Reproductive health risk and protective factors among youth in Lusaka, Zambia.

PURPOSE: To: (a) identify risk and protective factors for behaviors that expose Zambian youth to risk of HIV infection and, (b) assess whether research findings from the United States concerning protective factors in "high-risk" environments might apply to other settings. METHODS: A community-based sample of 2328 youth ages 10-24 years residing in Lusaka, Zambia was interviewed. Multivariate statistical methods were used to isolate risk and protective factors for selected sexual and contraceptive behaviors. Seven categories of factors were considered: sociodemographic factors, sexual-reproductive health knowledge and perceptions, nonsexual risk behaviors, peer influence, connections with parents and social institutions, and communication with sexual partners. RESULTS: A sizeable number of factors were associated with each outcome. Only two factors, school attendance and knowledge of AIDS, were associated with both lower levels of sexual activity and consistent use of condoms, and only engaging in higher-risk social activities with close friends was a risk factor for both. The effects of the other factors considered varied by outcome and gender. As in prior research, strong influences of peers were observed, but connections with parents and social institutions unexpectedly did not emerge as protective. CONCLUSION: Because of the number and diverse nature of factors influencing adolescent behaviors, it is unlikely that a single intervention will be found to immediately change sexual risk-taking behaviors in Zambia.     

Effects of intraocular rifampicin on retinal ganglion cell structure:a stereological and histopathological study

AIM: To determine the histopathological changes of rifampicin applied intravitreally on retinal ganglion cells by means of stereological and histopathological methods.METHODS: For this study twenty-four New Zealand adult rabbits were divided into four groups (n=6 for each group). 50μg/0.1mL (group 1), 100μg/0.1mL (group 2), 150μg/0.1mL (group 3) and 200μg/0.1mL (group 4), rifampicin were injected into the vitreous of the right eyes of animals, their left eyes were used as control (group 5). After the 28^th day of application, animals were anesthetised with xylazine (8mg/kg, IM) and then their eyes were enucleated immediately. Patterns were taken away and eyes were prepared for both stereological and electromicroscopic observation.RESULTS: Depending on the high dose of rifampicin, some histopathological changes such as cytoplasmic dilatation and damaged membrane were observed on the electromicroscopic level. Using quantitative examination, which was done at the light microscopic level, it was shown that the number of neurons decreased linearly as rifampicin dose increased when compared with the control group.CONCLUSION: Based on these findings, low-dose rifampicin (50μg/0.1mL) may be useful for treatment of the ocular diseases.     

Exclusive penile Kaposi''s sarcoma: report of an HIV-negative man successfully treated with radiotherapy

Kaposi's sarcoma (KS) is a rare neoplasm of endovascular cells with multifocal origin. The exact nature of the disease is not clear, but current data support the notion that KS is a vascular hyperplasia with a tight link to human herpesvirus 8 (HHV-8) infection. Classic KS occurs primarily on the lower extremities in elderly men living in the Mediterranean region. Penile involvement has rarely been reported in non-human immune deficiency virus (HIV) patients. Herein we present a 71-year-old HIV-negative man with isolated KS on the penis who was treated successfully with radiotherapy. A review of the literature is also presented.     

Attitudes of Iranian patients with skin problems towards using the Internet as a medical resource

BACKGROUND: Internet use has grown rapidly in Iran, but there is no information about how Iranian Internet users gather medical information through this medium. OBJECTIVE: To study the use of the Internet as a medical resource by Iranian patients with chronic dermatologic problems. METHODS: We carried out a structured interview of all patients 20-40 years of age attending a private dermatology clinic between July and September 2003 for chronic skin disease. RESULTS: Of the 205 patients enrolled in the study, 104 (50.8%) had computer access and 74 (36.1% of the total) had Internet access. Nine patients (4.4%) had performed a search on the Internet for their skin condition, but only one had used an academic website. CONCLUSION: Despite the significant growth in Internet use in Iran, it appears that the Internet is not a significant medical resource for patients in Iran.     

The prevalence and significance of fissured tongue and geographical tongue in psoriatic patients

BACKGROUND: Tongue lesions are not uncommon in psoriasis, but their significance is not clear. Aims. To determine the prevalence of tongue lesions in patients with psoriasis and to detect possible associations. METHODS: All consecutive patients with psoriasis seen in a dermatology clinic in northern Iran between January 2000 and January 2005 were enrolled in a prospective study. A questionnaire detailing the clinical and epidemiological features of the disease was completed for each patient, and all patients were examined for tongue lesions. RESULTS: In total, 306 patients with psoriasis were enrolled in the study (170 women, 136 men; female : male ratio 1.25 : 1; mean age 29.7 years; mean age at onset of psoriasis 23.3 years). Overall, 47 patients (15.4%) had tongue lesions; 25 (8.2%) had fissured tongue, 17 (5.6%) had geographical tongue (benign migratory glossitis) and 5 (1.6%) patients had both fissured and geographical tongue. Geographical tongue was seen in 7.2% of patients with early onset psoriasis and only in 1.3% of patients with late-onset psoriasis. Overall, patients with tongue lesions were found to have more nail and genital involvement. CONCLUSION: It appears that geographical tongue, but not fissured tongue, is more common in early onset psoriasis and may be an indicator of disease severity.     

Higher pH level, corresponding to that on the skin of patients with atopic eczema, stimulates the release of Malassezia sympodialis allergens

BACKGROUND: The opportunistic yeast Malassezia is a trigger factor in atopic eczema (AE). Around 30-80% of patients with AE have an IgE and/or T-cell reactivity to the yeast. Several IgE-binding components have been identified in Malassezia extracts and 11 allergens have been cloned and sequenced. The pH of the skin surface in patients with AE is higher than that of normal healthy skin. We here investigate whether different pH conditions mimicking those of AE skin and healthy skin can influence the production and release of Malassezia allergens. METHODS: Malassezia sympodialis (ATCC strain 42132) was cultured in Dixon broth at pH 6.1 to 5.0 for 1-15 days. Culture supernatants were analysed for the presence of IgE-binding components by immunoblotting. The M. sympodialis cells were analysed for allergen expression and production with immunocytochemistry and quantitative polymerase chain reaction. RESULTS: We found that M. sympodialis cells produce, express and release allergens to a greater extent when cultured at the higher pH. This was particularly true of a 67-kDa major allergen designated Mala s 12. CONCLUSIONS: The data suggest that the skin barrier in AE patients provides an environment that can enhance the release of allergens from M. sympodialis, which can contribute to the inflammation.