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41.
Keiji Matsunaga Asako Mizobuchi Hai Ying Fu Shohei Ishikawa Hayato Tada Masa-aki Kawashiri Ichiro Yokota Tsuyoshi Sasaki Shigeru Ito Jun Kunikata Takashi Iwase Tomohiro Hirao Katsunori Yokoyama Yoichi Hoshikawa Takuji Fujisawa Kazushige Dobashi Takashi Kusaka Tetsuo Minamino 《Journal of atherosclerosis and thrombosis》2022,29(6):839
Aim: Familial hypercholesterolemia (FH) is an underdiagnosed autosomal dominant genetic disorder characterized by high levels of plasma low-density lipoprotein cholesterol (LDL-C) from birth. This study aimed to assess the genetic identification of FH in children with high LDL-C levels who are identified in a universal pediatric FH screening in Kagawa, Japan. Method: In 2018 and 2019, 15,665 children aged 9 or 10 years underwent the universal lipid screening as part of the annual health checkups for the prevention of lifestyle-related diseases in the Kagawa prefecture. After excluding secondary hyper-LDL cholesterolemia at the local medical institutions, 67 children with LDL-C levels of ≥ 140 mg/dL underwent genetic testing to detect FH causative mutations at four designated hospitals. Results: The LDL-C levels of 140 and 180 mg/dL in 15,665 children corresponded to the 96.3 and 99.7 percentile values, respectively. Among 67 children who underwent genetic testing, 41 had FH causative mutations (36 in the LDL-receptor, 4 in proprotein convertase subtilisin/kexin type 9, and 1 in apolipoprotein B). The area under the curve of receiver operating characteristic curve predicting the presence of FH causative mutation by LDL-C level was 0.705, and FH causative mutations were found in all children with LDL-C levels of ≥ 250 mg/dL. Conclusion: FH causative mutations were confirmed in almost 60% of the referred children, who were identified through the combination of the lipid universal screening as a part of the health checkup system and the exclusion of secondary hyper-LDL cholesterolemia at the local medical institutions. 相似文献
42.
43.
Kazuhiko Sasai Rikuo Tanaka Mitsutoshi Kawamura Kazumitsu Honjo Naofumi Matsunaga Taishi Nakada Kiichi Homma Hiroshi Fujimura 《Journal of gastroenterology》1996,31(4):505-511
The requirement for well spread out chromosomes for the cytogenetic analysis of primary gastrointestinal tumors led us to
develop new techniques. These techniques involved two main procedures: (1) preliminary incubation with culture medium in the
presence of collagenase, Dispase, and colcemid, for 3h, and (2) treatment with an extremely hypotonic solution (0.044 M KCl)
for 30 min. The techniques were applied to 11 gastrointestinal malignancies (including 1 early gastric cancer and 1 metastatic
liver lesion of colon cancer) and significant increases (P<0.01) in the number of metaphases of analyzable karyotypes were obtained, compared with a previous method in which the standard
hypotonic molarity of KCL (0.075 M) was employed. The mean value for metaphase numbers of the analyzable karyotypes was 37.0±3.7%
in the 5 gastric cancers and 44.7±4.8% in the 5 colon cancers and 1 metastatic lesion. These values were three times and more
than twice, respectively, the values obtained by the previous method. A fluorescence in situ hybridization (FISH) study was
carried out on one cologenic tumor, the α-satellite centromere-specific probe 17 being used. Deletion of the long arm of chromosome
17 was demonstrated. The method proposed here could yield a sufficient number of metaphases without the use of tissue culture
that might cause alteration of karyotype. It can be employed with small biopsy specimens and in studies utilizing the FISH
technique. 相似文献
44.
Tsukasa Mori Koichi Handa Yasunori Terao Hiroaki Tanaka Akira Kiyonaga Munehiro Shindo Akira Matsunaga Jun Sasaki Kikuo Arakawa 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》1992,6(4):387-390
Summary A placebo-controlled, double-blind crossover study was undertaken in 10 normal subjects to examine the effects of arotinolol (10 mg bid), a nonselective beta blocker with alpha-blocking activity, on exercise capacity and hormone levels during exercise after a 2-week treatment period. Maximal oxygen uptake (VO2 max) and blood lactic acid concentration (LA) were measured during progressive exercise testing. An exercise intensity equivalent to 4 mmol/l of LA was used for the constant workload exercise test. Humoral factors were measured after 20 minutes of constant workload exercise. The administration of arotinolol significantly decreased systolic blood pressure and heart rate at rest and during exercise, but diastolic blood pressure did not change. No significant difference was found between arotinolol and placebo with regard to VO2 max and maximal workload. Plasma renin activity (PRA), aldosterone (PAC), and norepinephrine (NE) levels at rest and during exercise did not differ between the two treatments. In contrast, plasma epinephrine (EN) levels at rest and during exercise were significantly greater with arotinolol. Atrial natriuretic peptide (ANP) at rest did not differ between the two treatments. However, exercise caused a significant increase in ANP after arotinolol treatment. These findings suggest that arotinolol decreases blood pressure and heart rate without affecting exercise capacity. 相似文献
45.
