新疆地区维吾尔族、哈萨克族2型糖尿病代谢特征与饮食结构分析

新疆哈萨克族正常糖耐量人群食物中富含饱和脂肪酸和胆固醇,与多食蔬菜水果的维吾尔族相应人群比较,其甘油三酯水平较低,胆固醇水平正常;与维吾尔族人群比较,哈萨克族人群的2型糖尿病检出率低,且年龄偏高,有较多的异常代谢指标。     

儿童肺细粒棘球蚴病胸腔镜下内囊摘除术42例治疗体会

42例肺细粒棘球蚴病患儿胸腔镜下行内囊摘除术治疗,内囊完整摘除者占66.7%(28/42)、内囊穿刺摘除者占33.3%(14/42),术中操作不慎致囊肿破裂者占2.4%(1/42),平均手术时间为(96.70±10.90)min,术中平均出血量为(8.60±1.31)ml,平均住院时间为(10.20±1.10)d、术后并发症发生率为4.8%(2/42),3年远期随访,无复发。儿童肺细粒棘球蚴病胸腔镜下行内囊摘除术具有创伤小、术中出血少和并发症少,以及3年随访无复发等优点。     

室内污染物暴露对儿童呼吸道症状的影响研究

目的探讨主要室内污染物暴露水平对儿童呼吸道症状的影响。方法以横断面研究中医生确诊的98名中小学生哮喘患者为观察对象,同时选择99名健康学生为对照,研究对象年龄为4～17岁。在冬春季、夏秋季2个时段对儿童居室内常见污染物CO、CO2、NO2、可吸入颗粒（PM10）、甲醛、苯、甲苯进行监测。同时调查儿童家庭社会经济状况、父母哮喘及过敏疾病史、住房特征、室外交通污染等资料,由儿童母亲记录监测后1个月内呼吸道症状的发生次数和发生天数资料,采用Poisson回归模型分析呼吸道症状发生的天数与室内主要污染物暴露水平的联系。结果控制了潜在混杂因素后,哮喘患者喘息症状天数与室内甲醛、甲苯水平增加20μg/m^3有联系;干咳天数与甲醛增加20μg/m^3和NO2增加40μg/m^3有联系;夜间咳嗽天数与甲醛、苯每增加20μg/m^3和NO2增加40μg/m^3有联系;对照组儿童仅夜间咳嗽天数与甲醛暴露水平增加20μg/m^3有联系。结论高水平的室内污染物甲醛、苯、NO2可能会增加哮喘儿童呼吸道症状发作的风险。降低室内甲醛、苯、NO2的水平等干预措施可能会减少儿童哮喘症状的发作。     

Serum homocysteine concentration in patients with acute MI and chronic IHD

This was an observational study carried out in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka; with the active co-operation of Coronary Care Unit (CCU) of BSMMU & National Institute of Cardiovascular Disease (NICVD), Dhaka. This study was carried out from March 2002 to January 2003. Total seventy (70) subjects were studied. Out of them 20 were of Acute MI, 20 were Chronic ischemic heart disease (CHD) and 30 were age and sex matched healthy controls. Hospitalized diagnosed patients were selected by taking history, clinical examination and several investigations like ECG. Echocardiogram, Angiogram and several enzymes assay. Several studies in many countries showed that serum homocysteine (Hcy) was elevated in IHD Patient. Cardiovascular disease is alarmingly increasing in Bangladesh. So our aim and objective of the study was to find out the association of serum Hcy with Acute MI and chronic ischemic heart disease (CHD) patients in our population. Mean Hcy level of Acute MI were 21.16 +/- 4.56 (micromol/l), 27.55 +/- 10.40 (micromol/l) and that of control was 13.03 +/- 10.51(micromol/l). Serum Hcy was significantly higher in both cases than control. But insignificant difference was found between AMI vs CHD (P> 0.05). Quantitative measurement of serum Hcy was measured by fluorescence polarization Immunoassay (FPIA) in IMX analyzer (Abbott-USA).     

我国不同产地红花的质量分析

目的运用多指标、多成分定量方法,对不同产地的红花进行质量分析。方法按照《中国药典》(2010年版)一部红花"检查"项下杂质、水分、灰份和酸不溶性灰份、吸光度、浸出物、羟基红花黄色素A的检测方法检测。结果 23批不同产地红花的杂质含量为0.2%¹.8%,水分含量为5.6%1.8%,水分含量为5.6%⁸.68%,总灰分含量为4.69%8.68%,总灰分含量为4.69%²2.21%,酸不溶性灰分含量为1.08%22.21%,酸不溶性灰分含量为1.08%¹4.56%,红色素吸光度2.09014.56%,红色素吸光度2.090⁰.529 4,浸出物含量为35.50%0.529 4,浸出物含量为35.50%⁴3.10%,羟基红花黄色素A的含量1.08%43.10%,羟基红花黄色素A的含量1.08%².32%。结论对红花样品进行聚类分析,结果表明当样本层次聚类分析聚成2类时:新疆和田红花为一类,为不合格药材;其余产地的红花为一类均为合格药材;其中合格药材中新疆的昌吉、伊犁、塔城地区的样品聚为一类,四川和云南地区的样品聚为一类。说明产地对红花质量的综合评价具有一定的影响。     

