全文获取类型
收费全文 | 498篇 |
免费 | 23篇 |
专业分类
儿科学 | 18篇 |
妇产科学 | 27篇 |
基础医学 | 43篇 |
临床医学 | 63篇 |
内科学 | 88篇 |
皮肤病学 | 189篇 |
神经病学 | 11篇 |
特种医学 | 4篇 |
外科学 | 30篇 |
综合类 | 1篇 |
一般理论 | 1篇 |
预防医学 | 23篇 |
眼科学 | 1篇 |
药学 | 20篇 |
肿瘤学 | 2篇 |
出版年
2023年 | 2篇 |
2021年 | 18篇 |
2020年 | 7篇 |
2019年 | 23篇 |
2018年 | 16篇 |
2017年 | 9篇 |
2016年 | 10篇 |
2015年 | 10篇 |
2014年 | 12篇 |
2013年 | 27篇 |
2012年 | 20篇 |
2011年 | 54篇 |
2010年 | 20篇 |
2009年 | 29篇 |
2008年 | 28篇 |
2007年 | 23篇 |
2006年 | 27篇 |
2005年 | 27篇 |
2004年 | 13篇 |
2003年 | 12篇 |
2002年 | 13篇 |
2001年 | 10篇 |
2000年 | 18篇 |
1999年 | 10篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1994年 | 10篇 |
1993年 | 3篇 |
1992年 | 11篇 |
1991年 | 15篇 |
1990年 | 8篇 |
1989年 | 6篇 |
1988年 | 6篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有521条查询结果,搜索用时 15 毫秒
41.
N. Moore D. Montero R. Coulson F. De Abajo C. Kreft-Jais A. Biron J. L. Monteagudo 《Pharmacoepidemiology and drug safety》1994,3(3):157-162
The development of telematic exchange of information in pharmacovigilance has as a consequence the necessary development of the messages used to transmit the information. The first of these messages is the one used to transmit information on individual case reports. Common formats exist on paper, but these have not been applied to electronic transmission. A structured message for the transmission of single case information has been developed within the ENS European research programme, by three National Pharmacovigilance administrations, and reviewed by the relevant European bodies. It has been submitted to the Western European Edifact Board MD9 for admission as an EDIFACT message, so that it will be possible to exchange information concerning these single cases, using standard EDI methodology. 相似文献
42.
In type III von Willebrand disease (vWD) patients, the bleeding time was only partially corrected or not modified after cryoprecipitate infusion, although the levels and the multimeric structure of plasma von Willebrand factor (vWF) were normal. However, the adhesion of normal platelets on the vessel wall subendothelium in the presence of postinfusion patient plasma improved more significantly than the bleeding time. These results suggest a role of the vWF released from normal platelets which is absent in type III vWD platelets. In 5 patients transfusion of normal platelet concentrates performed 1 h after cryoprecipitate infusion without modification of the bleeding time (> 30 min) normalized this parameter, and platelet adhesion to the subendothelium elicited a marked improvement. These last results confirm the suggestion that platelet vWF plays an important 'in vivo' role in the hemostatic process, particularly in patients suffering from severe vWD. 相似文献
43.
44.
45.
B. Monteagudo M. Cabanillas C. de las Heras J.M. Cacharrón 《Actas dermo-sifiliográficas》2009,100(1):61-64
Anterior cervical hypertrichosis was described by Trattner and coworkers in 1991. It consists of a «tuft» of hair at the anterior cervical level just above the laryngeal prominence. To date, only 28 cases of anterior cervical hypertrichosis have been reported. Although it is normally an isolated finding, it may be associated with mental retardation, hallux valgus, retinal disorders, other hair disorders, facial dysmorphism, or sensory and motor peripheral neuropathy. We report the case of a 27-year-old woman who presented with this condition as an isolated finding. 相似文献
46.
47.
48.
Quintana LF Coll E Monteagudo I Collado S López-Pedret J Cases A 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2005,25(4):442-444
Vascular access-related complications are a frequent cause of morbidity in haemodialysis patients and generate high costs. We present the case of an adult patient with end-stage renal disease and recurrent vascular access thrombosis associated with the prothrombin mutation G20210A and renal graft intolerance. The clinical expression of this heterozygous gene mutation may have been favoured by inflammatory state, frequent in dialysis patients. In this patient, the inflammatory response associated with the renal graft intolerance would have favored the development of recurrent vascular access thrombosis in a adult heterozygous for prothrombin mutation G20210A. In the case of early dysfunction of haemodialysis vascular access and after ruling out technical problems, it is convenient to carry out a screening for thrombophilia. 相似文献
49.
de la Rubia J Cantero S Sanz GF Remigia MJ Monteagudo E Moscardó F Martín G Lorenzo I Jiménez C Martínez J Montesinos P Jarque I Sanz MA 《Bone marrow transplantation》2005,36(4):325-329
We evaluated the use of CD34+ selected allogeneic peripheral blood as a source of hematopoietic progenitors for allogeneic transplantation in 11 patients with aplastic anemia (AA). The median age was 17 years (range, 6--9), and the median time between diagnosis and transplant 1 month (range, 1--4). Conditioning consisted of cyclophosphamide (50 mg/kg per day) on days--7 to--4 and antithymocyte globulin (30 mg/kg per day) on days--4 to--2 in nine patients. Total lymphoid irradiation was added to the preparative regimen for two. Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine A and prednisone. Median doses of CD34+ and CD3+ cells infused were 3.91 x 10(6) and 0.3 x 10(6)/kg, respectively. The median time taken to achieve a neutrophil count >0.5 x 10(9)/l was 12 days and to recover a platelet count >20 x 10(9)/l, 13 days. Two patients developed acute GVHD grade I--II and one developed limited chronic GVHD. There were two treatment-related deaths. At a median follow-up of 44 months (range, 4--3), nine patients were alive with sustained and complete engraftment. This is a promising procedure in patients with AA, resulting in a rapid hematopoietic recovery, a low transplant-related mortality, and a low incidence of GVHD. 相似文献
50.
Investigation of plasma von Willebrand factor and circulating platelet aggregating activity in mitomycin C-related hemolytic-uremic syndrome 总被引:1,自引:0,他引:1
J Monteagudo A Pereira S Roig J C Reverter A Ordinas R Castillo 《American journal of hematology》1990,33(1):46-49
We have studied the ability of the plasma to induce aggregation of both homologous and heterologous platelets in four patients with hemolytic-uremic syndrome (HUS) associated with chemotherapy with mitomycin C (MMC). Neither platelet aggregation was elicited by patients' plasmas nor the in vitro addition of purified von Willebrand factor (vWF) had any effect on the aggregation pattern. In addition, ristocetin-induced binding of patients' vWF to formaldehyde-fixed platelets was normal, and multimeric vWF analysis revealed a normal structure of patients' plasmatic vWF whatever the clinical stage in which it was studied. These findings suggest that, in spite of the existence of common clinical and biological features in the various forms of HUS, the pathogenesis of MMC-related HUS may be, at least in part, different from that of the other forms of HUS in which both platelet-aggregating activity and alterations in the vWF are found. 相似文献