全文获取类型
收费全文 | 6812篇 |
免费 | 427篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 41篇 |
儿科学 | 277篇 |
妇产科学 | 251篇 |
基础医学 | 777篇 |
口腔科学 | 62篇 |
临床医学 | 1314篇 |
内科学 | 1180篇 |
皮肤病学 | 108篇 |
神经病学 | 504篇 |
特种医学 | 129篇 |
外科学 | 583篇 |
综合类 | 70篇 |
一般理论 | 9篇 |
预防医学 | 1032篇 |
眼科学 | 149篇 |
药学 | 313篇 |
1篇 | |
中国医学 | 5篇 |
肿瘤学 | 446篇 |
出版年
2023年 | 34篇 |
2022年 | 57篇 |
2021年 | 135篇 |
2020年 | 75篇 |
2019年 | 148篇 |
2018年 | 151篇 |
2017年 | 143篇 |
2016年 | 145篇 |
2015年 | 141篇 |
2014年 | 212篇 |
2013年 | 344篇 |
2012年 | 479篇 |
2011年 | 542篇 |
2010年 | 281篇 |
2009年 | 239篇 |
2008年 | 500篇 |
2007年 | 498篇 |
2006年 | 490篇 |
2005年 | 452篇 |
2004年 | 434篇 |
2003年 | 423篇 |
2002年 | 411篇 |
2001年 | 48篇 |
2000年 | 46篇 |
1999年 | 54篇 |
1998年 | 66篇 |
1997年 | 76篇 |
1996年 | 70篇 |
1995年 | 51篇 |
1994年 | 41篇 |
1993年 | 49篇 |
1992年 | 31篇 |
1991年 | 14篇 |
1990年 | 27篇 |
1989年 | 29篇 |
1988年 | 27篇 |
1987年 | 17篇 |
1986年 | 10篇 |
1985年 | 17篇 |
1984年 | 22篇 |
1983年 | 19篇 |
1982年 | 29篇 |
1981年 | 16篇 |
1980年 | 23篇 |
1979年 | 13篇 |
1978年 | 21篇 |
1977年 | 15篇 |
1976年 | 10篇 |
1975年 | 15篇 |
1966年 | 6篇 |
排序方式: 共有7251条查询结果,搜索用时 15 毫秒
11.
Velma Dobson Maureen Maguire Deborah Orel-Bixler Graham Quinn Gui-Shuang Ying 《Optometry and vision science》2003,80(9):650-654
PURPOSE: To compare visual acuity results obtained using the Lea Symbols chart with visual acuity results obtained with the Bailey-Lovie chart in school-aged children and adults using a within-subjects comparison of monocular acuity results. METHODS: Subjects were 62 individuals between 4.5 and 60 years of age, recruited from patients seen in five optometry clinics. Each subject had acuity of the right eye and the left eye tested with the Lea Symbols chart and the Bailey-Lovie chart, with order of testing varied across subjects. Outcome measures were monocular logarithm of the minimum angle of resolution (logMAR) visual acuity and inter-eye acuity difference in logMAR units for each test. RESULTS: Correlation between acuity results obtained with the two charts was high. There was no difference in absolute inter-eye acuity difference measured with the two acuity charts. However, on average, Lea Symbols acuity scores were one logMAR line better than Bailey-Lovie acuity scores, and this difference increased with worse visual acuity. CONCLUSIONS: The Lea Symbols chart provides a measure of inter-eye difference that is similar to that obtained with the Bailey-Lovie chart. However, the monocular acuity results obtained with the Lea Symbols chart differ from those obtained with the Bailey-Lovie chart, and the difference is dependent on the individual's absolute level of visual acuity. 相似文献
12.
Qualitative Data Analysis: An Introduction 总被引:1,自引:1,他引:0
13.
David Hirschwerk Christine C Ginocchio Maureen Bythrow Susan Condon 《Infection control and hospital epidemiology》2006,27(3):315-317
We cared for a patient with methicillin-resistant Staphylococcus aureus bacteremia who experienced clinical failure with daptomycin. The failure was accompanied by progressive elevation of the daptomycin minimum inhibitory concentration during treatment. DNA fingerprinting confirmed that the minimum inhibitory concentration elevation occurred within the same strain of methicillin-resistant Staphylococcus aureus. This observation provides important new information to clinicians who adopt this promising drug for treatment of serious infections caused by methicillin-resistant Staphylococcus aureus. 相似文献
14.
Mary Lou Galantino Michael Baime Maureen Maguire Philippe O Szapary John T Farrar 《Stress and health》2005,21(4):255-261
Work stress, burnout, and diminished empathy are prevalent issues for health‐care professionals. Mindfulness meditation (MM) is one commonly used strategy to manage stress. Measuring salivary cortisol allows for the assessment of serum cortisol level, a known stress level indicator. This study evaluated the association of subject‐reported stress symptoms and salivary cortisol in health‐care professionals, in an 8‐week MM program, with data collected prospectively at baseline and 8 weeks after program completion. Questionnaires [Profile of Mood States—Short Form (POMS‐SF), Maslach Burnout Inventory (MBI), and Interpersonal Reactivity Index (IRI)] measured mood, burnout and empathy. A paired t‐test between groups for pre/post‐salivary cortisol yielded no significant change. The POMS‐SF was most sensitive to change (mean increase 12.4; p = 0.020). Emotional exhaustion, measured in the MBI, was also affected by MM (mean decrease 4.54; p = 0.001). Changes in empathy may not have been captured due to either absence of effect of MM on empathy, subject number or scale sensitivity. Baseline and 8‐week correlations between salivary cortisol and survey results, and correlations between changes in these measures, were weak and not statistically significant. Nevertheless, psychometric results present a strong case for additional clinical trials of MM to reduce stress for health‐care professionals. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
15.
