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排序方式: 共有6229条查询结果,搜索用时 140 毫秒
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Eric A.J. Bleeker Wim H. de Jong Robert E. Geertsma Monique Groenewold Evelyn H.W. Heugens Marjorie Koers-Jacquemijns Dik van de Meent Jan R. Popma Anton G. Rietveld Susan W.P. Wijnhoven Flemming R. Cassee Agnes G. Oomen 《Regulatory toxicology and pharmacology : RTP》2013,65(1):119-125
In recent years, an increasing number of applications and products containing or using nanomaterials have become available. This has raised concerns that some of these materials may introduce new risks for humans or the environment. A clear definition to discriminate nanomaterials from other materials is prerequisite to include provisions for nanomaterials in legislation. In October 2011 the European Commission published the ‘Recommendation on the definition of a nanomaterial’, primarily intended to provide unambiguous criteria to identify materials for which special regulatory provisions might apply, but also to promote consistency on the interpretation of the term ‘nanomaterial’. In this paper, the current status of various regulatory frameworks of the European Union with regard to nanomaterials is described, and major issues relevant for regulation of nanomaterials are discussed. This will contribute to better understanding the implications of the choices policy makers have to make in further regulation of nanomaterials. Potential issues that need to be addressed and areas of research in which science can contribute are indicated. These issues include awareness on situations in which nano-related risks may occur for materials that fall outside the definition, guidance and further development of measurement techniques, and dealing with changes during the life cycle. 相似文献
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Anne-Esther Breyton Aurélie Goux Stéphanie Lambert-Porcheron Alexandra Meynier Monique Sothier Laurie VanDenBerghe Olivier Brack Emmanuel Disse Martine Laville Sophie Vinoy Julie-Anne Nazare 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2021,31(1):237-246
Background and aimsIn type 2 diabetes (T2D) patients, the reduction of glycemic variability and postprandial glucose excursions is essential to limit diabetes complications, beyond HbA1c level. This study aimed at determining whether increasing the content of Slowly Digestible Starch (SDS) in T2D patients’ diet could reduce postprandial hyperglycemia and glycemic variability compared with a conventional low-SDS diet.Methods and resultsFor this randomized cross-over pilot study, 8 subjects with T2D consumed a controlled diet for one week, containing starchy products high or low in SDS. Glycemic variability parameters were evaluated using a Continuous Glucose Monitoring System.Glycemic variability was significantly lower during High-SDS diet compared to Low-SDS diet for MAGE (Mean Amplitude of Glycemic Excursions, p < 0.01), SD (Standard Deviation, p < 0.05), and CV (Coefficient of Variation, p < 0.01). The TIR (Time In Range) [140–180 mg/dL[ was significantly higher during High-SDS diet (p < 0.0001) whereas TIRs ≥180 mg/dL were significantly lower during High-SDS diet. Post-meals tAUC (total Area Under the Curve) were significantly lower during High-SDS diet.ConclusionOne week of High-SDS Diet in T2D patients significantly improves glycemic variability and reduces postprandial glycemic excursions. Modulation of starch digestibility in the diet could be used as a simple nutritional tool in T2D patients to improve daily glycemic control.Registration numberin clinicaltrials.gov: NCT 03289494. 相似文献
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Niraj K. Tripathi A. Eric Schultze Renee C. Pearson Nancy E. Everds Glenn S. Elliott Lila Ramaiah Monique Y. Wells Kenneth S. Latimer Gail L. Walter Paula Katavolos Nathanial D. Collins Jacqueline Tarrant Dana B. Walker Michael J. Topper Holly L. Jordan Laurie G. O’Rourke Valerie B. Guilpin Charles W. Brockus Jeffrey E. McCartney 《Experimental and toxicologic pathology》2013,65(1-2):39
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Young Sexual Minority Males in the United States: Sociodemographic Characteristics And Sexual Attraction,Identity and Behavior 下载免费PDF全文
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Monique G. Kumar M.D. Rebecca S. Foreman M.D. David R. Berk M.D. Susan J. Bayliss M.D. 《Pediatric dermatology》2014,31(1):e28-e30
Primary hyperhidrosis is a common disorder affecting children and adolescents, and it can have a significant negative psychosocial effect. Treatment for pediatric hyperhidrosis tends to be limited by low efficacy, low adherence, and poor tolerance. Oral glycopyrrolate is emerging as a potential second‐line treatment option, but experience with safety, efficacy, and dosing is especially limited in children. We present an institutional review of 12 children with severe, refractory hyperhidrosis treated with oral glycopyrrolate; 11 (92%) noted improvement and 9 (75%) would recommend oral glycopyrrolate to their friends. No significant side effects were noted. Our retrospective analysis suggests that oral glycopyrrolate is safe and effective in children with hyperhidrosis. 相似文献