarian cancer, conservative management could be performed only in case of young patients who desire to preserve fertility function with: unilateral tumor (stage IA), grade 1 (and 2?), who underwent an adequate staging surgery (including peritoneal washings, omentectomy, multiple peritoneal biopsies, uterine curettage and complete pelvic and paraaortic lymphadenectomy) and with a careful follow-up. A conservative management should not be performed in patients with tumor stage > IA and/or grade 3. Removal of preserved ovary should be performed after completion of pregnancy(ies) in order to reduce the risk of ovarian recurrence. 相似文献