雷替曲塞联合微波消融治疗结直肠癌肝转移18例

目的观察雷替曲塞联合微波消融(PMCT)治疗结直肠癌肝转移的疗效。方法对无法手术切除、使用FOLFOX和FOLFIRI方案化疗病情进展、不愿意接受靶向治疗的结直肠癌肝转移患者18例行雷替曲塞联合PMCT化疗。结果 18例患者共42个病灶,经治疗后,病灶完全坏死36个,部分坏死6个。对6个未完全坏死病灶,再次行PMCT术,术后均完全坏死。随访过程中,3例患者出现新发病灶,包括肝外转移1例,肝内转移2例;中位生存时间为26个月,1年生存率为83.3%,2年生存率为66.7%。结论 PMCT联合雷替曲塞治疗结直肠癌肝转移安全有效,值得进一步研究。     

Assessing parasitic infestation of vegetables in selected markets in Metro Manila,Philippines

ObjectiveTo assess the parasitic infestation of vegetables in selected markets in Metro Manila, Philippines.MethodsA total of 80 vegetables were purchased from public and private markets in Munoz, Quezon City, and Alabang, Muntinlupa City. Vegetables were washed, and the washings were collected and examined for parasitic organisms.ResultsIn all vegetables examined, 36 of 80 (45.0%) were infested with parasitic organisms. Vegetables obtained from Muntinlupa City showed that 17 of 40 (42.5%) have parasitic infestation as compared with those obtained from Quezon City with 19 of 40 (47.5%). Significant differences on the parasitic organisms existed between the public and private markets and between the two locations (P<0.05).ConclusionsFindings indicate that vegetables can be potential source of parasitic infection. There is a need to be vigilant in ensuring that foodstuffs sold in our market systems are safe and fit for consumption.     

Review of Random Phase Encoding in Volume Holographic Storage

Random phase encoding is a unique technique for volume hologram which can be applied to various applications such as holographic multiplexing storage, image encryption, and optical sensing. In this review article, we first review and discuss diffraction selectivity of random phase encoding in volume holograms, which is the most important parameter related to multiplexing capacity of volume holographic storage. We then review an image encryption system based on random phase encoding. The alignment of phase key for decryption of the encoded image stored in holographic memory is analyzed and discussed. In the latter part of the review, an all-optical sensing system implemented by random phase encoding and holographic interconnection is presented.     

以运动系统为例的器官系统整合课程教学改革实践

为弥补"以学科为中心"的教学不足,以器官系统为中心的教学成为医学教学改革的趋势。本研究以"运动系统"为例,从教学实施、教学质量监督、配套考核制度和教学成效四方面探讨器官系统为中心的整合医学教学模式的实践情况。     

Momilactone B,an Allelochemical of Rice Hulls,Induces Apoptosis on Human Lymphoma Cells (Jurkat) in a Micromolar Concentration

Although momilactone B has been studied as an allelochemical of rice (Oryza sativa L.), to date we have no report showing the effect of momilactone B on mammalian cells. This study was undertaken to examine whether this allelochemical has anticancer activity on cancer cells. We show here that momilactone B at micromolar doses has antitumor efficacy by inducing apoptosis in several blood cancer cells including human leukemic T cells. In addition, our study elucidated that anticancer activity of momilactone B on human leukemic T cells resulted from the induction of apoptosis via caspase and mitochondria. From these results, momilactone B can be considered as a novel therapeutic strategy for human leukemic T cells from its direct apoptosis-inducing activity.     

Pretreatment Controlling Nutritional Status Score and Lactate Dehydrogenase as Predictive Markers of Survival in Patients with Malignant Peritoneal Mesothelioma

Objective: To investigate the relationships between the Controlling Nutritional Status (CONUT) score and ascites fluid lactate dehydrogenase (LDH) level, and prognosis in patients with malignant peritoneal mesothelioma (MPeM).

Methods: A total of 125 patients with MPeM were selected for the study using a pathological screening method. Once the diagnosis is established, before the treatment their clinical characteristics and nutritional evaluations were recorded including CONUT score and ascites LDH level. The associations between CONUT, ascites LDH, and other clinicopathological features including body mass index, asbestos exposure, pathological type, and treatment method were analyzed. Prognostic parameters predicting overall survival (OS) were analyzed by Cox regression.

Results: High CONUT score, high ascites LDH level were positively associated with poor prognosis in patients with MPeM according to univariate analyses (P?<?0.001, P?<?0.001, respectively), and CONUT score and ascites LDH were independent predictors of a poor prognosis according to multivariate analysis. When the CONUT score is greater than 3 and the ascites LHD is greater than 474?IU/l, it indicates a poor prognosis.

Conclusions: CONUT score and ascites LDH are important factors influencing the prognosis of MPeM patients and should thus be considered in clinical applications.     

国有资产在科研机构中管理措施探讨

国有资产是科研机构不断获得生存与发展的物质基础保障,对国有资产的有效管理及运作是提升科研机构综合服务水平及基础工作质量的必要前提和重要保障,是维持单位正常运作的关键。国有资产的管理工作必须以服务于科研机构为最大前提。本文简要阐释当前我国科研机构在国有资产管理工作中存在的主要问题,以及关于加强科研机构国有资产市场化运作的相关分析和具体措施研究,以供参考。