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排序方式: 共有8373条查询结果,搜索用时 15 毫秒
81.
Chuji Aso Toyoki Kunitake Masanobu Miura Katsuhisa K
yama 《Macromolecular chemistry and physics.》1968,117(1):153-162
Polymerizations of malealdehyde were carried out with alkalimetal alkoxides, AlEt3, pyridine, AlEt3? TiCl4 and BF3OEt2 as catalysts. All the polymers obtained with other catalysts than AlEt3 and AlEt3? TiCl4 were composed only of the cyclized unit (dialkoxydihydrofuran ring) (> 95%) and the 1.2-addition structure (< 5%). IR spectra of the polymers obtained with AlEt3 and AlEt3? TiCl4 catalysts were suggestive of the presence of five-membered lactone rings which may occur as a result of termination by hydride transfer. The steric structure (cis vs. trans) of the dialkoxydihydrofuran ring in polymer was inferred from the comparison of the IR spectra of the polymer with those of the isomeric dialkoxydihydrofurans in the 800 cm?1 region. Anionic catalysts gave higher contents of the cis configuration, while coordinated anionic catalysts gave comparable amounts of the cis and trans structures. 相似文献
82.
Detection of IgA-class circulating immune complexes (CIC) in sera from patients with IgA nephropathy using a solid-phase anti-C3 Facb enzyme immunoassay (EIA) 总被引:3,自引:0,他引:3 下载免费PDF全文
M Yagame Y Tomino M Miura T Tanigaki T Suga Y Nomoto H Sakai 《Clinical and experimental immunology》1987,67(2):270-276
The detection of circulating immune complexes (CIC) in sera from patients with IgA nephropathy is described. A solid-phase anti-C3 Facb enzyme immunoassay (EIA) was employed for detection of IgA-, IgG- and IgM-CIC in sera. The C1q-binding enzyme assay was also used for the detection of CIC in sera from these patients and healthy adults. Twenty-two patients with IgA nephropathy, 14 patients with other glomerular diseases and 19 healthy adults were examined by anti-C3 Facb EIA. The levels of IgA-CIC in sera from patients with IgA nephropathy were significantly higher than those in sera from patients with other glomerular diseases and healthy adults. CIC measured by the C1q-binding enzyme assay was detected in some patients with IgA nephropathy. The levels of serum IgA in patients with IgA nephropathy were significantly higher than those in patients with other glomerular diseases and healthy adults. However, there was no significant correlation between the levels of IgA-CIC in sera and those of serum IgA in patients with IgA nephropathy. There was also no significant correlation between the levels of IgA-CIC in sera and the degree of histopathological injuries in the patients. It is concluded that the solid-phase anti-C3 Facb EIA is useful for the detection of IgA-CIC in sera from patients with IgA nephropathy. 相似文献
83.
T-cell variant of classical Hodgkin's lymphoma with nodal and cutaneous manifestations demonstrated by single-cell polymerase chain reaction 总被引:4,自引:0,他引:4
Willenbrock K Ichinohasama R Kadin ME Miura I Terui T Meguro K Fukuhara O DeCoteau JF Hansmann ML 《Laboratory investigation; a journal of technical methods and pathology》2002,82(9):1103-1109
The atypical cells of CD30(+) cutaneous lymphoproliferative disorders (CD30CLD) are commonly of T-cell origin and frequently have a similar morphology as Hodgkin or Reed-Sternberg cells of Hodgkin's lymphoma (HL). HL is one of the tumors associated with CD30CLD. Although most studies support a B-cell derivation of the tumor cells in HL, recently a few cases of classical HL with T-cell genotype have been reported. We report a patient who presented with CD30CLD whose lymph nodes showed classical HL of mixed cellularity subtype at presentation. By single-cell PCR, the same clonal gene rearrangements of the T cell receptor-beta gene locus could be assigned to the CD30(+) and CD15(+) cells of both skin and lymph node. In a lymph node biopsy specimen taken in relapse after several courses of chemotherapy, the CD30(+) tumor cells were abundant. The T cell-derived tumor cells displayed aberrant expression of the Pax-5 gene in all specimens. A common clonal origin of both CD30CLD and HL of the lymph node in the patient presented here suggests that HL with T-cell genotype exists in association with CD30CLD as well as in sporadic cases and may share clonal origin with the skin tumor. 相似文献
84.
