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981.
Yuji Kasamaki M.D. Yukio Ozawa M.D. Masakatsu Ohta M.D. Akira Sezai M.D. Takashi Yamaki B.A. Mutsuo Kaneko Ph.D. Ichiro Watanabe M.D. Atsushi Hirayama M.D. Tomohiro Nakayama M.D. 《Annals of noninvasive electrocardiology》2011,16(2):156-164
Background: The International Conference on Harmonization E14 Guideline specifies detailed assessment of QT interval or corrected QT interval prolongation when developing new drugs. We recently devised new software to precisely measure the QT interval. Methods and Results: The QT intervals of all leads for a selected single heart beat were compared between automated measurement with the new software from Fukuda Denshi and manual measurement. With both automated and manual measurement, QT intervals obtained by the tangent method were shorter than those obtained by the differential threshold method, but the extent of correction was smaller. QT interval data obtained by the differential threshold method were more similar to values obtained by visual measurement than were data obtained by the tangent method, but the extent of correction was larger. Variability was related to the T‐wave amplitude and to setting the baseline and tangent in the tangent method, while skeletal muscle potential noise affected the differential threshold method. Drift, low‐amplitude recordings, and T‐wave morphology were problems for both methods. Among the 12 leads, corrections were less frequent for leads II and V3–V6. Conclusion: We conclude that, for a thorough assessment of the QT/QTc interval, the tangent method or the differential threshold method appears to be suitable because of smaller interreader differences and better reproducibility. Correction of data should be done by readers who are experienced in measuring the QT interval. It is also important for electrocardiograms to have little noise and for a suitable heart rate and appropriate leads to be selected. Ann Noninvasive Electrocardiol 2011;16(2):156–164 相似文献
982.
A 56-year-old man was diagnosed with esophageal cancer by upper gastrointestinal endoscopy for examination of dysphagia. The
patient had undergone total gastrectomy and jejunal interposition 4 years previously for a gastric cancer at the pT1N0M0
stage according to the UICC-TNM classification. Enhanced CT findings revealed a 3-cm-diameter mass located near the superior
mesenteric artery. We conducted subtotal esophagectomy associated with partial jejunectomy including mesojejunectomy. The
mass was histologically diagnosed to be mesojejunal lymph node metastasis from esophageal cancer. Mesojejunal lymph node
metastasis from esophageal cancer developing after total gastrectomy has been reported in only three cases including ours.
The present lymph node metastases may have occurred via the newly developed lymphatic drainage route through the esophagojejunostomy,
and this metastatic lymph node can be considered the regional lymph node. Therefore, resection of the interposed jejunal
limb with mesojejunectomy may be rational in surgery on esophageal cancer developing after total gastrectomy. 相似文献
983.
Kuriyama C Mori K Nakagawa Y Hoshikawa S Ozaki H Ito S Inoue M Ohta M Yoshida K 《Endocrine journal》2011,58(1):59-63
Red blood cell (RBC) zinc (Zn) concentration reflects a patient's mean thyroid hormone level over the preceding several months. The aim of this study was to examine whether RBC Zn level can be used as an indicator to distinguish painless thyroiditis-associated transient hypothyroidism (TH) from permanent hypothyroidism (PH). RBC Zn level was measured in 30 untreated PH patients with Hashimoto's thyroiditis and 7 untreated TH patients with painless thyroiditis in whom preceding transient thyrotoxicosis had been confirmed. RBC Zn concentration was significantly lower in TH patients than that in PH patients. There was a positive correlation between RBC Zn and serum TSH, and the latter was clearly lower in TH patients than that in PH patients. However, RBC Zn level was again significantly lower in TH patients than PH patients despite of the comparable serum TSH levels in both groups when RBC Zn was evaluated in patients with serum TSH levels of less than 50 mU/L. Thus TH patients could be identified with RBC Zn measurement, allowing us avoidance of unnecessarily prolonged T4 administration to them. 相似文献
984.
Iwamoto S Deguchi T Ohta H Kiyokawa N Tsurusawa M Yamada T Takase K Fujimoto J Hanada R Hori H Horibe K Komada Y 《International journal of hematology》2011,94(2):185-192
Although the antigen expression patterns of childhood acute lymphoblastic leukemia (ALL) are well known, little attention has been given to standardizing the diagnostic and classification criteria. We retrospectively analyzed the flow cytometric data from a large study of antigen expression in 1,774 children with newly diagnosed ALL in JPLSG. T- and B-lineage ALL accounted for 13 and 87% of childhood ALL cases, respectively. Cytoplasmic CD3 and CD7 antigens were positive in all T-ALL cases. More than 80% of T-ALL cases expressed CD2, CD5 and TdT. In B-lineage ALL, the frequencies of early pre-B, pre-B, transitional pre-B and B-ALL were 81, 15.5, 0.6 and 2.9%, respectively. More than 90% of early pre-B ALL cases expressed CD19, CD79a, CD22, CD10 and TdT. CD34 was expressed in three-fourths of early pre-B ALL cases. The frequencies of TdT and CD34 expression were lower in pre-B ALL than in early pre-B ALL. B-ALL showed less frequent expression of CD22, CD10, CD34 and TdT than other B-lineage ALL cases. Expression of CD13 and CD33, aberrant myeloid antigens, was significantly more frequently associated with B-lineage ALL than with T-ALL. Based on this retrospective study of antigen expression in 1,774 de novo childhood ALL cases in JPLSG, we propose standardized clinical guidelines for the immunophenotypic criteria for diagnosis and classification of pediatric ALL. 相似文献
985.
