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Lemnge M Alifrangis M Kafuye MY Segeja MD Gesase S Minja D Massaga JJ Rønn AM Bygbjerg IC 《The American journal of tropical medicine and hygiene》2006,75(2):188-193
In May 2003, we studied amodiaquine (AQ) efficacy in children < 5 years of age with uncomplicated falciparum malaria in Magoda and Mpapayu (with insecticide treated nets [ITNs]) and Mgome (without ITNs) in Muheza, Tanzania. The trial involved 28 days of follow-up, and data were adjusted by polymerase chain reaction (PCR) genotyping of msp1 and msp2 genes. Additionally, Pfcrt codon 72-76 polymorphisms were studied by PCR and sequence-specific oligonucleotide probe (SSOP) ELISA. In 54 cases with complete follow-up, a significant difference in late treatment failure (LTF) rates was seen (60.7% in ITN versus 88.5% in non-ITN villages, P = 0.02) before PCR correction. However, after PCR correction, 23 cases (60.5%) were confirmed as reinfections, giving a true LTF rate of 21.4% (6/28) and 34.6% (9/26) in the above settings, respectively. Frequency of Pfcrt CVIET haplotype mutation pretreatment was high (97.0%); the remaining samples were CVMNK. We conclude that AQ alone is no longer effective in the study area. 相似文献
23.
Kazaura MR Lie RT Irgens LM Didriksen A Kapstad M Egenaes J Bjerkedal T 《American journal of epidemiology》2004,159(4):358-363
The prevalence of gastroschisis in Norway, as reported to the Medical Birth Registry of Norway, increased regularly and sixfold from 0.5 to 2.9 per 10,000 births during 1967-1998. The prevalence was also consistently higher among children of younger mothers. The authors used age-period-cohort analysis to assess effects of both parents' age and year of birth (parental cohorts). Mother's and father's age were included in three different regression models. Apart from a significantly higher risk at a young maternal age, the authors also found higher risk at a young paternal age (1.6-fold per 10 years' reduction in father's age, 95% confidence interval: 1.0, 2.4). The time trend was highly significant regardless of whether it was ascribed to period, mother's year of birth, or father's year of birth. However, when father's year of birth was used to describe the time trend, no apparent additional effect of father's age was found, only for mother's age. The time trend is likely caused by environmental factors. Persistently increasing risks among children of young mothers may hypothetically be related to lifestyle factors. A contribution to risk also from fathers born in more recent years or from young fathers increases the likelihood that a factor related to modern lifestyles of young couples may be related to risk. 相似文献
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Penelope Latey Penelope Latey Pilates Practitioner Senior Lecturer course co-ordinator of the Grad. Cert. in the Pilates Method at the University of Technology Sydney Australia. Council Member ex-president of the Australian Pilates Method Association . This paper is modified from an annotated excerpt from the book Modern Pilates written by Penelope Latey. Due to be published September Allen Unwin Australia 《Journal of bodywork and movement therapies》2001,5(4):240
Until the mid-1980s the Pilates Method of exercise was little known outside the world of dance but has grown in popularity rapidly in the last decade: coming out of obscurity. Pilates method is much more than a list of exercises. It is a way of connecting and conditioning the whole being-body and mind. This article traces its history in context and examines the initial principles of the method, with the beginnings of modern developments. 相似文献
26.
Management of cervical cancer in pregnancy 总被引:5,自引:0,他引:5
Carcinoma of the cervix is the most common gynecologic cancer found during pregnancy. Management and treatment of this condition depend on cancer stage, estimated gestational age, and ethical, religious, and personal desires. Review of the medical literature in English from 1965 to 1998 is presented with recommendations for management. 相似文献
27.
