全文获取类型
收费全文 | 1914篇 |
免费 | 108篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 43篇 |
妇产科学 | 54篇 |
基础医学 | 271篇 |
口腔科学 | 32篇 |
临床医学 | 276篇 |
内科学 | 393篇 |
皮肤病学 | 17篇 |
神经病学 | 112篇 |
特种医学 | 66篇 |
外科学 | 290篇 |
综合类 | 9篇 |
预防医学 | 179篇 |
眼科学 | 7篇 |
药学 | 111篇 |
中国医学 | 1篇 |
肿瘤学 | 149篇 |
出版年
2023年 | 10篇 |
2022年 | 13篇 |
2021年 | 39篇 |
2020年 | 16篇 |
2019年 | 39篇 |
2018年 | 31篇 |
2017年 | 29篇 |
2016年 | 37篇 |
2015年 | 44篇 |
2014年 | 47篇 |
2013年 | 84篇 |
2012年 | 112篇 |
2011年 | 125篇 |
2010年 | 64篇 |
2009年 | 72篇 |
2008年 | 90篇 |
2007年 | 102篇 |
2006年 | 103篇 |
2005年 | 94篇 |
2004年 | 87篇 |
2003年 | 67篇 |
2002年 | 62篇 |
2001年 | 40篇 |
2000年 | 53篇 |
1999年 | 39篇 |
1998年 | 20篇 |
1997年 | 26篇 |
1996年 | 12篇 |
1995年 | 13篇 |
1994年 | 11篇 |
1992年 | 19篇 |
1991年 | 21篇 |
1990年 | 21篇 |
1989年 | 31篇 |
1988年 | 25篇 |
1987年 | 20篇 |
1986年 | 23篇 |
1985年 | 19篇 |
1984年 | 10篇 |
1983年 | 20篇 |
1982年 | 11篇 |
1980年 | 14篇 |
1979年 | 17篇 |
1978年 | 16篇 |
1977年 | 17篇 |
1976年 | 17篇 |
1975年 | 10篇 |
1973年 | 15篇 |
1969年 | 19篇 |
1968年 | 11篇 |
排序方式: 共有2025条查询结果,搜索用时 15 毫秒
71.
Andrea Dueregger Isabel Heidegger Philipp Ofer Bernhard Perktold Reinhold Ramoner Helmut Klocker Iris E. Eder 《Nutrients》2014,6(10):4491-4519
Prostate cancer (PCa), the most commonly diagnosed cancer and second leading cause of male cancer death in Western societies, is typically androgen-dependent, a characteristic that underlies the rationale of androgen deprivation therapy (ADT). Approximately 90% of patients initially respond to ADT strategies, however many experience side effects including hot flashes, cardiotoxicity, metabolic and musculoskeletal alterations. This review summarizes pre-clinical and clinical studies investigating the ability of dietary supplements to alleviate adverse effects arising from ADT. In particular, we focus on herbal compounds, phytoestrogens, selenium (Se), fatty acids (FA), calcium, and Vitamins D and E. Indeed, there is some evidence that calcium and Vitamin D can prevent the development of osteoporosis during ADT. On the other hand, caution should be taken with the antioxidants Se and Vitamin E until the basis underlying their respective association with type 2 diabetes mellitus and PCa tumor development has been clarified. However, many other promising supplements have not yet been subjected large-scale clinical trials making it difficult to assess their efficacy. Given the demographic trend of increased PCa diagnoses and dependence on ADT as a major therapeutic strategy, further studies are required to objectively evaluate these supplements as adjuvant for PCa patients receiving ADT. 相似文献
72.
Tait D. Shanafelt Colin P. West Christine Sinsky Mickey Trockel Michael Tutty Daniel V. Satele Lindsey E. Carlasare Lotte N. Dyrbye 《Mayo Clinic proceedings. Mayo Clinic》2019,94(9):1681-1694
ObjectiveTo evaluate the prevalence of burnout and satisfaction with work-life integration among physicians and other US workers in 2017 compared with 2011 and 2014.Participants and MethodsBetween October 12, 2017, and March 15, 2018, we surveyed US physicians and a probability-based sample of the US working population using methods similar to our 2011 and 2014 studies. A secondary survey with intensive follow-up was conducted in a sample of nonresponders to evaluate response bias. Burnout and work-life integration were measured using standard tools.ResultsOf 30,456 physicians who received an invitation to participate, 5197 (17.1%) completed surveys. Among the 476 physicians in the secondary survey of nonresponders, 248 (52.1%) responded. A comparison of responders in the 2 surveys revealed no significant differences in burnout scores (P=.66), suggesting that participants were representative of US physicians. When assessed using the Maslach Burnout Inventory, 43.9% (2147 of 4893) of the physicians who completed the MBI reported at least one symptom of burnout in 2017 compared with 54.4% (3680 of 6767) in 2014 (P<.001) and 45.5% (3310 of 7227) in 2011 (P=.04). Satisfaction with work-life integration was more favorable in 2017 (42.7% [2056 of 4809]) than in 2014 (40.9% [2718 of 6651]; P<.001) but less favorable than in 2011 (48.5% [3512 of 7244]; P<.001). On multivariate analysis adjusting for age, sex, relationship status, and hours worked per week, physicians were at increased risk for burnout (odds ratio, 1.39; 95% CI, 1.26-1.54; P<.001) and were less likely to be satisfied with work-life integration (odds ratio, 0.77; 95% CI, 0.70-0.85; P<.001) than other working US adults.ConclusionBurnout and satisfaction with work-life integration among US physicians improved between 2014 and 2017, with burnout currently near 2011 levels. Physicians remain at increased risk for burnout relative to workers in other fields. 相似文献
73.
