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排序方式: 共有3706条查询结果,搜索用时 15 毫秒
51.
Shuichi Ota Toshihiro Matsukawa Satoshi Yamamoto Shinichi Ito Motohiro Shindo Kazuya Sato Takeshi Kondo Kyuhei Kohda Hajime Sakai Akio Mori Tohru Takahashi Hiroshi Ikeda Hiroyuki Kuroda Yoshihito Haseyama Masaki Yamamoto Takeo Sarashina Makoto Yoshida Ryoji Kobayashi Mitsufumi Nishio Toshimichi Ishihara Yasuo Hirayama Yasutaka Kakinoki Hajime Kobayashi Takashi Fukuhara Masahiro Imamura Mitsutoshi Kurosawa 《European journal of haematology》2018,101(1):95-105
52.
Mayumi Anne Willgerodt Arlene Michaels Miller Beverly J. McElmurry 《Health care for women international》2013,34(5):467-480
Ethnic and racial diversity in the United States has led to increasing interest in research on biculturalism, yet the meaning and underlying processes of biculturalism in the context of development in young adults are not well understood. Fifteen interviews were conducted with second-generation Chinese American women to explore how being bicultural fit into their lives. Data analysis yielded a developmental map that reflected their experiences throughout life as minority women. Findings suggest that biculturalism is more than being functionally competent in two cultures, it is both a behavioral and psychological orientation in life. From the findings of this study, we have increased our knowledge of Asian American women's development and provided a foundation for nursing research with minority women. 相似文献
53.
Motomura K Masaki H Terada M Onizuka T Shimogama S Furumoto A Asoh N Watanabe K Oishi K Nagatake T 《Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases》2004,78(3):277-282
Corynebacterium propinquum, which is included in Corynebacterium group ANF-3, exists as a commensal in the oral flora. This organism has not yet been fully recognized as a respiratory pathogen. We previously reported that the first case with respiratory infection caused by C. propinquum. On the other hand, Corynebacterium pseudodiphtheriticum is recognized as a causative organism in respiratory infections. Recently we experienced two cases with C. propinquum respiratory infections in our hospital. Three types of the onset such as a community-acquired infection, a hospital-acquired infection, and a nursing home acquired infections were observed. Our analysis indicated that gram staining of the purulent sputum is an essential tool to evaluate whether C. propinquum is a respiratory pathogen or not, because this organism is a commensal bacteria. 相似文献
54.
Shinohara K Adachi M Matsui K Matsuda K Nagaya S Morishita E 《International journal of hematology》2008,87(3):256-259
The patient, a 20-year-old male, was found to have a slightly prolonged prothrombin time (PT). No episodes of bleeding were
noted. The measurement of coagulation factors revealed that the level of factor X (FX) activity was solely deficient, 51%
(normal range: 70–130% ), and that of FX antigen was 100%. Analysis of the entire FX gene revealed the novel missense mutation
of GTG to ATG, resulting in the substitution of the 196th amino acid valine → methionine. The mother and younger brother had a normal
PT time and expressed no episode of bleeding. The mother exhibited a normal level of FX activity and antigen; however the
younger brother showed a slight decrease in both the parameters. This mutation was not observed in the mother and younger
brother. Polymorphism is not observed at this point in healthy persons. The present novel FX mutation was named FX Hofu. 相似文献
55.
Risa Tamagawa-Mineoka Naoko Yasuoka Mayumi Ueta Norito Katoh 《Allergology international》2018,67(3):388-391
Background
Topical corticosteroids (TCS) can induce adverse effects, such as skin atrophy. Although TCS can cause increases in intraocular pressure (IOP), the effects of daily TCS use on IOP have not been fully elucidated. We evaluated the clinical doses of TCS and the change in the IOP during the daily treatment of atopic dermatitis (AD).Methods
We collected clinical data on a total of 65 patients who were diagnosed with AD and underwent 2 or more IOP measurements at our hospital.Results
Mean monthly facial steroid volumes of ≤11.8 g and ≤15.0 g of TCS were applied to 90% of the patients aged 2–12 years and those aged ≥13 years, respectively. During the treatment, there were no TCS-related increases in IOP in any patient.Conclusions
Our study suggests that TCS might not cause increases in IOP at the abovementioned doses. However, the IOP of steroid responders is known to be highly responsive to steroids. Therefore, patients who have steroids applied to their eyelids had better undergo regular IOP measurements at ophthalmological clinics. 相似文献56.
Toshio Tsuyuguchi Tadahiro Takada Yoshifumi Kawarada Yuji Nimura Keita Wada Masato Nagino Toshihiko Mayumi Masahiro Yoshida Fumihiko Miura Atsushi Tanaka Yuichi Yamashita Masahiko Hirota Koichi Hirata Hideki Yasuda Yasutoshi Kimura Horst Neuhaus Steven Strasberg Henry Pitt Jacques Belghiti Giulio Belli John A. Windsor Miin-Fu Chen Sun-Whe Kim Christos Dervenis 《Journal of hepato-biliary-pancreatic sciences》2007,14(1):46-51
The principal management of acute cholecystitis is early cholecystectomy. However, percutaneous transhepatic gallbladder drainage (PTGBD) may be preferable for patients with moderate (grade II) or severe (grade III) acute cholecystitis. For patients with moderate (grade II) disease, PTGBD should be applied only when they do not respond to conservative treatment. For patients with severe (grade III) disease, PTGBD is recommended with intensive care. Percutaneous transhepatic gallbladder aspiration (PTGBA) is a simple alternative drainage method with fewer complications; however, its clinical usefulness has been shown only by case-series studies. To clarify the clinical value of these drainage methods, proper randomized trials should be done. This article describes techniques of drainage for acute cholecystitis. 相似文献
57.
