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排序方式: 共有250条查询结果,搜索用时 527 毫秒
241.
Sinisa Ivankovi? Svetozar Musi? Marijan Goti? Nikola Ljubesi? 《Toxicology in vitro》2006,20(3):286-294
Two kinds of nanosize V(2)O(5) particles were synthesized in our own laboratory and concomitantly applied to V79 and L929 fibroblasts and SCCVII, B16F10 and FsaR tumor cells. The morphologies of the cells were monitored using an inverted inverse microscope equipped with digital camera, while quantitative determination of the cytotoxicity of nanosize V(2)O(5) particles was measured using crystal violet bioassay. Twenty four hours after the addition of nanosize V(2)O(5) particles (20muM), noticeable changes in the morphology and density of fibroblast and cancer cells were observed. Reculturing in a freshly prepared medium for the next 24h showed a high recovery effect on V79, SCCVII and B16F10 cells, while FsaR and L929 cells were seriously damaged and unable to recover. At a higher concentration of nanosize V(2)O(5) particles (100muM), the cytotoxicity of V(2)O(5) prevailed against the recovery effect in all cell types. Quantitative measurements have shown that the resistance of investigated cell cultures to the cytotoxicity of nanosize V(2)O(5) particles decreases in the order V79>SCCVII>B16F10>FsaR>L929. The high cytotoxic effect found on FsaR cells suggests that nanosize V(2)O(5) particles could be regarded as poisoning material in the treatment of FsaR fibrosarcoma cells. Possible mechanisms involved in the cytotoxicity of nanosize V(2)O(5) particles were discussed. 相似文献
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Kay Poulton Paul Wright Pamela Hughes Sinisa Savic Matthew Welberry Smith Malcolm Guiver Muir Morton David van Dellen Eleni Tholouli Robert Wynn Brendan Clark 《International journal of immunogenetics》2020,47(4):324-328
We analysed data from 80 patients who tested positive for SARS‐CoV‐2 RNA who had previously been HLA typed to support transplantation. Data were combined from two adjacent centres in Manchester and Leeds to achieve a sufficient number for early analysis. HLA frequencies observed were compared against two control populations: first, against published frequencies in a UK deceased donor population (n = 10,000) representing the target population of the virus, and second, using a cohort of individuals from the combined transplant waiting lists of both centres (n = 308), representing a comparator group of unaffected individuals of the same demographic. We report a significant HLA association with HLA‐ DQB1*06 (53% vs. 36%; p < .012; OR 1.96; 95% CI 1.94–3.22) and infection. A bias towards an increased representation of HLA‐A*26, HLA‐DRB1*15, HLA‐DRB1*10 and DRB1*11 was also noted but these were either only significant using the UK donor controls, or did not remain significant after correction for multiple tests. Likewise, HLA‐A*02, HLA‐B*44 and HLA‐C*05 may exert a protective effect, but these associations did not remain significant after correction for multiple tests. This is relevant information for the clinical management of patients in the setting of the current SARS‐CoV‐2 pandemic and potentially in risk‐assessing staff interactions with infected patients. 相似文献
244.
Sinisa Markovic Rima Paliskyte Wolfgang Rottbauer Jochen Wöhrle 《Cardiovascular Revascularization Medicine》2012,13(6):307-310
BackgroundEverolimus-eluting stent (EES) implantation was superior to paclitaxel-eluting stent (PES) implantation for treatment of de-novo coronary artery disease. We evaluated the outcome of EES compared with PES for treatment of restenosis in bare-metal and drug-eluting stents (DES).Methods and MaterialsIn a prospective observational study patients with in-stent restenosis (ISR) were treated with EES (N = 91) or PES (N = 107). Dual antiplatelet therapy was given for 6 months. Patients were scheduled for 6 months angiographic follow-up and 24 months clinical follow-up. Primary outcome measure was the occurrence of major adverse cardiac events (MACE) defined as a composite of cardiac death, any myocardial infarction and target lesion revascularization (TLR).ResultsBaseline data showed some differences between groups including frequency of DES restenosis, length of stented segment and reference vessel diameter. For EES versus PES occurrence of MACE (18.7% vs. 15.0%, p = 0.48) and need for TLR did not differ (13.2% vs. 9.3%, p = 0.39). In-stent late loss was similar with 0.20 ± 0.39 mm for EES and 0.18 ± 0.31 mm for PES (p = 0.34). Binary angiographic restenosis rate for the total segment was 18.0% and 16.7% (p = 0.85), respectively. In multivariable analysis the stented length (p = 0.014), minimal lumen diameter post stenting (p < 0.01) and repeated restenosis (p < 0.001) were risk factors for a higher late loss but not type of DES or presence of diabetes mellitus.ConclusionsIn this observational registry treatment of DES and BMS restenosis with EES versus PES implantation resulted in similar clinical and angiographic outcome. 相似文献
245.
