收费全文 | 1612182篇 |
免费 | 125621篇 |
国内免费 | 4137篇 |
耳鼻咽喉 | 20509篇 |
儿科学 | 51745篇 |
妇产科学 | 44829篇 |
基础医学 | 225672篇 |
口腔科学 | 41626篇 |
临床医学 | 146869篇 |
内科学 | 325790篇 |
皮肤病学 | 36222篇 |
神经病学 | 137397篇 |
特种医学 | 62618篇 |
外国民族医学 | 477篇 |
外科学 | 241534篇 |
综合类 | 34961篇 |
现状与发展 | 4篇 |
一般理论 | 655篇 |
预防医学 | 124423篇 |
眼科学 | 36380篇 |
药学 | 111984篇 |
2篇 | |
中国医学 | 3636篇 |
肿瘤学 | 94607篇 |
2021年 | 15252篇 |
2019年 | 15841篇 |
2018年 | 21629篇 |
2017年 | 16456篇 |
2016年 | 18407篇 |
2015年 | 20796篇 |
2014年 | 29598篇 |
2013年 | 43092篇 |
2012年 | 59936篇 |
2011年 | 63111篇 |
2010年 | 36743篇 |
2009年 | 34968篇 |
2008年 | 57856篇 |
2007年 | 61059篇 |
2006年 | 61300篇 |
2005年 | 59656篇 |
2004年 | 56779篇 |
2003年 | 53619篇 |
2002年 | 51622篇 |
2001年 | 74686篇 |
2000年 | 75758篇 |
1999年 | 63282篇 |
1998年 | 19372篇 |
1997年 | 17329篇 |
1996年 | 17214篇 |
1995年 | 16307篇 |
1994年 | 14752篇 |
1993年 | 13891篇 |
1992年 | 46689篇 |
1991年 | 44292篇 |
1990年 | 42150篇 |
1989年 | 40172篇 |
1988年 | 36759篇 |
1987年 | 35882篇 |
1986年 | 33418篇 |
1985年 | 31882篇 |
1984年 | 24606篇 |
1983年 | 20714篇 |
1982年 | 13114篇 |
1981年 | 11619篇 |
1979年 | 21120篇 |
1978年 | 15037篇 |
1977年 | 12482篇 |
1976年 | 11736篇 |
1975年 | 11904篇 |
1974年 | 14261篇 |
1973年 | 13773篇 |
1972年 | 12788篇 |
1971年 | 11612篇 |
1970年 | 11010篇 |
Objective
The teaching hospital of Nancy, France, implemented a specific multidisciplinary care pathway (French acronym AMDPL) to improve the management of patients presenting with Lyme borreliosis (LB) suspicion. We aimed to assess the first year of activity of this care pathway.Patients and methods
We included all patients managed in the AMDPL pathway from November 1, 2016 to October 31, 2017. The first step was a dedicated Lyme disease consultation with an infectious disease specialist. Following this consultation, the LB diagnosis was either confirmed and adequate treatment was prescribed, or a differential diagnosis was established and patients received adequate management, or further investigations were required and patients were offered multidisciplinary management as part of a day hospitalization.Results
A total of 468 patients were included. LB diagnosis was confirmed in 15% of patients (69/468), 49% of patients received a differential diagnosis, and 26% (122/468) of patients had the LB diagnosis ruled out without receiving any other diagnosis.Conclusions
This is to our knowledge the first multidisciplinary center implemented in France for the management of patients presenting with LB suspicion related to polymorphous signs and symptoms. Several diagnoses could be confirmed or corrected, although some symptoms and complaints could not be explained. This cohort could improve our knowledge of LB and its differential diagnoses. 相似文献Areas covered: This review provides an overview of existing pharmacotherapy for osteoporosis in women and explore state-of–the-art and emerging therapies to prevent bone loss, with an emphasis on the mechanism of action, indications and side effects.
Expert opinion: Bisphosphonates appear to be a reliable and cost-effective option, whereas denosumab has introduced a simpler dosing regimen and may achieve a linear increase in bone mineral density (BMD) with no plateau being observed, along with continuous anti-fracture efficacy. Abaloparatide, a parathyroid-hormone-related peptide (PTHrP)-analogue, approved by the FDA in April 2017, constitutes the first new anabolic osteoporosis drug in the US for nearly 15 years and has also proven its anti-fracture efficacy. Romosozumab, a sclerostin inhibitor, which induces bone formation and suppresses bone resorption, has also been developed and shown a significant reduction in fracture incidence; however, concerns have arisen with regard to increased cardiovascular risk. 相似文献