Laura R. Epstein Stella S. Lee Mayumi F. Miller Heather A. Lombardi 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(22)
Technological advances, such as genome editing and specifically CRISPR, offer exciting promise for the creation of products that address public health concerns, such as disease transmission and a sustainable food supply and enable production of human therapeutics, such as organs and tissues for xenotransplantation or recombinant human proteins to treat disease. The Food and Drug Administration recognizes the need for such innovative solutions and plays a key role in bringing safe and effective animal biotechnology products to the marketplace. In this article, we (the Food and Drug Administration/Center for Veterinary Medicine) describe the current state of the science, including advances in technology as well as scientific limitations and considerations for how researchers and commercial developers working to create intentional genomic alterations in animals can work within these limitations. We also describe our risk-based approach and how it strikes a balance between our regulatory responsibilities and the need to get innovative products to market efficiently. We continue to seek input from our stakeholders and hope to use this feedback to improve the transparency, predictability, and efficiency of our process. We think that working together, using appropriate science- and risk-based oversight, is the foundation to a successful path forward. 相似文献
58.
Kumagai S Kai Y Nagano M Zou B Kishimoto H Sasaki H 《Metabolic syndrome and related disorders》2005,3(3):213-220
The objective of this study was to examine the contribution of endurance fitness and visceral fat accumulation on the prevalence of metabolic syndrome in Japanese male patients with either an impaired glucose tolerance (IGT) or type 2 diabetes mellitus (DM). The subjects of this cross-sectional study consisted of 135 Japanese male patients with either IGT or type 2 DM who had not taken any medication or intervention. They were classified into three fitness categories (low, moderate, and high) based on the tertiles of their maximal oxygen uptake ( [Formula: see text] O(2)max) predicted by the Astrand nomogram using a cycle ergometer. Metabolic syndrome was defined based on the WHO criteria. The visceral fat area (VFA) was determined using a computed tomography scan. The age- and VFA-adjusted odds ratio was 3.49 (95% CI, 1.13-10.82) for subjects in the low fitness category in comparison to those in the high fitness category. We calculated the odds ratio for the prevalence of metabolic syndrome in the nine categories classified based on the three VFA and three [Formula: see text] (2)max levels. In Moderate- and Low- [Formula: see text] (2) max categories, the odds ratios increased in line with increases in the VFA level. The highest odds ratios were observed in the low fitness and high visceral fat group. In the High- [Formula: see text] O(2)max category, no significant odds ratios were observed in the Moderate- and High-VFA categories. These results indicate that a high degree of cardiorespiratory fitness positively contributed to the low prevalence of metabolic syndrome in Japanese male patients with IGT and type 2 DM. 相似文献
59.
M Morita H Saito T Honjo Y Saito S Tsuruta K M Kim M Tanaka K J Mori M Mayumi H Mikawa 《Blood》1991,77(8):1766-1775
Differentiation of a human eosinophilic leukemia cell line, EoL-1, induced by the culture supernatant of a human ATL cell line, HIL-3 (HIL-3 sup) was compared with differentiation induced by defined cytokines. HIL-3 sup induced EoL-1 cells to express eosinophilic granules and segmented nuclei after 6 to 9 days of incubation. HIL-3 sup also induced the expression of Fc epsilon receptor II (Fc epsilon RII/CD23) and an eosinophil differentiation antigen EO-1 mainly on eosinophilic granule (+) cells. Furthermore, HIL-3 sup induced EoL-1 cells to respond to an eosinophil chemotactic factor, platelet activating factor. HIL-3 cells express messenger RNA (mRNA) of interleukin-5 (IL-5), macrophage colony-stimulating factor (M-CSF), and IL-3 but not granulocyte CSF (G-CSF). Granulocyte-macrophage CSF (GM-CSF) and tumor necrosis factor-alpha (TNF-alpha) were detected in the HIL-3 sup. Recombinant IL-2 (rIL-2), rIL-3, rIL-4, rIL-5, rM-CSF, and rGM-CSF did not induce eosinophilic granules. rG-CSF induced a few eosinophilic granule (+) cells, and TNF-alpha, which did not induce eosinophilic granules by itself, enhanced the ability of G-CSF to induce them. However, G-CSF and TNF-alpha did not induce the expression of Fc epsilon RII and EO-1 antigen. Moreover, anti-G-CSF, anti-TNF-alpha, anti-GM-CSF, anti-IL-3, and anti-IL-5 antibodies did not suppress the effect of HIL-3 sup on the differentiation of EoL-1 cells. All the data suggest that HIL-3 sup contains an unidentified factor that induces differentiation of EoL-1 cells, and that EoL-1 cells and HIL-3 sup provide an important model for the examination of differentiation mechanisms and functions of eosinophils. 相似文献
60.
Mayumi Ishida Hideki Onishi Tatsuya Morita Yosuke Uchitomi Megumi Shimizu Satoru Tsuneto Yasuo Shima Mitsunori Miyashita 《Journal of pain and symptom management》2018,55(4):1061-1067.e1