Caseley Emily A. Lara-Reyna Samuel Poulter James A. Topping Joanne Carter Clive Nadat Fatima Spickett Gavin P. Savic Sinisa McDermott Michael F. 《Journal of clinical immunology》2022,42(1):158-170
Journal of Clinical Immunology - The NLRP3 inflammasome is a vital mediator of innate immune responses. There are numerous NLRP3 mutations that cause NLRP3-associated autoinflammatory diseases... 相似文献
246.
Sijanovic S Vidosavljevic D Sijanovic I 《The journal of obstetrics and gynaecology research》2011,37(9):1241-1245
This case report describes a case of heterotopic cervical ectopic pregnancy in a nulliparous woman that was successfully treated with single-dose local, intra-amniotic methotrexate injection in the gestational sac. Pregnancy was achieved spontaneously. The patient had previously undergone hysteroscopic myomectomy. By using local, single-dose treatment we avoided the continued effects of the drug on the intrauterine pregnancy and the possible adverse effect of systemically applied methotrexate. The treatment resulted in the term vaginal delivery of a healthy child and preserved the patient's fertility for future pregnancies. 相似文献
247.
Simunović VJ Petković M Miscia S Petrovic M Stallaerts R Busselmaier W Hebgen M Horsch A Horsch S Krzan M Svab I Ribaric S Zeleznik D Santa Barbara J Arapovic D Bozic T Duzel G Ljubic F Ostojić M Skocibusić S Spasojević N Zalihić A Radić R Mehić B Nakas-Ićindić E Kordić D Sapunar D Tomić S Ljuca F Pranjić N Selesković H Tahirović H Tihić N Bosnjak ZJ Gamulin S Kuzman I Mandić Z Kamberović S Hiljadnikova M Tanović H 《Croatian medical journal》2008,49(1):18-21
248.
249.
Alfredo R. Galassi MD PhD FESC FSCAI Giuseppe Vadalà MD Laura Maniscalco PhD Gabriele Gasparini MD Dens Jo MD Nenad Z. Bozinovic MD Sevket Gorgulu MD Thomas Gehrig MD Luca Grancini MD Imre Ungi MD Eugenio La Scala MD Andrew Ladwiniec MD Sinisa Stojkovic MD PhD Alessio La Manna MD PhD Carlo Tumscitz MD Simon Elhadad MD Gerald S. Werner MD Georgios Sianos MD Roberto Garbo MD Mauro Carlino MD Kambis Mashayekhi MD Carlo di Mario MD PhD 《Catheterization and cardiovascular interventions》2023,102(5):864-877
Background
The recent development and widespread adoption of antegrade dissection re-entry (ADR) techniques have been underlined as one of the antegrade strategies in all worldwide CTO consensus documents. However, historical wire-based ADR experience has suffered from disappointing long-term outcomes.Aims
Compare technical success, procedural success, and long-term outcome of patients who underwent wire-based ADR technique versus antegrade wiring (AW).Methods
One thousand seven hundred and ten patients, from the prospective European Registry of Chronic Total Occlusions (ERCTO), underwent 1806 CTO procedures between January 2018 and December 2021, at 13 high-volume ADR centers. Among all 1806 lesions attempted by the antegrade approach, 72% were approached with AW techniques and 28% with wire-based ADR techniques.Results
Technical and procedural success rates were lower in wire-based ADR than in AW (90.3% vs. 96.4%, p < 0.001; 87.7% vs. 95.4%, p < 0.001, respectively); however, wire-based ADR was used successfully more often in complex lesions as compared to AW (p = 0.017). Wire-based ADR was used in most cases (85%) after failure of AW or retrograde procedures. At a mean clinical follow-up of 21 ± 15 months, major adverse cardiac and cerebrovascular events (MACCEs) did not differ between AW and wire-based ADR (12% vs. 15.1%, p = 0.106); both AW and wire-based ADR procedures were associated with significant symptom improvements.Conclusions
As compared to AW, wire-based ADR is a reliable and effective strategy successfully used in more complex lesions and often after the failure of other techniques. At long-term follow-up, patient's MACCEs and symptoms improvement were similar in both antegrade techniques. 相似文献250.
Sanjin Musa Elma Catovic Baralija Veronica Ivey Sawin Anthony Nardone Mirza Palo Sinisa Skocibusic Mia Blazevic Seila Cilovic Lagarija Gorana Ahmetovic-Karic Alma Ljuca Sanela Dostovic-Halilovic Rozalija Nedic Lorenzo Subissi Rawi Ibrahim Golubinka Boshevska Isabel Bergeri Richard Pebody Aisling Vaughan 《Influenza and other respiratory viruses》2023,17(8):e13182