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51.
Image noise reduction technology allows significant reduction of radiation dosage in cardiac device implantation procedures 下载免费PDF全文
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Elisabeth Michaelsen 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1921,161(1-2):226-241
Ohne Zusammenfassung 相似文献
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Feeding behaviors during home‐based treatment of moderate acute malnutrition using corn‐soy blends or lipid‐based nutrient supplements 下载免费PDF全文
Ann‐Sophie Iuel‐Brockdorf Albertine Ouedraogo Christian Ritz Tania Aase Draebel Per Ashorn Suzanne Filteau Kim F. Michaelsen 《Maternal & child nutrition》2017,13(4)
Feeding behaviors have an important impact on children's nutritional status and are essential to consider when implementing nutrition programs. The objective of this study was to explore and compare feeding behaviors related to supplementary feeding with corn‐soy blends (CSB) and lipid‐based nutrient supplements (LNS) based on best practice feeding behaviors. The study was conducted as part of a randomized controlled trial assessing the effectiveness of new formulations of CSB and LNS and comprised 1,546 children from 6 to 23 months. The study included a mixed methods approach using questionnaires, focus group discussions and home visits and interviews with a subsample of 20 caretakers of trial participants. We found that LNS, compared to CSB, were more likely to be mixed into other foods (OR [95% CI] 1.7 [1.3–2.2], p = <.001), served with a meal (OR [95% CI] 1.6 [1.1–2.3], p = <.018)or between meals (OR [95% CI] 1.5 [1.1–1.9], p = <.005), and fed using an encouraging feeding style (mean difference in percentage points [95% CI] 23% [6%:40%], p = .01). CSB were more likely to be fed using a forced feeding style (mean difference in percentage points [95% CI] 18% [3%:33%], p = .02) and were often observed to be served unprepared. The main differences in feeding behaviors between the two diet groups were linked to how and when supplements were served. Educational instructions should therefore be adapted according to the supplement provided; when providing CSB, efforts should be made to promote an encouraging feeding style, and emphasis should be made to ensure preparations are made according to recommendations. 相似文献
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Waldmann TA; Goldman CK; Bongiovanni KF; Sharrow SO; Davey MP; Cease KB; Greenberg SJ; Longo DL 《Blood》1988,72(5):1805-1816
Human T-cell lymphotropic virus I (HTLV-I)-induced adult T-cell leukemia (ATL) cells constitutively express interleukin-2 (IL-2) receptors identified by the anti-Tac monoclonal antibody (MoAb), whereas normal resting cells do not. This observation provided the scientific basis for a trial of intravenous anti-Tac in the treatment of nine patients with ATL. The patients did not suffer untoward reactions and did not have a reduction in the normal formed elements of the blood, and only one of the nine produced antibodies to the anti-Tac MoAb. Three patients had transient mixed, partial, or complete remissions lasting from 1 to more than 8 months after anti-Tac therapy, as assessed by routine hematologic tests, immunofluorescence analysis of circulating cells, and molecular genetic analysis of HTLV-I provirus integration and of the T-cell receptor gene rearrangement. The precise mechanism of the antitumor effects is unclear; however, the use of a MoAb that prevents the interaction of IL-2 with its receptor on ATL cells provides a rational approach for the treatment of this malignancy. 相似文献
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Murine B-cell hybridoma cells producing an immunoglobulin G1 (K13), specific for human immunoglobulin kappa chains were inoculated intraperitoneally in mice. After intraperitoneal injection of 10(6) K13 hybridoma cells, superficial intraperitoneal implants and ascites developed, resulting in death after 10 +/- 3 days (mean +/- SD). An immunoradiometric assay was developed to measure K13 in murine blood, ascites and culture supernatant. The assay utilized polymer beads coated with human immunoglobulin G. The amount K13 bound to the particles was measured with a 125I-labelled monoclonal rat antibody (LO-MG1-13) specific for mouse IgG1. The assay could be used over a wide working range (2-500 micrograms/l). Kinetic studies suggested that about 10(5) secreting cells were required for detection of K13 in blood. After injection of 10(6) cells, K13 was measurable in blood 1 day later in all animals. Nine of 33 mice injected with 10(5) or less cells survived, and initially showed rising K13 blood levels followed by decreasing blood levels. In conclusion, a close relationship was established between i.p. growth of the hybridoma K13 cell line and the MAb blood levels. The basic concepts of this assay can readily be adopted for other clones with the limitation that pure antigen is needed for solid phase extraction of the MAb from mouse blood. 相似文献
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S. Kvaly R. Langholm O. Kaalhus T. Michaelsen S. Funderud A. Foss Abrahamsen T. Godal 《International journal of cancer. Journal international du cancer》1984,33(2):173-177
The reactivity of two monoclonal antibodies indentifying antigens related to B-cell activation, B3/25 (the transferrin receptor) and BB-1 (the B-lymphoblast-1-antigen), was examined on cell suspensions from 75 cases of monoclonal B-cell lymphomas. The expression of B3/25 antigen was correlated to DNA synthesis as measured by spontaneous 3H-thymidine incorporation (p= 0.0003) and histopathologically high-grade malignancy (p= 0.00003). Furthermore, B3/25 expression was associated with survival since the patients with B3/25-negative tumors survived longer than those with B3/25-positive tumors (p= 0.018). B3/25 expression also defined a larger group of patients with shorter survival than did histopathology alone, 28 cases versus 16 cases, respectively. On the other hand, the BB-1 antigen did not reveal an association with DNA synthesis, high-grade malignancy or survival. However, the findings indicated that BB-1 may be related to B-cell maturation/differentiation. 相似文献