全文获取类型
收费全文 | 3155篇 |
免费 | 250篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 48篇 |
儿科学 | 72篇 |
妇产科学 | 140篇 |
基础医学 | 523篇 |
口腔科学 | 45篇 |
临床医学 | 386篇 |
内科学 | 663篇 |
皮肤病学 | 113篇 |
神经病学 | 254篇 |
特种医学 | 95篇 |
外科学 | 286篇 |
综合类 | 67篇 |
预防医学 | 159篇 |
眼科学 | 73篇 |
药学 | 246篇 |
中国医学 | 17篇 |
肿瘤学 | 242篇 |
出版年
2023年 | 19篇 |
2022年 | 32篇 |
2021年 | 90篇 |
2020年 | 58篇 |
2019年 | 84篇 |
2018年 | 94篇 |
2017年 | 89篇 |
2016年 | 80篇 |
2015年 | 120篇 |
2014年 | 147篇 |
2013年 | 192篇 |
2012年 | 259篇 |
2011年 | 273篇 |
2010年 | 177篇 |
2009年 | 150篇 |
2008年 | 223篇 |
2007年 | 202篇 |
2006年 | 179篇 |
2005年 | 153篇 |
2004年 | 131篇 |
2003年 | 114篇 |
2002年 | 93篇 |
2001年 | 72篇 |
2000年 | 41篇 |
1999年 | 63篇 |
1998年 | 28篇 |
1997年 | 19篇 |
1996年 | 13篇 |
1995年 | 6篇 |
1994年 | 15篇 |
1993年 | 6篇 |
1992年 | 12篇 |
1991年 | 21篇 |
1990年 | 20篇 |
1989年 | 15篇 |
1988年 | 27篇 |
1987年 | 16篇 |
1986年 | 16篇 |
1985年 | 10篇 |
1984年 | 16篇 |
1983年 | 4篇 |
1981年 | 5篇 |
1980年 | 5篇 |
1979年 | 8篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1975年 | 3篇 |
1974年 | 5篇 |
1971年 | 4篇 |
1969年 | 2篇 |
排序方式: 共有3429条查询结果,搜索用时 0 毫秒
101.
Robert S Gerhard ;Chad WM Ritenour ;Michael Goodman ;Dipak Vashi ;Wayland Hsiao 《Asian journal of andrology》2014,16(6):858-863
Previous studies have described racial and socioeconomic disparities in the treatment of infertility. Patient factors such as attitudes and awareness may be contributing factors. Since primary care is often the setting that serves as an entry into other areas of medicine, we sought to evaluate men's attitudes and awareness of male infertility in the primary care setting. To do this, we performed a cross-sectional survey of men's attitudes toward men's health issues in 210 men from two primary care clinic waiting rooms in Atlanta, Georgia. The survey was self-administered with closed-ended question items and was approximately 20 min in length. Of the 310 men approached, 210 agreed to participate and returned completed surveys. Overall, 52% of men said they were "very" or "somewhat" familiar with infertility and 25% were familiar with treatments for infertility. Some men had heard of surgery (21%) and medication (35%) as treatments for male infertility. Awareness and familiarity with the condition was greater in high socioeconomic status men (i.e. college graduates or those with income 〉$100 k per year) but did not differ by race on multivariate analysis. Attitudes toward infertility varied by race with non-Caucasian men being more likely to indicate that infertility is a serious condition, to be concerned about infertility, and to believe it decreases a man's quality-of-life. Therefore, a lack of awareness, but not negative attitudes, may contribute to previously-described disparities in the treatment of infertility. 相似文献
102.
103.