根管预备锥度的变化对根管壁应力影响的三维有限元分析

目的：分析上颌第一前磨牙在不同的根管预备条件下,根管壁应力及其分布的变化情况。 方法：建立上颌第一前磨牙（单根Ⅳ型根管）的三维有限元模型，在此基础上建立不同条件下根管预备后的修改模型，充填修改模型。运用特定的有限元分析软件，计算修改模型牙根各部分在垂直或侧方加载时根管壁所受应力的最大值及其分布的情况。 结果：根管预备后锥度增大会引起根管壁所受应力值增加，该变化主要出现在根中上1/3段，侧方加压时根管壁产生的应力均比垂直加压时根管壁产生的应力大。根管主尖锉为25号和根管主尖锉为30号时其根管壁所受应力值大小差别不大。结论：在不同的根管预备条件下，其根管壁所受的应力值也不同，其中根管预备锥度的变化对根管壁应力的影响较大，尤其是在侧方加压时。     

Characteristics of patients admitted with stroke

Population based study on stroke morbidity and mortality is lacking in our country. We described the clinical pattern of patients with stroke admitted in Neuromedicine Unit, Chittagong Medical College Hospital, Bangladesh. One hundred and six consecutive patients were included in the study. Clinical diagnosis of stroke, initial assessment, and assessment of outcome of stroke were performed by the neurologists. On admission blood glucose, and creatinine level was estimated, and an electrocardiogram was recorded. Fasting lipid level estimation and CT-scan of brain were performed for patients who could afford the cost. The mean age of the patients was 60.0 +/-13.7 years and the highest occurrence of stroke was found in the age group of 61 - 70 years. The proportions of rural, semiurban and urban patients were 46.2%, 27.4% and 26.4% respectively. A large portion of the patients were found illiterate (47.2%), and only one patient had postgraduate education. The average per capita income was found 1159 +/-762 taka per month. About one-fourth of the patients had diabetes (21.7%). Hypertension, ischemic heart disease and dyslipidemia were found in 59.4%, 18.9% and 11.3% respectively. The cause of hospitalization was altered consciousness (58.5%), right hemiplegia (32.1%), and left hemiplegia (31.1%) either alone or in combination. The mean duration of hospital stay was 5.25 +/-2.19 days. Fifty percent partially and 35% satisfactorily recovered, and 7 (6.6%) patients expired. Patients from lower socioeconomic group were admitted in the hospital. A considerable number of stroke patients had hypertension and diabetes.     

Role of cardiac troponin I in staging and prognosis of congestive heart failure subjects

Congestive heart failure is the one of the major cardiovascular disorder that is increasing in incidence and cause of death globally. Mortality rate has increased 40%-50% in advanced cardiac failure and 15%-25% in mild to moderate cardiac failure within one year of diagnosis. There is no established biochemical marker for the diagnosis, prognosis and staging of heart failure. Cardiac Troponin I may be a novel useful tool in identifying patients with Heart failure who are at increased risk for progressive ventricular dysfunction and death. Thirty six congestive heart failure cases and thirty six healthy controls were included in this study and serum cardiac troponin I and Ejection fraction were measured. All the study subjects were grouped according to the NYHA class they belong. Cardiac troponin I was significantly higher in CHF cases than the controls. Troponin I also significantly differed among groups. EF of cases was significantly lower than the controls and also differed among groups. A significant negative correlation between cardiac troponin I and progressive decline of ejection fraction was evident in this study. Cardiac troponin I increased progressively with progression of heart failure. Thus, Cardiac troponin I could be used to stratify patients undergoing heart failure in to high and low risk groups for future cardiac events. Cardiac troponin I could also be used as a very important marker for the prognosis of the patients with congestive heart failure.     

当归注射液对血瘀证大鼠肠系膜淋巴微循环的影响

目的 :探讨活血化瘀中药当归对淋巴微循环的影响。方法 :16只血瘀症大鼠被随机分成实验组和对照组 ,每组 8只。实验组给予当归注射液 (2 0 m g/ kg)进行第 1次治疗 ,2 0 min后给予输血 +当归 (2 0 mg/ kg)进行第 2次治疗 ;对照组给予生理盐水代替当归注射液治疗。通过微循环显微电视录像技术连续观察记录肠系膜淋巴微循环的变化。结果 :实验组大鼠经当归注射液第 1次治疗后 ,微淋巴管收缩幅度明显增加 ,自主收缩频率增强 ,收缩分数 (Index )、总收缩活性指数 (Index )及淋巴管动力学指数 (L.D Index)显著高于对照组(P均 <0 .0 5 )。第 2次治疗后 ,可见微淋巴管口径扩张 ,自主收缩频率、Index 、L .D Index均显著高于对照组(P均 <0 .0 1) ,而 Index 与对照组比较无明显差异 (P>0 .0 5 )。结论 :当归注射液能明显增强血瘀证大鼠肠系膜淋巴管自主收缩频率及收缩性 ,补充血容量后微淋巴管口径明显扩张 ,淋巴液回流增加。