Serum and Cerebrospinal Fluid Pharmacokinetics of Intravenous and Oral Lamivudine in Human Immunodeficiency Virus-Infected Children 总被引:3,自引:3,他引:0
下载免费PDF全文
![点击此处可从《Antimicrobial agents and chemotherapy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Brigitta U. Mueller Linda L. Lewis Geoffrey J. Yuen Maureen Farley Amy Keller Joseph A. Church Jonathan C. Goldsmith David J. Venzon Marc Rubin Philip A. Pizzo Frank M. Balis 《Antimicrobial agents and chemotherapy》1998,42(12):3187-3192
We studied the pharmacokinetics of intravenously and orally administered lamivudine at six dose levels ranging from 0.5 to 10 mg/kg of body weight in 52 children with human immunodeficiency virus infection. A two-compartment model with first-order elimination from the central compartment was simultaneously fitted to the serum drug concentration-time data obtained after intravenous and oral administration. The maximal concentration at the end of the 1-h intravenous infusion and the area under the concentration-time curve after oral and intravenous administration increased proportionally with the dose. The mean clearance of lamivudine (± standard deviation) in the children was 0.53 ± 0.19 liter/kg/h (229 ± 77 ml/min/m2 of body surface area), and the mean half-lives at the distribution and elimination phases were 0.23 ± 0.18 and 2.2 ± 2.1 h, respectively. Clearance was age dependent when normalized to body weight but age independent when normalized to body surface area. Lamivudine was rapidly absorbed after oral administration, and 66% ± 25% of the oral dose was absorbed. Serum lamivudine concentrations were maintained above 1 μM for ≥8 h of 24 h on the twice daily oral dosing schedule with doses of ≥2 mg/kg. The cerebrospinal fluid drug concentration measured 2 to 4 h after the dose was 12% (range, 0 to 46%) of the simultaneously measured serum drug concentration. A limited-sampling strategy was developed to estimate the area under the concentration-time curve for concentrations in serum at 2 and 6 h. 相似文献
16.
Joyce J. Fitzpatrick Sheila Ryan DeWitt Baldwin Roger Bulger Jean Johnson-Pawlson Christopher McLaughlin Maureen Kelley Leopold Selketr Bernardine Lacey Charlene Hanson Robin Harvan Patricia Hinton Walker David Sluyter Mary Joan Ladden Neal Vanselow 《Journal of Midwifery & Women's Health》1998,43(1):61-65
In 1995, the National League for Nursing commissioned a Panel on Interdisciplinary/Transdisciplinary Education. The focus of the Panel's work was to examine educational issues that transcend the health professions and to make recommendations for future implementation of an interdisciplinary approach to addressing them. This article is being simultaneously published by several professional journals. The goal is to seek as much feedback as possible. 相似文献
17.
Naomi Chaytor Maureen Schmitter-Edgecombe 《Journal of the International Neuropsychological Society》2004,10(4):489-503
Age-related declines in working memory performance have been associated with deficits in inhibition, strategy use, processing speed, and monitoring. In the current study, cross-sectional and longitudinal methodologies were used to investigate the relative contribution of these components to age-related changes in working memory. In Experiment 1, a sample of 140 younger and 140 older adults completed an abstract design version of the Self-Ordered Pointing Task modeled after Shimamura and Jurica (1994). Experiment 1 revealed that only processing speed and monitoring explained age differences in SOPT performance. Participants in Experiment 2 were 53 older adults who returned 4 years after the initial testing and 53 young adults. A task that assessed the ability to generate and monitor an internal series of responses as compared to an externally imposed series of responses was also administered. Experiment 2 replicated the key findings from Experiment 1 and provided some further evidence for age-related internal monitoring difficulties. Furthermore, the exploratory longitudinal analysis revealed that older age and lower intellectual abilities tended to be associated with poorer performance on the SOPT at Time 2. 相似文献
18.
Carol E. Golin Katherine Tiller E. Byrd Quinlivan Catherine A. Grodensky Maureen Boland 《AIDS and behavior》2007,11(1):72-83
The epidemiology of HIV infection in the US in general, and in the southeast, in particular, has shifted dramatically over the past two decades, increasingly affecting women and minorities. The site for our intervention was an infectious diseases clinic based at a university hospital serving over 1,300 HIV-infected patients in North Carolina. Our patient population is diverse and reflects the trends seen more broadly in the epidemic in the southeast and in North Carolina. Practicing safer sex is a complex behavior with multiple determinants that vary by individual and social context. A comprehensive intervention that is client-centered and can be tailored to each individual’s circumstances is more likely to be effective at reducing risky behaviors among clients such as ours than are more confrontational or standardized prevention messages. One potential approach to improving safer sex practices among people living with HIV/AIDS (PLWHA) is Motivational Interviewing (MI), a non-judgmental, client-centered but directive counseling style. Below, we describe: (1) the development of the Start Talking About Risks (STAR) MI-based safer sex counseling program for PLWHA at our clinic site; (2) the intervention itself; and (3) lessons learned from implementing the intervention. 相似文献
19.
20.