全文获取类型
收费全文 | 3212篇 |
免费 | 180篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 47篇 |
妇产科学 | 77篇 |
基础医学 | 384篇 |
口腔科学 | 100篇 |
临床医学 | 247篇 |
内科学 | 710篇 |
皮肤病学 | 107篇 |
神经病学 | 491篇 |
特种医学 | 108篇 |
外科学 | 539篇 |
综合类 | 8篇 |
预防医学 | 107篇 |
眼科学 | 29篇 |
药学 | 173篇 |
中国医学 | 3篇 |
肿瘤学 | 269篇 |
出版年
2024年 | 4篇 |
2023年 | 24篇 |
2022年 | 70篇 |
2021年 | 133篇 |
2020年 | 81篇 |
2019年 | 83篇 |
2018年 | 118篇 |
2017年 | 102篇 |
2016年 | 117篇 |
2015年 | 111篇 |
2014年 | 172篇 |
2013年 | 205篇 |
2012年 | 282篇 |
2011年 | 284篇 |
2010年 | 169篇 |
2009年 | 143篇 |
2008年 | 244篇 |
2007年 | 208篇 |
2006年 | 176篇 |
2005年 | 186篇 |
2004年 | 175篇 |
2003年 | 164篇 |
2002年 | 111篇 |
2001年 | 9篇 |
2000年 | 7篇 |
1999年 | 13篇 |
1998年 | 10篇 |
1997年 | 4篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1985年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有3419条查询结果,搜索用时 15 毫秒
41.
42.
43.
Kellie Hamill Ria Jumabhoy Piyumi Kahawage Massimiliano de Zambotti Elizabeth M Walters Sean P. A. Drummond 《Journal of sleep research》2020,29(1)
Accurate assessment of sleep can be fundamental for monitoring, managing and evaluating treatment outcomes within diseases. A proliferation of consumer activity trackers gives easy access to objective sleep. We evaluated the performance of a commercial device (Fitbit Alta HR) relative to a research‐grade actigraph (Actiwatch Spectrum Pro) in measuring sleep before and after a cognitive behavioural intervention in insomnia disorder. Twenty‐five individuals with DSM‐5 insomnia disorder (M = 50.6 ± 15.9 years) wore Fitbit and Actiwatch and completed a sleep diary during an in‐laboratory polysomnogram, and for 1 week preceding and following seven weekly sessions of cognitive‐behavioural intervention for insomnia. Device performance was compared for sleep outcomes (total sleep time, sleep latency, sleep efficiency and wake after sleep onset). The analyses assessed (a) agreement between devices across days and pre‐ to post‐treatment, and (b) whether pre‐ to post‐treatment changes in sleep assessed by devices correlated with clinical measures of change. Devices generally did not significantly differ from each other on sleep variable estimates, either night to night, in response to sleep manipulation (pre‐ to post‐treatment) or in response to changes in environment (in the laboratory versus at home). Change in sleep measures across time from each device showed some correlation with common clinical measures of change in insomnia, but not insomnia diagnosis as a categorical variable. Overall, the Fitbit provides similar estimates of sleep outside the laboratory to a research grade actigraph. Despite the similarity between Fitbit and Actiwatch performance, the use of consumer technology is still in its infancy and caution should be taken in its interpretation. 相似文献
44.
45.
46.
47.
48.
Alessandro Mandurino-Mirizzi Stefano Cornara Alberto Somaschini Andrea Demarchi Marco Galazzi Sebastiano Puccio Claudio Montalto Gabriele Crimi Marco Ferlini Rita Camporotondo Massimiliano Gnecchi Maurizio Ferrario Luigi Oltrona-Visconti Gaetano M. De Ferrari 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2021,31(2):608-614
Background and aimsDespite elevated serum uric acid (eSUA) has been identified as independent risk factor for cardiovascular diseases, its prognostic value in the setting of ST-segment elevation myocardial infarction (STEMI) is still controversial. Although the mechanisms of this possible relationship are unsettled it has been suggested that eSUA could trigger the inflammatory response. This study sought to investigate the association between eSUA with short- and long-term mortality and with inflammatory response in patients with STEMI treated with primary percutaneous coronary intervention (pPCI).Methods and resultsBlood samples were collected on admission and at 24 and 48 h after pPCI: the inflammatory biomarkers C-reactive protein (CRP), neutrophil count and neutrophil to lymphocytes ratio (NLR) were considered. Baseline eSUA was defined as ≥6.8 mg/dl. Cumulative 30-days and 1-year mortalities were estimated using the Kaplan-Meyer analysis. Multivariable analyses were performed by Cox proportional hazard models.In the 2369 patients with STEMI considered, 30-day mortality was 5.8% among patients with eSUA and 2% among patient with normal SUA level (p < 0.001); 1-year mortality was 8.5% vs 4%, respectively (p < 0.001). At multivariable analyses eSUA was an independent predictor of 30-day mortality (HR 1.196, 95%CI 1.006–1.321, p = 0.042) and 1-year mortality (HR 1.178, 95%CI 1.052–1.320, p = 0.005). eSUA patients presented higher values in on admission CRP (p < 0.001) and in neutrophil count and NLR at 24 h (respectively, p = 0.020 and p < 0.001) and at 48 h (p = 0.018 and p < 0.001) compared to patients with normal SUA levels.ConclusionsElevated serum uric acid is associated with higher short- and long-term mortality and with a greater inflammatory response after reperfusion in patients with STEMI treated with primary PCI. 相似文献
49.
50.
Manuele Casale Emanuela Vesperini Massimiliano Potena Marco Pappacena Federica Bressi Peter Jarden Baptista Fabrizio Salvinelli 《Sleep & breathing》2012,16(2):413-417