全文获取类型
收费全文 | 5268篇 |
免费 | 237篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 87篇 |
儿科学 | 329篇 |
妇产科学 | 66篇 |
基础医学 | 713篇 |
口腔科学 | 81篇 |
临床医学 | 324篇 |
内科学 | 923篇 |
皮肤病学 | 100篇 |
神经病学 | 318篇 |
特种医学 | 92篇 |
外科学 | 714篇 |
综合类 | 178篇 |
一般理论 | 4篇 |
预防医学 | 401篇 |
眼科学 | 150篇 |
药学 | 620篇 |
中国医学 | 32篇 |
肿瘤学 | 380篇 |
出版年
2023年 | 42篇 |
2022年 | 141篇 |
2021年 | 211篇 |
2020年 | 117篇 |
2019年 | 142篇 |
2018年 | 157篇 |
2017年 | 103篇 |
2016年 | 141篇 |
2015年 | 181篇 |
2014年 | 219篇 |
2013年 | 240篇 |
2012年 | 400篇 |
2011年 | 391篇 |
2010年 | 211篇 |
2009年 | 164篇 |
2008年 | 299篇 |
2007年 | 266篇 |
2006年 | 283篇 |
2005年 | 215篇 |
2004年 | 212篇 |
2003年 | 178篇 |
2002年 | 133篇 |
2001年 | 111篇 |
2000年 | 109篇 |
1999年 | 98篇 |
1998年 | 46篇 |
1997年 | 31篇 |
1996年 | 21篇 |
1995年 | 20篇 |
1994年 | 18篇 |
1993年 | 30篇 |
1992年 | 59篇 |
1991年 | 37篇 |
1990年 | 34篇 |
1989年 | 60篇 |
1988年 | 45篇 |
1987年 | 22篇 |
1986年 | 30篇 |
1985年 | 29篇 |
1984年 | 24篇 |
1983年 | 38篇 |
1981年 | 13篇 |
1980年 | 18篇 |
1979年 | 23篇 |
1978年 | 13篇 |
1975年 | 11篇 |
1973年 | 18篇 |
1972年 | 13篇 |
1971年 | 12篇 |
1970年 | 13篇 |
排序方式: 共有5512条查询结果,搜索用时 0 毫秒
81.
82.
Schofield MJ Minichiello V Mishra GD Plummer D Savage J 《International journal of STD & AIDS》2000,11(5):313-323
Our objective was to examine associations between self-reported sexually transmitted infections (STIs) and sociodemographic, lifestyle, health status, health service use and quality of life factors among young Australian women; and their use of family planning and sexual health clinics and associations with health, demographic and psychosocial factors. The study sample comprised 14,762 women aged 18-23 years who participated in the mailed baseline survey for the Australian Longitudinal Study on Women's Health, conducted in 1996. The main outcome measures are self report of ever being diagnosed by a doctor with an STI, including chlamydia, genital herpes, genital warts or other STIs, and use of family planning and sexual health clinics. The self-reported incidence of STI was 1.7% for chlamydia, 1.1% genital herpes, 3.1% genital warts, and 2.1% other STIs. There was a large number of demographic, health behaviour, psychosocial and health service use factors significantly and independently associated with reports of having had each STI. Factors independently associated with use of family planning clinic included unemployment, current smoking, having had a Pap smear less than 2 years ago, not having ancillary health insurance, having consulted a hospital doctor and having higher stress and life events score. Factors independently associated with use of a sexual health clinic included younger age, lower occupation status, being a current or ex-smoker, being a binge drinker, having had a Pap smear, having consulted a hospital doctor, having poorer mental health and having higher life events score. This study reports interesting correlates of having an STI among young Australian women aged 18-23. The longitudinal nature of this study provides the opportunity to explore the long-term health and gynaecological outcomes of having STIs during young adulthood. 相似文献
83.
84.
K K Pant V K Verma N Mishra N Singh J N Sinha K P Bhargava 《Japanese heart journal》1983,24(1):127-133
In the present study, the effects of morphine and pethidine on coronary vessel resistance (CPP), blood pressure (BP), and experimental myocardial infarction-induced cardiac arrhythmia were investigated. Both morphine and pethidine induced a fall in CPP and BP and inhibited the cardiac arrhythmia. The morphine effects on CPP and BP were largely blocked by mepyramine. The effects of pethidine, on the other hand, were not blocked by mepyramine, propranolol, or atropine. An interesting dose dependent inhibition of cardiac arrhythmia was observed with pethidine. 相似文献
85.