Yung‐Luen Shih Hung‐Sheng Shang Yung‐Liang Chen Shu‐Ching Hsueh Hsiao‐Min Chou Hsu‐Feng Lu Ming‐Zhe Lee Hsin‐Tu Hou Ying‐Ying Chuang Mei‐Hui Lee Kuo‐Wei Chen Jing‐Gung Chung 《Environmental toxicology》2019,34(5):659-665
Ouabain, a cardiotonic steroid, was used for the treatment of heart failure and atrial fibrillation and induces cancer cell apoptosis in many human cancer cells including human leukemia cells. However, there are no reports to show the effects on immune responses in a leukemia mouse model. In this study, WEHI‐3 cell generated leukemia mice were developed and treated by oral ouabain at 0, 0.75, 1.5, and 3 mg/kg for 15 days. Results indicated that ouabain did not affect body appearance, but decreased liver and spleen weights, B‐ and T‐cell proliferation at all three doses treatment and increased CD19 cells at 3.0 mg/kg treatment, decreased CD3, CD11b, and Mac‐3 cells levels compared with positive control. Furthermore, ouabain increased the macrophage phagocytosis from peripheral blood mononuclear cell and peritoneal cavity at all three doses treatment and increased NK cell activities. Ouabain restored GOT, GPT and LDH levels in WEHI‐3 leukemia mice in vivo. 相似文献
104.
105.
Cheng‐Wen Lin Hsien‐Kuo Chin Shou‐Lun Lee Chang‐Fang Chiu Jing‐Gung Chung Zi‐Yin Lin Chia‐Yung Wu Ying‐Chen Liu Yung‐Ting Hsiao Chia‐Hsien Feng Li‐Yuan Bai Jing‐Ru Weng 《Environmental toxicology》2019,34(9):983-991
Oral squamous cell carcinoma (OSCC) is the fifth common cause of cancer mortality in Taiwan with high incidence and recurrence and needs new therapeutic strategies. In this study, ursolic acid (UA), a triterpenoid, was examined the antitumor potency in OSCC cells. Our results showed that UA inhibited the proliferation of OSCC cells in a dose‐ and time‐dependent manner in both Ca922 and SCC2095 oral cancer cells. UA induced caspase‐dependent apoptosis accompanied with the modulation of various biological biomarkers including downregulating Akt/mTOR/NF‐κB signaling, ERK, and p38. In addition, UA inhibited angiogenesis as evidenced by abrogation of migration/invasion and blocking MMP‐2 secretion in Ca922 cells. Interestingly, UA induced autophagy in OSCC cells, as manifested by LC3B‐II conversion and increased p62 expression and accumulation of autophagosomes. Inhibition by autophagy inhibitor enhanced UA‐mediated apoptosis in Ca922 cells. The experiment provides a rationale for using triterpenoid in the treatment of OSCC. 相似文献
106.
Ming-Hung Hu Yuan-Bin Yu Yu-Chung Huang Jyh-Pyng Gau Liang-Tsai Hsiao Jin-Hwang Liu Ming-Huang Chen Tzeon-Jye Chiou Po-Min Chen Cheng-Hwai Tzeng Chun-Yu Liu 《Annals of hematology》2014,93(6):1023-1029
Patients with immune thrombocytopenia (ITP) may be at increased risk of infection because of the steroids and other immunosuppressive agents used in its treatment. This study aimed to identify events that are associated with infection within 6 months of diagnosis and the impact that infection has on survival. We retrospectively evaluated 239 patients (107 men, 132 women; median age 61 years) diagnosed between January 1997 and August 2011. Every patient received steroid treatment according to the platelet count and the extent of bleeding. Logistic regression analysis was used to identify risk factors associated with the development of infection within 6 months of ITP being diagnosed. Sixty-two patients (25.9 %) developed an infection within 6 months of diagnosis. Multivariate analysis revealed that a lower absolute lymphocyte count (ALC) at diagnosis (<1?×?109/l) was an independent risk factor for infection (P?=?0.039; 95 % confidence interval, 1.033–3.599; odds ratio, 1.928). The time to infection event is significant shorter in those of low ALC, compared with those of higher ALC (P?=?0.032). Furthermore, the 1-year mortality rate after ITP diagnosis was significantly higher in those patients who developed an infection (P?=?0.001). ITP patients with a low absolute lymphocyte count at diagnosis have an increased risk of infection, and those who develop infections have lower 1-year survival. 相似文献
107.
108.
