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71.
Akatsuki Kokaze Mamoru Ishikawa Naomi Matsunaga Masao Yoshida Masao Satoh Koji Teruya Yumi Masuda Rie Honmyo Yoshiko Uchida Yutaka Takashima 《Hypertension research》2007,30(3):213-218
NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity in the Japanese population, and the ND2-237Met genotype may exert antiatherogenic effects. To investigate whether ND2-237 Leu/Met polymorphism is associated with risk of hypertension, we conducted a cross-sectional study of 398 Japanese male subjects. The frequency of hypertension was significantly higher in ND2-237Leu genotypic men than in ND2-237Met genotypic men. On analysis of covariance, the interaction between ND2-237 Leu/Met polymorphism and habitual drinking was significantly associated with both systolic blood pressure and diastolic blood pressure. Multiple logistic regression analysis revealed that the ND2-237Met genotype, particularly in younger subjects (age <60 years), had a lower odds ratio for hypertension than the ND2-237Leu genotype. Moreover, the association of ND2-237 Leu/Met polymorphism with hypertension may depend on the frequency of alcohol consumption. The odds ratio for hypertension was significantly higher in daily drinkers with ND2-237Leu when compared with non- or ex-drinkers with ND2-237Leu. However, the association between the ND2-237Met genotype and hypertension may not depend on the frequency of alcohol consumption. The present results suggest that ND2-237 Leu/Met polymorphism is associated with hypertension and that modification of hypertension risk is dependent on alcohol consumption in middle-aged Japanese men. 相似文献
72.
Mari Terada Satoshi Kutsuna Tomiteru Togano Sho Saito Noriko Kinoshita Yumiko Shimanishi Tetsuya Suzuki Yusuke Miyazato Makoto Inada Takahito Nakamoto Hidetoshi Nomoto Satoshi Ide Mitsuhiro Sato Kenji Maeda Akihiro Matsunaga Masahiro Satake Keiji Matsubayashi Hirokazu Tsuno Makiko Kojima Madoka Kuramistu Kenta Tezuka Emi Ikebe Kazu Okuma Isao Hamaguchi Katsuyuki Shiratori Motohiko Sato Yuiko Kawakami Kumi Inaba Saori Igarashi Reina Yamauchi Mina Matsumura Keiko Ishimaru Bijuan Zhang Chika Kuge Maiko Ishihara Miho Gouda Keiko Tanaka Yukihito Ishizaka Norio Ohmagari 《Transfusion》2021,61(7):1998-2007
73.
Sho Saito Kayoko Hayakawa Shinya Tsuzuki Masahiro Ishikane Maki Nagashima Kazuhisa Mezaki Yuko Sugiki Taichi Tajima Nobuaki Matsunaga Satoshi Ide Noriko Kinoshita Yoshiki Kusama Yumiko Fujitomo Takato Nakamoto Yuta Toda Mitsuo Kaku Eiichi N. Kodama Norio Ohmagari 《Antimicrobial agents and chemotherapy》2021,65(3)
74.
Hiroaki Saito Kozo Miyatani Seigo Takaya Tomoyuki Matsunaga Yoji Fukumoto Tomohiro Osaki Toshiro Wakatsuki Masahide Ikeguchi 《Yonago acta medica》2013,56(3):73-78
Background
Although the clinicopathologic features and prognosis of Borrmann type advanced gastric cancer has been well characterized, those of advanced gastric cancer simulating early gastric cancer (AGC simulating EGC) still remains unclear.Methods
We reviewed 1985 gastric cancer patients who had undergone gastrectomy at our hospital to determine the clinicopathologic characteristics, susceptible sites for lymph node metastasis, and prognosis of AGC simulating EGC in comparison with Borrmann type advanced gastric cancer.Results
Among 102 patients with AGC simulating EGC, 100 patients (98%) had tumors with depressed type appearance. The frequencies of serosal invasion, lymph node metastasis, lymphatic vessel invasion, blood vessel invasion, and liver metastasis were significantly lower in AGC simulating EGC than in Borrmann type tumors. The prognosis of AGC simulating EGC was significantly better than that of the Borrmann type tumors. Multivariate analysis indicated that the gross appearance was an independent prognostic factor. In patients with AGC simulating EGC which invaded to the the muscularis propria (MP), most lymph node metastasis was restricted with the perigastric lymph nodes (1st-titer lymph nodes) and lymph node metastasis to 2nd-titer lymph nodes was only observed at station 8a.Conclusion
AGC simulating EGC is less advanced in comparison with Borrmann type advanced gastric cancer. Based on the results of susceptible sites for lymph node metastasis in the current study, limited lymph node dissection could be indicated for AGC simulating EGC whose depth of invasion is MP. 相似文献75.
