全文获取类型
收费全文 | 3999篇 |
免费 | 275篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 68篇 |
儿科学 | 71篇 |
妇产科学 | 54篇 |
基础医学 | 534篇 |
口腔科学 | 49篇 |
临床医学 | 501篇 |
内科学 | 721篇 |
皮肤病学 | 28篇 |
神经病学 | 475篇 |
特种医学 | 208篇 |
外科学 | 516篇 |
综合类 | 49篇 |
一般理论 | 9篇 |
预防医学 | 455篇 |
眼科学 | 54篇 |
药学 | 278篇 |
中国医学 | 8篇 |
肿瘤学 | 212篇 |
出版年
2023年 | 36篇 |
2022年 | 67篇 |
2021年 | 119篇 |
2020年 | 75篇 |
2019年 | 123篇 |
2018年 | 137篇 |
2017年 | 90篇 |
2016年 | 109篇 |
2015年 | 140篇 |
2014年 | 163篇 |
2013年 | 218篇 |
2012年 | 316篇 |
2011年 | 327篇 |
2010年 | 195篇 |
2009年 | 128篇 |
2008年 | 265篇 |
2007年 | 243篇 |
2006年 | 210篇 |
2005年 | 235篇 |
2004年 | 195篇 |
2003年 | 170篇 |
2002年 | 192篇 |
2001年 | 47篇 |
2000年 | 55篇 |
1999年 | 54篇 |
1998年 | 32篇 |
1997年 | 20篇 |
1996年 | 16篇 |
1995年 | 17篇 |
1994年 | 13篇 |
1993年 | 18篇 |
1992年 | 21篇 |
1991年 | 35篇 |
1990年 | 23篇 |
1989年 | 12篇 |
1988年 | 19篇 |
1987年 | 12篇 |
1986年 | 15篇 |
1985年 | 16篇 |
1984年 | 10篇 |
1983年 | 6篇 |
1981年 | 5篇 |
1980年 | 11篇 |
1979年 | 9篇 |
1978年 | 7篇 |
1976年 | 5篇 |
1975年 | 6篇 |
1974年 | 5篇 |
1973年 | 8篇 |
1970年 | 5篇 |
排序方式: 共有4290条查询结果,搜索用时 15 毫秒
71.
72.
J L Richard P Ducimetière G Bonnaud J R Claude J Lellouch D Schwartz J Di Mattéo 《Archives des maladies du coeur et des vaisseaux》1977,70(5):531-540
The Paris prospective study in an epidemiological study of 7,453 middle-aged men born in France, and initially free from ischaemic heart disease. The current mean follow-up time is 4 years. The mean annual incidence is 5.1 per 1000, which is about one half that found in similar american studies. This incidence is related to the cholesterol level, to the blood pressure, to cigarette consumption when the smoke is inhaled, to diabetes mellitus, and to major abnormalities on the electrocardiogram. These five factors are mutually independant in their prediction of the risk of future illness. A formula has been derived by statistical analysis, and takes these five factors into account: the incidence of illness rises exponentially as a function of this formula. New cases of ischaemic heart disease are distributed, but with a very patchy incidence, in this population, of which only a very small number remain disease-free. A table has been drawn up to show the probability of a middle aged male contracting ischeamic heart disease within 4 years, and takes the 5 factors into account: this probability varies between 0.5 per cent and 34 per cent. 相似文献
73.
Matt Tincani Maia Bloomfield Cucchiarra S. Kenneth Thurman Mark R. Snyder Catherine M. McCarthy 《Child & youth care forum》2014,43(3):315-337
Background
Over a decade ago, the National Research Council (NRC) published the influential book, Educating Children with Autism.Objective
To survey parents and state-level special education administrators to evaluate how NRC’s recommendations, as published in Educating Children with Autism, have impacted educational practices for children with autism in the US.Methods
149 parents of children with autism and 35 state-level special education administrators from 35 states were surveyed on the degree to which they agreed with NRC’s recommendations and the degree to which they believed NRC’s recommendations have been implemented.Results
Parents and administrators agreed with most NRC recommendations; however, disagreements between parents and administrators were evident regarding labeling of students with autism, intensity of services, and training of staff. Conversely, parents and administrators concurred that the recommendations had been poorly to modestly implemented, overall. Lowest levels of implementation were found for training of qualified staff, research-based curricula, and mental health supports for families. Qualitative analysis of parents’ comments highlighted that vigorous advocacy was necessary for their children to receive appropriate services consistent with NRC’s recommendations.Conclusions
Over a decade following publication of Educating Children with Autism, most of NRC’s recommendations have not been fully implemented. Policy makers should focus particular attention on improving professional training, disseminating research-based practices, and providing mental health supports for families. 相似文献74.