Host resistance to Listeria monocytogenes infection is enhanced but resistance to Staphylococcus aureus infection is reduced in acute graft-versus-host disease in mice 下载免费PDF全文
Miura T Mizuki D Sasaki S Hasegawa S Sashinami H Nakane A 《Infection and immunity》2000,68(7):4340-4343
Acute graft-versus-host disease (GVHD) is characterized by the production of high levels of T helper 1 (Th1)-type cytokines. Bone marrow transplantation from allogeneic C57BL/6 cells to CBF(1) mice produced acute GVHD. Host resistance to Th1-driven Listeria monocytogenes was enhanced, whereas host resistance to Th2-driven Staphylococcus aureus was reduced during acute GVHD. These results suggest that opposite host responses are observed between Th1-driven and Th2-driven bacterial infections in acute GVHD. 相似文献
85.
Noriko Kimura Mika Watanabe Tsuneo Ookuma Wakako Miura Takao Noshiro Yukio Miura Hiroshi Nagura 《Endocrine pathology》1994,5(3):178-182
Pheochromocytoma usually shows prominent nuclear atypia, but the presence of such atypical cells is known to be an unreliable
predictor of malignancy. DNA ploidy of pheochromocytomas has been analyzed by flow cytometry or photospectrometry on paraffinem-bedded
tissue, but the results were controversial. We performed DNA analysis on cytology specimens of 11 pheochromocytomas using
an image analysis system. All tumors had a mixed pattern of a large population of diploid cells and a small population of
polyploid cells. DNA content correlated with nuclear size, and larger cells had more DNA content. Such larger tumor cells
had polyploid nuclei, such as 4 C, 8 C, 16 C, and 32 C, in both malignant and benign pheochromocytomas. The larger polyploid
nuclei may result from difficulty of duplication at the mitotic phase of the cell cycle. 相似文献
86.
Hisao Kondo Midori Miura Yoshinori Itokawa 《Pflügers Archiv : European journal of physiology》1993,422(4):404-406
To clarify the mechanism of oxidative stress in skeletal muscle atrophied by immobilization, we investigated the change of antioxidant enzyme activities in a typical slow red muscle, the soleus. Atrophied soleus muscles were collected from male Wistar rats (16 weeks old), one ankle joint of which had been immobilized in the fully extended position for 7 days. Also, soleus muscles were collected from intact age-matched rats as control. The activities of Mn-containing superoxide dismutase (Mn-SOD), Cu,Zn-containing superoxide dismutase (Cu,Zn-SOD), Se-dependent glutathione peroxidase (Se-GSHPx), glutathione S-transferase (GST), catalase, and glutathione reductase (GSSGRx) were measured. The activities of Cu,Zn-SOD, GST, and GSSGRx were significantly higher in atrophied muscles, while the others were unchanged. Increased Cu,Zn-SOD and unchanged Mn-SOD levels might reflect increased generation of superoxide anions in the cytoplasm rather than in the mitochondria. Owing to the enhancement of Cu,Zn-SOD and the unaltered Se-GSHPx and catalase activities, hydrogen peroxide is thought to be increased in the cytoplasm. Because there is also an increase of iron in the microsomes of atrophied muscles, the production of hydroxyl radicals, the most aggressive of radicals, might consequently be elevated. 相似文献
87.
