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排序方式: 共有1007条查询结果,搜索用时 31 毫秒
41.
Kazuhiro Suzumura Tadamichi Hirano Nobukazu Kuroda Yuji Iimuro Toshihiro Okada Masaki Hashimoto Seiki Hasegawa Jiro Fujimoto 《General thoracic and cardiovascular surgery》2013,61(11):651-654
Solitary mediastinal metastasis of hepatocellular carcinoma (HCC) is extremely rare. We report a case of solitary mediastinal metastasis arising from HCC treated by video-assisted thoracic surgery (VATS). A 75-year-old man underwent hepatic resection and transcatheter arterial embolization for HCC. The level of protein induced by vitamin K antagonist was subsequently found to be elevated. Computed tomography showed a 2-cm mediastinal tumor. 18F-fluorodeoxy-glucose positron emission tomography revealed slight uptake by the tumor. VATS was performed. The histopathological diagnosis was metastatic HCC of the lymph nodes. The postoperative course was uneventful, with a postoperative hospital stay of 6 days. There has been no recurrence at 4 months after surgery. VATS is a minimally invasive and useful treatment for solitary mediastinal metastasis of HCC. 相似文献
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43.
Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?
Toru?MizuguchiEmail author Toshihiko?Torigoe Fukino?Satomi Hiroaki?Shima Goro?Kutomi Shigenori?Ota Masayuki?Ishii Hiroshi?Hayashi Sumiyo?Asakura Yoshihiko?Hirohashi Makoto?Meguro Yasutoshi?Kimura Toshihiko?Nishidate Kenji?Okita Masaho?Ishino Atsushi?Miyamoto Masamitsu?Hatakenaka Noriyuki?Sato Koichi?Hirata 《Surgery today》2016,46(2):139-148
Pancreatic tumors are chemoresistant and malignant, and there are very few therapeutic options for pancreatic cancer, as the disease is normally diagnosed at an advanced stage. Although attempts have been made to develop vaccine therapies for pancreatic cancer for a couple of decades, none of the resultant protocols or regimens have succeeded in improving the clinical outcomes of patients. We herein review vaccines tested within the past few years, including peptide, biological and multiple vaccines, and describe the three sets of criteria used to evaluate the therapeutic activity of vaccines in solid tumors. 相似文献
44.
Masaki Shimomura Hideaki Morishita Takaaki Meguro Shiro Seto Mitsuaki Kimura Minoru Hamazaki Ayako Hashimoto Yuka Sugiyama Hiroshi Kimura 《Pediatrics international》2016,58(7):639-642
Herein, we report the case of a 13‐year‐old boy with multiple recurrent ulcers on his legs. He developed severe sinusitis at 10 years of age and had significant weight loss (6 kg) in the 2 months prior to admission. Histology of tissue biopsied from the ulcer indicated small vessel vasculitis and granulomatous inflammation. Given that these findings met the diagnostic criteria for granulomatosis with polyangiitis (GPA), he was treated with immunosuppressive agents. Further pathology, however, indicated Epstein–Barr virus (EBV)‐encoded RNA (EBER) in most lymphocytes in the same sample. The EBER‐positive lymphocytes were mainly CD4‐positive T cells. The EBV‐DNA load in the peripheral blood was also abnormally increased (1.0 × 104 copies/μg DNA). Thus, the diagnosis was established as chronic active EBV infection (CAEBV). This case illustrates the necessity of careful differential diagnosis of CAEBV owing to its clinical resemblance and pathological overlap with GPA. 相似文献
45.
Kelly ME Schültke E Fiedler S Nemoz C Guzman R Corde S Esteve F LeDuc G Juurlink BH Meguro K 《Physics in medicine and biology》2007,52(4):1001-1012
K-edge digital subtraction angiography (KEDSA), a recently developed synchrotron-based technique, utilizes monochromatic radiation and allows acquisition of high-quality angiography images after intravenous administration of contrast agent. We tested KEDSA for its suitability for intravenous cerebral angiography in an animal model. Adult male New Zealand rabbits were subjected to either angiography with conventional x-ray equipment or synchrotron-based intravenous KEDSA, using an iodine-based contrast agent. Angiography with conventional x-ray equipment after intra-arterial administration of contrast agent demonstrated the major intracranial vessels but no smaller branches. KEDSA was able to visualize the major intracranial vessels as well as smaller branches in both radiography mode (planar images) and tomography mode. Visualization was achieved with as little as 0.5 ml kg-1 of iodinated contrast material. We were able to obtain excellent visualization of the cerebral vasculature in an animal model using intravenous injection of contrast material, using synchrotron-based KEDSA. 相似文献
46.
Tohru Tamaki Mitsuko Tanaka Masamichi Katori Makoto Osanai Mitsuo Yasuhara Jun-ichi Meguro Kazutaka Kukita Motoki Yonekawa Akio Kawamura 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》1998,2(4):308-310
Abstract: The barrier of ABO-incompatible kidney transplantation is the presence of anti-A and anti-B antibodies in the recipient's circulating blood. Double filtration plasmapheresis (DFPP) is usually used to eliminate those antibodies. We tried cryofiltration apheresis (CRYO) in 2 recipients. Patient 1 was a 45-year-old male with B, Rh(±). The titers of IgM anti-A antibody were only reduced from ×64 to ×32 by the end of 3 sessions of standard CRYO. Renal allografting was not performed. Case 2 was a 29-year-old male with B, Rh(+). CRYO was introduced for 3 sessions. The initial IgM and IgG titers were ×128 and negative, respectively. The standard CRYO system was modified by temperature, treated volume, and filter pore size. The IgM anti-A antibody titer was markedly reduced to ×2 after the final session of CRYO. The donor was a 56-year-old father with A, Rh(+). Tacrolimus, azathio-prine, methylprednisolone, and antilymphocyte globulin were used as the introductory immunosuppression therapy. 相似文献
47.