Melanie M. Saw Jenny Chamberlain Michelle Barr Matt P. G. Morgan John R. Burnett Kwok M. Ho 《Neurocritical care》2014,20(2):209-216
Background
Traumatic brain injury (TBI) is a significant cause of death and disability in young adults, but not much is known about the incidence and characteristics of blood–brain barrier (BBB) dysfunction in this group. In this proof of concept study, we sought to quantify the incidence of BBB dysfunction (defined as a cerebrospinal fluid (CSF)–plasma albumin quotient of ≥0.007) and examine the relationship between plasma and CSF levels of proteins and electrolytes, in patients with severe TBI.Methods
We recruited 30 patients, all of whom were receiving hypertonic 20 % saline infusion for intracranial hypertension and had external ventricular drains in situ. Simultaneous CSF and blood samples were obtained. Biochemical testing was performed for sodium, osmolality, potassium, glucose, albumin, immunoglobulin-G, and total protein.Results
Eleven patients (37 %) showed evidence of impairment of passive BBB function, with a CSF–plasma albumin quotient of ≥0.007. There were strong positive correlations seen among CSF–plasma albumin quotient and CSF–plasma immunoglobulin-G quotient and CSF–plasma total protein quotient (r = 0.967, P < 0.001 and r = 0.995, P < 0.001, respectively). We also found a higher maximum intracranial pressure (24 vs. 21 mmHg, P = 0.029) and a trend toward increased mortality (27 vs. 11 %, P = 0.33) in patients with BBB disruption.Conclusions
In summary, passive BBB dysfunction is common in patients with severe TBI, and may have important implications for effectiveness of osmotherapy and long-term outcomes. Also, our results suggest that the CSF–plasma total protein quotient, a measurement which is readily available, can be used instead of the CSF–plasma albumin quotient for evaluating BBB dysfunction. 相似文献75.
76.
Hassan Awada Reda Z. Mahfouz Jibran Durrani Ashwin Kishtagari Deepa Jagadeesh Alan E. Lichtin Brian T. Hill Betty K. Hamilton Hetty E. Carraway Aziz Nazha Navneet S. Majhail Ronald Sobecks Valeria Visconte Matt Kalaycio Mikkael A. Sekeres Jaroslaw P. Maciejewski 《British journal of haematology》2020,189(2):318-322
T-cell large granular lymphocytic leukaemia (T-LGLL) is a chronic clonal lymphoproliferative disorder of cytotoxic T lymphocytes which commonly occurs in older patients and is often associated with autoimmune diseases. Among 246 patients with T-LGLL seen at our institution over the last 10 years, we encountered 15 cases following solid organ or haematopoietic stem cell transplantation. Here, we studied the clinical characterization of these cases and compared them to de novo T-LGLL. This experience represented a clear picture of the intricate nature of the disease manifestation and the complexities of several immune mechanisms triggering the clonal expansion. 相似文献
77.
Manoj K. Mittal MD Joel S. Tieder MD MPH Kathryn Westphal MD Erin Sullivan MPH Matt Hall PhD Risa Bochner MD Adam Cohen MD Jennifer Y. Colgan MD Atima C. Delaney MD Amy M. DeLaroche MBBS Thomas Graf MD Beth Harper MD Ron L. Kaplan MD Hannah C. Neubauer MD Mark I. Neuman MD MPH Nirav Shastri MD Victoria Wilkins MD MPH Allayne Stephans MD 《Academic emergency medicine》2023,30(6):662-670
78.
Anderson Rech MS Regis Radaelli MS Adriano M. De Assis PhD João R. Fernandes MS Aline Longoni PhD Magdolna M. Vozari‐Hampe PhD Ronei S. Pinto PhD Cristiane Matté PhD 《Muscle & nerve》2014,50(1):79-86
Introduction: In this study we examined oxidative stress and skeletal muscle damage resulting from acute strength, aerobic, or concurrent exercise in rats. Methods: The animals were divided into control (C), strength (SE), aerobic (AE), and combined (CE) exercise groups. They were euthanized at 3 different time‐points (6, 24, and 48 h) after acute exercise. Results: SE exercise rats had increased dichlorofluorescein oxidation at 6 h post‐exercise and decreased superoxide dismutase activity at all time‐points. Glutathione peroxidase activity and sulfhydryl levels were increased in the AE group at 48 h post‐exercise. Serum lactate dehydrogenase activity was increased in the SE and CE groups at 24 h and in the AE group at 48 h. Echo intensity was elevated at 24 h for all groups. Conclusions: Forty‐eight hours was sufficient for complete recovery from oxidative stress and muscle damage in the SE and CE groups, but not in the AE group. Muscle Nerve 50 : 79–86, 2014 相似文献
79.
80.