46.
Haruno Nishimuro Hirofumi Ohnishi Midori Sato Mayumi Ohnishi-Kameyama Izumi Matsunaga Shigehiro Naito Katsunari Ippoushi Hideaki Oike Tadahiro Nagata Hiroshi Akasaka Shigeyuki Saitoh Kazuaki Shimamoto Masuko Kobori 《Nutrients》2015,7(4):2345-2358
Quercetin is a promising food component, which can prevent lifestyle related diseases. To understand the dietary intake of quercetin in the subjects of a population-based cohort study and in the Japanese population, we first determined the quercetin content in foods available in the market during June and July in or near a town in Hokkaido, Japan. Red leaf lettuce, asparagus, and onions contained high amounts of quercetin derivatives. We then estimated the daily quercetin intake by 570 residents aged 20–92 years old in the town using a food frequency questionnaire (FFQ). The average and median quercetin intakes were 16.2 and 15.5 mg day−1, respectively. The quercetin intakes by men were lower than those by women; the quercetin intakes showed a low correlation with age in both men and women. The estimated quercetin intake was similar during summer and winter. Quercetin was mainly ingested from onions and green tea, both in summer and in winter. Vegetables, such as asparagus, green pepper, tomatoes, and red leaf lettuce, were good sources of quercetin in summer. Our results will help to elucidate the association between quercetin intake and risks of lifestyle-related diseases by further prospective cohort study and establish healthy dietary requirements with the consumption of more physiologically useful components from foods. 相似文献
47.
Matsuda Hiroshi Okita Kyoji Motoi Yumiko Mizuno Toshiki Ikeda Manabu Sanjo Nobuo Murakami Koji Kambe Taiki Takayama Toshiki Yamada Kei Suehiro Takashi Matsunaga Keiko Yokota Takanori Tateishi Ukihide Shigemoto Yoko Kimura Yukio Chiba Emiko Kawashima Takahiro Tomo Yui Tachimori Hisateru Kimura Yuichi Sato Noriko 《Annals of nuclear medicine》2022,36(12):1039-1049
Annals of Nuclear Medicine - Amyloid positron emission tomography (PET) can reliably detect senile plaques and fluorinated ligands are approved for clinical use. However, the clinical impact of... 相似文献
48.
Akatsuki Kokaze Mamoru Ishikawa Naomi Matsunaga Masao Yoshida Masao Satoh Koji Teruya Yumi Masuda Rie Honmyo Yoshiko Uchida Yutaka Takashima 《Hypertension research》2007,30(3):213-218
NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity in the Japanese population, and the ND2-237Met genotype may exert antiatherogenic effects. To investigate whether ND2-237 Leu/Met polymorphism is associated with risk of hypertension, we conducted a cross-sectional study of 398 Japanese male subjects. The frequency of hypertension was significantly higher in ND2-237Leu genotypic men than in ND2-237Met genotypic men. On analysis of covariance, the interaction between ND2-237 Leu/Met polymorphism and habitual drinking was significantly associated with both systolic blood pressure and diastolic blood pressure. Multiple logistic regression analysis revealed that the ND2-237Met genotype, particularly in younger subjects (age <60 years), had a lower odds ratio for hypertension than the ND2-237Leu genotype. Moreover, the association of ND2-237 Leu/Met polymorphism with hypertension may depend on the frequency of alcohol consumption. The odds ratio for hypertension was significantly higher in daily drinkers with ND2-237Leu when compared with non- or ex-drinkers with ND2-237Leu. However, the association between the ND2-237Met genotype and hypertension may not depend on the frequency of alcohol consumption. The present results suggest that ND2-237 Leu/Met polymorphism is associated with hypertension and that modification of hypertension risk is dependent on alcohol consumption in middle-aged Japanese men. 相似文献
49.
Sho Saito Kayoko Hayakawa Shinya Tsuzuki Masahiro Ishikane Maki Nagashima Kazuhisa Mezaki Yuko Sugiki Taichi Tajima Nobuaki Matsunaga Satoshi Ide Noriko Kinoshita Yoshiki Kusama Yumiko Fujitomo Takato Nakamoto Yuta Toda Mitsuo Kaku Eiichi N. Kodama Norio Ohmagari 《Antimicrobial agents and chemotherapy》2021,65(3)
50.
Isoshima Daichi Yamashiro Keisuke Matsunaga Kazuyuki Taniguchi Makoto Matsubara Takehiro Tomida Shuta Ota Shinzo Sato Michiyoshi Shimoe Yutaka Kohriyama Tatsuo Arias Zulema Omori Kazuhiro Yamamoto Tadashi Takashiba Shogo 《Odontology / the Society of the Nippon Dental University》2021,109(1):239-249
Odontology - There is no conclusive evidence regarding a causal relationship between periodontitis and atherosclerosis. In this study, we examined the microbiome in the oral cavity and atheromatous... 相似文献