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina 总被引:4,自引:0,他引:4 下载免费PDF全文
Ooto S Akagi T Kageyama R Akita J Mandai M Honda Y Takahashi M 《Proceedings of the National Academy of Sciences of the United States of America》2004,101(37):13654-13659
It has long been believed that the retina of mature mammals is incapable of regeneration. In this study, using the N-methyl-D-aspartate neurotoxicity model of adult rat retina, we observed that some Müller glial cells were stimulated to proliferate in response to a toxic injury and produce bipolar cells and rod photoreceptors. Although these newly produced neurons were limited in number, retinoic acid treatment promoted the number of regenerated bipolar cells. Moreover, misexpression of basic helix-loop-helix and homeobox genes promoted the induction of amacrine, horizontal, and rod photoreceptor specific phenotypes. These findings demonstrated that retinal neurons regenerated even in adult mammalian retina after toxic injury. Furthermore, we could partially control the fate of the regenerated neurons with extrinsic factors or intrinsic genes. The Müller glial cells constitute a potential source for the regeneration of adult mammalian retina and can be a target for drug delivery and gene therapy in retinal degenerative diseases. 相似文献
48.
Elisa De Franco Ccile Saint‐Martin Klaus Brusgaard Amy E. Knight Johnson Lydia Aguilar‐Bryan Pamela Bowman Jean‐Baptiste Arnoux Annette Rnholt Larsen May Sanyoura Siri Atma W. Greeley Raúl Calzada‐Len Bradley Harman Jayne A. L. Houghton Elisa Nishimura‐Meguro Thomas W. Laver Sian Ellard Daniela del Gaudio Henrik Thybo Christesen Christine Bellann‐Chantelot Sarah E. Flanagan 《Human mutation》2020,41(5):884-905
The most common genetic cause of neonatal diabetes and hyperinsulinism is pathogenic variants in ABCC8 and KCNJ11. These genes encode the subunits of the β‐cell ATP‐sensitive potassium channel, a key component of the glucose‐stimulated insulin secretion pathway. Mutations in the two genes cause dysregulated insulin secretion; inactivating mutations cause an oversecretion of insulin, leading to congenital hyperinsulinism, whereas activating mutations cause the opposing phenotype, diabetes. This review focuses on variants identified in ABCC8 and KCNJ11, the phenotypic spectrum and the treatment implications for individuals with pathogenic variants. 相似文献
49.
Takenori Okada Yasuhiko Hayashi Mamoru Toyofuku Michinori Imazu Masaya Otsuka Tadamichi Sakuma Hironori Ueda Hideya Yamamoto Nobuoki Kohno 《Circulation journal》2008,72(9):1430-1435
Background The efficacy of sirolimus-eluting stents (SESs) has not been established in dialysis patients. Methods and Results This study was a non-randomized observational single-center registry in a community hospital: data for 80 consecutive dialysis patients who underwent percutaneous coronary intervention (PCI) with SES were compared with those of a historical group of consecutive 124 dialysis patients treated with bare-metal stents (BMS). After 1 year, the cumulative incidence of major adverse cardiac events (MACE), comprising cardiac death, nonfatal myocardial infarction, stent thrombosis, or target lesion revascularization (TLR), was 25.2% in the SES group and 38.2% in the BMS group (p=0.048). In multivariate analysis, use of SES remained an independent predictor of MACE at 1 year after PCI (risk ratio 0.70, 95% confidence interval 0.52-0.93, p=0.015). Rates of TLR were 21.7% in the SES group and 30.9% in the BMS group and (p=0.15). Subgroup analysis showed that use of SES was effective in patients with small vessels, non-diabetic patients, and patients without highly calcified lesions. Conclusions In dialysis patients, the implantation of SES was moderately effective in reducing MACE at 1 year after PCI as compared with BMS. However, the TLR rate at 1 year was relatively higher than previously reported. (Circ J 2008; 72: 1430 - 1435). 相似文献
50.
This study investigated whether oral malodour with plaque-related periodontal disease was associated with the prevalence of periodontopathic bacteria in saliva and tongue debris. The subjects were 30 patients who visited the Breath Odour Clinic. An oral examination was performed at baseline and two months after periodontal treatment, and included measuring the volatile sulphur compounds (VSCs) in mouth air. The proportions of five periodontopathic bacteria versus all bacteria in saliva and tongue debris were determined using real-time polymerase chain reaction. The subjects were classified into four groups based on the existence of VSCs above the organoleptic threshold level (TVSC) and a periodontal pocket ?4 mm (PD4). At baseline, the group with TVSC/PD4 had higher proportions of periodontopathic bacteria in saliva compared to those with TVSC/no PD4 and no TVSC/no PD4, but there were no differences in the proportions in tongue debris among the four groups. At follow-up, the proportion of periodontopathic bacteria in the saliva of the group with TVSC/PD4 was significantly reduced, as compared to that at baseline, and the VSCs and periodontal health improved. The results suggested that the reduction in VSCs in mouth air of subjects with periodontal disease might be associated with the prevalence of periodontopathic bacteria in saliva. 相似文献