B.K. Mishra P. Shukla M. Aslam A.A. Siddiqui S.V. Madhu 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):839-842
Background
It is being increasingly reported that some of the youth onset diabetes patients cannot be classified clearly as type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) based on usual criteria and the term double diabetes (DD) coined for these cases.Aim
The objective of the study was to find out the prevalence of DD in youth onset diabetes patients from east Delhi and neighboring NCR region.Methods
A total of 200 patients with youth onset diabetes below 25 years of age were recruited from a tertiary care hospital in East Delhi. Clinical history, family history of diabetes and anthropometry of patients were recorded. Fasting serum C-peptide, Anti-IA2-antibody and Anti-GAD-antibody were measured in all patients. Patients positive for Anti-GAD-antibody (>1.05 U/ml) and C-peptide level >0.3 nmol/l were characterized as DD patients. Patients negative for Anti-GAD-antibody and C-peptide >0.3 nmol/l were kept under the category of T2DM. Patients with low C-peptide level along with one of the following, positive Anti-GAD-antibody, positive Anti-IA2-antibody and diabetic ketoacidosis (DKA) were considered as T1DM. Remaining patients were kept under the unknown category.Results
Mean age of study subjects was 18.2 ± 7.1 years. Seven percent (7%) of the subjects were classified as DD, 51% as T1DM, 13% as T2DM and 29% were kept under the unknown category. Mean age of subjects with 22.2 ± 9.7, 16.9 ± 6.7, 20.6 ± 7.7 and 19.4 ± 7.4 years in DD, T1DM, T2DM and unknown category respectively. Mean BMI of subjects with DD, T1DM, T2DM and unknown category was 19.8 ± 5.7, 16.6 ± 3.7, 19.3 ± 4.1 and 18.0 ± 4.6 kg/m2 respectively.Conclusion
Double diabetes is an important occurrence among youth onset diabetes subjects. Only half of the subjects with youth onset of diabetes had T1DM. 相似文献86.
87.
V. S. Yadav K. P. Mishra D. P. Singh S. Mehrotra Dr. V. K. Singh 《Immunopharmacology and immunotoxicology》2013,35(3):485-497
Curcumin (diferuloylmethane), found in the spice turmeric, exhibits anti-inflammatory, antioxidant, and chemopreventive activities. However, the effect of curcumin on the immunological responses largely remains unknown. In this study we have investigated the effect of curcumin on mitogen (phytohaemagglutinin; PHA) stimulated T-cell proliferation, natural killer (NK) cell cytotoxicity, production of cytokines by human peripheral blood mononuclear cells (PBMCs), nitric oxide (NO) production in mouse macrophage cells, RAW-264.7. Furthermore, we have carried out an electromobility shift assay to elucidate the mechanism of action of curcumin at DNA protein interaction level. We observed that curcumin inhibits PHA-induced T-cell proliferation, interleukin-2 production, NO generation, and lipopolysachharide-induced nuclear factor-κB (NF-κB) and augments NK cell cytotoxicity. Our results suggest that curcumin most likely inhibits cell proliferation and cytokine production by inhibiting NF-κB target genes involved in the induction of these immune parameters. 相似文献
88.
Amit Mishra Megha Maheshwari Deepak Chhangani Noriko Fujimori-Tonou Fumito Endo Ajay Prakash Joshi Nihar Ranjan Jana Koji Yamanaka 《Neurobiology of aging》2013
Protein aggregation and ordered fibrillar amyloid deposition inside and outside of the central nervous system cells is the common pathologic hallmark of most aging-related neurodegenerative disorders. Dominant mutations in the gene encoding superoxide dismutase 1 (SOD1) protein are linked to familial amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by progressive degeneration of motor neurons, leading to muscle paralysis and death. The major histochemical hallmark in the remaining motor neurons of ALS is the intracellular accumulation of ubiquitinated inclusions consisting of insoluble aberrant protein aggregates. However, the molecular pathomechanisms underlying the process have been elusive. Here for the first time, we report that E6-AP, a homologous to E6-AP C terminus-type E3 ubiquitin ligase depleted in ALS mouse models before neurodegeneration. E6-AP coimmunoprecipitates with the SOD1 protein and is predominantly mislocalized in mutant SOD1-containing inclusion bodies. Overexpression of E6-AP increases the ubiquitination and facilitates degradation of SOD1 proteins. Finally, we show that the overexpression of E6-AP suppresses the aggregation and cell death mediated by mutated SOD1 proteins and cellular protective effect is more prominent when E6-AP is overexpressed along with Hsp70. These data suggest that enhancing the activity of E6-AP ubiquitin ligase might be a viable therapeutic strategy to eliminate mutant SOD1-mediated toxicity in ALS. 相似文献
89.
90.
Susovan Banerjee Shikha Goyal Saumyaranjan Mishra Deepak Gupta Shyam Singh Bisht Venketesan K Kushal Narang Tejinder Kataria 《The British journal of radiology》2021,94(1122)
Artificial intelligence (AI) applications, in the form of machine learning and deep learning, are being incorporated into practice in various aspects of medicine, including radiation oncology. Ample evidence from recent publications explores its utility and future use in external beam radiotherapy. However, the discussion on its role in brachytherapy is sparse. This article summarizes available current literature and discusses potential uses of AI in brachytherapy, including future directions. AI has been applied for brachytherapy procedures during almost all steps, starting from decision-making till treatment completion. AI use has led to improvement in efficiency and accuracy by reducing the human errors and saving time in certain aspects. Apart from direct use in brachytherapy, AI also contributes to contemporary advancements in radiology and associated sciences that can affect brachytherapy decisions and treatment. There is a renewal of interest in brachytherapy as a technique in recent years, contributed largely by the understanding that contemporary advances such as intensity modulated radiotherapy and stereotactic external beam radiotherapy cannot match the geometric gains and conformality of brachytherapy, and the integrated efforts of international brachytherapy societies to promote brachytherapy training and awareness. Use of AI technologies may consolidate it further by reducing human effort and time. Prospective validation over larger studies and incorporation of AI technologies for a larger patient population would help improve the efficiency and acceptance of brachytherapy. The enthusiasm favoring AI needs to be balanced against the short duration and quantum of experience with AI in limited patient subsets, need for constant learning and re-learning to train the AI algorithms, and the inevitability of humans having to take responsibility for the correctness and safety of treatments. 相似文献