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991.
JR Seaward PA Wilson CA Stone 《Annals of the Royal College of Surgeons of England》2010,92(8):639-642
INTRODUCTION
Soft-tissue sarcoma resections are often highly complex procedures that demand meticulous pre-operative planning in order to maximise the potential for complete excision with clear margins, while preserving vital neurovascular structures and muscle groups.SUBJECTS AND METHODS
We present a computer-aided model for surgical planning using Microsoft Powerpoint as a tool for cross referencing magnetic resonance images and normal anatomical diagrams.RESULTS
Using this system the operator follows a sequence of pre-planned steps, minimising intra-operative decision making and unexpected adverse events. Four case studies are discussed.CONCLUSIONS
The visual plan optimises the potential to meet surgical and oncological goals, and serves as an excellent nct to the operation note for documentation of the procedure. 相似文献992.
993.
Perlis RH Huang J Purcell S Fava M Rush AJ Sullivan PF Hamilton SP McMahon FJ Schulze TG Schulze T Potash JB Zandi PP Willour VL Penninx BW Boomsma DI Vogelzangs N Middeldorp CM Rietschel M Nöthen M Cichon S Gurling H Bass N McQuillin A Hamshere M;Wellcome Trust Case Control Consortium Bipolar Disorder Group Craddock N Sklar P Smoller JW 《The American journal of psychiatry》2010,167(12):1499-1507
994.
M Heuer G Taeger GM Kaiser D Nast-Kolb CA Kühne S Ruchholtz R Lefering A Paul S Lendemans the Trauma Registry of The DGU 《European journal of medical research》2010,15(6):258-265
Objective
Non-operative management of blunt splenic injury in adults has been applied increasingly at the end of the last century. Therefore, the lifelong risk of overwhelming post-splenectomy infection has been the major impetus for preservation of the spleen. However, the prevalence of posttraumatic infection after splenectomy in contrast to a conservative management is still unknown. Objective was to determine if splenectomy is an independent risk factor for the development of posttraumatic sepsis and multi-organ failure.Methods
13,433 patients from 113 hospitals were prospective collected from 1993 to 2005. Patients with an injury severity score > 16, no isolated head injury, primary admission to a trauma center and splenic injury were included. Data were allocated according to the operative management into 2 groups (splenectomy (I) and conservative managed patients (II)).Results
From 1,630 patients with splenic injury 758 patients undergoing splenectomy compared with 872 non-splenectomized patients. 96 (18.3%) of the patients with splenectomy and 102 (18.5%) without splenectomy had apparent infection after operation. Additionally, there was no difference in mortality (24.8% versus 22.2%) in both groups. After massive transfusion of red blood cells (> 10) non-splenectomy patients showed a significant increase of multi-organ failure (46% vs. 40%) and sepsis (38% vs. 25%).Conclusions
Non-operative management leads to lower systemic infection rates and mortality in adult patients with moderate blunt splenic injury (grade 1-3) and should therefore be advocated. Patients with grade 4 and 5 injury, patients with massive transfusion of red blood cells and unstable patients should be managed operatively. 相似文献995.
Tiago M. Castilho Karen Goldsmith‐Pestana Caterin Lozano Liliana Valderrama Nancy G. Saravia Diane McMahon‐Pratt 《European journal of immunology》2010,40(10):2816-2829
Leishmania (Viannia) organisms are the most prevalent etiologic agents of human cutaneous leishmaniasis in the Americas. Nevertheless, our knowledge of the immunological mechanisms exploited by L. (Viannia) organisms remains limited and the mechanisms underlying disease are not well understood. Here, we report the development of a BALB/c mouse model of L. (V.) panamensis infection that is able to reproduce chronic disease, with persistent infection and clinically evident lesions for over 1 year. The immune response of the mouse resembles that found for L. (V.) panamensis‐infected patients with chronic and recurrent lesions, presenting a mixed Th1/Th2 response with the presence of TNF‐α, IFN‐γ, IL‐10 and IL‐13. Using immunodeficient mice, the critical role for IL‐13 and/or IL‐4Rα in determining susceptibility to chronic infection was evident. With the induction of healing in the immunodeficient mice, increases in IFN‐γ and IL‐17 were found, concomitant with parasite control and elimination. Specifically, increases in CD4+ (but not CD8+) T cells producing IFN‐γ were observed. These results suggest that IL‐13 represents an important target for disease control of L. (V.) panamensis infection. This murine model should be useful to further understand the pathology associated with chronic disease and to develop methods for the treatment and prevention of leishmaniasis caused by L. (Viannia) parasites. 相似文献
996.
997.
目的通过研究周期蛋白D1(CyclinD1)在先天性胆脂瘤和后天性胆脂瘤的表达,探讨其表达差异的意义。方法选取我院就诊的60例中耳胆脂瘤患者,其中先天性胆脂瘤25例,后天性胆脂瘤35例;同时选取同期3例慢性中耳炎手术患者正常耳廓后皮肤组织作为对照组。采用免疫组化方法检测胆脂瘤组织中CyclinD1的表达。结果 CyclinD1免疫组化染色在先天性胆脂瘤和后天性胆脂瘤中均为阳性表达,但后天性胆脂瘤中阳性表达率高于先天性胆脂瘤,其差异具有统计学意义(P<0.01);CyclinD1在正常皮肤中不表达。结论 CyclinD1在后天性胆脂瘤上皮表达增强,可能是炎症刺激所致。 相似文献
998.
The chlorinated englerins (3-9) were isolated from Phyllanthus engleri and shown to selectively inhibit the growth of renal cancer cells. The compounds were shown to be extraction artifacts produced by exposure to chloroform decomposition products during their isolation. The most active compound, 3, was synthesized from englerin A (1). 相似文献
999.
1000.