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991.
Guidelines for blood utilization review 总被引:11,自引:0,他引:11
L Stehling ; NL Luban ; KC Anderson ; MH Sayers ; A Long ; S Attar ; SF Leitman ; SA Gould ; MS Kruskall ; LT Goodnough ; et al. 《Transfusion》1994,34(5):438-448
Hospitals are required by accrediting agencies to perform blood utilization review. Specific areas that must be addressed are the ordering, distribution, handling, dispensing, and administration of blood components. Monitoring the effects of transfusion on patients is also required. The format of the review process and the criteria for appropriate blood utilization must be developed by each institution. This article provides examples of areas that can be reviewed and procedures that may be used. However, the suggested laboratory values must not be interpreted as defining indications or criteria for transfusion. Each transfusion committee, or its equivalent, is responsible for developing its own institutional blood utilization procedures and audit criteria. Review and approval by the medical staff prior to implementation are essential. The procedures must also be reviewed and revised on a regular basis. 相似文献
992.
993.
Griffin JD; Sabbath KD; Herrmann F; Larcom P; Nichols K; Kornacki M; Levine H; Cannistra SA 《Blood》1985,66(4):788-795
Expression of HLA-DR surface antigens by granulocyte/monocyte colony- forming cells (CFU-GM) may be important in the regulation of proliferation of these cells. Using immunological techniques to enrich for progenitor cells, we investigated the expression of HLA-DR in subsets of CFU-GM. "Early" (day 14) CFU-GM express higher levels of HLA- DR than do "late" (day 7) CFU-GM. Among late CFU-GM, cells destined to form monocyte (alpha-naphthyl acetate esterase-positive) colonies express higher levels of HLA-DR than do CFU-GM destined to form granulocyte (chloroacetate esterase-positive) colonies. Because high- level expression of DR antigen was a marker for monocyte differentiation, we examined several lymphokines for their effects on both DR expression and in vitro commitment to monocyte differentiation by myeloid precursor cells. DR antigen density could be increased by more than twofold over 48 hours upon exposure to gamma-interferon (gamma-IFN), whereas colony-stimulating factors had no effect. This was associated with a dose-dependent inhibition of total CFU-GM number, and a relative, but not absolute, increase in the ratio of monocyte colonies to granulocyte colonies. Similarly, in day 7 suspension cultures of purified myeloid precursor cells, gamma-IFN inhibited cell proliferation and increased the ratio of monocytes to granulocytes. Thus, despite the induction of high levels of HLA-DR antigen on precursor cells (a marker of monocyte commitment), the dominant in vitro effect of gamma-IFN was inhibition of granulocyte differentiation. 相似文献
994.
大鼠原位肝移植模型建立方法的若干问题探讨 总被引:2,自引:0,他引:2
目的探讨建立大鼠原位肝移植模型的方法与技术。方法用改进的二袖套法行100例Lewis→BN大鼠原位肝移植,术中门静脉、肝下下腔静脉用袖套法吻合,肝上下腔静脉用缝合法吻合,胆管内支架法完成胆道重建。结果供体手术时间(30.9±5.0)min,供肝修整时间(10.0±3.0)min,受体手术时间(50.0±5.5)min,无肝期为(23.0±2.5)min。手术成功率为92%(术后存活2 d以上),1周存活率为87%,1个月存活率为84%。结论通过提高手术技巧,熟悉各种并发症的原因和预防处理措施,可以减少并发症的发生,提高手术成功率,延长大鼠术后存活时间。 相似文献
995.
996.
OBJECTIVES: To determine the usefulness of electrocardiography (ECG) and chest radiography (CXR) in evaluation of patients referred to the pediatric cardiologist for the evaluation of heart murmur or chest pain. DESIGN: In this prospective study, 106 consecutive outpatients were categorized with no heart disease, possible heart disease, or definite heart disease based on history and physical examination; they then underwent ECG and CXR. Studies were reviewed and the examining cardiologist could change the diagnosis and order an echocardiogram. SETTING: Academic pediatric cardiology practice. RESULTS: In patients thought to have no heart disease, the diagnosis was changed to definite heart disease in four solely on the basis of abnormal CXR or ECG. In 25 patients thought to have possible heart disease, the diagnosis was changed to no heart disease (7) or definite heart disease (5) after review of the CXR and ECG. All 25 patients diagnosed with definite heart disease had this confirmed by abnormal CXR (2), ECG (3), both abnormal CXR and ECG, or echocardiogram (18). CONCLUSIONS: ECG and CXR helped diagnose heart disease in four patients thought to have no heart disease, helped to rule out lesions in seven patients with possible heart disease, helped diagnose heart disease in five patients thought to have possible heart disease, and helped confirm heart disease in nine patients. In these days of cost containment, routine ECG and CXR continue to be valuable tools for the pediatric cardiologist in evaluation of patients with heart murmurs or chest pain. 相似文献
997.
Modulation of leucine transaminase activity by dietary means 总被引:4,自引:0,他引:4
998.
999.
Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases 总被引:4,自引:2,他引:4
Phaneuf D; Wakamatsu N; Huang JQ; Borowski A; Peterson AC; Fortunato SR; Ritter G; Igdoura SA; Morales CR; Benoit G; Akerman BR; Leclerc D; Hanai N; Marth JD; Trasler JM; Gravel RA 《Human molecular genetics》1996,5(1):1-14
We have generated mouse models of human Tay-Sachs and Sandhoff diseases by
targeted disruption of the Hexa (alpha subunit) or Hexb (beta subunit)
genes, respectively, encoding lysosomal beta-hexosaminidase A (structure,
alpha) and B (structure, beta beta). Both mutant mice accumulate GM2
ganglioside in brain, much more so in Hexb -/- mice, and the latter also
accumulate glycolipid GA2. Hexa -/- mice suffer no obvious behavioral or
neurological deficit, while Hexb -/- mice develop a fatal neurodegenerative
disease, with spasticity, muscle weakness, rigidity, tremor and ataxia. The
Hexb -/- but not the Hexa -/- mice have massive depletion of spinal cord
axons as an apparent consequence of neuronal storage of GM2. We propose
that Hexa -/- mice escape disease through partial catabolism of accumulated
GM2 via GA2 (asialo- GM2) through the combined action of sialidase and
beta-hexosaminidase B.
相似文献
1000.