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31.
Irum Shaheen Khuram Shahzad Ahmad Camila Zequine Ram K. Gupta Andrew Thomas Mohammad Azad Malik 《RSC advances》2020,10(14):8115
Transitional metal oxide nanomaterials are considered to be potential electrode materials for supercapacitors. Therefore, in the past few decades, huge efforts have been devoted towards the sustainable synthesis of metal oxide nanomaterials. Herein, we report a synergistic approach to synthesize spherical-shaped CoMoO4 electrode materials using an inorganic–organic template via the hydrothermal route. As per the synthesis strategy, the precursor solution was reacted with the organic compounds of E. cognata to tailor the surface chemistry and morphology of CoMoO4 by organic species. The modified CoMoO4 nanomaterials revealed a particle size of 23 nm by X-ray diffraction. Furthermore, the synthesized material was scrutinized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, field emission scanning electron microscopy and energy dispersive spectroscopy. The optical band gap energy of 3.6 eV was calculated by a Tauc plot. Gas chromatography-mass spectrometry identified cyclobutanol (C4H8O) and octodrine (C8H19N) as the major stabilizing agents of the CoMoO4 nanomaterial. Finally, it was revealed that the bioorganic framework-derived CoMoO4 electrode exhibited a capacitance of 294 F g−1 by cyclic voltammetry with a maximum energy density of 7.3 W h kg−1 and power density of 7227.525 W kg−1. Consequently, the nanofeatures and organic compounds of E. cognata were found to enhance the electrochemical behaviour of the CoMoO4-fabricated electrode towards supercapacitor applications.Transitional metal oxide nanomaterials are considered to be potential electrode materials for supercapacitors. 相似文献
32.
33.
Shahzad M. Ali MD Clancy J. Clark MD Victor M. Zaydfudim MD MPH Florencia G. Que MD David M. Nagorney MD 《Annals of surgical oncology》2013,20(6):2023-2028
Background
Historically, direct vascular extension of intrahepatic cholangiocarcinoma (ICC) has often been considered a contraindication to resection. However, recent studies have suggested safety and efficacy of hepatectomy with major vascular resection in this patient population. The aim of this study was to investigate the short and long-term clinical outcomes of patients with ICC treated with hepatectomy with or without major vascular resection.Methods
This retrospective cohort study included all patients with ICC who underwent major liver resection between 1997 and 2011. Clinical outcomes were compared between patients treated with major hepatectomy and vascular resection (VR) and those without vascular resection (NVR). Kaplan–Meier survival estimates were used to compare overall survival (OS) between patients in VR and NVR groups.Results
A total of 121 patients (median age 60; 42 % male) underwent major hepatectomy for ICC. Major vascular resection was performed in 14 (12 %) patients (IVC = 9, PV = 5). Age, sex, American Society of Anesthesiology (ASA) class, tumor size, lymph node status, and CA-19 9 were comparable (all p ≥ 0.184) between VR and NVR groups. Major postoperative complications (Dindo-Clavien ≥3) occurred in four (29 %) patients in the VR group and 17 (16 %) in the NVR group (p = 0.263). Postoperative death occurred in one patient in the VR group due to liver failure. Median OS did not differ between patients treated with and without vascular resection (32 vs. 49 months, respectively, p = 0.268).Conclusions
Hepatectomy combined with IVC or PV resection can be safely performed in patients with ICC. Major vascular resection does not affect short and long-term outcomes in this patient population. 相似文献34.
Anmar M. Nassir Naiyer Shahzad Ibrahim A.A. Ibrahim Iqbal Ahmad Shadab Md Mohammad R. Ain 《Saudi Pharmaceutical Journal》2018,26(6):876-885
Resveratrol (RL), a natural polyphenol, is known for its diverse biological effects against various human cancer cell lines. But low aqueous solubility, poor bioavailability, and stability limit its efficacy against prostate cancer. In this study polymeric nanoparticles encapsulating resveratrol (RLPLGA) were designed and their cytotoxic and mode of apoptotic cells death against prostate cancer cell line (LNCaP) was determined. Nanoparticles were prepared by solvent displacement method and characterized for particle size, TEM, entrapment efficiency, DSC and drug release study. RLPLGA exhibited a significant decrease in cell viability with 50% and 90% inhibitory concentration (IC50 and IC90) of 15.6?±?1.49 and 41.1?±?2.19?μM respectively against the LNCaP cells. This effect was mediated by apoptosis as confirmed by cell cycle arrest at G1-S transition phase, externalization of phosphatidylserine, DNA nicking, loss of mitochondrial membrane potential and reactive oxygen species generation in LNCaP cells. Furthermore, significantly greater cytotoxicity to LNCaP cells was observed with nanoparticles as compared to that of free RL at all tested concentrations. RLPLGA nanoparticles presented no adverse cytotoxic effects on murine macrophages even at 200?μM. Our findings support the potential use of developed resveratrol loaded nanoparticle for the prostate cancer chemoprevention/ chemotherapy with no adverse effect on normal cells. 相似文献
35.