Saito N Takahashi M Akahata W Ido E Hidaka C Ibuki K Miura T Hayami M Takahashi H 《Tissue antigens》2005,66(6):674-682
The hereditary conservation in the genetically encoded CD1D sequences of various primates was analyzed. Genomic CD1D sequences of 17 rhesus macaques with distinct origins, eight Indian and nine Chinese, were examined and differences of only one or two nucleotides were detected and the consensus sequence of rhesus CD1D was determined. CD1D consensus sequences of three African green monkeys (AGMs) and the rhesus monkeys were then compared to study the evolutionary differences among interspecies. The CD1D consensus sequence determined from AGMs apparently differed by seven nucleotides from the rhesus consensus sequence, and nucleotide difference induced only three amino acid changes within Exon3, corresponding to the alpha2 domain of CD1d having a hydrophobic ligand-binding pocket. Such changes in the alpha2 domain may alter the characteristics of the SIV-derived glycolipid/lipid antigens presented by each CD1d molecule to innate natural killer T cells. In addition, the CD1D genomic sequences of three chimpanzees (chimps) were determined. To our surprise, although Exon2 and Exon3 reflecting antigen-binding alpha1 and alpha2 domains in chimps' CD1D were identical to that in humans except one amino acid, three amino acids within Exon4, reflecting alpha3 domain, were distinct from humans, and one of them was identical to those in rhesus and AGM CD1D. On the basis of the findings, the evolutionary relationship of the CD1d molecules among the various primates and their HIV-1/SIV susceptibility will be discussed. 相似文献
88.
Tadashi Yasuda Hirokazu Imai Yasushi Nakamoto Akira B. Miura Shiegki Inomata 《Virchows Archiv : an international journal of pathology》1992,421(4):297-303
Summary The pathogenesis of the nodular lesion in diabetic glomerulosclerosis is described in association with fibrils. Thirteen diabetic patients with glomerular nodular lesions and 9 diabetics without the nodules were examined by electron microscopy using periodic acid-thio-carbohydrazide-silver proteinate staining. In cases of nodular glomerulosclerosis, abundant fibrillar structures mixed with electron-dense material were detected within the nodule and the mesangial matrix. They were also occasionally observed along the subendothelial space of the glomerular capillary walls. On the cross-section, these fibrils, including the lucent periphery, were 34 nm wide. Immunohistologically, collagen V and collagen VI were detected in nodular lesions. In contrast, in cases of the diffuse type of glomerulosclerosis, the widened mesangium was composed of dense material, which resembled the original mesangial matrix. The above fibrils were not detected in the mesangium. These findings suggest that the accumulation of the peculiar fibrils in the glomerular mesangium is a major pathogenic factor in the formation of Kimmelstiel-Wilson nodules. 相似文献
89.
Yoshida A; Araki Y; Motoyama M; Kim SY; Sung H; Araki S; Miura K; Shirai M 《Human reproduction (Oxford, England)》1997,12(11):2499-2503
The objective of this study was to determine whether or not abnormalities
in the autosomal structure of the male partner have any influence on
fertilization and early embryo development after intracytoplasmic sperm
injection (ICSI). Thirty-seven couples in whom the male partners were
examined by the same andrologist were included in this study. Six couples
(group I) in whom the male partner possessed autosomal structural
abnormality underwent seven ICSI cycles. As a control group, 31 couples
(group II) in which the male partner was karyotypically normal underwent 41
ICSI cycles. Although the normal fertilization rates seen in group I were
significantly higher than those in group II (P < 0.05), there was no
significant difference in the cleavage rates between the two groups. We did
not perform the analysis of the female partner's chromosomes, but we
surmise that structural autosomal abnormalities in the male partner do not
adversely influence fertilization at ICSI and early development of embryos.
相似文献
90.
Y. Nose M. Nakamura T. Inoue O. Nakagaki Y. Watanabe M. Yokota T. Tajimi A. Kuroiwa J. Hattori M. Miura 《Medical & biological engineering & computing》1980,18(6):727-730
The reliability of the Japanese public telephone facilities to transmit electrocardiograms (e.c.g.) for computer interpretation
was assessed. The International Business Machine's (IBM) e.c.g. computer program by Bonner was used. No appreciable distortion
of e.c.g. was observed following repeated transmission from hospitals separated by 1000 km. Thirty-four normal and 66 abnormal
e.c.g.s. were transmitted twice. Identical results were observed in 97% of normals and 92% of abnormals.
Following these fundamental experiments, 1236 patients' e.c.g.s. were transmitted for computer intepretation. The study showed
that 98·6% (1219 cases) were technically satisfactory and 1·4% (17 cases) were not. The 17 unsatisfactory cases were classified
into ten unreceivable data formats, six inconsistent measurements and one unacceptable noise level.
The authors concluded that the Japanese public telephone facilities were acceptable for the transmission of e.c.g.s. for computer
interpretation. 相似文献