全文获取类型
收费全文 | 5794篇 |
免费 | 416篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 47篇 |
儿科学 | 240篇 |
妇产科学 | 136篇 |
基础医学 | 918篇 |
口腔科学 | 53篇 |
临床医学 | 622篇 |
内科学 | 1134篇 |
皮肤病学 | 62篇 |
神经病学 | 683篇 |
特种医学 | 140篇 |
外科学 | 589篇 |
综合类 | 39篇 |
预防医学 | 630篇 |
眼科学 | 52篇 |
药学 | 462篇 |
中国医学 | 26篇 |
肿瘤学 | 400篇 |
出版年
2024年 | 6篇 |
2023年 | 36篇 |
2022年 | 69篇 |
2021年 | 162篇 |
2020年 | 96篇 |
2019年 | 149篇 |
2018年 | 164篇 |
2017年 | 124篇 |
2016年 | 140篇 |
2015年 | 171篇 |
2014年 | 194篇 |
2013年 | 298篇 |
2012年 | 408篇 |
2011年 | 481篇 |
2010年 | 253篇 |
2009年 | 234篇 |
2008年 | 398篇 |
2007年 | 409篇 |
2006年 | 383篇 |
2005年 | 378篇 |
2004年 | 373篇 |
2003年 | 337篇 |
2002年 | 318篇 |
2001年 | 38篇 |
2000年 | 23篇 |
1999年 | 42篇 |
1998年 | 64篇 |
1997年 | 59篇 |
1996年 | 57篇 |
1995年 | 41篇 |
1994年 | 37篇 |
1993年 | 33篇 |
1992年 | 20篇 |
1991年 | 17篇 |
1990年 | 17篇 |
1989年 | 15篇 |
1988年 | 15篇 |
1987年 | 16篇 |
1986年 | 9篇 |
1985年 | 10篇 |
1984年 | 21篇 |
1983年 | 13篇 |
1982年 | 17篇 |
1981年 | 15篇 |
1980年 | 20篇 |
1979年 | 11篇 |
1978年 | 12篇 |
1977年 | 5篇 |
1976年 | 4篇 |
1973年 | 5篇 |
排序方式: 共有6233条查询结果,搜索用时 15 毫秒
991.
Delphine Renolleau-Courtois Aurore Lamouroux-Delay Stéphane Delpierre Monique Badier Françoise Lagier-Tessonnier Alain Palot 《The Journal of asthma》2014,51(5):552-558
Objective: We assessed retrospectively the feasibility of a home-based respiratory rehabilitation (RR) program for asthmatics under optimal pharmacological treatment, as this type of care can reduce costs and offer a more patient-friendly approach for subjects with persistent asthma. Methods: Fifty-two patients with persistent asthma were recruited to the RR program (20 males, 32 females, 54?±?11 (SD) years, forced expiratory volume in one second 71?±?33% of predicted mean value, BMI 29.9?±?7.9?kg/m2). This two-month protocol comprised education sessions, respiratory physiotherapy and an exercise training program at home and in groups supervised by an adapted physical activity instructor. Results: Thirty-nine patients completed the whole RR program, i.e. 25% dropout. The dropout rate was significantly higher with respect to younger patients in employment. The number of exacerbations decreased significantly during the year following the program, regardless of whether the patients had dropped out (p?0.02) or not (p?0.001). The distance walked during a 6-min walking test increased by 33?m (p?0.001). Several indices measured during a cycle ergometer test increased significantly after RR: peak oxygen uptake (10%), oxygen uptake at ventilatory threshold (12%) and maximum load (19%), all at a similar maximum heart rate. Concerning quality of life assessment, the Short-Form-36 Item Health Survey revealed a non-significant improvement in the “health change” item after RR (p?0.07). Conclusions: This study demonstrates the potential of a home-based program in the treatment and rehabilitation of patients with asthma. Both functional and physiologic indices improved during the follow-up period. 相似文献
992.
993.