Isoshima Daichi Yamashiro Keisuke Matsunaga Kazuyuki Taniguchi Makoto Matsubara Takehiro Tomida Shuta Ota Shinzo Sato Michiyoshi Shimoe Yutaka Kohriyama Tatsuo Arias Zulema Omori Kazuhiro Yamamoto Tadashi Takashiba Shogo 《Odontology / the Society of the Nippon Dental University》2021,109(1):239-249
Odontology - There is no conclusive evidence regarding a causal relationship between periodontitis and atherosclerosis. In this study, we examined the microbiome in the oral cavity and atheromatous... 相似文献
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77.
Y Matsunaga A Kawaguchi K Kobayashi Y Kinomura M Kobayashi Y Asada K Minami S Suzuki K Chida 《The British journal of radiology》2015,88(1052)
Objective:
The aims of this study are to propose a new set of Japanese diagnostic reference levels (DRLs) for 2014 and to study the impact of tube voltage and the type of reconstruction algorithm on patient doses. The volume CT dose index (CTDIvol) for adult and paediatric patients is assessed and compared with the results of a 2011 national survey and data from other countries.Methods:
Scanning procedures for the head (non-helical and helical), chest and upper abdomen were examined for adults and 5-year-old children. A questionnaire concerning the following items was sent to 3000 facilities: tube voltage, use of reconstruction algorithms and displayed CTDIvol.Results:
The mean CTDIvol values for paediatric examinations using voltages ranging from 80 to 100 kV were significantly lower than those for paediatric examinations using 120 kV. For adult examinations, the use of iterative reconstruction algorithms significantly reduced the mean CTDIvol values compared with the use of filtered back projection. Paediatric chest and abdominal scans showed slightly higher mean CTDIvol values in 2014 than in 2011. The proposed DRLs for adult head and abdominal scans were higher than those reported in other countries.Conclusion:
The results imply that further optimization of CT examination protocols is required for adult head and abdominal scans as well as paediatric chest and abdominal scans.Advances in knowledge:
Low-tube-voltage CT may be useful for reducing radiation doses in paediatric patients. The mean CTDIvol values for paediatric scans showed little difference that could be attributed to the choice of reconstruction algorithm.Since the introduction of CT in the 1970s, it has been established worldwide as one of the most important imaging modalities in diagnostic radiology. In the past decade, various dose-reduction techniques, such as tube current modulation1 and low tube voltage,2 have been shown to reduce radiation exposure. In particular, the use of an iterative reconstruction (IR) algorithm, in contrast to a filtered back projection (FBP) algorithm, has provided diagnostically acceptable images using low-radiation-dose CT.3,4Since estimates of the cancer risk attributable to the use of diagnostic X-rays have been reported,5,6 radiological technologists should aim to optimize scan parameters in order to avoid excessive radiation exposure. One powerful tool in this optimization applies the concept of diagnostic reference levels (DRLs). The DRLs of CT examinations are generally expressed in terms of the volume CT dose index (CTDIvol) or dose–length product. The DRL is used in medical imaging with ionizing radiation to indicate whether, in routine conditions, the patient dose from a specified procedure is unusually high or low; DRLs are usually reviewed at regular intervals and could be specific to a country or region.7 Surveys of DRLs for CT examination of adults8–11 and children12,13 have been reported in several countries.The current DRLs in Japan were established as target values by the Japan Association of Radiological Technologists in 2006. The DRLs refer to a set of medical exposure guidelines, although there are several issues with these guidelines.14 First, no more than two examinations (head and abdomen) are listed in DRLs, and they contain no information about the CT examination of children. Second, the DRL for abdomen examination employs a 30-cm phantom, whereas a 32-cm phantom is more commonly used worldwide. Therefore, a new set of Japanese DRLs has become an urgent necessity. In 2011, Asada et al15 reported mean CTDIvol values for the head (non-helical and helical), chest and upper abdomen of both adults and children, which were obtained using a nationally distributed questionnaire. The aims of this study are to propose a new set of Japanese DRLs for 2014 and to study the impact of tube voltage and the type of reconstruction algorithm on patient doses. The CTDIvol for both adults and children have been assessed and compared with both the results of the 2011 survey and data from other countries. 相似文献78.
79.
80.