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501.
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Adolph Michaelsen 《Pflügers Archiv : European journal of physiology》1889,45(1):622-624
Ohne Zusammenfassung 相似文献
503.
Risks for upper respiratory infections in infants during their first months in day care included environmental and child‐related factors 下载免费PDF全文
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Austarheim I Mahamane H Sanogo R Togola A Khaledabadi M Vestrheim AC Inngjerdingen KT Michaelsen TE Diallo D Paulsen BS 《Journal of ethnopharmacology》2012,139(1):221-227
Ethnopharmacological relevance
The study documented medicinal plants that are traditionally used for treatment of malaria in Shinile District, eastern Ethiopia, and evaluated selected medicinal plants for their antiplasmodial activities against Plasmodium berghei.Materials and methods
The study was conducted in four kebeles of Shinile District, Somali Region, Ethiopia. A total of 15 traditional healers were sampled based on recommendations of local elders and administrators. Specimens of the reported antimalarial plants were collected and stored at the Mini Herbarium of the Aklilu Lemma Institute of Pathobiology, Addis Ababa University, following identification. Crude aqueous and ethanol extracts of Aloe sp., Azadirachta indica and Tamarindus indica were tested in vivo against Plasmodium berghei. The three plants were selected based on the frequency antimalarial use report by healers.Results
The study revealed 27 antimalarial plants, the majority of which were harvested from the wild. Root was the most frequently sought plant part. Most of the remedies were used in decoction form. Aloe sp., Azadirachta indica and Tamarindus indica were the most commonly reported plants for their antimalarial use. For the in vivo test, all the plant extracts were given to mice orally. Ethanol and aqueous leaf extracts of Aloe sp. caused 73.94% and 58.10% parasitaemia suppression, respectively at dose of 650 mg/kg. Ethanol extract of Azadirachta indica leaves induced 54.79% parasitaemia suppression at the dose of 650 mg/kg and its water extract induced 21.47% parasite suppression at a similar dose. Water extract of the fruits of Tamarindus indica showed the highest parasitaemia suppression (81.09%) at the dose of 650 mg/kg. Most Plasmodium berghei infected mice treated with high dose of plant extracts survived relatively longer compared to their respective controls although the difference was not significant.Conclusions
The result of this study may support the traditional use of Aloe sp., Azadirachta indica and Tamarindus indica in the study area against malaria. Results of this study can be used as a basis for further phytochemical and pharmacological investigations in the effort for search of new and locally affordable antimalarial agents. 相似文献506.
Data on accretion in bone size and bone mineral content (BMC) are needed to evaluate bone mineralisation during childhood. Whole body bone mineral content (BMC) and bone area (BA) were determined by dual energy x ray absorptiometry (Hologic 1000/W) with a one year interval in healthy girls (n = 192) and boys (n = 140) aged 6-19 years. Annual accretion in BMC (DeltaBMC (g/year)) and BA (DeltaBA (cm2/year)) according to sex and pubertal stages were calculated. DeltaBA and DeltaBMC were highly significantly associated with pubertal stages in girls and boys. Centile curves for DeltaBA and DeltaBMC according to sex and age were constructed using the LMS method. Peak DeltaBA and DeltaBMC values were reached earlier in girls (12.3 and 12.5 years, respectively) than in boys (13.4 and 14. 2 years, respectively). The DeltaBA peak was dissociated in time from the DeltaBMC peak, indicating that increase in bone size occurs before increase in bone mineral content. Assuming that 32.2% of BMC consist of calcium, the median (90th centile) annual bone calcium accretion in pubertal stage III was 220 mg/day (302) and 317 mg/day (386) for girls and boys, respectively. To obtain an average bone calcium accretion, a high calcium absorption is needed during puberty. This may have implications for dietary calcium requirements at this time. 相似文献
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Stine Asferg Petterson Mia Dahl Sørensen Mark Burton Mads Thomassen Torben A. Kruse Signe Regner Michaelsen Bjarne Winther Kristensen 《Brain pathology (Zurich, Switzerland)》2023,33(1):e13111
Glioblastoma is the most common primary malignant brain tumor in adults with an overall survival of only 14.6 months. Hypoxia is known to play a role in tumor aggressiveness but the influence of hypoxia on the immune microenvironment is not fully understood. The aim of this study was to investigate the expression of immune-related proteins in normoxic and hypoxic tumor areas by digital spatial profiling. Tissue samples from 10 glioblastomas were stained with a panel of 40 antibodies conjugated to photo-cleavable oligonucleotides. The free oligo-tags from normoxic and hypoxic areas were hybridized to barcodes for digital counting. Differential expression patterns were validated by Ivy Glioblastoma Atlas Project (GAP) data and an independent patient cohort. We found that CD44, Beta-catenin and B7-H3 were upregulated in hypoxia, whereas VISTA, CD56, KI-67, CD68 and CD11c were downregulated. PD-L1 and PD-1 were not affected by hypoxia. Focusing on the checkpoint-related markers CD44, B7-H3 and VISTA, our findings for CD44 and VISTA could be confirmed with Ivy GAP RNA sequencing data. Immunohistochemical staining and digital quantification of CD44, B7-H3 and VISTA in an independent cohort confirmed our findings for all three markers. Additional stainings revealed fewer T cells and high but equal amounts of tumor-associated microglia and macrophages in both hypoxic and normoxic regions. In conclusion, we found that CD44 and B7-H3 were upregulated in areas with hypoxia whereas VISTA was downregulated together with the presence of fewer T cells. This heterogeneous expression should be taken into consideration when developing novel therapeutic strategies. 相似文献
509.
Naeem Bhojani Kyo Chul Koo Kahina Bensaadi Abdulghafour Halawani Victor KF. Wong Ben H. Chew 《BJU international》2023,132(6):678-685