Efstathios Kastritis Ashutosh Wechalekar Stefan Schönland Vaishali Sanchorawala Giampaolo Merlini Giovanni Palladini Monique Minnema Murielle Roussel Arnaud Jaccard Ute Hegenbart Shaji Kumar Maria T. Cibeira Joan Blade Meletios A. Dimopoulos 《British journal of haematology》2020,190(3):346-357
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated coronavirus disease 2019 (COVID-19) is primarily manifested as a respiratory tract infection, but may affect and cause complications in multiple organ systems (cardiovascular, gastrointestinal, kidneys, haematopoietic and immune systems), while no proven specific therapy exists. The challenges associated with COVID-19 are even greater for patients with light chain (AL) amyloidosis, a rare multisystemic disease affecting the heart, kidneys, liver, gastrointestinal and nervous system. Patients with AL amyloidosis may need to receive chemotherapy, which probably increases infection risk. Management of COVID-19 may be particularly challenging in patients with AL amyloidosis, who often present with cardiac dysfunction, nephrotic syndrome, neuropathy, low blood pressure and gastrointestinal symptoms. In addition, patients with AL amyloidosis may be more susceptible to toxicities of drugs used to manage COVID-19. Access to health care may be difficult or limited, diagnosis of AL amyloidosis may be delayed with detrimental consequences and treatment administration may need modification. Both patients and treating physicians need to adapt in a new reality. 相似文献
994.
BACKGROUNDBiliary dilation is frequently related to obstruction; however, non-obstructive factors such as age and previous cholecystectomy have also been reported. In the past two decades there has been a dramatic increase in opiate use/dependence and utilization of cross-sectional abdominal imaging, with increased detection of biliary dilation, particularly in patients who use opiates.AIMTo evaluate associations between opiate use, age, cholecystectomy status, ethnicity, gender, and body mass index utilizing our institution’s integrated informatics platform. METHODSOne thousand six hundred and eighty-five patients (20% sample) presenting to our Emergency Department for all causes over a 5-year period (2011-2016) who had undergone cross-sectional abdominal imaging and had normal total bilirubin were included and analyzed.RESULTSCommon bile duct (CBD) diameter was significantly higher in opiate users compared to non-opiate users (8.67 mm vs 7.24 mm, P < 0.001) and in patients with a history of cholecystectomy compared to those with an intact gallbladder (8.98 vs 6.72, P < 0.001). For patients with an intact gallbladder who did not use opiates (n = 432), increasing age did not predict CBD diameter (r2 = 0.159, P = 0.873). Height weakly predicted CBD diameter (r2 = 0.561, P = 0.018), but weight, body mass index, ethnicity and gender did not.CONCLUSIONOpiate use and a history of cholecystectomy are associated with CBD dilation in the absence of an obstructive process. Age alone is not associated with increased CBD diameter. These findings suggest that factors such as opiate use and history of cholecystectomy may underlie the previously-reported association of advancing age with increased CBD diameter. Further prospective study is warranted. 相似文献
995.
Oudejans CB Go AT Visser A Mulders MA Westerman BA Blankenstein MA van Vugt JM 《Clinical chemistry》2003,49(9):1445-1449
996.
Summary The aim of the present investigation was to study the effect of aging upon the metabolism and the responsiveness to insulin
of epididymal adipose tissue from rats (6 weeks, 6 and 24 months). Basal glucose metabolism by these tissues and adipocytes
was positively related to cell size, for each age group. But age per se plays an important role: for the same diameter, the
U-14C-glucose oxidation to CO2 and its incorporation into triglycerides decreased markedly between 6 weeks and 6 months, as reported previously, and decreased
still further between 6 months and 24 months, for any diameter. In contrast, insulin responsiveness of adipose tissue fragments
and fat cells was negatively correlated to adipose cell size, when we analyzed the role of cell diameter for a group of given
age. When comparing the sensitivity to hormone for a given cell volume but at different ages, it appeared that insulin resistance
increased considerably between 6 weeks and 6 months and was still more marked in old age. The mechanisms underlying these
facts have been discussed. 相似文献
997.