74.
South Africa Every Death Counts Writing Group Bradshaw D Chopra M Kerber K Lawn JE Bamford L Moodley J Pattinson R Patrick M Stephen C Velaphi S 《Lancet》2008,371(9620):1294-1304
South Africa is one of the few developing countries with a national confidential inquiry into maternal deaths. 164 health facilities obtain audit data for stillbirths and neonatal deaths, and a new audit network does so for child deaths. Three separate reports have been published, providing valuable information about avoidable causes of death for mothers, babies, and children. These reports make health-system recommendations, many of which overlap and are intertwined with the scarcity of progress in addressing HIV/AIDS. The leaders of these three reports have united to prioritise actions to save the lives of South Africa's mothers, babies, and children. The country is off-track for the health-related Millennium Development Goals. Mortality in children younger than 5 years has increased, whereas maternal and neonatal mortality remain constant. This situation indicates the challenge of strengthening the health system because of high inequity and HIV/AIDS. Coverage of services is fairly high, but addressing the gaps in quality and equity is essential to increasing the number of lives saved. Consistent leadership and accountability to address crosscutting health system and equity issues, and to prevent mother-to-child transmission of HIV, would save tens of thousands of lives every year. Audit is powerful, but only if the data lead to action. 相似文献
75.
76.
77.
Michael Heuser Carola Schlarmann Vera Dobbernack Victoria Panagiota Lutz Wiehlmann Carolin Walter Fabian Beier Patrick Ziegler Haiyang Yun Sofia Kade Aylin Kirchner Liu Huang Christian Koenecke Matthias Eder Tim H. Brümmendorf Martin Dugas Arnold Ganser Felicitas Thol 《Haematologica》2014,99(9):e165-e167
78.
Rabia Shahswar Gernot Beutel Piroska Klement Alina Rehberg Razif Gabdoulline Christian Koenecke Dominik Markel Hendrik Eggers Matthias Eder Michael Stadler Lothar Hambach Steve Ehrlich Gudrun Göhring Brigitte Schlegelberger Elke Dammann Marlene Reuter Martin Wichmann Blerina Neziri Arnold Ganser Felicitas Thol Michael Heuser 《British journal of haematology》2020,188(3):e11-e15
79.
A. Wanka A. Arnberger B. Allex R. Eder H.-P. Hutter P. Wallner 《Zeitschrift für Gerontologie und Geriatrie》2014,47(6):468-474
Ever since the 2003 heat wave that caused 70,000 heat deaths, the dramatic consequences of climate change and rising temperatures in Europe have become an intensively researched topic. During heat waves, the older urban adult population is at highest risk. The STOPHOT project is the first investigation in Austria to establish a comprehensive knowledge base on heat perception, awareness of heat risks and adaptive/coping behaviours among older adults. The main research questions include: (1) Does climate change endanger the chances of successful ageing in urban areas? (2) How do age, social inequalities and the living environment intersect with environmental stressors in affecting successful ageing? (3) Which heat adaption strategies do older adults deploy and to what extent can they mediate heat stress in an effort to increase chances of successful ageing under the conditions of climate change? The results indicate that climate change and rising temperatures are in fact one important determinant of whether and how an older person can maintain well-being in later life. Older adults (>?65 years) with a low socio-economic status and poor health conditions, who tend to be socially isolated, are most at risk. However, no ‘heat island effect’ of the residential environment could be found. How much a person suffers from heat stress is highly dependent on the adaption strategies deployed. Adaption strategies of older urban residents mostly centred on body-related measures, such as drinking more or wearing lighter clothes, and indoor-centred measures, particularly avoiding the outdoors. 相似文献
80.
Talal F. Al-Azemi Mickey Vinodh Fatemeh H. Alipour Abdirahman A. Mohamod 《RSC advances》2019,9(40):23295
Bulky perneopentyloxy-pillar[5]arene (Pillar-1) was synthesized and its conformational mobility was investigated using variable-temperature 1H NMR spectroscopy. The host–guest interactions between Pillar-1 and n-octyltrimethylammonium hexafluorophosphate (OMA) were investigated, and the formation of a 1 : 1 complex was revealed via1H NMR. Planar-chiral isomers were synthesized via the reaction of a hydroxy-functionalized pillar[5]arene with chiral derivatization agent (S)-(+)-MTPA-Cl. The (Sp, R)-and (Rp, R)-forms of the pillar[5]arene diastereomers were isolated by HPLC, and their structures were analyzed by 19F NMR. HPLC measurements indicated that racemization did not take place at 40 °C for 72 h.Bulky perneopentyloxy-pillar[5]arene was synthesized. Complexation behavior and conformational mobility were investigated using 1H NMR spectroscopy. Isolation of planar-chiral pillar[5]arenes using a chiral derivatization agent were carried out. 相似文献