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81.
B. L. McGee D. A. Wright D. J. Fisher 《Archives of environmental contamination and toxicology》1998,34(1):34-40
A 96-h exposure to aqueous cadmium (Cd) is the recommended reference toxicity test for 10-day sediment bioassays with the
estuarine amphipod, Leptocheirus plumulosus (US EPA 1994). This water-only test was used to assess the influence of organism size, sex, and nutritional status on the
sensitivity of laboratory-cultured L. plumulosus to Cd. In addition, the response of field-collected amphipods was compared to similarly sized laboratory animals to assess
potential seasonal changes in Cd sensitivity. Lipid content of test organisms was measured in these seasonal experiments and
those evaluating effects of nutritional status because of its potential as an indicator of physiological condition. LC50 values of laboratory animals size-sorted on nested 500-, 710-, and 1000-μm mesh sieves, increased with size class: 0.36,
0.65, and 0.88 mg Cd/L, respectively. Gravid females were less sensitive than males or mature females to aqueous Cd. Studies
on the influence of the molt cycle on Cd toxicity indicated enhanced sensitivity of immediate postmolt animals that may explain
some of the observed differences in Cd tolerance. Nutritional effects were investigated by comparing the sensitivity of fed
and starved laboratory-reared amphipods. Starved juveniles and adults were significantly smaller than their fed counterparts
and exhibited a 28–43% reduction in lipid content, respectively. However, comparison of LC50 values indicated no significant differences in sensitivity to Cd between starved and fed juveniles (0.23 vs 0.30 mg Cd/L)
or adults (0.37 vs 0.52 mg Cd/L). Field-collected amphipods were typically more sensitive to Cd than laboratory animals, regardless
of the season, although their lipid content varied, ranging from 6.6% in August to 13.7% in November. Results are discussed
with respect to the use and interpretation of toxicity tests with this species.
Received: 18 February 1997/Accepted: 5 May 1997 相似文献
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Autoradiography of mouse liver after the administration of 35S-sodium sulphate shows transient concentration of the isotope in sinusoidal walls. This phenomenon is markedly exaggerated in the acute stages of carbon tetrachloride (CCl4) poisoning with radioactivity appearing over viable sinusoidal cells and extracellular necrotic spaces. This is maintained for several days and there is condensation of the isotope over prominent reticulin fibres in the centrilobular zones during the stage of recovery. Negative results are obtained if the sinusoidal cells are included in the necrotic process as induced by CCl4 or by the local application of cold to the surface of the liver. It is concluded that liver sinusoidal cells have a capacity for mucopolysaccharide synthesis which is exaggerated following the induction of hepatocyte injury. There is also evidence for continuing synthesis of sulphated mucopolysaccharide in the cirrhotic liver in relation to fibrous trabeculae and hepatocyte degeneration. 相似文献
86.
Media Exchange Method for Demonstrating Killing of L-Phase Variants in Solid Media by Normal Human Serum 下载免费PDF全文
Normal human serum has been shown to kill L-phase variants in a fluid system by the action of antibody plus complement. Previous studies, however, failed to demonstrate such killing in solid media. This failure probably resulted from inhibition of complement by medium components such as agar and NaCl. A method was developed which circumvents the problems of the anticomplementary properties of agar media and the requirement of some L-phase variants for concentrations of salt that inhibit complement. Using this method, we have demonstrated in solid media the killing by normal human serum of the L-phase variants of Staphylococcus aureus, Proteus mirabilis, Streptococcus pyogenes, S. faecalis, Pseudomonas aeruginosa, and Salmonella typhi. This method provides a relatively simple and graphic means for studying host humoral factors lethal for L-phase variants. 相似文献
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I S Benjamin T Than S Ryan M C Rodger J O McGee L H Blumgart 《British journal of experimental pathology》1978,59(4):333-336
Prolyl hydroxylase activity and collagen biosynthesis have been measured at intervals following 2 extents of hepatic resection in rats. Prolyl hydroxylase activity is validated as a measure of collagen biosynthesis. The levels rise to a peak at 72 h and thereafter decline. The implications for the process of liver regeneration are discussed. 相似文献
89.
Wall-defective microbial variants: terminology and experimental design 总被引:18,自引:0,他引:18
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