Circulating regulatory anti-T cell receptor antibodies in patients with myasthenia gravis 总被引:2,自引:0,他引:2 下载免费PDF全文
Jambou F Zhang W Menestrier M Klingel-Schmitt I Michel O Caillat-Zucman S Aissaoui A Landemarre L Berrih-Aknin S Cohen-Kaminsky S 《The Journal of clinical investigation》2003,112(2):265-274
Serum anti-T cell receptor (TCR) Ab's are involved in immune regulation directed against pathogenic T cells in experimental models of autoimmune diseases. Our identification of a dominant T cell population expressing the Vbeta5.1 TCR gene (TCRBV5-1), which is responsible for the production of pathogenic anti-acetylcholine receptor (AChR) autoantibodies in HLA-DR3 patients with early-onset myasthenia gravis (EOMG), prompted us to explore the occurrence, reactivity, and regulatory role of anti-TCR Ab's in EOMG patients and disease controls with clearly defined other autoantibodies. In the absence of prior vaccination against the TCR, EOMG patients had elevated anti-Vbeta5.1 Ab's of the IgG class. This increase was restricted largely to EOMG cases with HLA-DR3 and with less severe disease, and it predicted clinical improvement in follow-up studies. EOMG patient sera containing anti-TCR Ab's bound specifically the native TCR on intact Vbeta5.1-expressing cells and specifically inhibited the proliferation and IFN-gamma production of purified Vbeta5.1-expressing cells to alloantigens in mixed lymphocyte reaction and the proliferation of a Vbeta5.1-expressing T cell clone to an AChR peptide, indicating a regulatory function for these Ab's. This evidence of spontaneously active anti-Vbeta5.1 Ab's in EOMG patients suggests dynamic protective immune regulation directed against the excess of pathogenic Vbeta5.1-expressing T cells. Though not sufficient to prevent a chronic, exacerbated autoimmune process, it might be boosted using a TCR peptide as vaccine. 相似文献
998.
999.
1000.
Peter K.-F. Chiu Chi-Fai Ng Axel Semjonow Yao Zhu Sébastien Vincendeau Alain Houlgatte Massimo Lazzeri Giorgio Guazzoni Carsten Stephan Alexander Haese Ilse Bruijne Jeremy Yuen-Chun Teoh Chi Ho Leung Paola Casale Chih Hung Chiang Lincoln Guan-Lim Tan Edmund Chiong Chao Yuan Huang Monique J. Roobol 《European urology》2019,75(4):558-561
Asians have a lower incidence of prostate cancer (PC). We compared the performance of the Prostate Health Index (PHI) for 2488 men in different ethnic groups (1688 Asian and 800 European men from 9 sites) with PSA 2–20 ng/ml and PHI test and transrectal ultrasound-guided biopsy results available. Of these, 1652 men had PSA 2–10 ng/ml and a normal digital rectal examination and underwent initial biopsy. The proportions of PC (Gleason ≥6) and higher-grade PC (HGPC, Gleason ≥7) across different PHI ranges were compared. The performance of PSA and PHI was compared using the area under the receiver operating characteristic curve (AUC) and decision curve analyses (DCA). Among Asian men, HGPC would be diagnosed in 1.0%, 1.9%, 13%, and 30% of men using PHI thresholds of <25, 25–35, 35–55, and >55, respectively. At 90% sensitivity for HGPC (PHI >30), 56% of biopsies and 33% of Gleason 6 PC diagnoses could have been avoided. Among European men, HGPC would be diagnosed in 4.1%, 4.3%, 30%, and 34% of men using PHI thresholds of <25, 25–35, 35–55, and >55, respectively. At 90% sensitivity for HGPC (PHI >40), 40% of biopsies and 31% of Gleason 6 PC diagnoses could have been avoided. AUC and DCA confirmed the benefit of PHI over PSA. The benefit of PHI was also seen at repeat biopsy (n = 397) and for PSA 10–20 ng/ml (n = 439). PHI is effective in cancer risk stratification for both European and Asian men. However, population-specific PHI reference ranges should be used.