全文获取类型
收费全文 | 14499篇 |
免费 | 896篇 |
国内免费 | 70篇 |
专业分类
耳鼻咽喉 | 71篇 |
儿科学 | 546篇 |
妇产科学 | 348篇 |
基础医学 | 2032篇 |
口腔科学 | 253篇 |
临床医学 | 1422篇 |
内科学 | 3083篇 |
皮肤病学 | 367篇 |
神经病学 | 1462篇 |
特种医学 | 311篇 |
外科学 | 1496篇 |
综合类 | 85篇 |
一般理论 | 16篇 |
预防医学 | 1187篇 |
眼科学 | 295篇 |
药学 | 970篇 |
中国医学 | 25篇 |
肿瘤学 | 1496篇 |
出版年
2024年 | 14篇 |
2023年 | 150篇 |
2022年 | 225篇 |
2021年 | 506篇 |
2020年 | 307篇 |
2019年 | 430篇 |
2018年 | 472篇 |
2017年 | 379篇 |
2016年 | 379篇 |
2015年 | 471篇 |
2014年 | 616篇 |
2013年 | 795篇 |
2012年 | 1235篇 |
2011年 | 1160篇 |
2010年 | 690篇 |
2009年 | 582篇 |
2008年 | 986篇 |
2007年 | 992篇 |
2006年 | 945篇 |
2005年 | 861篇 |
2004年 | 827篇 |
2003年 | 768篇 |
2002年 | 617篇 |
2001年 | 71篇 |
2000年 | 61篇 |
1999年 | 93篇 |
1998年 | 110篇 |
1997年 | 95篇 |
1996年 | 85篇 |
1995年 | 64篇 |
1994年 | 52篇 |
1993年 | 59篇 |
1992年 | 46篇 |
1991年 | 37篇 |
1990年 | 20篇 |
1989年 | 22篇 |
1988年 | 22篇 |
1987年 | 21篇 |
1986年 | 17篇 |
1985年 | 25篇 |
1984年 | 23篇 |
1983年 | 18篇 |
1982年 | 17篇 |
1981年 | 10篇 |
1980年 | 15篇 |
1979年 | 11篇 |
1978年 | 9篇 |
1977年 | 9篇 |
1972年 | 7篇 |
1971年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 125 毫秒
151.
Anna M. Hood Allison A. King Melanie E. Fields Andria L. Ford Kristin P. Guilliams Monica L. Hulbert Jin‐Moo Lee Desiree A. White 《Pediatric blood & cancer》2019,66(10)
Individuals with sickle cell disease (SCD) experience cognitive deficits; however, it remains unclear whether medical treatments for SCD improve cognition. Given that executive abilities are typically impaired in individuals with SCD, they were the focus of the current study. Our primary hypothesis was that executive abilities would be higher acutely soon after a blood transfusion in children and young adults with SCD. We used tests from the NIH Toolbox to assess executive abilities in 27 participants with SCD receiving chronic transfusion in comparison to 34 participants with SCD receiving hydroxyurea (HU) and 41 non‐SCD demographically matched controls, all of whom were tested at two time points. Participants in the transfusion group completed cognitive testing within 3 days after a transfusion (soon after transfusion) and then within 3 days before their next transfusion (long after transfusion) over an interval of 3‐7 weeks. We found that executive abilities were significantly poorer for the transfusion and HU groups than for the control group. In support of our primary hypothesis, executive abilities for the transfusion group were significantly better soon after a transfusion compared to long after a transfusion, χ2(1) = 17.8, P < .0001. Our results demonstrate that executive abilities were higher acutely following a blood transfusion. These findings have implications for daily functioning, medical decision making, and academic achievement in children and young adults with SCD. 相似文献
152.
153.
Benjamin W. Teh Constantine S. Tam Sasanka Handunnetti Leon J. Worth Monica A. Slavin 《Blood reviews》2018,32(6):499-507
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia with infections a leading cause of morbidity and mortality. Recently there has been a paradigm shift from the use of chemo-immunotherapies to agents targeting specific B-lymphocyte pathways. These agents include ibrutinib, idelalisib and venetoclax. In this review, the risks and timing of infections associated with these agents are described, taking into account disease and treatment status. Treatment with ibrutinib as monotherapy or in combination with chemo-immunotherapies is not associated with additional risk for infection. In contrast, the use of idelalisib is associated with a 2-fold risk for severe infection and opportunistic infections. Venetoclax does not appear to be associated with additional infection risk. The evolving spectrum of pathogens responsible infections in CLL patients, especially those with relapsed and refractory disease are described, and prevention strategies (prophylaxis, monitoring and vaccination) are proposed. 相似文献
154.
155.
156.
Angel Agis-Torres Monica S?lhuber Maria Fernandez J.M. Sanchez-Montero 《Current Neuropharmacology》2014,12(1):2-36
The lack of an adequate therapy for Alzheimer''s Disease (AD) contributes greatly to the continuous growing
amount of papers and reviews, reflecting the important efforts made by scientists in this field. It is well known that AD is
the most common cause of dementia, and up-to-date there is no prevention therapy and no cure for the disease, which
contrasts with the enormous efforts put on the task. On the other hand many aspects of AD are currently debated or even
unknown. This review offers a view of the current state of knowledge about AD which includes more relevant findings
and processes that take part in the disease; it also shows more relevant past, present and future research on therapeutic
drugs taking into account the new paradigm “Multi-Target-Directed Ligands” (MTDLs). In our opinion, this paradigm
will lead from now on the research toward the discovery of better therapeutic solutions, not only in the case of AD but
also in other complex diseases. This review highlights the strategies followed by now, and focuses other emerging targets
that should be taken into account for the future development of new MTDLs. Thus, the path followed in this review goes
from the pathology and the processes involved in AD to the strategies to consider in on-going and future researches. 相似文献
157.