以正常在校大学生为实验对象 ,按徐凤纳甲法的 10日开穴按时取穴 ,在相同条件下观察了电针阳经开穴对心收缩时间间期 (STI)的效应差异。结果发现 ,按时电针后 ,六条阳经的开穴对STI各指标的影响均有所不同。其中大肠经组开穴的PEPI电针前后差值间的差异有着显著意义 (P <0 0 5 ) ,三焦经组开穴的LVETI电针前后差值间的差别有着显著意义 (P <0 0 5 )。本实验结果表明 ,按照徐凤纳甲法的 10日开穴按时取穴电针 ,各阳经开穴的电针效应之间有着一定的差异性。 相似文献
28.
Origuchi T Yamaguchi S Inoue A Kazaura Y Matsuo N Abiru N Kawakami A Eguchi K 《Modern rheumatology / the Japan Rheumatism Association》2011,21(5):495-499
We aimed to retrospectively review the incidence of pre-diabetes mellitus (preDM), one of the factors in metabolic syndrome
screening, in patients with rheumatic diseases. We examined the levels of hemoglobin A1c (HbA1c) in a total of 498 patients
with rheumatic diseases between April 2007 and March 2008 at the Department of Rheumatology in Nagasaki University Hospital.
Of the 498 patients, 409 (82.1%) had HbA1c levels higher than 5.6% (National Glycohemoglobin Standardization Program; NGSP)
and were recommended for health guidance with a focus on metabolic syndrome. Serum HbA1c levels higher than 6.0%, a possible
indicator of DM, were seen in 227 patients (45.6%). Serum HbA1c levels higher than 6.5%, which constitute a high risk for
DM, were found in 115 patients (23.1%). PreDM increased gradually with age. Our results suggest that the incidence of preDM
may be higher in patients with rheumatic diseases than in patients with other diseases and that these patients should receive
healthcare guidance to prevent metabolic syndrome. 相似文献
29.
Method D Segeja Bruno P Mmbando Misago D Seth John P Lusingu Martha M Lemnge 《BMC infectious diseases》2010,10(1):1-7
Background
Scrub typhus is a mite-borne bacterial infection of humans caused by Orientia tsutsugamushi that causes a generalized vasculitis that may involve the tissues of any organ system. The aim of this study was to identify factors associated to severe complications from scrub typhus.Methods
We conducted this prospective, case-control study on scrub typhus patients who presented to the Department of Internal Medicine at Chosun University Hospital between September, 2004 and December, 2006. Cases were 89 scrub typhus patients with severe complications and controls were 119 scrub typhus patients without severe complications.Results
There were significant differences in the absence of eschar, white blood cell (WBC) counts, hemoglobin, albumin, serum creatinine, fibrinogen, C-reactive protein (CRP), and active partial thromboplastin time (aPTT) between the two groups. Multivariate analysis demonstrated that only the following four factors were significantly associated with the severe complications of scrub typhus: (1) age ≥ 60 years (odd ratio [OR] = 3.13, P = 0.002, confidence interval [CI] = 1.53-6.41), (2) the absence of eschar (OR = 6.62, P = 0.03, CI = 1.22-35.8, (3) WBC counts > 10, 000/mm3 (OR = 3.6, P = 0.001, CI = 1.65-7.89), and (4) albumin ≤ 3.0 g/dL (OR = 5.01, P = 0.004, CI = 1.69-14.86).Conclusions
Our results suggest that clinicians should be aware of the potential for complications, when scrub typhus patients are older (≥ 60 years), presents without eschar, or laboratory findings such as WBC counts > 10, 000/mm3, and serum albumin level ≤ 3.0 g/dL. Close observation and intensive care for scrub typhus patients with the potential for complications may prevent serious complications with subsequent reduction in its mortality rate. 相似文献30.
中医科专病专护的做法与成效 总被引:1,自引:0,他引:1
为顺应护理学科的飞速发展,提高专科护理质量,本文在深入开展整体护理,培养护理人员高素质的同时,开展专病专护工作.在实施具有中医特色的、以中西医结合的护理方法对本科专治的7个特殊病种进行分类实施;并制定了一系列有效的护理措施,在临床实践中取得了初步成效. 相似文献