Perwez Alam Naiyer Shahzad Arvind K. Gupta Amal M. Mahfoz Ghazi A. Bamagous Saeed S. Al-Ghamdi Nasir A. Siddiqui 《Toxicology and Environmental Health Sciences》2018,10(3):220-227
Objective
The present study was proposed to assess the in vitro free radical-scavenging activity of B. diffusa methanolic extract (BDME) and its modulatory effect against streptozotocin (STZ) induced diabetes in male Wistar rats.Methods
Experimental diabetes was induced in Wistar albino rats by administering single dose of STZ 40 mg/kg. One week later rats with blood glucose level >200 mg/dL were segregated as diabetes in three groups each containing 6 rats in number.Results
Total phenolic content in B. diffusa methanol extract (BDME) was found to be 87 mg of gallic acid equivalents/g extract and total flavonoid content found to be 54.1 mg of quercetin equivalents/g extract. Its extract also exhibited DPPH (IC50, 163.1±6.7 μg/mL), nitric oxide (295 μg/mL) and H2O2 (159±5.25 μg/mL) radical scavenging activity. Pre-treatment with BDME (100 and 200 mg/kg b.w.) in streptozotocin-induced diabetic rats resulted in significant improvement in blood glucose, blood plasma enzymes SGOT, SGPT and ALP, weight loss, total protein, serum insulin and liver glycogen levels. Furthermore, it restores the activity of antioxidant enzymes viz. SOD, CAT and GPx.Conclusion
Thus, the result suggests that BDME employed significant anti-diabetic effect in Wistar rats which is associated with its free radical scavenging and antioxidant activity.36.
37.
Sattar Abida K. Shahzad Hania Masroor Taleaa Martins Russell Seth Zahid Nida Amersi Farin F. 《Annals of surgical oncology》2022,29(10):6314-6322
Annals of Surgical Oncology - Surgical site infections after breast surgery range from 1 to 16%. Both the American Society of Breast Surgeons (ASBrS) and the American Association of Plastic... 相似文献
38.
Francesco Leonardi Fabrizio Rivera Alessandra Zorzan Syed Mohsin Ali 《Journal of orthopaedics and traumatology》2014,15(2):131-136
Background
Torsional malalignment syndrome (TMS) is a well defined condition consisting of a combination of femoral antetorsion and tibial lateral torsion. The axis of knee motion is medially rotated. This may lead to patellofemoral malalignment with an increased Q angle and chondromalacia, patellar subluxation and dislocation. Conservative management is recommended in all but the most rare and severest cases. In these cases deformity correction requires osteotomies at two levels per limb.Materials and methods
From 1987 to 2002 in our institution three patients underwent double femoral and tibial osteotomy for TMS bilateral correction (12 osteotomies). All patients were reviewed at mean follow-up of 16 years.Results
At final follow-up no patients reported persistence of knee or hip pain. At clinical examination both lower limbs showed a normal axis and a normal patella anterior position. Pre-operative femoral version measurement showed an average hip internal rotation of 81.5° (range 80°–85°) and average hip external rotation of 27.2° (10°–40°). Thigh–foot angle measurement showed an average value of 38.6° (32°–45°). At final follow-up femoral version measurement showed an average hip internal rotation of 49° (range 45°–55°) and average hip internal rotation of 44.3° (20°–48°) (Figs. 1, 2, 3, 4, 5, 6). Thigh–foot angles measurement showed an average value of 21.6° (18°–24°) outward.Conclusion
We recommend a clinical, radiographical and CT scan evaluation of all torsional deformity. In cases of significant deformity, internally rotating the tibia alone is not sufficient. Ipsilateral outward femoral and inward tibial osteotomies are our current recommendation for TMS, both performed at the same surgical setting. 相似文献39.
Sajjad Mohsin I. Rayyif Hamzah Basil Mohammed Carmen Curuiu Alexandra Ctlina Bîrc Alexandru Mihai Grumezescu Bogdan tefan Vasile Lia Mara Diu Veronica Lazr Mariana Carmen Chifiriuc Grigore Mihescu Alina Maria Holban 《Materials》2021,14(11)
Zinc oxide (ZnO) nanoparticles (NPs) have been investigated for various skin therapies in recent years. These NPs can improve the healing and modulate inflammation in the wounds, but the mechanisms involved in such changes are yet to be known. In this study, we have designed a facile ZnO nano-coated dressing with improved antimicrobial efficiency against typical wound pathogens involved in biofilm and chronic infections. ZnO NPs were obtained by hydrothermal method and characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Fourier-transform infrared spectroscopy. Antibacterial and antibiofilm effects were evaluated against laboratory and clinical isolates of significant Gram-negative (Pseudomonas aeruginosa and Escherichia coli) and Gram-positive (Staphylococcus aureus and Enterococcus faecalis) opportunistic pathogens, by quantitative methods. Our results have shown that the developed dressings have a high antibacterial efficiency after 6–24 h of contact when containing 0.6 and 0.9% ZnO NPs and this effect is similar against reference and clinical isolates. Moreover, biofilm development is significantly impaired for up to three days of contact, depending on the NPs load and microbial species. These results show that ZnO-coated dressings prevent biofilm development of main wound pathogens and represent efficient candidates for developing bioactive dressings to fight chronic wounds. 相似文献
40.
Pulmonary arterial hypertension (PAH) is a debilitating disease associated with significant morbidity and a high mortality if left untreated. Over the past 5 years, there have been significant advances with regard to the understanding of the pathogenesis, diagnosis and classification of PAH. The availability of newer drugs has resulted in a radical change in the management of this disease with significant improvement in both the quality of life and mortality. One of the recent drugs is an orally active dual endothelin receptor antagonist, bosentan; this drug has shown to improve the exercise capacity and survival in patients with PAH. This review article discusses the pharmacology of bosentan and summarises the current available evidence for the safety and efficacy of bosentan for the treatment of PAH. 相似文献