158.
Monica Tang Sallie-Anne Pearson Andrea L. Schaffer Craig R. Lewis Thomas John Robert J. Simes Chee Khoon Lee 《Journal of Geriatric Oncology》2021,12(6):930-936
ObjectivesOlder adults constitute the majority of patients with lung cancer. However, they are under-represented in clinical trials as eligibility criteria often restrict enrolment based on comorbidities that are common with aging. We aimed to describe comorbidities relating to trial exclusion criteria in older adults with lung cancer, determine the proportion that would typically be excluded from trials, and examine the impact on treatment uptake.Materials and MethodsWe conducted a population-based study of people aged ≥65 years diagnosed with metastatic lung cancer using linked data for clients of the Australian Government Department of Veterans' Affairs (2005–2015). We defined trial-typical patients based on the absence of comorbidities related to the following: inadequate organ (cardiac, renal, hepatic, marrow) function; cognitive dysfunction; poor performance status (PS); prior malignancy within 5 years. We report systemic therapy uptake within 3 months of diagnosis.ResultsOur study included 677 patients (median age 84). Over half (53.4%) were not trial-typical, with the most common reasons being poor PS (37.5%), cardiac disease (19.2%), and prior cancer (12.9%). Eighty-two (12.1%) received systemic therapy. Patients with poor PS, cardiac disease, and dementia had lower treatment uptake rates. However, there was no significant difference in treatment uptake between trial-typical and non-trial-typical patients (13.4 vs 11.0%).ConclusionMore than half of older adults with advanced lung cancer would be typically excluded from trial participation. Future clinical trials of older adults need to consider broader eligibility criteria to better reflect this population to gain the best evidence for their care. 相似文献
159.
Amy M. Lampard Akihiro Nishi Monica L. Baskin Tiffany L. Carson 《Behavioral medicine (Washington, D.C.)》2013,39(2):112-119
This study aimed to assess the psychometric properties of a child-report, multidimensional measure of physical activity (PA) parenting, the Activity Support Scale for Multiple Groups (ACTS-MG), in African American and non-Hispanic white families. The ACTS-MG was administered to children aged 5 to 12 years. A three factor model of PA parenting (Modeling of PA, Logistic Support, and Restricting Access to Screen-based Activities) was tested separately for mother's and fathers' PA parenting. The proposed three-factor structure was supported in both racial groups for mothers’ PA parenting and in the African American sample for fathers’ PA parenting. Factorial invariance between racial groups was demonstrated for mother's PA parenting. Building on a previous study examining the ACTS-MG parent-report, this study supports the use of the ACTS-MG child-report for mothers’ PA parenting. However, further research is required to investigate the measurement of fathers’ PA parenting across racial groups. 相似文献
160.
Rohan S. Virgincar Zackary I. Cleveland S. Sivaram Kaushik Matthew S. Freeman John Nouls Gary P. Cofer Santiago Martinez‐Jimenez Mu He Monica Kraft Jan Wolber H. Page McAdams Bastiaan Driehuys 《NMR in biomedicine》2013,26(4):424-435
In this study, hyperpolarized 129Xe MR ventilation and 1H anatomical images were obtained from three subject groups: young healthy volunteers (HVs), subjects with chronic obstructive pulmonary disease (COPD) and age‐matched controls (AMCs). Ventilation images were quantified by two methods: an expert reader‐based ventilation defect score percentage (VDS%) and a semi‐automated segmentation‐based ventilation defect percentage (VDP). Reader‐based values were assigned by two experienced radiologists and resolved by consensus. In the semi‐automated analysis, 1H anatomical images and 129Xe ventilation images were both segmented following registration to obtain the thoracic cavity volume and ventilated volume, respectively, which were then expressed as a ratio to obtain the VDP. Ventilation images were also characterized by generating signal intensity histograms from voxels within the thoracic cavity volume, and heterogeneity was analyzed using the coefficient of variation (CV). The reader‐based VDS% correlated strongly with the semi‐automatically generated VDP (r = 0.97, p < 0.0001) and with CV (r = 0.82, p < 0.0001). Both 129Xe ventilation defect scoring metrics readily separated the three groups from one another and correlated significantly with the forced expiratory volume in 1 s (FEV1) (VDS%: r = –0.78, p = 0.0002; VDP: r = –0.79, p = 0.0003; CV: r = –0.66, p = 0.0059) and other pulmonary function tests. In the healthy subject groups (HVs and AMCs), the prevalence of ventilation defects also increased with age (VDS%: r = 0.61, p = 0.0002; VDP: r = 0.63, p = 0.0002). Moreover, ventilation histograms and their associated CVs distinguished between subjects with COPD with similar ventilation defect scores, but visibly different ventilation patterns. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献