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Omar Abdel-Wahab Jie Gao Mazhar Adli Anwesha Dey Thomas Trimarchi Young Rock Chung Cem Kuscu Todd Hricik Delphine Ndiaye-Lobry Lindsay M. LaFave Richard Koche Alan H. Shih Olga A. Guryanova Eunhee Kim Sheng Li Suveg Pandey Joseph Y. Shin Leon Telis Jinfeng Liu Parva K. Bhatt Sebastien Monette Xinyang Zhao Christopher E. Mason Christopher Y. Park Bradley E. Bernstein Iannis Aifantis Ross L. Levine 《The Journal of experimental medicine》2013,210(12):2641-2659
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Patwardhan V Paul S Corey KE Mazhar SM Richter JM Thiim M Chung RT 《Digestive diseases and sciences》2011,56(11):3316-3322
Background
Regular screening of cirrhotic patients for hepatocellular carcinoma (HCC) has been suboptimal, but there is little data regarding specific risk factors for reduced screening. 相似文献97.
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Jonathan Shamash Wendy Ansell Constantine Alifrangis Benjamin Thomas Peter Wilson Sara Stoneham Danish Mazhar Anne Warren Tristan Barrett Susanna Alexander Sarah Rudman Michelle Lockley Daniel Berney Anju Sahdev 《British journal of cancer》2021,124(2):368
Background The germ cell supranetwork multidisciplinary team (SMDT) for the Anglian Network covers a population of 7.5 million.Methods We reviewed 10 years of SMDT discussion and categorised them into five domains ((1) overall outcome, (2) chemotherapy regimens—untreated disease and salvage therapy, (3) radiology, (4) pathology and (5) complex cases) to assess the impact of the SMDT.Results A total of 2892 new cases were reviewed. In the first 5 years, patients with good prognosis disease had poorer survival in low-volume vs high-volume centres (87.8 vs 95.3, p = 0.02), but the difference was no longer significant in the last 5 years (93.3 vs 95.1, p = 0.30). Radiology review of 3206 scans led to rejection of the diagnosis of progression in 26 cases and a further 10 cases were down-staged. There were 790 pathology reviews by two specialised uropathologists, which lead to changes in 75 cases. 18F-fluorodeoxyglucose (18FDG) PET-CT was undertaken during this time period but did not help to predict who would have viable cancer. A total of 26 patients with significant mental health issues who were unable to give informed consent were discussed.Conclusion SMDT working has led to an improvement in outcomes and refining of treatment in patients with germ cell tumours.Subject terms: Germ cell tumours, Health policy 相似文献
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Relative lung deposition of salbutamol following inhalation from a spacer and a Sidestream jet nebulizer following an acute exacerbation 总被引:1,自引:1,他引:0
Mazhar SH Ismail NE Newton DA Chrystyn H 《British journal of clinical pharmacology》2008,65(3):334-337
Background
Studies comparing inhalation methods in acute exacerbations have not assessed lung deposition.Methods
Five 100-μg salbutamol doses were inhaled from a metered dose inhaler plus spacer (MDI + SP) and 5 mg was nebulized (NEB) following acute exacerbation hospitalization. Urinary salbutamol excretion was determined at 30 min (USAL0.5) and over 24 h (USAL24) postinhalation together with forced expiratory volume in 1 s (FEV1).Results
The USAL0.5 mean ratio (90% confidence interval) post MDI + SP and NEB [n = 19 asthma, 11 chronic obstructive pulmonary disease (COPD)] was 1.01 (0.81, 1.26). USAL24 was less (P < 0.001) following MDI + SP, whereas FEV1 was similar. Only a small difference between asthmatics and COPD patients was observed for the MDI + SP in that the USAL0.5 was higher in the asthmatics for the spacer method.Conclusion
The relative lung deposition after inhaling 500 μg salbutamol from MDI + SP is similar to 5 mg from a Sidestream nebulizer following an acute exacerbation.What is already known about this subject
- Studies have shown that a large volume spacer attached to a metered dose inhaler provides similar bronchodilator effects to nebulized dosing during the management of patients following an acute exacerbation.
- Due to the high doses used, these effects could be measured at the top of the dose–response relationship and the response limited due to the patient''s exacerbation.
- Although clinical end-points are the gold standard to show comparability, some indication of similar lung deposition is useful to consolidate any claims.
What this study adds
- The urinary pharmacokinetic method we have used postinhalation provides an index of lung deposition for inhalation methods that can be incorporated into the routine management of patients with an acute exacerbation.
- This is the first study to identify and compare lung deposition and systemic delivery for inhalation methods within the setting of the routine management of asthma and chronic obstructive pulmonary disease patients following hospitalization due to an acute exacerbation.
- The study highlights the comparability of the doses for the two inhalation methods evaluated with respect to lung deposition, systemic delivery and bronchodilator response.