Akutagawa T Ohta T Hasegawa T Nakamura T Christensen CA Becher J 《Proceedings of the National Academy of Sciences of the United States of America》2002,99(8):5028-5033
Molecular "nanowire" structures composed of the charge transfer complex of a bis-tetrathiafulvalene substituted macrocycle and tetrafluorotetracyanoquinodimethane were constructed on mica substrates by employing the Langmuir-Blodgett technique. The nanowires transferred from a dilute aqueous potassium chloride subphase had typical dimensions of 2.5 nm x 50 nm x 1 microm. The nanowires are oriented to specific directions, corresponding to the directions of the potassium-ion array on the mica surface having sixfold symmetry. Such correlation between the nanowires and the substrate surface was also observed when a dilute aqueous rubidium chloride subphase was used. On the other hand, the correlation completely disappeared when the subphase contained divalent cations, indicating that the molecular nanowires orient by recognizing the monocation array on the mica surface. The nanowires formed by the vertical dipping method coexist with the monolayers. Only nanowire structures are, however, observed when we apply the horizontal lifting method. Based on the crystal structure of a related complex, a possible structure of the nanowires is presented. The conductivity of the nanowires was estimated to be of the order of 10(-3) S x cm(-1). The nanowires formed specific (regular) structures such as T-shape junctions, suggesting their use in construction of future molecular nanoscale devices. 相似文献
986.
Ogawa Y Masuzaki H Ebihara K Shintani M Aizawa-Abe M Miyanaga F Nakao K 《Journal of diabetes and its complications》2002,16(1):119-122
Leptin is a major adipocyte-derived hormone that is involved in the regulation of food intake and energy expenditure. Plasma leptin concentrations are elevated in obese subjects, suggesting its pathophysiological role in obesity-related lifestyle-related diseases. We have recently succeeded in the generation of transgenic skinny mice overexpressing leptin. They exhibit increased glucose metabolism and insulin sensitivity accompanied by a significant increase in insulin signaling for glucose utilization in the skeletal muscle and liver. They also show blood pressure elevation through the sympathetic activation. Introduction of the lethal yellow agouti (A(y)) allele into transgenic skinny mice results in late-onset obesity and diabetes with blood pressure elevation similar to those found in nontransgenic agouti mice (A(y)/+ mice). After caloric restriction, blood pressure elevation is reversed but insulin resistance still remains in A(y)/+ mice in parallel with a reduction of plasma leptin concentrations. By contrast, blood pressure elevation is sustained but insulin resistance is reversed in transgenic mice overexpressing leptin with the A(y) allele (Tg/+:A(y)/+ mice), which remain hyperleptinemic. Collectively, our data suggest the pathophysiologic and therapeutic implication of leptin in obesity-related insulin resistance and hypertension. 相似文献
987.
988.
989.
Ryuji SAKAKIBARA Kuniko TSUNOYAMA Hiroyasu HOSOI Osamu TAKAHASHI Megumi SUGIYAMA Masahiko KISHI Emina OGAWA Hitoshi TERADA Tomoyuki UCHIYAMA Tomonori YAMANISHI 《Lower urinary tract symptoms.》2010,2(1):16-21
Objectives: To compare three positions for defecation by measuring abdominal pressure and the anorectal angle simultaneously. Methods: We recruited six healthy volunteers. The videomanometric measures included simultaneous fluoroscopic images, abdominal pressures, subtracted rectal pressures and anal sphincter pressures. Three positions were used: sitting, sitting with the hip flexing at 60 ° with respect to the rest of the body, and squatting with the hip flexing at 22.5 ° with respect to the rest of the body. Results: Basal abdominal pressure before defecation on hip‐flex sitting was lower than that with normal sitting, although the difference did not reach statistical significance. Basal abdominal pressure before defecation on squatting (26 cmH2O) was lower than that with normal sitting (P < 0.01). Abdominal pressure increase (strain) on hip‐flex sitting was lower than that with normal sitting, although this difference did not reach statistical significance. Similarly, the abdominal pressure increase on squatting was smaller than that with normal sitting, and yet the difference did not reach statistical significance. The rectoanal angle on defecation on hip‐flex sitting did not differ from that with normal sitting. The rectoanal angle on defecation on squatting (126 °) was larger than that with normal sitting (100 °) (P < 0.05), and was also larger than that with hip‐flex sitting (99 °) (P < 0.01). Conclusion: The results of the present study suggest that the greater the hip flexion achieved by squatting, the straighter the rectoanal canal will be, and accordingly, less strain will be required for defecation. 相似文献
990.
Hyohun Park Toshihide Shima Kanji Yamaguchi Hironori Mitsuyoshi Masahito Minami Kohichiroh Yasui Yoshito Itoh Toshikazu Yoshikawa Michiaki Fukui Goji Hasegawa Naoto Nakamura Mitsuhiro Ohta Hiroshi Obayashi Takeshi Okanoue 《Journal of gastroenterology》2011,46(1):101-107