Hao-Yuan Wang Ching-Fen Yang Tzeon-Jye Chiou Sheng-Hsiang Yang Jyh-Pyng Gau Yuan-Bin Yu Chun-Yu Liu Jin-Hwang Liu Po-Min Chen Hui-Chi Hsu Chang-Phone Fung Cheng-Hwai Tzeng Liang-Tsai Hsiao 《Medicine》2014,93(27)
Delayed diagnosis of hematological malignancies in immunocompetent patients with fever of unknown origin (FUO) remains an exhausting challenge for non-hematologist physicians. This retrospective cohort study aimed to establish a scoring system, “bone marrow (BM) score”, to identify FUO patients who require early bone marrow biopsy (BMB) to diagnose hematological disease.Two cohorts, comprising 85 (training) and 20 (validation) eligible immunocompetent patients, with FUOs diagnosed between January 1, 2006 and July 31, 2013, underwent BMBs and were enrolled in the study. Demographic, laboratory, imaging, diagnostic, and outcome data were collected and retrospectively analyzed. Factors associated with hematological etiologies diagnosed using BMBs in the training cohort were identified and scored according to the relative hazards. These were further validated using the validation cohort.For the training cohort, 29 of 85 (34.1%) patients had hematological etiologies diagnosed using BMB. Seven factors significantly predicted the diagnostic yield of hematological diseases in the BM and were scored, with the 6 points for leucoerythroblastic changes in peripheral blood smears, 5.5 for elevated ferritin level (>1000 ng/mL), 4 for splenomegaly, 2 for thrombocytopenia, 1.5 for each of elevated lactate dehydrogenase levels and anemia, and 1 for neutropenia. When the cut-off value of the scoring system was set to 6, its sensitivity and specificity to diagnose hematological diseases in the BM of immunocompetent FUO patients were 93% and 58%, respectively. For the validation cohort, 7 of 20 (35%) patients had hematological disease, and all had BM scores higher than the cut-off, with the sensitivity and specificity at 100% and 77%, respectively.As immunocompetent FUO patients with hematological disease have poor prognoses, the “BM score” is valuable for non-hematologist physicians to identify immunocompetent FUO patients requiring early BMB. 相似文献
109.
Panostotic Expansile Bone Disease With Massive Jaw Tumor Formation and a Novel Mutation in the Signal Peptide of RANK 下载免费PDF全文
Anne L Schafer Steven Mumm Ivan El‐Sayed William H McAlister Andrew E Horvai Andrea M Tom Edward C Hsiao Frederick V Schaefer Michael T Collins Mark S Anderson Michael P Whyte Dolores M Shoback 《Journal of bone and mineral research》2014,29(4):911-921
Precise regulation of bone resorption is critical for skeletal homeostasis. We report a 32‐year‐old man with a panostotic expansile bone disease and a massive hemorrhagic mandibular tumor. Originally from Mexico, he was deaf at birth and became bow‐legged during childhood. There was no family history of skeletal disease. Puberty occurred normally, but during adolescence he experienced difficulty straightening his limbs, sustained multiple fractures, and developed a bony tumor on his chin. By age 18 years, all limbs were misshapen. The mandibular mass grew and protruded from the oral cavity, extending to the level of the lower ribs. Other bony defects included a similar maxillary mass and serpentine limbs. Upon referral at age 27 years, biochemical studies showed serum alkaline phosphatase of 1760 U/L (Nl: 29‐111) and other elevated bone turnover markers. Radiography of the limbs showed medullary expansion and cortical thinning with severe bowing. Although the jaw tumors were initially deemed inoperable, mandibular mass excision and staged partial maxillectomy were eventually performed. Tumor histopathology showed curvilinear trabeculae of woven bone on a background of hypocellular fibrous tissue. Fibrous dysplasia of bone was suspected, but there was no mutation in codon 201 of GNAS in samples from blood or tumor. His clinical and radiographic findings, elevated serum markers, and disorganized bone morphology suggested amplified receptor activator of NF‐κB (RANK) signaling, even though his disorder differed from conditions with known constitutive activation of RANK signaling (eg, familial expansile osteolysis). We found a unique 12‐base pair duplication in the signal peptide of TNFRSF11A, the gene that encodes RANK. No exon or splice site mutations were found in the genes encoding RANK ligand or osteoprotegerin. Alendronate followed by pamidronate therapies substantially decreased his serum alkaline phosphatase activity. This unique patient expands the phenotypes and genetic basis of the mendelian disorders of RANK signaling activation. © 2014 American Society for Bone and Mineral Research. 相似文献
110.